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Animal Models and Experimental Medicine 2020年第4期3卷 283-284,I0002页

作者： chuan qin Chinese Association for Laboratory Animal Sciences BeijingChina Institute of Laboratory Animal Science Chinese Academy of Medical Science and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina

The 2nd Longtan Science Conference and the 40th anniversary of the Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences&Comparative Medicine Center,Peking Union Medical *** November 19-20,2020,the 2nd Longtan Science Conference and the 40th anniversary celebrations of the Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences&Comparative Medicine Center,Peking Union Medical College(hereinafter referred to as"ILAS")were held in *** conference was jointly organized by the Institute and the Chinese Association for Laboratory Animal Sciences.

关键词： supporting jointly anniversary

Constructive Texture Steganography Based on Compression Mapping of Secret Messages

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Computer Modeling in Engineering & Sciences 2020年第7期124卷 393-410页

作者： Fengyong Li Zongliang Yu chuan qin College of Computer Science and Technology Shanghai University of Electric PowerShanghaiChina School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghaiChina

This paper proposes a new constructive texture synthesis steganographic scheme by compressing original secret ***,we divide the original message into multiple bit blocks,which are transferred to decimal values and compressed into small decimal values by recording their interval sign ***,a candidate pattern is generated by combining the given source pattern and boundary extension ***,we segment the candidate pattern into multiple candidate patches and use affine transformation algorithm to locate secret positions on a blank canvas,which are used to hide the sign characters by mapping the candidate ***,we select the candidate patches with minimal mean square error to represent secret bits to generate stego image by image *** experiments demonstrate that compared with existing texture steganographic methods,our method has a better visual quality,higher embedding capacity and security performance,while maintaining strong anti-steganalysis capability.

关键词： Constructive steganography texture synthesis compression mapping patch

Image Information Hiding Method Based on Image Compression and Deep Neural Network

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Computer Modeling in Engineering & Sciences 2020年第8期124卷 721-745页

作者： Xintao Duan Daidou Guo chuan qin College of Computer and Information Engineering Henan Normal UniversityXinxiang453007China School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai200093China

Image steganography is a technique that hides secret information into the cover image to protect information *** current image steganography is mainly to embed a smaller secret image in an area such as a texture of a larger-sized cover image,which will cause the size of the secret image to be much smaller than the cover ***,the problem of small steganographic capacity needs to be solved *** paper proposes a steganography framework that combines image *** this framework,the Vector Quantized Variational AutoEncoder(VQ-VAE)is used to achieve the compression of the secret *** compressed and reconstructed image is visually indistinguishable from the original image and facilitates more embedded data information ***,the compressed image is transmitted to a SegNet deep neural network that contains a set of encoders and decoders to achieve image hiding and *** results show that the steganographic framework guarantees the quality of steganography while its relative steganographic capacity reaches ***,Peak Signal-to-Noise Ratio(PSNR)and Structural Similarity Index(SSIM)values can reach 42 dB and 0.94,respectively.

关键词： Image steganography deep neural network VQ-VAE SegNet

C-CORE:Clustering by Code Representation to Prioritize Test Cases in Compiler Testing

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2069-2093页

作者： Wei Zhou Xincong Jiang chuan qin School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai200240China Hikvision Research Institute Hangzhou Hikvision Digital Technology Co.Ltd.Hangzhou310051China

Edge devices,due to their limited computational and storage resources,often require the use of compilers for program ***,ensuring the security and reliability of these compilers is of paramount importance in the emerging field of edge *** widely used testing method for this purpose is fuzz testing,which detects bugs by inputting random test cases into the target ***,this process consumes significant time and *** improve the efficiency of compiler fuzz testing,it is common practice to utilize test case prioritization *** researchers use machine learning to predict the code coverage of test cases,aiming to maximize the test capability for the target compiler by increasing the overall predicted coverage of the test ***,these methods can only forecast the code coverage of the compiler at a specific optimization level,potentially missing many optimization-related *** this paper,we introduce C-CORE(short for Clustering by Code Representation),the first framework to prioritize test cases according to their code representations,which are derived directly from the source *** approach avoids being limited to specific compiler states and extends to a broader range of compiler ***,we first train a scaled pre-trained programming language model to capture as many common features as possible from the test cases generated by a *** this pre-trained model,we then train two downstream models:one for predicting the likelihood of triggering a bug and another for identifying code representations associated with ***,we cluster the test cases according to their code representations and select the highest-scoring test case from each cluster as the high-quality test *** reduction in redundant testing cases leads to time *** evaluation results reveal that code representations are better at distinguishing test capabilities,and C-CORE significantly enhanc

关键词： Compiler testing test case prioritization code representation

New Family of 3-DOF UP-Equivalent Parallel Mechanisms with High Rotational Capability

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Chinese Journal of Mechanical Engineering 2018年第1期31卷 66-77页

作者： Wei Ye qin-chuan Li Xin-Xue Chai Faculty of Mechanical Engineering and Automation Zhejiang Sci-Tech University

Parallel mechanisms(PMs) having the same motion characteristic with a UP kinematic chain(U denotes a universal joint, and P denotes a prismatic joint) are called UP-equivalent PMs. They can be used in many applications, such as machining and milling. However, the existing UP-equivalent PMs suffer from the disadvantages of strict assembly requirements and limited rotational capability. Type synthesis of UP-equivalent PMs with high rotational capability is *** special 2 R1 T motion is briefly discussed and the fact that the parallel module of the Exechon robot is not a UP-equivalent PM is disclosed. Using the Lie group theory, the kinematic bonds of limb chains and their mechanical generators are presented. Structural conditions for constructing such UP-equivalent PMs are proposed,which results in numerous new architectures of UP-equivalent PMs. The high rotational capability of the synthesized mechanisms is illustrated by an example. The advantages of no strict assembly requirements and high rotational capability of the newly developed PMs will facilitate their applications in the manufacturing industry.

关键词： Parallel mechanism Group theory Type synthesis High rotational capability

Characteristics of animal models for COVID-19

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Animal Models and Experimental Medicine 2022年第5期5卷 401-409页

作者： Feifei Qi chuan qin Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases NHC Key Laboratory of Human Disease Comparative MedicineInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina National Center of Technology Innovation for Animal Model BeijingChina

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of coronavirus disease 2019(COVID-19),the most consequential pandemic of this century,threatening human health and public ***-CoV-2 has been continuously evolving through mutation of its genome and variants of concern have *** World Health Organization R&D Blueprint plan convened a range of expert groups to develop animal models for COVID-19,a core requirement for the prevention and control of SARS-CoV-2 *** animal model construction techniques developed during the SARS-CoV and MERS-CoV pandemics were rapidly deployed and applied in the establishment of COVID-19 animal *** date,a large number of animal models for COVID-19,including mice,hamsters,minks and nonhuman primates,have been *** diseases produce unique mani-festations according to the characteristics of the pathogen and modes of *** we classified animal model resources around the infection route of SARS-CoV-2,and summarized the characteristics of the animal models constructed via transnasal,localized,and simulated transmission routes of infection.

关键词： animal model characteristics establishment SARS-CoV-2

The molecular regulation of autophagy in antimicrobial immunity

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Journal of Molecular Cell Biology 2022年第4期14卷 3-17页

作者： chuan qin Yalan Lu Lin Bai Kewei Wang Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences&Comparative Medical CenterPeking Union Medical CollegeBejing100021China

Autophagy is a catabolic process that can degrade worn-out organelles and invading *** activation of autophagy regulates innate and adaptive immunity,playing a key role in the response to microbial *** infection may cause different consequences such as the elimination of invaders through autophagy or xenophagy,host cell death,and symbiotic *** adapt to the autophagy mechanism and further relieve intracellular stress,which is conducive to host cell survival and microbial *** regulation of autophagy forms a complex network through which host immunity is modulated,resulting in a variety of pathophysiological *** of the autophagic pathway is an essential target for the development of antimicrobial drugs.

关键词： autophagy microbe antimicrobial immunity endoplasmic reticulum stress unfolded protein response apoptosis infectious disease

Message for the new year-Life and Hope in 2023

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Animal Models and Experimental Medicine 2023年第1期6卷 1-1,I0002页

作者： chuan qin Chinese Association for Laboratory Animal Sciences BeijingChina Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

According to the traditional Chinese zodiac,2023 is the Year of the Rabbit,which holds the meaning of life and hope due to the rabbit's vigorous reproductive *** the past 5 years AMEM has flourished,initial hopes have been realized and the journal has gone from strength to *** the gradual rise in submissions and the journal's increasing influence,in 2022 AMEM changed from quarterly to bimonthly,and successively launched seven themed sections-columns-includ-ing neurodegenerative disease,cardiovascular disease,and so on.

关键词： journal Rabbit rabbit

Message from animal models and experimental medicine for 2024-Striving for excellence with distinctive features

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Animal Models and Experimental Medicine 2024年第1期7卷 1-1,I0002页

Since its inception,Animal Models and Experimental Medicine(AMEM)has received 632 articles in total from 52 countries and regions includ-ing China,Iran,the United States,India,Nigeria,Israel,Germany,Iraq,Italy,Japan,Australia,Bangladesh,Belgium,Brazil,and Canada,among *** has become an important international exchange plat-form for innovative research achievements in the field of laboratory animal science and basic medicine.

关键词： Israel Canada innovative

Focus on cutting-edge research to improve the influence of Animal Models and Experimental Medicine

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Animal Models and Experimental Medicine 2022年第1期5卷 1-1,I0002页

作者： chuan qin C hinese Association for Laboratory Animal Sciences BeijingChina 2 Institute of Laboratory Animal SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

The year 2022 marks the fifth year of the publication of Animal Models and Experimental Medicine( AMEM). We are intensely proud of the publication of each paper, because we recognize that all our efforts are worthwhile to provide a platform for communication and sharing of outstanding scientific results and reinforce the discipline position of animal models and experimental medicine.

关键词： Focus Animal Medicine