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Catalyst-free 2+2 Photodimerization of l,4-Bis[2-(4-pyridyl)ethenyl]-benzene in Solution Under Low Power UV Irradiation

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Chemical Research in Chinese Universities 2020年第5期36卷 816-820页

作者： chu ning XU Shuping XU Weiqing State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012P.R.China

Two different kinds of configurations of 1,4-bis[2-(4-pyridyl)etheny 1]-benzene(trans-bpeb and c/5-bpeb)were achieved,and a bpeb dimer was synthesized in dimethyl sulfoxide(DMSO).Compared with the previous work that synthesized the bpeb dimer or polymer in crystal with a template agent needed,the reaction occurred in a solu・tion phase in the present method.A hand-held ultraviolet lamp(365 nm)with the power of 12 W and the Watt density of 0.35 mW/cm2 can realize the photodimerization of bpeb,instead of the high-power mercury lamp in most previous *** other 2+2 cycloaddition in liquid state using catalysts even noble metals,no catalysts were required here,which is *** the trans-pbeb can start the cycloaddition and the formation of the close J-aggregations of Zra≪5-pbeb in DMSO is a precondition for explaining the 2+2 *** productivity for the 2+2 cycloaddition product was achieved as 55.6%.

关键词： 2+2 Photodimerization 1,4-Bis[2-(4-pyridyl)ethenyl]-benzene Catalyst-free

铁死亡调控因子花生四烯酸脂氧合酶-15与肿瘤相关性的研究进展

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包头医学院学报 2024年第6期40卷 90-96页

作者：褚宁高芳贾彦彬包头医学院基础医学与法医学院内蒙古包头014040 包头医学院医学技术与麻醉学院

铁死亡(Ferroptosis)是一种铁依赖性的新型的细胞程序性死亡(PCD)方式。花生四烯酸脂氧合酶-15(Arachidonate 15-lipoxygenase,ALOX15)是铁死亡的重要调控因子,它可以催化多不饱和脂肪酸(Polyunsaturated fatty acid,PUFA)生成脂质氢过氧化物,从而促进铁死亡的发生。ALOX15参与了多种癌症的发生发展,并发挥重要作用。本文对铁死亡的重要调控因子ALOX15与乳腺癌、食管癌、胃癌、结直肠癌以及前列腺癌的相关性进行综述,为相关肿瘤的研究提供参考。

关键词：铁死亡花生四烯酸脂氧合酶-15 肿瘤

A comprehensive review on the chemical constituents,sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra

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Natural Products and Bioprospecting 2023年第1期13卷 30-92页

作者： Jin-ning chu Premanand Krishnan Kuan-Hon Lim School of Pharmacy University of Nottingham MalaysiaJalan Broga43500 SemenyihSelangorMalaysia Foundation in Science University of Nottingham MalaysiaJalan Broga43500 SemenyihSelangorMalaysia

Sarcandra glabra(Thunb.)Nakai is a perennial evergreen herb categorised within the Sarcandra Gardner genus under the Chloranthaceae *** to tropical and subtropical regions of East Asia and India,this species is extensively distributed across China,particularly in the southern regions(Sichuan,Yunnan,and Jiangxi).In addition to its high ornamental value,*** has a rich history of use in traditional Chinese medicine,evident through its empirical prescriptions for various ailments like pneumonia,dysentery,fractures,bruises,numbness,amenorrhea,rheumatism,and other ***,modern pharmacological studies have revealed various biological activities,such as antitumour,anti-bacterial,anti-viral anti-inflammatory and immunomodulatory *** diverse chemical constituents of *** have fascinated natural product researchers since the *** date,over 400 compounds including terpenoids,coumarins,lignans,flavonoids,sterols,anthraquinones,organic acids,and organic esters have been isolated and characterised,some featuring unprecedented *** review comprehensively examines the current understanding of ***’s phytochemistry and pharmacology,with emphasis on the chemistry and biosynthesis of its unique chemotaxonomic marker,the lindenane-type sesquiterpenoids.

关键词： Sarcandra glabra CaoShanHu Traditional Chinese medicine Lindenane-type sesquiterpenoids Biosynthetic pathway Biological activities

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文冠果种子发育基因表达分析内参基因的选择

林业科学研究 2024年第3期37卷 79-85页

作者：李麟坤梁重钧宁楚龙张薇姜国维张鑫王利兵中国林业科学研究院林业研究所北京100091 西北农林科技大学林学院陕西杨凌712199

[目的]验证ACT基因是否适用于文冠果种子发育的相关基因表达分析,并筛选出在文冠果基因表达分析中最稳定的内参基因。[方法]本研究采用了4种数学算法(ΔCT、BestKeeper、NormFinder、geNorm)评估12个候选内参基因的表达稳定性,并利用在... 详细信息

[目的]验证ACT基因是否适用于文冠果种子发育的相关基因表达分析,并筛选出在文冠果基因表达分析中最稳定的内参基因。[方法]本研究采用了4种数学算法(ΔCT、BestKeeper、NormFinder、geNorm)评估12个候选内参基因的表达稳定性,并利用在线工具RefFinder综合评价。[结果]在文冠果不同发育时期种子内参基因综合评分排名为PP2A>Tip41> EF-1α>18r>UCE>β-TUB>UBQ>α-TUB>CYP>SAM>ACT>GADPH;在文冠果不同组织内参基因综合评分排名为PP2A>Tip41>CYP>18r>UBQ>SAM>EF-1α>UCE>GADPH>α-TUB>ACT>β-TUB。[结论] PP2A和Tip41基因是文冠果基因表达分析最稳定的内参基因。

关键词：文冠果内参基因基因表达种子发育

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The Necessary and Sufficient Conditions for Two Kinds of Matrix Equtions Having Semipositive Subdefinite Solutions

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Chinese Quarterly Journal of Mathematics 2002年第4期17卷 62-68页

作者：何楚宁湖南师范大学数学系湖南长沙410081

Finding solutions of matrix equations in given set SR n×n is an active research field. Lots of investigation have done for these cases, where S are the sets of general or symmetric matrices and symmetric positive definite or sysmmetric semiposite definite matrices respectively . Recently, however, attentions are been paying to the situation for S to be the set of general(semi) positive definite matrices(called as semipositive subdefinite matrices below) . In this paper the necessary and sufficient conditions for the following two kinds of matrix equations having semipositive, subdefinite solutions are obtained. General solutions and symmetric solutions of the equations (Ⅰ) and (Ⅱ) have been considered in in detail.

关键词： semipositive subdefinite symmetric semipositie definite generalized singualr value decomposition

Phenylboronic acid modified mucoadhesive nanoparticle drug carriers facilitate weekly treatment of experimentally- induced dry eye syndrome

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Nano Research 2015年第2期8卷 621-635页

作者： Shengyan Liu chu ning Chang Mohit S. Verma Denise Hileeto Alex Muntz Ulrike Stahl Jill Woods LyndonW. Jones Frank X. Gu Department of Chemical Engineering University of Waterloo Waterloo N2L 3G1 Canada Waterloo Institute for Nanotechnology University of Waterloo Waterloo N2L3G1 Canada Centre for Contact Lens Research University of Waterloo Waterloo N2L3G1 Canada

Topical formulations, commonly applied for treatment of anterior eye diseases, require frequent administration due to rapid clearance from the ocular surface, typically through the lacrimal drainage system or through over-spillage onto the lids. We report on a mucoadhesive nanoparticle drug delivery system that may be used to prolong the precorneal residence time of encapsulated drugs. The nanoparticles were formed from self-assembly of block copolymers composed of poly（D, L-lactide） and Dextran. The enhanced mucoadhesion properties were achieved by surface functionalizing the nanoparticles with phenylboronic acid. The nanoparticles encapsulated up to 12 wt.% of Cyclosporine A （CycA） and sustained the release for up to five days at a clinically relevant dose, which led us to explore the therapeutic efficacy of the formulation with reduced administration frequency. By administering CycA-loaded nanoparticles to dry eye-induced mice once a week, inflammatory infiltrates were eliminated and the ocular surface completely recovered. The same once a week dosage of the nanoparticles also showed no signs of physical irritation or inflammatory responses in acute （1 week） and chronic （12 weeks） studies in healthy rabbit eyes. These findings indicate that the nanoparticles may significantly reduce the frequency of administration for effective treatment of anterior eye diseases without causing ocular irritation.

关键词： biocompatibility copolymer mucoadhesion nanoparticle drug delivery ophthalmology

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矩阵在置换分块下的广义逆通式

湖南师范大学自然科学学报 2006年第4期29卷 1-5页

作者：何楚宁湖南师范大学数学与计算机科学学院中国长沙410081

对任意矩阵A∈Rrm×n,存在置换矩阵P,Q使得PAQ=AA1211AA1222,A11∈Rrr×r.讨论了分块矩阵A11A12A21A22的14类Moore-penrose型广义逆的通式.通过将这些通式分别乘以置换矩阵可得到任意矩阵相应的Moore-penrose型广义逆的通式.

关键词：分块矩阵通式 Moore-penrose型广义逆置换矩阵

明中叶以降西海蒙古与明朝对河湟洮岷地方秩序的重塑

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西北民族研究 2022年第3期 58-70页

作者：褚宁广东第二师范学院马克思主义学院广州510303

明中叶以降,大批东蒙古部落突破长城防线,辗转南牧青海,及至“隆庆和议”“仰华寺会晤”后达到巅峰,并逐渐向黄河南岸的莽剌、捏工二川转场,导致明朝主导下的河湟洮岷地方秩序被打破,酿成万历十八年的“洮河危机”。明朝不得已派遣深谙... 详细信息

明中叶以降,大批东蒙古部落突破长城防线,辗转南牧青海,及至“隆庆和议”“仰华寺会晤”后达到巅峰,并逐渐向黄河南岸的莽剌、捏工二川转场,导致明朝主导下的河湟洮岷地方秩序被打破,酿成万历十八年的“洮河危机”。明朝不得已派遣深谙蒙古事务的郑洛坐镇经略。郑洛及其后继者采取一系列举措,才最终缓和了紧张局势。在平息“海患”的过程中,明朝逐步强化了对河湟洮岷地方社会的整合,这可视为其在西海蒙古压力下扭转区域关系失衡所作出的一种加速反应。明朝在汉藏走廊的经略无疑深受西北地缘形势变化的影响,客观上推进了王朝制度向“西番”地区的延伸,深化了蒙、“番”、汉各族群的交往交流交融,为日后西部疆域的稳定与中华民族多元一体格局的形成奠定了重要基础。

关键词：西番西番诸卫西海蒙古河湟洮岷郑洛

Feasibility of endoscopic treatment and predictors of lymph node metastasis in early gastric cancer

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World Journal of Gastroenterology 2019年第35期25卷 5344-5355页

作者： Yu-ning chu Ya-Nan Yu Xue Jing Tao Mao Yun-Qing Chen Xiao-Bin Zhou Wen Song Xian-Zhi Zhao Zi-Bin Tian Department of Gastroenterology the Affiliated Hospital of Qingdao University Qingdao 266003 Shandong Province China Department of Pathology the Affiliated Hospital of Qingdao University Qingdao 266003 Shandong Province China Department of Epidemiology and Health Statistics School of Public Health Qingdao University Qingdao 266021 Shandong Province China Endoscopy Center the Affiliated Hospital of Qingdao University Qingdao 266003 Shandong Province China

BACKGROUND Endoscopic submucosal dissection (ESD) has been routinely performed in applicable early gastric cancer (EGC) patients as an alternative to conventional surgical operations that involve lymph node dissection. The indications for ESD have been recently expanded to include larger, ulcerated, and undifferentiated mucosal lesions, and differentiated lesions with slight submucosal invasion. The risk of lymph node metastasis (LNM) is the most important consideration when deciding on a treatment strategy for EGC. Despite the advantages over surgical procedures, lymph nodes cannot be removed by ESD. In addition, whether patients who meet the expanded indications for ESD can be managed safely remains controversial. AIM To determine whether the ESD indications are applicable to Chinese patients and to investigate the predictors of LNM in EGC. METHODS We retrospectively analyzed 12552 patients who underwent surgery for gastric cancer between June 2007 and December 2018 at the Affiliated Hospital of Qingdao University. A total of 1262 (10.1%) EGC patients were eligible for inclusion in this study. Data on the patients’ clinical, endoscopic, and histopathological characteristics were collected. The absolute and expanded indications for ESD were validated by regrouping the enrolled patients and determining the positive LNM results in each subgroup. Predictors of LNM in patients were evaluated by univariate and multivariate analyses. RESULTS LNM was observed in 182 (14.4%) patients. No LNM was detected in the patients who met the absolute indications (0/90). LNM occurred in 4/311 (1.3%) patients who met the expanded indications. According to univariate analysis, LNM was significantly associated with positive tumor marker status, medium (20-30 mm) and large (>30 mm) lesion sizes, excavated macroscopic-type tumors, ulcer presence, submucosal invasion (SM1 and SM2), poor differentiation, lymphovascular invasion (LVI), perineural invasion, and diffuse and mixed Lauren’s type

关键词： Early gastric cancer Lymph node metastasis Predictors Endoscopic submucosal dissection Expanded indications