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中西合璧的老人支持体系——香港所追求的全面照顾模式

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人口与发展 2010年第3期16卷 75-80页

作者：周永新赵环香港大学社会工作及社会行政学系华东理工大学社会工作系上海200072

以老人照顾体系发展的四个阶段,回顾香港过去五十年来从家庭维系传统孝亲价值,政府角色对照顾责任的厘清,传统家庭对机构照料的忌讳,到近年来从"在社区照顾"发展至"就地养老"的概念;从人口结构的变化、社会经济发展的变迁以及政府角色... 详细信息

以老人照顾体系发展的四个阶段,回顾香港过去五十年来从家庭维系传统孝亲价值,政府角色对照顾责任的厘清,传统家庭对机构照料的忌讳,到近年来从"在社区照顾"发展至"就地养老"的概念;从人口结构的变化、社会经济发展的变迁以及政府角色与责任的不同作了探讨剖析。说明"全面照顾模式"如何结合上述价值与社会体系背景,将政府与民间的各层面力量融入成为全方位、多面向与多选项的照顾体系,说明了对于政策制定者、服务提供者以及社区工作者这又意味着什么样的挑战。

关键词：全面照顾模式老人支持体系香港

Profiles and removal efficiency of polycyclic aromatic hydrocarbons by two different types of sewage treatment plants in Hong Kong

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Journal of Environmental Sciences 2017年第3期29卷 196-206页

作者： Yu Bon Man Ka Lai chow Zhang Cheng wing Yin Mo Yung Hau Chan James Chung Wah Lam Frankie Tat Kwong Lau wing Cheong Fung Ming Hung Wong Consortium on Health EnvironmentEducation and Research(CHEER)and Department of Science and Environmental StudiesThe Education University of Hong KongTai PoHong KongChina Department of Environmental Engineering Jinan UniversityGuangzhou 510630China State Key Laboratory in Marine Pollution Croucher Institute for Environmental SciencesHong Kong Baptist University and City University of Hong KongKowloon TongHong KongChina Department of Geography Hong Kong Baptist UniversityKowloon TongHong KongChina College of Environment Sichuan Agricultural UniversityChengdu 611130China State Key Laboratory in Marine Pollution and Research Centre for the Oceans and Human Health City University of Hong KongKowioon TongHong KongChina The Drainage Services Department The Government of the Hong Kong Special Administrative RegionHong KongChina

Sewage discharge could be a major source of polycyclic aromatic hydrocarbons （PAHs） in the coastal waters. Stonecutters Island and Shatin Sewage Treatment Works （SCISTW and STSTW） in Hong Kong, adopted chemically enhanced primary treatment and biological treatment, respectively. This study aimed at （1） determining the removal efficiencies of PAHs, （2） comparing the capabilities in removing PAHs, and （3） characterizing the profile of each individual PAHs, in the two sewage treatment plants （STPs）. Quantification of 16 PAHs was conducted by a Gas Chromatography. The concentrations of total PAHs decreased gradually along the treatment processes （from 301 ± 255 and 307 ± 217 ns/L to 14.9 ± 12.1 and 63.3 ± 54.1 ng/L in STSTW and SCISTW, respectively）. It was noted that STSTW was more capable in removing total PAHs than SCISTW with average total removal effidency 94.4% ± 4.12% us. 79.2% ± 7.48% （p 〈 0.05）. The removal of PAHs was probably due to sorption in particular matter, confirmed by the higher distribution coefficient of individual and total PAHs in solid samples （dewatered sludge contained 92.5% and 74.7% of total PAHs in SCISTW and STSTW, respectively） than liquid samples （final efffluent-total contained 7.53% and 25.3% of total PAHs in STSTW and SCISTW, respectively）. Despite the impressive capability of STSTW and SCISTW in removing PAHs, there was still a considerable amount of total PAHs （1.85 and 39.3 ks/year, respectively for the two STPs） being discharged into Hone Kon coastal waters, which would be an environmental concern.

关键词： Sewage treatment plantsPAHsRemoval efficiencySludgeSewage

GEMFIBROZIL　INDUCED　MYOSITIS：A　CASE　REPORT　WITH　LIGHT　MICROSCOPIC　AND　ULTRASTRUCTURAL　STUDY

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Chinese Medical Sciences Journal 1994年第2期9卷 129-131页

作者： $$$$Louis Tsun-cheung chow MRCPath FRCPA FACA and wing-hing chow MRCP (Institute of Pathology,Queen Elizabeth Hospital,Hong Kong ) Institute of Pathology Queen Elizabeth Hospital Hong Kong.

ＧＥＭＦＩＢＲＯＺＩＬＩＮＤＵＣＥＤＭＹＯＳＩＴＩＳ：ＡＣＡＳＥＲＥＰＯＲＴＷＩＴＨＬＩＧＨＴＭＩＣＲＯＳＣＯＰＩＣＡＮＤＵＬＴＲＡＳＴＲＵＣＴＵＲＡＬＳＴＵＤＹ￥ＬｏｕｉｓＴｓｕｎ－ｃｈｅｕｎｇＣｈｏｗ；ＭＲＣＰａ... 详细信息

ＧＥＭＦＩＢＲＯＺＩＬＩＮＤＵＣＥＤＭＹＯＳＩＴＩＳ：ＡＣＡＳＥＲＥＰＯＲＴＷＩＴＨＬＩＧＨＴＭＩＣＲＯＳＣＯＰＩＣＡＮＤＵＬＴＲＡＳＴＲＵＣＴＵＲＡＬＳＴＵＤＹ￥ＬｏｕｉｓＴｓｕｎ－ｃｈｅｕｎｇＣｈｏｗ；ＭＲＣＰａｔｈ；ＦＲＣＰＡ；ＦＡＣＡａｎｄＷ...

关键词： gemfibrozil 肌肉综合症药物治疗药物不良反应肌炎

The Dynamics and Evolution of Poles and Rogue Waves for Nonlinear Schrdinger Equations

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Communications in Theoretical Physics 2017年第9期67卷 290-294页

作者： Tin Lok CHIU Tian Yang LIU Hiu Ning CHAN Kwok wing chow Department of Mechanical Engineering University of Hong Kong Pokfulam Hong Kong China

Rogue waves are unexpectedly large deviations from equilibrium or otherwise calm positions in physical systems, e.g. hydrodynamic waves and optical beam intensities. The profiles and points of maximum displacements of these rogue waves are correlated with the movement of poles of the exact solutions extended to the complex plane through analytic continuation. Such links are shown to be surprisingly precise for the first order rogue wave of the nonlinear Schr¨odinger(NLS) and the derivative NLS equations. A computational study on the second order rogue waves of the NLS equation also displays remarkable agreements.

关键词： poles rogue waves nonlinear Schrodinger equations

A joint computational-experimental study of intracranial aneurysms:Importance of the aspect ratio

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Journal of Hydrodynamics 2016年第3期28卷 462-472页

作者： Simon Sui-Man LAI Abraham Yik-Sau TANG Anderson Chun-On TSANG Gilberto Ka-Kit LEUNG Alfred Cheuk-Hang YU Kwok wing chow Department of Electrical and Electronic Engineering University of Hong Kong Hong Kong China Department of Mechanical Engineering University of Hong Kong Hong Kong China Department of Surgery Li Ka Shing Faculty of Medicine University of Hong Kong Hong Kong China Department of Electrical and Computer Engineering University of Waterloo Ontario Canada

Rupture of a cerebral aneurysm （abnormal swelling of blood vessel in the brain） will cause subarachnoid hemorrhage, and will result in an alarming rate of mortality and morbidity. A joint computational-experimental study is conducted to assess the importance of the aspect ratio in the dynamics of blood flow. The aspect ratio is defined here to be the ratio of the height of the aneurysm to the linear dimension of the neck. Idealized models of such aneurysms located near a bifurcation point were investigated. Numerical simulations for hemodynamic properties like shear stress and flow rate were performed. The computational results were verified experimentally with specially fabricated phantoms, blood mimicking fluid and Doppler ultrasound imaging. Excellent agreements were obtained. Two features are highlighted, providing information in the intensely debated link between rupture risk and geometric factors. On increasing the aspect ratios, firstly, a jet impinging on the distal part of the neck can be observed, and secondly, a region of positive shear stress gradient can be found there. Furthermore, computational analyses for four patient-specific models were conducted to correlate with the results of idealized models and to provide further clinical insight.

关键词： intracranial aneurysms aspect ratio Doppler ultrasound

A proximity-induced covalent fluorescent probe for selective detection of bromodomain 4

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Chinese Chemical Letters 2018年第7期29卷 1147-1150页

作者： Ling Feng Mohit Chhabra wing Ho So Qing Zhu Jiang Xia Hongyan sun Department of Chemistry and Center of Super-Diamond and Advanced Films (COSDAF) City University of Hong Kong Key Laboratory of Biochip Technology Biotech and Health Centre Shenzhen Research Institute of City University of Hong Kong Department of Chemistry The Chinese University of Hong Kong College of Biotechnology and bioengineering Zhejiang University of Technology

Lysine acetylation is one of the most prevalent and important posttranslational modifications(PTMs) in proteins. The process can be recognized by bromodomains(BRDs), which are a class of proteininteraction modules involved in chromatin remodeling and transcriptional activation. The development of BRD fluorescent probes will be useful for monitoring the activity of BRDs in living cells as well as aiding inhibitor development. Herein we designed a peptide-based probe based on the proximity-induced protein conjugation reaction. The peptide-based probe is capable of covalently and selectively reacting with the unique cysteine residue in the bromodomain through proximity effect. Our experimental data showed that the probe displayed noticeable fluorescence response upon addition of BRD4(1). In-gel fluorescence scanning demonstrated that BRD4(1) can be covalently labelled by the probe. Moreover, the probe was shown to selectively detect BRD4(1) over other proteins. We envision that the probe developed in this study will provide a useful tool to further investigate the biological roles of BRDs.

关键词： Peptide-based probe Bromodomain Fluorescent probe Proximity effect Peptides

Long-term clinical outcomes of drug-eluting stents ***-metal stents in Chinese geriatric patients

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Journal of Geriatric Cardiology 2013年第4期10卷 330-335页

作者： Pak-Hei Chan Sha-Sha Liu Hung-Fat Tse wing-Hing chow Man-Hong Jim Hee-Hwa HO Chung Wah Siu Department of Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong 102 Pokfulam Rd Hong Kong China Cardiac Medical Unit Grantham Hospital 125 Wong Chuk Hang Rd Aberdeen Hong Kong China

BACKGROUND & OBJECTIVE: Little is known about the relative efficacies of percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and bare-metal stents (BMS) in elderly patients。 The objective of this study was to evaluate the clinical outcome for geriatric patients who received either DES or BMS。 METHODS: From January 2002 to October 2005, 199 consecutive Chinese geriatric patients (≥ 75 years old) underwent PCI with coronary DES or BMS implantation at our institution。 We analyzed the major clinical end points that included all-cause mortality, cardiovascular death, myocardial infarction, target lesion revascularization (TLR), stent thrombosis, and bleeding complications。 RESULTS: The three-year cumulative rates of all-cause mortality, cardiovascular death, and myocardial infarction were significantly lower in the DES group (6.3%,3.6%,5.4%) compared with the BMS group (16.2%,11.5%,14.9%; P <0.05)。 No significant differences were found in the three-year cumulative rate for target lesion revascularization (6.3% vs4.6%, P =0.61) or stent thrombosis (3.6% vs2.3%, P =0.70)。 Likewise, there were no statistically significant differences in the cumulative rate for intracranial hemorrhage, or major and minor hemorrhage at three years。 CONCLUSIONS: DES-based PCI was associated with a significant reduction in the three-year cumulative rate of all-cause mortality, cardiovascular death, and myocardial infarction compared with BMS, without increased risk of TLR, stent thrombosis, or bleeding complications at three years in this group of Chinese geriatric patients。

关键词： Bare-metal stents Drug-eluting stents Geriatric patients Percutaneous coronary intervention

The Hong Kong consensus recommendations on the diagnosis and management of pancreatic cystic lesions

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 715-735,I0019-I0020页

作者： Tan-To Cheung Yuk Tong Lee Raymond Shing-Yan Tang Wong Hoi She Kai Chi Cheng Chin Cheung Cheung Keith Wan Hang Chiu Kenneth Siu Ho Chok wing sun chow Tak wing Lai Wai-Kay Seto Thomas Yau Department of Surgery Queen Mary HospitalThe University of Hong KongHong KongChina Gastroenterologist in private practice Hong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Surgery Kwong Wah HospitalHong KongChina Department of Surgery Tuen Mun HospitalHong KongChina Department of Radiology&Imaging Queen Elizabeth HospitalHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Surgery Princess Margaret HospitalHong KongChina Department of Medicine School of Clinical MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina

Background:The finding of pancreatic cystic lesions(PCL)on incidental imaging is becoming increasingly *** studies report a prevalence of 2.2-44.7%depending on the population,imaging modality and indication for imaging,and the prevalence increases with *** with PCL are at risk of developing pancreatic cancer,a disease with a poor *** publication summarizes recommendations for the diagnosis and management of PCL and post-operative pancreatic exocrine insufficiency(PEI)from a group of local ***:Clinical evidence was consolidated from narrative reviews and consensus statements formulated during two online meetings in March *** expert panel included gastroenterologists,hepatobiliary surgeons,oncologists,radiologists,and ***:Patients with PCL require careful investigation and follow-up due to the risk of malignant transformation of these *** should undergo clinical investigation and pancreas-specific imaging to classify lesions and understand the risk profile of the *** indicated,patients should undergo pancreatectomy to excise *** pancreatectomy,patients are at risk of PEI,leading to gastrointestinal dysfunction and ***,such patients should be monitored for symptoms of PEI,and promptly treated with pancreatic enzyme replacement therapy(PERT).Patients with poor response to PERT may require increases in dose,addition of a proton pump inhibitor,and/or further investigation,including tests for pancreatic *** are also at risk of new-onset diabetes mellitus after pancreatectomy;they should be screened and treated with insulin if ***:These statements are an accurate summary of our approach to the diagnosis and management of patients with PCL and will be of assistance to clinicians treating these patients in a similar clinical landscape.

关键词： Pancreatic cystic lesions pancreatic endocrine insufficiency pancreatic enzyme replacement therapy

Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong

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World Journal of Gastroenterology 2006年第14期12卷 2223-2228页

作者： Kam Hoi Chan Chun wing Chan Wai Hung chow Wai Keung Kwan Chi Kwan Kong Ka Fung Mak Miu Yi Leung Lin Kiu Lau Department of Medicine Yan Chai Hospital Tsuen Wan Hong Kong SAR China Department of Surgery Yan Chai Hospital Tsuen Wan Hong Kong SAR China Department of Radiology Yah Chai Hospital Tsuen Wan Hong Kong SAR Chin Department of Pathology Yah Chai Hospital Tsuen Wan Hong Kong SAR China

AIM： To investigate the prevalence and clinical pattern of gastrointestinal stromal tumors （GISTs） in Hong Kong Chinese, and to assess the impact of introduction of CD117 on the disease incidence. METHODS： From the database of the Department of Pathology of Yan Chai Hospital, 47 patients, with GISTs from September 1995 to December 2003 were included in this study. Ten GISTs were diagnosed before the introduction of CD117. The clinical features, tumor characteristics, and treatment were analyzed. Factors predicting tumor related death or recurrence were studied with Cox proportional hazard model. RESULTS： The patients included 26 males and 21 females, with a mean age of 66.6 years （SD 13.1, range 29-87 years）. The estimated prevalence of GISTs was 13.4-15.6 per 100 000 people, with an annual inddence of 1.68-1.96 per 100 000 people. The annual incidence of GISTs before and after the introduction of CD117 was 1.1 per 100 000 people and 2.1 per 100 000 people respectively. Stomach （34 patients, 72.3%） was the most common location for the tumor, followed by the small intestine （8 patients, 17.0%）, esophagus （2 patients, 4.3%）, omentum （2 patients, 4.3%） and colon （1 patient, 2.1%）. Thirty-one patients （66%） had complete tumor resection. Eleven out of 16 deaths （23%） were tumor-related. The median survival time was 26 too. Five-year survival rate was 61.3%. The significant factors associated with tumor-related death or recurrence were incomplete resection, tumor size 5 cm or above, invasion to the adjacent organ or presence of metastasis, CONCLUSION： The incidence of GIST in Hong Kong is comparable to that in the United States but lower than that in Finland. The true incidence of GISTs could be underestimated before the introduction of CD117. Incomplete resection, tumor size 5 cm or above, invasion to the adjacent organ or presence of metastasis are factors predicting tumor-related death or recurrence.

关键词： Gastrointestinal tumor GIST Prognostic factors, Clinical features Incidence