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factors associated with DAA virological treatment failure and resistance-associated substitutions description in HIV/HCV coinfected patients

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World Journal of Hepatology 2018年第11期10卷 856-866页

作者： Dominique Salmon Pascale Trimoulet Camille Gilbert Caroline Solas Eva Lafourcade Julie Chas Lionel Piroth Karine Lacombe Christine Katlama Gilles Peytavin Hugues Aumaitre Laurent Alric franoois Boué Philippe morlat Isabelle Poizot-martin Eric Billaud Eric Rosenthal Alissa Naqvi Patrick miailhes firouzé Bani-Sadr Laure Esterle Patrizia Carrieri franoois Dabis Philippe Sogni Linda Wittkop 无 Assistance Publique des Hopitaux de Paris Hopitaux Universitaires Paris CentreHopital Hotel DieuUnitédes Maladies infectieuses et tropicalesParis 75004France Université Paris Descartes Sorbonne Paris CitéParis 75006France Trimoulet CHU de BordeauxHopital PellegrinLaboratoire de VirologieBordeaux 33000France Trimoulet CNRS-UMR 5234Microbiologie fondamentale et PathogénicitéUniversitéde BordeauxBordeaux 3000France Philippe morlat Laure EsterleFrancois DabisLinda WittkopUniv.BordeauxISPEDInsermBordeaux Population Health Research Centerteam MORPH3EUSUMR 1219CIC-EC 1401Bordeaux F-33000France APHm Hopital La TimoneLaboratoire de Pharmacocinétique et ToxicologieMarseille 13005France Centre Hospitalier Universitaire de Dijon Département d'InfectiologieDijon cedex 21079France INSERm-CIC 1342 Universitéde Bourgogne Dijon 21000France Assistance Publique des Hopitaux de Paris GHUEP site Saint-AntoineServices Maladies infectieuses et tropicalesParis 75011France UniversitéPierre et marie Curie UMR S1136Institut Pierre Louis d' Epidémiologie et de SantéPubliqueParis 75646France UniversitéParis-Sorbonne Paris 75005France Assistance Publique des Hopitaux de Paris Hopital PitiéSalpêtrière Services Maladies infectieuses et tropicalesParis 75013France Assistance Publique des Hopitaux de Paris Hopital Bichat-Claude BernardLaboratoire de PharmacologieParis 75877France IAmE UMR 1137Sorbonne Paris CitéINSERMUniversitéParis DiderotParis 75890France Centre Hospitalier de Perpignan Service Maladies infectieuses et tropicalesPerpignan 66000Franc Centre Hospitalier Universitaire de Toulouse Hopital PurpanService Médecine interne-Pole DigestifToulouse 31300France UmR 152 IRD UniversitéToulouseⅢ Paul SabatierToulouse 31330France Hopital Antoine-Béclère Assistance Publique des Hopitaux de ParisUniversitéParis SudService Médecine interne et immunologieClamart 92140France Centre Hospitalier Universitaire de Bordeaux Service de médecine interneHopital Saint-AndréBordeaux 33000France Uni

AImTo describe factors associated with treatment failure and frequency of resistance-associated substitutions （RAS）.mETHODSHuman immunodefciency virus （HIV）/hepatitis C virus （HCV） coinfected patients starting a first direct-acting antiviral （DAA） regimen before february 2016 and included in the french ANRS CO13 HEPAVIH cohort were eligible. failure was defned as：（1） non-response [HCV-RNA remained detectable during treatment, at end of treatment （EOT）]; and （2） relapse （HCV-RNA suppressed at EOT but detectable thereafter）. Sequencing analysis was performed to describe prevalence of drug class-specifc RAS. factors associated with failure were determined using logistic regression *** 559 patients, 77% had suppressed plasmaHIV-RNA 〈 50 copies/mL at DAA treatment initiation41% were cirrhotic, and 68% were HCV treatmentexperienced. Virological treatment failures occurred in22 patients and were mainly relapses （17, 77%） thenundefined failures （3, 14%） and non-responses （29%）. mean treatment duration was 16 wk overall. Posttreatment NS3, NS5A or NS5B RAS were detected in10/14 patients with samples available for sequencinganalysis. After adjustment for age, sex, ribavirin useHCV genotype and treatment duration, low platelecount was the only factor signifcantly associated with ahigher risk of failure （OR： 6.5; 95%CI： 1.8-22.6）. CONCLUSIONOnly 3.9% HIV-HCV coinfected patients failed DAAregimens and RAS were found in 70% of those failingLow platelet count was independently associated withvirological failure.

关键词： Human immunodeficiency virus Hepatitis C virus Direct-acting antiviral Treatment virological failure Resistant associated mutations

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发育不良性pointillist痣

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世界核心医学期刊文摘（皮肤病学分册） 2005年第10期1卷 25-25页

作者： moreno-Ramirez D ferrandiz L Rios-martin J.J Camacho f.m 李晓莉 Department of Dermatology Pigmented Lesion and Teledermatology Clinic University Hospital Virgen Macarena Avenida Dr Fedriani S/N 41073 Seville Spain.Dr

Background: Three cases of pointillist nevus,which is a distinctive clinical type of benign melanocytic nevus with variegated pigment, have been described in the literature to date. Observations: A 24-year-old man presented with an acquired melanocytic lesion composed of multiple tiny pigmented dots. Dermoscopy revealed multiple brown globules on a reddish skin-colored background, and histologic examination demonstrated architectural disorder with cytologic atypia. Conclusion: To the best of our knowledge, we report a case of dysplastic pointillist nevus.

关键词：不良性 pointillist 黑色素细胞组织学检查色素斑皮色

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烤烟,白肋烟和香料烟(Nicotiana tabacum)烟叶中镉浓度的调查

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中国烟草学报 2006年第6期12卷 48-48页

作者： LLUGON-mOULIN N martin f KRAUSS m R RAmEY P B ROSSIL 吴晓芸（译）康婧（校）菲莫国际研发部c／o菲莫产品公司 2000 Neuchatel瑞士菲莫国际管理公司 Leaf Agronom1001 Lausanne瑞士菲莫研究中心 4201 Commerce RoadRichmond佛吉尼亚州23234美国不详

镉（Cd）是一种被国际癌症研究机构归类为已知的人类致癌物质（Class 1），也是烟草制品中潜在的致癌物质之一。在诸如烟草（Nicotiana tabacum L．）之类的作物植株中镉的积聚可导致人类接触到镉金属。利用感应耦合等离子体-质谱法，... 详细信息

镉（Cd）是一种被国际癌症研究机构归类为已知的人类致癌物质（Class 1），也是烟草制品中潜在的致癌物质之一。在诸如烟草（Nicotiana tabacum L．）之类的作物植株中镉的积聚可导致人类接触到镉金属。利用感应耦合等离子体-质谱法，我们对来自不同国家的3种主要烟草种类（烤烟，自肋烟和香料烟）的755个烟叶样本中的镉含量进行了测定。其目的是对来自不同地理区域的烟叶中的镉积聚模式进行鉴别。

关键词：镉(Cd) 香料烟白肋烟烟叶烤烟感应耦合等离子体浓度烟草制品

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Parent Initial Charge Differentiated C60r+ fragmentation in Low Energy He+-C60 Collisions

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ImP & HIRfL Annual Report 2004年 132-132页

作者： Chen Li,R.Bredy,J.Bernard,m.C.Buchet-poulizac1,S.martin LASIm Universite Lyon1 Campus de la Dona f-69622 Villeurbanne Cedex france LASIm Universite Lyon1 Campus de la Dona f-69622 Villeurbanne Cedex france LASIm Universite Lyon1 Campus de la Dona f-69622 Villeurbanne Cedex france LASIm Universite Lyon1 Campus de la Dona f-69622 Villeurbanne Cedex france LASIm Universite Lyon1 Campus de la Dona f-69622 Villeurbanne Cedex france

In ion-fullerene C60 frontal collisions, an amount of energy is deposited in the C60 target leading to the fragmentation of the C60. Theoretical and experimental investigations have demonstrated that the fragmentation scheme of the C60 depends not only on the total excitation energy but also on the nature of the primary electronic and nuclear excitation mechanism. Up to now, the commonly accepted interpretation of the observed mass spectra obtained in ion-C60 experiments is to consider the multi-fragmentation of the C60 being mainly due to the primary electronic interaction. The efficient transfer of the electronic excitation energy towards vibronic modes induces the breakup of the C60 cage in a statistical decay process.

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Parent Initial Charge Differentiated C_(60)^(r+) fragmentation in Low Energy He^+-C_(60) Collisions

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2004年第1期 111-111页

作者： Chen Li R.Bredy J.Bernard m.C.Buchet-poulizac1 S.martin LASIm Universite Lyon1 Campus de la Dona F-69622 Villeurbanne Cedex FranceLASIM Universite Lyon1 Campus de la Dona F-69622 Villeurbanne Cedex FranceLASIM Universite Lyon1 Campus de la Dona F-69622 Villeurbanne Cedex FranceLASIM Universite Lyon1 Campus de la Dona F-69622 Villeurbanne Cedex FranceLASIM Universite Lyon1 Campus de la Dona F-69622 Villeurbanne Cedex France

关键词：富勒烯C60 正面碰撞低能量破碎家长 He 激发能量离子光谱

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工程师应知人力资源管理

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1989年

作者：（美）马　丁（martin D.D.）（美）谢　尔（Shell R.L.）李光林译

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青春期阴毛早现患儿及雄激素增高症少女黑皮素-4受体(mC4R)基因突变分析

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世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 50-50页

作者： Roldan martin m.B. White C. Kammerer C. Witchel S.f. 朱国栋

To determine if variants in the melanocortin-4 receptor (m-C4R) gene are associated with premature pubarche (PP) in children and hyperandrogenism (HA) in adolescent girls, we performed single-strand conformational polymorphism (S-SCP) in 75 children (69 girls/six boys) with PP, 53 adolescent girls with HA, and 95 healthy adult control subjects. DNA sequence analysis of the conformers identified by SSCP revealed variants in six patients (two silent and one missense) and in none of the control subjects.

关键词：基因突变分析 mC4R 带型错义突变

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不动产顾问第一版

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丛书名： mBA丛书

1998年

作者：（美）马丁·J.迈尔斯（martin J.miles）仝晓秋王文华译

本书主要内容包括：主要的投资新方法，如何估价不动产，如何筹措购置产业的资金等。

ISBN: (纸本)7500104995

本书主要内容包括：主要的投资新方法，如何估价不动产，如何筹措购置产业的资金等。

关键词：经济经济计划与管理城市与市政经济

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Stable femtosecond X-rays with tunable polarization from a laser-driven accelerator

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Light(Science & Applications) 2017年第1期6卷 410-416页

作者： Andreas Döpp Benoit mahieu Agustin Lifschitz Cedric Thaury Antoine Doche Emilien Guillaume Gabriele Grittani Olle Lundh martin Hansson Julien Gautier michaela Kozlova Jean Philippe Goddet Pascal Rousseau Amar Tafzi Victor malka Antoine Rousse Sebastien Corde Kim Ta Phuoc Laboratoire d’Optique Appliquée ENSTACNRS UMR7639Ecole PolytechniqueChemin de la Hunière91761 PalaiseauFrance Present address:Ludwig-maximilians-Universität münchen Fakultät für PhysikAm Coulombwall 1Garching 85748Germany ELI Beamlines Project Institute of Physics of the ASCRNa Slovance 218221 Prague 8Czech Republic Department of Physics Lund UniversityPO Box 11822100 LundSweden Department of Physics and Complex Systems Weizmann Institute of Science76100 RehovotIsrael

Technology based on high-peak-power lasers has the potential to provide compact and intense radiation sources for a wide range of innovative *** particular,electrons that are accelerated in the wakefield of an intense laser pulse oscillate around the propagation axis and emit *** betatron source,which essentially reproduces the principle of a synchrotron at the millimeter scale,provides bright radiation with femtosecond duration and high spatial ***,despite its unique features,the usability of the betatron source has been constrained by its poor control and *** this article,we demonstrate the reliable production of X-ray beams with tunable *** ionization-induced injection in a gas mixture,the orbits of the relativistic electrons emitting the radiation are reproducible and *** observe that both the signal and beam profile fluctuations are significantly reduced and that the beam pointing varies by less than a tenth of the beam *** polarization ratio reaches 80%,and the polarization axis can easily be *** anticipate a broad impact of the source,as its unprecedented performance opens the way for new applications.

关键词： laser-plasma interaction laser-wakefield acceleration synchrotron light sources

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Notes for genera:Ascomycota

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fungal Diversity 2017年第5期86卷 1-594页

作者： Nalin N.Wijayawardene Kevin D.Hyde Kunhiraman C.Rajeshkumar David L.Hawksworth Hugo madrid Paul m.Kirk Uwe Braun Rajshree V.Singh Pedro W.Crous martin Kukwa Robert Lücking Cletus P.Kurtzman Andrey Yurkov Danny Haelewaters Andre´Aptroot H.Thorsten Lumbsch Einar Timdal Damien Ertz Javier Etayo Alan J.L.Phillips Johannes Z.Groenewald moslem Papizadeh Laura Selbmann monika C.Dayarathne Gothamie Weerakoon E.B.Gareth Jones Satinee Suetrong Qing Tian Rafael f.Castanda-Ruiz Ali H.Bahkali Ka-Lai Pang Kazuaki Tanaka Dong Qin Dai Jariya Sakayaroj martina Hujslová Lorenzo Lombard Belle D.Shenoy Ave Suija Sajeewa S.N.maharachchikumbura Kasun m.Thambugala Dhanushka N.Wanasinghe Bharati O.Sharma Subhash Gaikwad Gargee Pandit Laura Zucconi Silvano Onofri Eleonora Egidi Huzefa A.Raja Rampai Kodsueb marcela E.S.Caceres Sergio Perez-Ortega Patrícia O.fiuza Josiane Santana monteiro Larissa N.Vasilyeva Roger G.Shivas maria Prieto mats Wedin Ibai Olariaga Adebola Azeez Lateef Yamini Agrawal Seyed Abolhassan Shahzadeh fazeli mohammad Ali Amoozegar Guo Zhu Zhao Walter P.Pfliegler Gunjan Sharma magdalena Oset mohamed A.Abdel-Wahab Susumu Takamatsu Konstanze Bensch Nimali Indeewari de Silva AndréDe Kesel Anuruddha Karunarathna Saranyaphat Boonmee Donald H.Pfister Yong-Zhong Lu Zong-Long Luo Nattawut Boonyuen Dinushani A.Daranagama Indunil C.Senanayake Subashini C.Jayasiri milan C.Samarakoon Xiang-Yu Zeng mingkwan Doilom Luis Quijada Sillma Rampadarath Gabriela Heredia Asha J.Dissanayake Ruvishika S.Jayawardana Rekhani H.Perera Li Zhou Tang Chayanard Phukhamsakda margarita Hernańdez-Restrepo Xiaoya ma Saowaluck Tibpromma Luis f.P.Gusmao Darshani Weerahewa Samantha C.Karunarathna Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China mushroom Research foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand National fungal Culture Collection of India(NfCCI) Biodiversity and Palaeobiology(Fungi)GroupAgharkar Research InstitutePuneMaharashtra 411004India Royal Botanic Gardens KewRichmondSurrey TW93DSUK Department of Life Sciences The Natural History MuseumCromwell RoadLondon SW75BDUK Jilin Agricultural University Changchun 130118JilinPeople’s Republic of China Centro de Geno´mica y Bioinforma´tica Facultad de CienciasUniversidad Mayor de ChileCamino La Pira´mide 5750HuechurabaSantiagoChile martin-Luther-Universita¨t Institut fu¨r BiologieBereich Geobotanik und Botanischer GartenHerbariumNeuwerk 2106099 Halle(Saale)Germany Westerdijk fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Plant Taxonomy and Nature Conservation Faculty of BiologyUniversity of Gdan´skWita Stwosza 5980-308 Gdan´skPoland Botanic Garden and Botanical museum Königin-Luise-Str.6-814195 BerlinGermany mycotoxin Prevention and Applied microbiology Research Unit National Center for Agricultural Utilization ResearchAgricultural Research ServiceU.S.Department of AgriculturePeoriaIL 61604USA Leibniz Institute DSmZ-German Collection of microorganisms and Cell Cultures Inhoffenstraße 7B38124 BrunswickGermany farlow Reference Library and Herbarium of Cryptogamic Botany Harvard University22 Divinity AvenueCambridgeMA 02138USA Department of Organismic and Evolutionary Biology Harvard University22 Divinity AvenueCambridgeMA 02138USA ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Science&Education The Field Museum1400

Knowledge of the relationships and thus the classification of fungi,has developed rapidly with increasingly widespread use of molecular techniques,over the past 10–15 years,and continues to *** genera have been found to be polyphyletic,and their generic concepts have subsequently been *** names have thus been introduced for species which are phylogenetically distinct from the type species of particular *** ending of the separate naming of morphs of the same species in 2011,has also caused changes in fungal generic *** order to facilitate access to all important changes,it was desirable to compile these in a single *** present article provides a list of generic names of Ascomycota(approximately 6500 accepted names published to the end of 2016),including those which are *** and summaries of the changes since the last edition of‘Ainsworth&Bisby’s Dictionary of the fungi’in 2008 are *** notes include the number of accepted species,classification,type species(with location of the type material),culture availability,life-styles,distribution,and selected publications that have appeared since *** work is intended to provide the foundation for updating the ascomycete component of the"Without prejudice list of generic names of fungi"published in 2013,which will be developed into a list of protected generic *** will be subjected to the XIXth International Botanical Congress in Shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists,and scrutiny by procedures determined by the Nomenclature Committee for fungi(NCf).The previously invalidly published generic names Barriopsis,Collophora(as Collophorina),Cryomyces,Dematiopleospora,Heterospora(as Heterosporicola),Lithophila,Palmomyces(as Palmaria)and Saxomyces are validated,as are two previously invalid family names,Bartaliniaceae and *** species of Lalaria,which were invalidly published are trans

关键词： Article 59 Classification One name Pleomorphic fungi Taxonomy

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