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Journal of Materials Science & Technology 2020年第24期59卷 195-202页

作者： Kyungeun Jung Du Hyeon kim Jaemin kim Sunglim Ko Jae Won choi ki Chul kim Sang-Geul Lee Man-Jong Lee Department of Advanced Technology Fusion Konkuk UniversitySeoul05029Republic of Korea a Department of Chemistry Konkuk UniversitySeoul05029Republic of Korea Department of Mechanical Design and Production Engineering Konkuk UniversitySeoul05029Republic of Korea Division of Chemical Engineering Konkuk UniversitySeoul05029Republic of Korea Daegu Center Korea Basic Science InstituteDaegu41566Republic of Korea

The effect of ultraviolet-ozone(UVO)irradiation on amorphous(am)SnO_(2) and its impact on the photoconversion efficiency of MAPbI3-based perovskite solar cells were investigated in *** treatment was found to increase the amount of chemisorbed oxygen on the am-SnO_(2) surface,reducing the surface energy and contact *** changes in the am-SnO_(2) surface lowered the Gibbs free energy for the densification of perovskite films and facilitated the formation of homogeneous perovskite *** addition,the Fermi energy of the UVO-treated am-SnO_(2) shifted upwards to achieve an ideal band offset for MAPbI3,which was verified by theoretical calculations based on the density functional *** achieved a champion efficiency of 19.01% with a statistical reproducibility of 17.01±1.34% owing to improved perovskite film densification and enhanced charge transport/extraction,which is considerably higher than the 13.78±2.15% of the ***,UVO-treated,am-SnO_(2)-based devices showed improved stability and less hysteresis,which is encouraging for the future application of up-scaled perovskite solar cells.

关键词： UV-ozone Amorphous SnO_(2) Electron selective layers Planar perovskite solar cells Hysteresis

Endoluminal closure of an unrecognized penetrating stab wound of the duodenum with endoscopic band ligation: A case report

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World Journal of Clinical Cases 2019年第20期7卷 3271-3275页

作者： Dae Hoon kim Hanlim choi ki Bae kim Hyo Yung Yun Joung-Ho Han Department of Surgery Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644South Korea Department of Internal Medicine Chungbuk National University HospitalChungbuk National University College of MedicineCheongju-si 28644South Korea

BACKGROUND A penetrating injury of a hollow viscus is an obvious indication for an exploratory laparotomy,but is not typically an indication for endoscopic *** SUMMARY A 27-year-old man visited the emergency department with a self-inflicted abdominal stab *** to the colon and ileum were detected,but an injury to the second portion of the duodenum was *** the day following admission to our institution,the patient became hemodynamically unstable with massive hematochezia,although there was no evidence of bleeding in the Levin tube or Jackson-Pratt *** thus performed an upper gastrointestinal endoscopy and discovered a missed duodenal injury that was actively *** endoscopic band ligation was performed for hemostasis and closure of the *** patient was subsequently discharged without any *** A penetrating injury of the duodenum can be overlooked,so careful abdominal exploration is very *** a missed duodenal injury is suspected,a cautious endoscopic approach may be helpful.

关键词： Penetrating abdominal injury Endoluminal treatment Unrecognized duodenal injury Case report

Review of recent progresses on flexible oxide semiconductor thin film transistors based on atomic layer deposition processes

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Journal of Semiconductors 2018年第1期39卷 105-116页

作者： Jiazhen Sheng ki-Lim Han TaeHyun Hong Wan-Ho choi Jin-Seong Park Division of Materials Science and Engineering Hanyang University

The current article is a review of recent progress and major trends in the field of flexible oxide thin film transistors（TFTs）, fabricating with atomic layer deposition（ALD） processes. The ALD process offers accurate controlling of film thickness and composition as well as ability of achieving excellent uniformity over large areas at relatively low temperatures. First, an introduction is provided on what is the definition of ALD, the difference among other vacuum deposition techniques, and the brief key factors of ALD on flexible devices. Second, considering functional layers in flexible oxide TFT, the ALD process on polymer substrates may improve device performances such as mobility and stability, adopting as buffer layers over the polymer substrate, gate insulators, and active layers. Third, this review consists of the evaluation methods of flexible oxide TFTs under various mechanical stress conditions. The bending radius and repetition cycles are mostly considering for conventional flexible devices. It summarizes how the device has been degraded/changed under various stress types（directions）. The last part of this review suggests a potential of each ALD film, including the releasing stress, the optimization of TFT structure, and the enhancement of device performance. Thus, the functional ALD layers in flexible oxide TFTs offer great possibilities regarding anti-mechanical stress films, along with flexible display and information storage application fields.

关键词： atomic layer deposition(ALD) oxide semiconductor thin film transistor flexible device mechanical stress

Hybrid Friction Stir Welding of High-carbon Steel

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Journal of Materials Science & Technology 2011年第2期27卷 127-130页

作者： Don-Hyun choi Chang-Yong Lee Byung-Wook Ahn Jung-Hyun choi Yun-Mo Yeon Keun Song Seung-Gab Hong Won-Bae Lee ki-Bong Kang Seung-Boo Jung School of Advanced Materials Science and Engineering Sungkyunkwan University 300 Cheoncheon-dongJangan-guSuwonGyeonggi-do 440-746South Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology 335 GwahangnoYuseong-guDaejeon 305-701South Korea Department of Advanced Materials Application Suwon Science College 9-10Botong-liJeongnam-myeonHwasungGyeonggi-do 445-742South Korea Technical Research Lab POSCO Corp.Goedong-dongNam-guPohangGyeongbuk790-785South Korea

A high-carbon steel joint,SK5（0.84 wt% C）,was successfully welded by friction stir welding（FSW）,both without and with a gas torch,in order to control the cooling rate during *** welding,the weld zone comprised gray and black regions,corresponding to microstructural variation：a martensite structure and a duplex structure of ferrite and cementite,*** volume fraction of the martensite structure and the Vickers hardness in the welds were decreased with the using of the gas torch,which was related with the lower cooling rate.

关键词： Friction stir welding High-carbon steel Transformation Martensite

Detection of early gastric cancer using hydro-stomach CT:Blinded vs unblinded analysis

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World Journal of Gastroenterology 2011年第8期17卷 1051-1057页

作者： ki Jeong Park Min Woo Lee Ji Hyun Koo Yulri Park Heejung kim Dongil choi Soon Jin Lee Department of Radiol-ogy and Center for Imaging Science Samsung Medical Center Sungkyunkwan University School of Medicine

AIM:To evaluate the difference in diagnostic performance of hydro-stomach computed tomography(CT) to detect early gastric cancer(EGC) between blinded and unblinded analysis and to assess independent factors affecting visibility of cancer ***:Two radiologists initially blinded and then unblinded to gastroscopic and surgical-histological findings independently reviewed hydro-stomach CT images of 110 patients with single *** graded the visibility of cancer foci for each of three gastric segments(upper,middle and lower thirds) using a 4-point scale(1:definitely absent,2:probably absent,3:probably present,and 4:definitely present).The sensitivity and specificity for detecting an EGC were *** and interobserver agreements were *** visibility of an EGC was evaluated with regard to tumor size,invasion depth,gastric segments,histological type and gross morphology using univariate and multivariate ***:The respective sensitivities and specificities [reviewer 1:blinded,20%(22/110) and 98%(215/220);unblinded,27%(30/110) and 100%(219/220)/reviewer 2:blinded,19%(21/110) and 98%(216/220);unblinded,25%(27/110) and 98%(215/220)] were not significantly *** intraobserver agreements were good(weighted κ = 0.677 and 0.666),interobserver agreements were fair(blinded,0.371) or moderate(unblinded,0.558).For both univariate and multivariate analyses,the tumor size and invasion depth were statistically significant factors affecting ***:The diagnostic performance of hydrostomach CT to detect an EGC was not significantly different between blinded and unblinded *** tumor size and invasion depth were independent factors for visibility.

关键词： Stomach neoplasm Computed tomography Water Early detection of cancer Sensitivity

Molecular mechanisms of ZD1839 (Iressa)-induced apoptosis in human leukemic U937 cells

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Acta Pharmacologica Sinica 2007年第8期28卷 1205-1214页

作者： Dong-oh MOON Moon-ok kiM Jae-dong LEE Yung-hyun choi Min-ki LEE Gi-young kiM Faculty of Applied Marine Science Cheju National UniversityJeju Special Self-Governing Province 690-756Republic of Korea Department of Microbiology Pusan National UniversityBusan 614-052Republic of Korea Department of Biochemistry Dongeui University College of Oriental MedicineBusan 614-052Republic of Korea Department of Internal Medicine Pusan National University College o MedicineBusan 602-739Republic of Korea

Aim:To investigate the molecular mechanisms of ZD1839-induced apoptosis inhuman leukemic U937 ***:The inhibition of human leukemic U937 cellgrowth was assessed by 3-（4,5-dimethyl-2-thiazolyl）-2,5-diphnyl-2H-tetrazolimbromide（MTT）assays,lactate dehydrogenase（LDH）release,and cell *** expression of anti- and pro-apoptotic proteins was detected byWestern blot ***:This study demonstrated that ZD 1839 inducedapoptosis in leukemic U937 cells by the downregulation of Bcl-2,caspase activa-tion and subsequent apoptotic *** with ZD 1839 and the caspase-3 inhibitor z-DEVD-fmk blocked apoptosis,indicating that caspase-3 activation isat least partially responsible for ZD1839-induced *** ectopic expres-sion of Bcl-2 attenuated caspase-3 activation,PARP cleavage,and subsequentindicators of apoptosis,including sub-G1DNA content and LDH *** indicate that the downregulation of Bcl-2 plays a major role in the initiationof ZD1839-induced apoptosis,and that the activation of a caspase cascade isinvolved in the execution of ***,ZD 1839 treatment triggeredthe activation of p38 mitogen-activated protein kinase（MAPK）and the down-regulation of c-Jun-N-terminal kinase（JNK）,extracellular signal-regulated kinase（ERK）and phosphatidyl inositol 3-kinase（PI3K）/*** inhibition of the ERKand PI3K/Akt pathways also significantly increased cellular ***:ZD 1839 activated caspase-3 and the inhibited Bcl-2 in human leukemic U937 cellsthrough the downregulation of the ERK and PI3K/Akt pathways.

关键词： ZD1839(Iressa) apoptosis caspase-3 Bcl-2 mitogen-activated protein kinases

Prediction of nephrotoxicity induced by cisplatin combination chemotherapy in gastric cancer patients

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World Journal of Gastroenterology 2011年第30期17卷 3510-3517页

作者： Hyung Hwan Moon Kyung Won Seo ki Young Yoon Yeon Myung Shin Kyung Hyun choi Sang Ho Lee Department of Surgery Kosin University College of Medicine602-703 BusanSouth Korea

AIM:To evaluate the treatment options for nephrotoxicity due to cisplatin combination ***:We retrospectively reviewed patients who had received cisplatin combination chemotherapy for gastric cancer between January 2002 and December *** investigated patients who had shown acute renal failure(ARF),and examined their clinical characteristics,laboratory data,use of preventive measures,treatment cycles,the amount of cisplatin administered,recovery period,subsequent treatments,and renal status between the recovered and unrecovered ***:Forty-one of the 552 patients had serum creatinine(SCR)levels greater than 1.5 mg/*** found that pre-ARF SCR,ARF SCR,and ARF glomerular filtration rates were significantly associated with renal status postARF between the two groups(P=0.008,0.026,0.026,respectively).On the receiver operating characteristic curve of these values,a 1.75 mg/dL ARF SCR value had 87.5%sensitivity and 84.8%specificity(P=0.011).CONCLUSION:Cessation or reduction of chemotherapy should be considered for patients who have an elevation of SCR levels during cisplatin combination chemotherapy.

关键词： Acute renal failure Cisplatin Drug toxicities Nephrotoxicity

Electrodeposited copper oxides with a suppressed interfacial amorphous phase using mixed-crystalline ITO and their enhanced photoelectrochemical performances

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Journal of Energy Chemistry 2023年第7期82卷 277-286,I0007页

作者： Ji Hoon choi Hae-Jun Seok Dongchul Sung Dong Su kim Hak Hyeon Lee Suklyun Hong Han-ki kim Hyung Koun Cho School of Advanced Materials Science and Engineering Sungkyunkwan University2066Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea Department of Physics Graphene Research Instituteand GRI-TPC International Research CenterSejong UniversitySeoul 05006Republic of Korea

The effectiveness of photoelectrochemical(PEC)water splitting is significantly restricted by insufficient light harvesting,rapid charge recombination,and slow water reduction *** the presence of amorphous phases in the interfaces hinders the overcome of these inherent limitations,a photoelectrode must be built ***,we artificially controlled the crystallographic orientation of indium tin oxide(ITO)to determine the orientation with the smallest lattice mismatch at the Cu_(2)O interface,thus significantly reducing the amorphous phase in the early stage of electrodeposition ***[222]/[400]mixed orientation ITO primarily exposed the{400}surface planes and accelerated charge transfer by forming an optimal interface with preferentially grown(111)oriented Cu_(2)O and minimized amorphous *** addition,the ITO surface energy was calculated using density functional theory to theoretically verify which plane is more active for growing the photoactivation *** rationally designed ITO/Cu_(2)O/Al-dope Zn O/TiO_(2)/Rh-P device,with each layer serving a specific purpose,achieved a photocurrent density of 8.23 mA cm^(-2)at 0 VRHEunder AM 1.5 G illumination,providing a standard method for effective solar-to-hydrogen conversion photocathodes.

关键词： Photoelectrochemical water splitting Cu_(2)O ITO Hydrogen Surface energy DFT

8-Hydroxydeoxyguanosine:Not mere biomarker for oxidative stress,but remedy for oxidative stress-implicated gastrointestinal diseases

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World Journal of Gastroenterology 2012年第4期18卷 302-308页

作者： Chan-Young Ock Eun-Hee kim Duck Joo choi Ho Jae Lee ki-Baik Hahm Myung Hee Chung Lab of Translational Medicine Gachon University of Medicine and ScienceLee Gil Ya Cancer and Diabetes Institute Department of Gastroenterology Gachon Graduate School of MedicineGil Hospital Sungkyunkwan University Samsung Advanced Institute for Biomedical Research

Reactive oxygen species （ROS） attack guanine bases in DNA easily and form 8-hydroxydeoxyguanosine （8-OHdG）, which can bind to thymidine rather than cytosine, based on which, the level of 8-OHdG is gen- erally regarded as a biomarker of mutagenesis conse- quent to oxidative stress. For example, higher levels of 8-OHdG are noted in Helicobacter pylori-associated chronic atrophic gastritis as well as gastric cancer. However, we have found that exogenous 8-OHdG can paradoxically reduce ROS production, attenuate the nuclear factor-KB signaling pathway, and ameliorate the expression of proinflammatory mediators such as interleukin （IL）-I, IL-6, cyclo-oxygenase-2, and induc- ible nitric oxide synthase in addition to expression of nicotinamide adenine dinucleotide phosphate oxidase （NOX）-I, NOX organizer-1 and NOX activator-1 in vari- ous conditions of inflammation-based gastrointestinal （GI） diseases including gastritis, inflammatory bowel disease, pancreatitis, and even colitis-associated carci- nogenesis. Our recent finding that exogenous 8-OHdG was very effective in either inflammation-based or oxidative-stress-associated diseases of stress-related mucosal damage has inspired the hope that synthetic 8-OHdG can be a potential candidate for the treatment of inflammation-based GI diseases, as well as the pre- vention of inflammation-associated GI cancer. In this editorial review, the novel fact that exogenous 8-OHdG can be a functional molecule regulating oxidative- stress-induced gastritis through either antagonizing Rac-guanosine triphosphate binding or blocking the signals responsible for gastric inflammatory cascade is introduced.

关键词： 8-hydroxydeoxyguanosine Oxidative stress Inflammation Carcinogenesis Prevention

Hypothyroid effects on astrocytes and microglia in the adult rat hippocampus

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Neural Regeneration Research 2009年第12期4卷 1078-1082页

作者： Choong Hyun Lee Jung Hoon choi In Koo Hwang ki-Yeon Yoo Hyung-Cheul Shin Moo-Ho Won Department of Anatomy and Neurobiology and Institute of Neurodegeneration and NeuroregenerationCollege of MedicineHallym University South Korea Institute of Naturat Medicine Hallym University Department ofAnatomy and Cell Biology College of Veterinary Medicine and BK21 Program for Veterinary ScienceSeoul National Unlversity South Korea Institute of Natural Medicine Hallym University Department of Physiology College of MedicineHallym University

BACKGROUND： Thyroid hormones modulate proliferation of astrocytes and microglia depending on maturation stage and localization. Studies have demonstrated that triiodothyronine treatment or thyroidectomy during developmental stages results in morphological alterations and changes in the number of astrocytes and microglia. Little is known about the effects of hypothyroidism on astrocytes and microglia in adults. OBJECTIVE： To investigate the effects of hypothyroidism on morphology and number of astrocytes and microglia in the adult rat hippocampus. DESIGN, TIME AND SETTING： A randomized, controlled, neuroendocrinological, animal study was performed at the College of Medicine, Hallym University, South Korea between May 2008 and April 2009. MATERIALS： Methimazole, rabbit anti-glial fibrillary acidic protein （GFAP） antiserum, and rabbit anti-lba-1 antiserum were purchased from Sigma, USA. Rabbit anti-GFAP polyclonal antibody was provided by Chemicon, USA. Rabbit anti-lba-1 polyclonal antibody was purchased from Wako, Japan. Terminal deoxynucleotidyl transferase dUTP-biotin nick-end-labeling （TUNEL） kit was provided by Roche Molecular Biochemicals, Mannheim, Germany. METHODS： Hypothyroidism was induced in Wistar rats via methimazole administration （0.025%） in drinking water for 5 weeks, starting at 6 months of age. MAIN OUTCOME MEASURES： Following methimazole treatment, hippocampai neuronal death was determined using TUNEL staining. The morphology and number of GFAP and lba-1 immunoreactive cells were detected by immunohistochemistry. Hippocampal GFAP and lba-1 protein levels were detected by Western blot analysis. Serum-free triiodothyronine and thyroxine levels were quantified. RESULTS： TUNEL-positive neurons were not observed in the hippocampus of euthyroid and hypothyroid rats. Compared with the euthyroid rats, the number of GFAP immunoreactive astrocytes was decreased, and serum triiodothyronine and thyroxine levels were significantly decreased. In contrast, the numb

关键词： astrocytes hippocampus hypothyroidism microglia Wistar rats