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Sectoral changes of the peripapillary choroidal thickness in patients with unilateral branch retinal vein occlusion

International Journal of Ophthalmology(English edition) 2019年第3期12卷 472-479页

作者： Na Eun Lee Hae min Kang Jeong Hoon choi Hyoung Jun Koh Sung Chul Lee Department of Ophthalmology Catholic Kwandong University College of Medicine International St. Mary's Hospital choikang Seoul Eye Clinic Institute of Vision Research Department of Ophthalmology Yonsei University College of Medicine

AIM: To investigate sectoral changes in the mean peripapillary choroidal thickness(PCT) in patients with unilateral branch retinal vein occlusion(BRVO). METHODS: This retrospective, interventional study included 41 patients with acute, unilateral BRVO without macular edema. All patients completed at least a 6-month follow-up period. The PCT was measured at eight locations(temporal, superotemporal, superior, superonasal, nasal, inferonasal, inferior, and inferotemporal). In addition to calculating the average of all locations, the peripapillary choroidal area was divided into four sectors: superior(average of superotemporal PCT, superior PCT, and superonasal PCT), temporal, inferior(average of inferotemporal PCT, inferior PCT, and inferonasal PCT), and nasal. RESULTS: In the BRVO-affected eyes, the mean PCT was 177.7±69.8 μm(range, 70.1-396.0 μm) at baseline and 127.8±54.8 μm(range, 56.4-312.1 μm) at 6 mo(P<0.001). In the non-affected contralateral eyes, the mean PCT was 192.5±60.6 μm(range, 61.4-365.0 μm) at baseline and 165.9±61.1 μm(range, 56.8-326.8 μm) at 6 mo(P<0.001). In sectoral analysis, the mean PCT in each sector was significantly reduced in over 6 mo in the BRVO-affected eyes(all P<0.001). In the non-affected contralateral eyes, the mean PCT was not significantly changed in any sector over the 6-month follow-up period(superior sector, P=0.143; temporal sector, P=0.825; inferior sector, P=0.192; and nasal sector, P=0.599).CONCLUSION: Sectoral analysis shows that the mean PCTs in all sectors are reduced significantly over 6 mo in the BRVO-affected eyes, but not in the non-affected contralateral eyes.

关键词： branch retinal vein occlusion choroid choroidal thickness peripapillary choroidal thickness

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Protective effects of edible insect protein extracts from Protaetia brevitarsis against H_(2)O_(2)-induced oxidative stress in mouse C2C12 myoblast cells

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Food Bioscience 2023年第2期52卷 435-443页

作者： Jae Hoon Lee Tae-Kyung Kim min-Cheol Kang Bum-Keun Kim Yun-Sang choi Research Group of Food Processing Korea Food Research InstituteWanju55365Republic of Korea

Edible insects have been attracting significant attention not only for their nutritional superiority but also for their excellent bio-functional *** this study,the apoptotic protective effects of water-soluble protein(WPB)and salt-soluble protein(SPB)extracts derived from Protaetia brevitarsis against hydrogen peroxide(H_(2)O_(2))-induced oxidative stress in C2C12 cells were *** and SPB were confirmed to exhibit radical scavenging and ferric-ion reducing *** addition,WPB and SPB treatments effectively restored the decreased cell viability of the C2C12 cells induced by H2O2 treatment,and showcased protective effects against apoptosis and mitochondrial dysfunction by regulating the expressions of pro-and anti-apoptotic ***,our data indicated that protein extracts from Protaetia brevitarsis could be beneficial for the prevention and treatment of diseases associated with apoptosis induced by oxidative stress.

关键词： Edible insect protein extract Protaetia brevitarsis Antioxidant Anti-Apoptosis C2C12 myoblast cells

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Stretchable and colorless freestanding microwire arrays for transparent solar cells with flexibility

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Light(Science & Applications) 2019年第1期8卷 47-59页

作者： Sung Bum Kang Ji-Hwan Kim Myeong Hoon Jeong Amit Sanger Chan Ul Kim Chil-min Kim Kyoung Jin choi Department of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Emerging Materials Science Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea

Transparent solar cells(TSCs)are emerging devices that combine the advantages of visible transparency and light-toelectricity ***,existing TSCs are based predominantly on organics,dyes,and perovskites;however,the rigidity and color-tinted transparent nature of those devices strongly limit the utility of the resulting TSCs for realworld ***,we demonstrate a flexible,color-neutral,and high-efficiency TSC based on a freestanding form of n-silicon microwires(SiMWs).Flat-tip SiMWs with controllable spacing are fabricated via deep-reactive ion etching and embedded in a freestanding transparent polymer *** light transmittance can be tuned from ~10 to 55% by adjusting the spacing between the *** TSCs,a heterojunction is formed with a p-type polymer in the top portion of the n-type flat-tip *** contact with an indium-doped ZnO film occurs at the bottom,and the side surface has an Al2O3 passivation ***,slanted-tip SiMWs are developed by a novel solventassisted wet etching method to manipulate light ***-difference time-domain simulation revealed that the reflected light from slanted-tip SiMWs helps light-matter interactions in adjacent *** TSC based on the slanted-tip SiMWs demonstrates 8%efficiency at a visible transparency of 10% with *** efficiency is the highest among Si-based TSCs and comparable with that of state-of-the-art neutral-color TSCs based on organic–inorganic hybrid perovskite and ***,unlike others,the stretchable and transparent platform in this study is promising for future TSCs.

关键词： transparent transparency spacing

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Ethyl acetate fraction of Sargassum pallidum extract attenuates particulate matter-induced oxidative stress and inflammation in keratinocytes and zebrafish

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Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 137-146页

作者： Wook Chul Kim Ji-Won Park Bohyun Yun WonWoo Lee Kyung-min choi Seung-Hong Lee Department of Medical Science Soonchunhyang UniversityAsan 31538Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do 58762Republic of Korea Department of Pharmaceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

Objective:To evaluate the effect of the ethyl acetate fraction derived from Sargassum pallidum extract against particulate matter(PM)-induced oxidative stress and inflammation in HaCaT cells and ***:HaCaT cells and zebrafish were used to evaluate the protective effects of the ethyl acetate fraction of Sargassum pallidum extract against PM-induced oxidative stress and *** production of nitric oxide(NO),intracellular ROS,prostaglandin E_(2)(PGE_(2)),and pro-inflammatory cytokines,and the expression levels of COX-2,iNOS,and NF-κB were evaluated in PM-induced HaCaT ***,the levels of ROS,NO,and lipid peroxidation were assessed in the PM-exposed zebrafish ***:The ethyl acetate fraction of Sargassum pallidum extract significantly decreased the production of NO,intracellular ROS,and PGE_(2) in PM-induced HaCaT *** addition,the fraction markedly suppressed the levels of pro-inflammatory cytokines and inhibited the expression levels of COX-2,iNOS,and NF-κ***,it displayed remarkable protective effects against PM-induced inflammatory response and oxidative stress,represented by the reduction of NO,ROS,and lipid peroxidation in ***:The ethyl acetate fraction of Sargassum pallidum extract exhibits a protective effect against PM-induced oxidative stress and inflammation both in vitro and in vivo and has the potential as a candidate for the development of pharmaceutical and cosmeceutical products.

关键词： Particulate matter Inflammation Oxidative stress Sargassum pallidum Ethyl acetate fraction Zebrafish

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Effects of dietary supplementation of bacteriophage cocktail on health status of weanling pigs in a non-sanitary environment

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1661-1677页

作者： YoHan choi Abdolreza Hosseindoust Sang Hun Ha Joeun Kim YeJin min YongDae Jeong JunYoung Mun SooJin Sa JinSoo Kim Swine Science Division National Institute of Animal ScienceRural Development AdministrationCheonan 31000Republic of Korea Department of Animal Industry Convergence Kangwon National UniversityChuncheon 24341Republic of Korea

Background The study evaluated the effects of bacteriophage cocktail(BP)and ZnO administered during weaning time for piglets exposed to a non-sanitary *** bacteriophages were designed to eliminate Escherichia coli(K88,K99 and F41),Salmonella(typhimurium and enteritidis),and Clostridium perfreingens(types A and C).Forty 21-day-old crossbreed piglets were assigned to four treatments,including the PC(sanitary environment),NC(nonsanitary environment),BP(NC plus 108 pfu/kg BP),and ZO(NC plus 2,500 mg/kg ZnO).Piglets in the NC,BP and ZO were kept in a non-sanitary environment for 14 d,which was contaminated with the feces of infected *** Pigs in the BP and ZO treatments had a higher final body weight compared with the *** NC treatment showed the highest concentration of inflammatory cytokines including interleukin(IL)-1β,IL-6 and tumor necrosis factor-αin the *** administration of BP and ZO showed lower myeloperoxidase concentrations compared with the *** NC treatment showed a lower concentration of superoxide dismutase in serum compared with the *** the treatments in non-sanitary environment,the NC treatment showed a higher concentration of malondialdehyde compared with the *** PC treatment showed a lower concentration of butyric acid in the feces compared with the BP *** non-sanitary treatments,the villus height in the duodenum was greater in the BP and ZO compared with the *** lower abundance of Proteobacteria phylum was observed in the BP and PC treatments compared with the *** highest relative abundance of Eubacterium was recorded in the BP *** abundance of Megasphaera and Schwartzia was higher in the NC pigs compared with the BP *** abundance of Desulfovibrio was lower in the supplemented treatments(BP and ZO)compared with non-supplemented(NC and PC).The abundance of Cellulosilyticum genera was higher in the BP and ZO treatments rather than in the *** piglets in the NC treatment had the

关键词： Antioxidant Cytokines Diarrhea Fecal score Inflammation Microbiota Proteobacteria

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Single-cell RNA sequencing of mitoticarrested prospermatogonia with DAZL::GFP chickens and revealing unique epigenetic reprogramming of chickens

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Journal of Animal Science and Biotechnology 2022年第5期13卷 1305-1325页

作者： Hyeon Jeong choi Kyung min Jung Deivendran Rengaraj Kyung Youn Lee Eunhui Yoo Tae Hyun Kim Jae Yong Han Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences Seoul National UniversitySeoul 08826South Korea Department of Animal Science Pennsylvania State UniversityState CollegePA 16801USA

Background:Germ cell mitotic arrest is conserved in many vertebrates,including birds,although the time of entry or exit into quiescence phase *** arrest is essential for the normal differentiation of male germ cells into spermatogonia and accompanies epigenetic reprogramming and meiosis inhibition from embryonic development to ***,mitotic arrest was not well studied in chickens because of the difficulty in obtaining pure germ cells from relevant developmental ***:We performed single-cell RNA sequencing to investigate transcriptional dynamics of male germ cells during mitotic arrest in DAZL::GFP *** differentially expressed gene analysis and K-means clustering to analyze cells at different developmental stages(E12,E16,and hatch),we found that metabolic and signaling pathways were regulated,and that the epigenome was reprogrammed during mitotic *** particular,we found that histone H3K9 and H3K14 acetylation(by HDAC2)and DNA demethylation(by DNMT3B and HELLS)led to a transcriptionally permissive chromatin ***,we found that global DNA demethylation occurred gradually after the onset of mitotic arrest,indicating that the epigenetic-reprogramming schedule of the chicken genome differs from that of the mammalian *** hypomethylation persisted after hatching,and methylation was slowly re-established 3 weeks ***:We found a unique epigenetic-reprogramming schedule of mitotic-arrested chicken prospermatogonia and prolonged hypomethylation after *** will provide a foundation for understanding the process of germ-cell epigenetic regulation in several species for which this process is not clearly *** findings on the biological processes related to sex-specific differentiation of prospermatogonia could help studying germline development in vitro more elaborately.

关键词： DAZL::GFP chickens DNA methylation Epigenetic reprogramming Histone acetylation Male germ cell Mitotic arrest Prospermatogonia Single-cell RNA sequencing

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Temporal population dynamics of dinoflagellate Prorocentrum minimum in a semi-enclosed mariculture pond and its relationship to environmental factors and protozoan grazers

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Chinese Journal of Oceanology and Limnology 2010年第1期28卷 75-81页

作者：许恒龙 min Gi-Sik choi Joong-Ki 朱明壮姜勇 AL-RASHEID Khaled A.S. Laboratory of Protozoology KLMOcean University of China Department of Biological Sciences Inha University Department of Oceanography Inha University Zoology Department King Saud University

The ecological processes and interrelationships between protists,either autotrophic or heterotrophic,and environmental factors in mariculture ponds are largely *** study investigated the temporal dynamics of potentially harmful dinoflagellate,Prorocentrum minimum (Pavillard) Schiller,and its relationship to physico-chemical factors and protozoan grazers over a complete cycle in a semi-enclosed shrimp-farming pond near Qingdao,Northern *** occurred frequently in low numbers from June to August,followed by a sharp increase from the middle of August,reaching a single maximum peak value of 2.2×105 cells L-1 in *** variation in abundance was positively correlated with dissolved nitrogen,but showed a significant inverse relationship to abundance of the dominant ciliates,Tintinnopsis lohmanni and Askenasia *** results provide statistical evidence that the number of *** increased with increasing nitrogen,and the suppression or shortening of algal bloom may be associated with protozoan grazers,such as Tintinnopsis lohmanni,in mariculture ponds.

关键词： dinoflagellate harmful algae Prorocentrum minimum shrimp-farming

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Improving toughness of medium-Mn steels after friction stir welding through grain morphology tuning

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Journal of Materials Science & Technology 2022年第23期118卷 243-254页

作者： Mun Sik Jeong Tak min Park Dong-Il Kim Hidetoshi Fujii Hye Ji Im Pyuck-Pa choi Seung-Joon Lee Jeongho Han Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Department of Advanced Materials Engineering Korea Polytechnic UniversitySiheung 15073Republic of Korea Joining and Welding Research Institute Osaka UniversityOsaka 567-0047Japan Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Materials Science and Engineering Northwestern UniversityEvanstonIL 60208USA

This work demonstrated the viability of friction stir welding for the welding of medium-Mn steels when used as cryogenic vessel materials for liquefied gas *** used an intercritically annealed Fe-7 Mn-0.2 C-3 Al(wt.%)steel with a dual-phase(α'martensite andγ_(R) retained austenite)nanolaminate structure as a base material and systematically compared its microstructure and impact toughness after friction stir and tungsten inert gas *** friction stir welded specimen exhibited a large amount ofγ_(R) phase owing to a relatively low temperature during welding,whereas the tungsten inert gas welded specimen comprised only theα'***,the friction stir welded steel exhibited a tuned morphology of nanoscale globular microstructure at the weld zone and did not exhibit any prior austenite grain boundary due to active recrystallization caused by deformation during *** preserved fraction ofγ_(R) and morphological tuning in the weldment improved the impact toughness of the friction stir welded steel at low *** the steel processed by tungsten inert gas welding,the notch crack propagated rapidly along the prior austenite grain boundaries-weakened by Mn and P segregations-resulting in poor impact ***,the friction stir welded steel exhibited a higher resistance against notch crack propagation due to the slow crack propagation along the ultrafine ferrite/ferrite(α/α)interfaces,damage tolerance by the active transformation-induced plasticity from the large amount ofγR,and enhanced boundary cohesion by suppressed Mn and P segregations.

关键词： Charpy impact test Transformation-induced plasticity Friction stir welding Phase stability Medium-Mn steel

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Subacute electroacupuncture at Baihui (GV 20) and Dazhui (GV 14) promotes post-stroke functional recovery via neurogenesis and astrogliosis in a photothrombotic stroke mouse model

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Journal of Traditional Chinese Medicine 2019年第6期39卷 833-841页

作者： Young-Wook Park Gi Yoon Heo min Jae Kim Seo-Yeon Lee Byung Tae choi Hwa Kyoung Shin Division of Meridian and Structural Medicine School of Korean MedicinePusan National UniversityYangsanGyeongnam 50612Republic of Korea Department of Korean Medical Science School of Korean MedicinePusan National UniversityYangsanGyeongnam 50612Republic of Korea Graduate Training Program of Korean Medicine for Healthy-Aging Pusan National UniversityYangsanGyeongnam 50612Republic of Korea Korean Medical Science Research Center for Healthy-Aging Pusan National UniversityYangsanGyeongnam 50612Republic of Korea

OBJECTIVE:To investigate the optimal timing and underlying mechanism of electroacupuncture(EA)at Baihui(GV 20)and Dazhui(GV 14)for improved long-term functional recovery after focal cerebral ischemia in a photothrombotic stroke mouse ***:Totally 50 adult male C57 BL/6 J mice were assigned into 5 groups:(a)the control group,sham-operated mice(n=10);(b)the vehicle group,focal cerebral ischemia induction without EA(n=10);(c)the acute EA group,mice received EA immediately post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(d)the subacute EA group,mice received EA 4 days post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(e)the delayed EA *** stimulation(2 Hz,2 V for 20 min)was applied to acupuncture points(acupoints),Baihui(GV 20)and Dazhui(GV 14),once a day for 7 consecutive days beginning immediately(acute treatment),4 d(subacute treatment)and 10 d(delayed treatment)after focal cerebral ischemia in C57 BL/6 J *** assessments were conducted 21 and 28 d post-ischemia and histopathological analyses were performed 28 days ***:The subacute EA treatment at Baihui(GV20)and Dazhui(GV 14)significantly improved functional recovery compared to the vehicle group 28 d after ischemic brain injury,although brain atrophy was not *** number of Neu N+and Neu N+/Brd U+cells as well as GFAP intensity in the ipsilateral cortex were significantly increased in the subacute group compared to the vehicle group 28 d *** concluded that EA stimulation 4 d post-ischemia(subacute treatment)enhanced neurogenesis and astrogliosis,likely contributing to long-term functional recovery following focal cerebral ***:Our findings suggest that the timing of the EA therapy at Baihui(GV 20)and Dazhui(GV 14)determines the therapeutic effects in mice with focal cerebral ischemia induced by photothrombotic occlusion.

关键词： Electroacupuncture Stroke Astrocytes Neurogenesis Post-stroke remodeling

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Controlling the contact levels of details for fast and precise haptic collision detection

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Frontiers of Information Technology & Electronic Engineering 2017年第8期18卷 1117-1130页

作者： A Ram choi Sung min KIM Mee Young SUNG Department of Computer Science and Engineering lncheon National University lncheon Korea

For accurate and stable haptic rendering, collision detection for interactive haptic applications has to be done by filling in or covering target objects as tightly as possible with bounding volumes （spheres, axis-aligned bounding boxes, oriented bounding boxes, or polytopes）. In this paper, we propose a method for creating bounding spheres with respect to the contact levels of details （CLOD）, which can fit objects while maintaining the balance between high speed and precision of collision detection. Our method is composed mainly of two parts： bounding sphere formation and two-level collision detection. To specify further, bounding sphere formation can be divided into two steps： creating spheres and clustering spheres. Two-level collision detection has two stages as well： fast detection of spheres and precise detection in spheres. First, bounding spheres are created for initial fast probing to detect collisions of spheres. Once a collision is probed, a more precise detection is executed by examining the distance between a haptie pointer and each mesh inside the colliding boundaries. To achieve this refmed level of detection, a special data structure of a bounding volume needs to be defined to include all mesh information in the sphere. After performing a number of experiments to examine the usefulness and performance of our method, we have concluded that our algorithm is fast and precise enough for haptic simulations. The high speed detection is achieved through the clustering of spheres, while detection precision is realized by voxel-based direct collision detection. Our method retains its originality through the CLOD by distance-based clustering.

关键词： Collision detection Haptic rendering Bounding sphere Clustering Contact levels of details (CLOD)

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