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Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues

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World Journal of Gastroenterology 2006年第35期12卷 5651-5657页

作者： Kyung-Hee Kim jin-Sung choi Il-jin Kim Ja-Lok Ku Jae-Gahb Park Laboratory of Cell Biology Korean Cell Line Bank Cancer Research Institute Seoul National University College of Medicine Seoul 110-744 Korea Laboratory of Cell Biology Korean Cell Line Bank Cancer Research Institute Seoul National University College of Medicine Seoul 110-744

AIM： To verify the expression and methylation status of the MAGE-A1 and MAGE-A3 genes in colorectal cancer tissues and cancer cell lines. METHODS： We evaluated promoter demethylation status of the MAGE-A1 and MAGE-A3 genes by RT-PCR analysis and methylation-specific PCR （MS-PCR）, as well as sequencing analysis, after sodium bisulfite modification in 32 colorectal cancer cell lines and 87 cancer tissues. RESULTS： Of the 32 cell lines, MAGE-A1 and MAGE-A3 expressions were observed in 59% and 66%, respectively. Subsequent to sodium bisulfite modification and MSPCR analysis, the promoter hypomethylation of MAGE-A1 and MAGE-A3 was confirmed in both at 81% each. Promoter hypomethylation of MAGE-A1 and MAGE-A3 in colorectal cancer tissues was observed in 43% and 77%, respectively. Hypomethylation of MAGE-A1 and MAGE-A3 genes in corresponding normal tissues were observed in 2% and 6%, respectively. CONCLUSION： The promoter hypomethylation of MAGE genes up-regulates its expression in colorectal carcinomas as well as in gastric cancers and might play a significant role in the development and progression of human colorectal carcinomas.

关键词： MAGE-A1 MAGE-A3 Promoter Hypomethylation Colorectal cancer

Electrodeposited Ni-W-TiC Composite Coatings:Effect of TiC Reinforcement on Microstructural and Tribological Properties

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Acta Metallurgica Sinica(English Letters) 2020年第4期33卷 573-582页

作者： jin Hyuk choi Gobinda Gyawali Dhani Ram Dhakal Bhupendra Joshi Soo Wohn Lee Department of Materials Metal Engineering Sun Moon University31460 AsanSouth Korea Department of Fusion Science and Technology Sun Moon UniversityTangjeong Myeon31460 AsanChungnamSouth Korea Department of Environmental and Bio-Chemical Engineering Sun Moon University31460 AsanSouth Korea

Ni-W-TiC composite coatings were prepared via electrodeposition technique by dispersing the different amount of TiC particles into the plating *** Ni-W and Ni-W-TiC composite coatings containing different concentrations of TiC particles were characterized by using the scanning electron microscope,X-ray diffraction technique,Vickers microhardness test,surface roughness test,and tribology *** results show that the Ni-W coatings containing reinforced TiC particles have shown a typical FCC Ni-W crystal structure with significantly higher Vickers *** amount of dispersed TiC particles into the plating bath considerably affected codeposition weight percent of TiC into the Ni-W matrix,as revealed by the EDS ***-W-TiC samples demonstrated the decreased abrasive wear as compared to Ni-W coating and no characteristic features observed for the adhesive ***,an improvement in coefficient of friction was observed in Ni-W-TiC composite coating as compared to Ni-W coating.

关键词： Ni-W alloy Composite coating Microhardness Wear Coefficient of friction

SnO2@Co3O4 hollow nano-spheres for a Li-ion battery anode with extraordinary performance

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Nano Research 2014年第8期7卷 1128-1136页

作者： Won-Sik Kim Yoon hwa Hong-Chan Kim Jong-Hyun choi Hun-Joon Sohn Seong-Hyeon Hong Department of Materials Science and Engineering and Research Institute of Advanced Materials Seoul National University Seoul151-744 Republic of Korea

SnO2@Co3O4 hollow nano-spheres have been prepared using the template-based sol-gel coating technique and their electrochemical performance as an anode for lithium-ion battery （LIB） was investigated. The size of synthesized hollow spheres was about 50 nm with the shell thickness of 7-8 nm. The fabricated SnO2@Co3O4 hollow nano-sphere electrode exhibited an extraordinary reversible capacity （962 mAh-g-1 after 100 cycles at 100 mA-g-1）, good cyclability, and high rate capability, which was attributed to the Co-enhanced reversibility of the Li20 reduction reaction during cycling.

关键词： hollow sphere lithium-ion battery anode SnO2 Co3O4

Population trend and spatio-temporal distribution of Greater White-fronted(Anser albifrons)and Bean Geese(Anser fabalis)in Korea

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Avian Research 2024年第4期15卷 458-465页

作者： Eun-Jeong Kim Wee-Heang Hur hwa-Jung Kim Yu-Seong choi Dongwon Kim Who-Seung Lee Sejeong Han Hyerin Joo Chang-Yong choi Department of Agriculture Forestryand BioresourcesSeoul National UniversitySeoul08826Republic of Korea Research Institute of Agriculture and Life Science Seoul National UniversitySeoul08826Republic of Korea National Migratory Birds Center National Institute of Biological ResourcesIncheon22689Republic of Korea Division for Natural Environment Korea Environment InstituteSejong30147Republic of Korea

Geese have undergone significant changes in their distribution and population size due to human-induced *** improve our understanding of the two main geese populations in East Asia—Greater White-fronted(Anser albifrons;GWFG)and Bean Geese(Anser fabalis sensu lato;BEAG),which includes the Tundra ***(TDBG)and Taiga Bean Geese ***(TGBG),this study estimated their long-and short-term trends and the migration strategies based on their distribution during the migratory and wintering seasons,using nationwide census data collected over 24 years in South *** TRIM(TRends and Indices for Monitoring data)analysis supported a robust long-term population increase since 1999,recently stabilizing around 150,000 individuals in GWFG and 100,000 in TDBG,*** TGBG stabilized at around 7000 with no significant change of population over *** shorter-term trends within a season suggested that wintering populations of GWFG and TDBG in China might stop over in Korea in their autumn migration before their sea-crossing,evidenced by the large congregation near the Yellow Sea coast followed by a gradual *** contrast to autumn,there was no similar peak in spring migration,suggesting the potential for elliptical migration of some populations around the Yellow *** findings indicate a growing East Asian population and imply one of the migration strategies of the Greater White-fronted and Tundra Bean *** collaborating with recent tracking data,long-term monitoring efforts could offer more detailed insights into population trends and migration strategies,thereby contributing to the effective management and conservation of goose species in East Asia.

关键词： Bean Goose Anser fabalis East Asia Greater White-fronted Goose Anser albifrons Long-term monitoring Spatiotemporal distribution Non-breeding

Delayed inflammatory response evoked in nasal alloplastic implants after COVID-19 vaccination: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8298-8303页

作者： Min-Gi Seo Eun Kyung choi Kyu jin Chung Department of Plastic and Reconstructive Surgery College of MedicineYeungnam UniversityDaegu 42415South Korea Department of Anesthesiology and Pain Medicine College of MedicineYeungnam UniversityDaegu 42415South Korea

BACKGROUND Delayed inflammatory reactions(DIRs)in alloplast rhinoplasty are a rare complication that may occur several months to years after *** exact causes and mechanisms are unclear,but several triggering factors,including infections,trauma,dental procedures,and vaccination,have been *** SUMMARY A 39-year-old male patient who had undergone augmentation rhinoplasty 8 years ago had DIRs after the administration of the first dose of the mRNA Pfizer coronavirus disease 2019(COVID-19)*** suddenly had tender,erythematous swelling on his face 6 d after *** there was no improvement in the patient’s condition after the conservative treatment,surgical removal of an alloplastic nasal implant was *** after the surgery,the DIRs and accompanying symptoms ameliorated rapidly.A histological study conducted during surgery was fibrosis and small fragments of the hyaline *** The correlation between DIRs and COVID-19 vaccination has not been reported yet and the exact mechanism is *** the uncontrolled inflammatory reactions on the nose leave serious sequelae,surgeons should be conscious of the correlation between COVID-19 vaccines and DIRs associated with nasal alloplastic *** further histological or microbiological studies should be performed to determine the cause of DIRs.

关键词： Delayed inflammatory reactions Alloplast rhinoplasty Silicone COVID-19 Vaccination Case report

Endovascular treatment of traumatic renal artery pseudoaneurysm with a Stanford type A intramural haematoma:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9760-9767页

作者： Yook Kim jin Young Lee jin Suk Lee jin Bong Ye Se Heon Kim Young Hoon Sul Su Young Yoon Jung Hee choi Hanlim choi Department of Radiology Chungbuk National University HospitalCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Trauma Surgery Chungbuk National University HospitalCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Trauma Surgery College of MedicineChungbuk National UniversityCheongju-si 28644Chungcheongbuk-doSouth Korea Cardiovascular and Thoracic Surgery Chungbuk National University HospitalCheongju-si 28644Chungcheongbuk-doSouth Korea Anesthesiology and Pain Medicine Chungbuk National University HospitalCheongju-si 28644Chungcheongbuk-doSouth Korea Department of Surgery Chungbuk National University HospitalCheongju-si 28644Chungcheongbuk-doSouth Korea

BACKGROUND Aortic intramural hematoma(IMH) associated with aortic branch tear and intramurally located pseudoaneurysm after blunt trauma has not been ***,we report a case of progressive type A aortic IMH associated with a pseudoaneurysm arising from the injured proximal renal artery after blunt *** SUMMARY During logging operations,a 66-year-old man experienced blunt force trauma after being injured by a fallen *** arrived at our trauma center with a left flank pain *** tomography(CT) revealed a pseudoaneurysm arising from the proximal renal artery(localized within the aortic media) and Stanford type A IMH.A covered stent was deployed along the left main renal artery,bridging the pseudoaneurysm and covering the parent artery,successfully excluding the pseudoaneurysm as confirmed using ***,although the degree of the pseudoaneurysm decreased,follow-up CT revealed remnant pseudoaneurysm,likely caused by an ***,a covered stent was additionally installed through the previously deployed covered *** exclusion of the pseudoaneurysm was confirmed using final *** the 7-mo follow-up CT scan,the IMH and pseudoaneurysm completely disappeared with no evidence of stent-related *** Endovascular treatment such as stent-graft placement can be an effective and safe treatment for traumatic renal artery injury.

关键词： Aortic intramural hematoma Blunt trauma Intimomedial tear Renal arterial injury Stent-graft Case report

Effect of Pulse and Direct Current Electrodeposition on Microstructure,Surface,and Scratch Resistance Properties of Ni-W Alloy and Ni-W-SiC Composite Coatings

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Acta Metallurgica Sinica(English Letters) 2020年第10期33卷 1321-1330页

作者： Sami Bin Humam Gobinda Gyawali Dhani Ram Dhakal jin-Hyuk choi Soo Wohn Lee Department of Environmental and Bio-Chemical Engineering Sun Moon UniversityAsan 31460Korea Department of Fusion Science and Technology Sun Moon UniversityAsan 31460Korea

The present work aims to study the influence of direct current and pulse current techniques as well as embedded SiC nanoparticles on the mechanical properties of the electrodeposited Ni-W *** electrodeposited coatings were studied for morphological,microstructural,mechanical,and scratch resistance properties using the surface roughness tester,scanning electron microscopy,energy-dispersive X-ray spectroscopy,X-ray diffraction,Vickers microhardness,and scratch *** of pulse current exhibited relatively homogeneous and smooth surface of the coatings.A remarkable increment of microhardness was observed in both Ni-W and Ni-W-SiC coatings prepared under pulse current as compared to the direct current ***,the scratch test revealed a considerable improvement in the scratch resistance behavior of the Ni-W alloy and the composite coatings from the pulsed current ***,the application of pulse current not only improved the surface-and microstructure-related properties but also enhanced the Vickers microhardness and scratch resistance properties of the *** addition,the reduction in micro-cracks revealed the improvement in scratch resistance properties of the coatings due to the incorporated SiC nanoparticles into the Ni-W alloy matrix.

关键词： Ni-W-SiC composite Surface Microstructure Microhardness Scratch resistance

Atomically thin heterostructure with gap-mode plasmon for overcoming trade-off between photoresponsivity and response time

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Nano Research 2021年第5期14卷 1305-1310页

作者： Khang June Lee Cheolmin Park Hyeok Jun jin Gwang Hyuk Shin Sung-Yool choi School of Electrical Engineering Center for Advanced Materials Discovery towards 3D DisplaysKorea Advanced Institute of Science and Technology291 Daehak-roYuseong-guDaejeon34141Republic of Korea

Two-dimensional(2D)materials have recently provided a new perspective on optoelectronics because of their unique layered structure and excellent physical ***,their potential use as optoelectric devices has been limited by the trade-off between photoresponsivity and response ***,based on a vertically stacked atomically thin p-n junction,we propose a gap-mode plasmon structure that simultaneously enables enhanced responsivity and rapid *** atomically thin 2D materials act as a spacer for enhancing the gap-mode plasmons,and their short transit length in the vertical direction allows fast photocarrier *** demonstrate a high responsivity of up to 8.67 A/W with a high operation speed that exceeds 35 MHz under a 30 nW laser *** photocurrent,absorption,and a numerical simulation are used to verify the effectiveness of the gap-mode plasmons in the *** believe that the design strategy proposed in this study can pave the way for a platform to overcome the trade-off between responsivity and response time.

关键词： atomically thin heterostructure gap-mode plasmons photodetectors high responsivity fast response time

Intimate atomic Cu-Ag interfaces for high CO2RR selectivity towards CH4 at low over potential

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Nano Research 2021年第10期14卷 3497-3501页

作者： Chungseok choi jin Cai Changsoo Lee Hyuck Mo Lee Mingjie Xu Yu Huang Department of Materials Science and Engineering University of CaliforniaLos AngelesCA 90095USA Hydrogen Energy Department Korea Institute of Energy Research152 Gajeong-roYuseong-guDaejeon 34129Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Irvine Materials Research Institute(IMRI) University of CaliforniaIrvineCA 92697USA Department of Materials Science and Engineering University of CaliforniaIrvineCA 92697USA

Developing highly efficient electrochemical catalysts for carbon dioxide reduction reaction(CO_(2)RR)provides a solution to battle global warming issues resulting from ever-increasing carbon footprint due to human ***(Cu)is known for its efficiency in CO_(2)RR towards value-added hydrocarbons;hence its unique structural properties along with various Cu alloys have been extensively explored in the past ***,we demonstrate a two-step approach to achieve intimate atomic Cu-Ag interfaces on the surface of Cu nanowires,which show greatly improved CO_(2)RR selectivity towards methane(CH4).The specially designed Cu-Ag interfaces showed an impressive maximum Faradaic efficiency(FE)of 72%towards CH4 production at-1.17 V(*** hydrogen electrode(RHE)).

关键词： electrochemical CO_(2)reduction reaction catalyst copper silver bimetallic interface