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Intracellular zinc signaling via Kruppel-like transcription factor 6 promotes HuD expression in pancreatic β cell

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Genes & Diseases 2024年第4期11卷 24-27页

作者： Seongho Cha chongtae Kim Myeongwoo jung Seungyeon Ryu Sukyoung Han wook Kim Eun Kyung Lee Department of Biochemistry Department of Biomedicine&Health SciencesCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Catholic Institute for Visual Science College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Molecular Science&Technology Ajou UniversitySuwon 16499South Korea

Dysfunction of pancreaticβcells caused by zinc deficiency is related to the pathogenesis of diabetes.1 Impaired zinc homeostasis in diabetes is associated with reduced zinc transporters.2 Down-regulation of HuD,an es... 详细信息

关键词： βcell homeostasis zinc

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不同结晶器保护渣的剪切变稀行为

连铸 2016年第4期41卷 69-78页

作者： SHIN Seung-Ho cho jung-wook 刘青浦项科技大学材料科学与工程系浦项科技大学钢铁研究院北京科技大学钢铁冶金新技术国家重点实验室北京100083

在连铸过程中，结晶器保护渣在通过控制润滑来实现较好的可浇性和铸坯质量方面起到重要作用。在缺乏结晶器保护渣不同热物性的情况下，黏度是判断结晶器保护渣润滑性能的必要参数。许多研究人员（包括笔者）证实了熔融的结晶器保护渣的... 详细信息

在连铸过程中，结晶器保护渣在通过控制润滑来实现较好的可浇性和铸坯质量方面起到重要作用。在缺乏结晶器保护渣不同热物性的情况下，黏度是判断结晶器保护渣润滑性能的必要参数。许多研究人员（包括笔者）证实了熔融的结晶器保护渣的流变性能。实际操作中，在剪切速度约为10-40s^-1的结晶器上表面，为减少卷渣，需要高黏度保护渣；但是在剪切速度为100～1000s^-1的结晶器壁，为了保证最大的润滑性能，保护渣黏度应该低。因此，这个特定的属性可能有利于实际连铸过程。目前的研究试图通过用旋转黏度计测量CaO—CaF2-SiO2、CaO-CaF2-B2O3-SiO2和CaO-CaF2-SiO2-Si3N4基保护渣体系的黏度来表征该体系的黏弹性（名为流变性能）。旋转黏度计配备一个1623K温度下受控氧逸度的熔炉。而且，通过拉曼光谱和XPS分析来了解结晶器保护渣黏弹性和结构之间的关系。根据结果，所有经检测的结晶器保护渣都具有流变性能，当剪切速率增大时，黏度降低。应用Os—wald-De Waele指数模型来定量每个结晶器保护渣的剪切变稀度，得出每个结晶器保护渣的聚合度与剪切变稀行为的强度大体上成比正。

关键词：结晶器保护渣非牛顿流体剪切变稀碱度聚合度

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Realizing High Thermoelectric Performance in n-Type Se-Free Bi2Te3 Materials by Spontaneous Incorporation of FeTe2 Nanoinclusions

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Energy & Environmental Materials 2024年第4期7卷 344-354页

作者： Jamil Ur Rahman Woo Hyun Nam Yong-Jae jung Jong Ho Won Jong-Min Oh Nguyen Van Du Gul Rahman Víctor M.García-Suárez Ran He Kornelius Nielsch jung Young cho Won-Seon Seo Jong wook Roh Sang-il Kim Soonil Lee Kyu Hyoung Lee Hyun Sik Kim Weon Ho Shin Leibniz Institute for Solid State and Materials Research Advanced Materials Convergence R&D Division Korea Institute of Ceramic Engineering & Technology Department of Electronic Materials Engineering Kwangwoon University Department of Energy Engineering Dankook University Faculty of Fundamental Science Phenikaa University Department of Physics Quaid-i-Azam University Departamento de Física Universidad de Oviedo Nanomaterials and Nanotechnology Research Center-CINN Department of Materials Science and Engineering Yonsei University School of Nano & Materials Science and Engineering Kyungpook National University Department of Materials Science and Engineering University of Seoul School of Materials Science and Engineering Changwon National University

Bi2Te3-based materials have drawn much attention from the thermoelectric community due to their excellent thermoelectric performance near room ***,the stability of existing n-type Bi2（Te,Se）3materials is still low due to the evaporation energy of Se (37.70 kJ mol-1) being much lower than that of Te (52.55 kJ mol-1).The evaporated Se from the material causes problems in interconnects of the module while degrading the efficiency.

关键词： Bi2Te3 energy harvesting FeTe2 nanoinclusion n-type materials thermoelectric

Real-Time Tunable Gas Sensing Platform Based on SnO_(2) Nanoparticles Activated by Blue Micro-Light-Emitting Diodes

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Nano-Micro Letters 2024年第12期16卷 103-119页

作者： Gi Baek Nam jung-El Ryu Tae Hoon Eom Seung Ju Kim Jun Min Suh Seungmin Lee Sungkyun choi Cheon Woo Moon Seon Ju Park Soo Min Lee Byungsoo Kim Sung Hyuk Park Jin wook Yang Sangjin Min Sohyeon Park Sung Hwan cho Hyuk Jin Kim Sang Eon Jun Tae Hyung Lee Yeong Jae Kim Jae Young Kim Young Joon Hong Jong-In Shim Hyung-Gi Byun Yongjo Park Inkyu Park Sang-Wan Ryu Ho Won Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Research Laboratory of Electronics Department of Mechanical EngineeringMassachusetts Institute of TechnologyCambridgeMA 02139USA Ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Display Materials Engineering Soonchunhyang UniversityAsan 31538Republic of Korea Department of Photonics and Nanoelectronics BK21 FOUR ERICA-ACE CenterHanyang University ERICAAnsan 15588Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok 25913Republic of Korea Advance Institute of Convergence Technology Seoul National UniversitySuwon 16229Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Physics Chonnam National UniversityGwangju 500-757Republic of Korea

Micro-light-emitting diodes(μLEDs)have gained significant interest as an activation source for gas sensors owing to their advantages,including room temperature operation and low power ***,despite these benefits,challenges still exist such as a limited range of detectable gases and slow *** this study,we present a blueμLED-integrated light-activated gas sensor array based on SnO_(2)nanoparticles(NPs)that exhibit excellent sensitivity,tunable selectivity,and rapid detection with micro-watt level power *** optimal power forμLED is observed at the highest gas response,supported by finite-difference time-domain ***,we first report the visible light-activated selective detection of reducing gases using noble metal-decorated SnO_(2)*** noble metals induce catalytic interaction with reducing gases,clearly distinguishing NH3,H2,and ***-time gas monitoring based on a fully hardwareimplemented light-activated sensing array was demonstrated,opening up new avenues for advancements in light-activated electronic nose technologies.

关键词： Micro-LED Gas sensor array Low power consumption Metal decoration Real-time detection

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Optimal sequential therapy using tyrosine kinase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study

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Asian Journal of Urology 2024年第3期11卷 450-459页

作者： jung Ki Jo Seong Il Seo MinYong Kang Jinsoo Chung Cheol Kwak Sung-Hoo Hong Cheryn Song Jae Young Park Chang wook Jeong Seok Hwan choi Sung Han Kim Eu Chang Hwang Chan Ho Lee Hakmin Lee Department of Urology Medical and Digital EngineeringCollege of MedicineHanyang UniversitySeoulRepublic of Korea Department of Urology Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Urology National Cancer CenterGoyangRepublic of Korea Department of Urology Seoul National University HospitalSeoulRepublic of Korea Department of Urology Kangnam St Mary’s HospitalSeoulRepublic of Korea Department of Urology Asan Medical CenterSeoulRepublic of Korea Department of Urology Korea University Ansan HospitalAnsanRepublic of Korea Department of Urology Kyungpook National University HospitalDaeguRepublic of Korea Department of Urology Chonnam National University Hwasun HospitalHwasunRepublic of Korea Department of Urology Inje University Busan Paik HospitalBusanRepublic of Korea Department of Urology Seoul National University Bundang HospitalSeongnamRepublic of Korea

Objective:The purpose of the study was to identify the best sequence of therapy beginning with a tyrosine kinase inhibitor(TKI)as the first-line therapy for patients with metastatic renal cell carcinoma(mRCC)in terms of overall survival(OS),progression-free survival(PFS),and rates of discontinuation and adverse effects during the treatment ***:This is a retrospective,nationwide multicenter study of patients with mRCC after diagnosis at 10 different tertiary medical centers in Korea from January 1992 to December *** focused on patients at either“favorable”or“intermediate”risk according to the International mRCC Database Consortium criteria,and they were followed up(median 335 days).Finally,a total of 1409 patients were selected as the study *** generated a Cox proportional hazard model adjusted for covariates,and the different therapy schemes were statistically tested in terms of OS as well as *** addition,frequencies of discontinuation and adverse events were compared among the therapy ***:Of the primary patterns of treatment sequences(24 sequences),“sunitinib epazopanib”and“sunitinibeeverolimuseimmunotherapy”showed the most beneficial results in both OS and PFS with significantly lower hazards than“sunitinib”,which is the most commonly treated agent in *** that the“TKIeTKI”structure showed relatively higher discontinuation rates with higher adverse effects,the overall beneficial sequence would be“sunitinibeeverolimuseimmunotherapy”.Conclusion:Among several sequential therapy starting with TKIs,“sunitinibeeverolimuse immunotherapy”was found to be the best scheme for mRCC patients with“favorable”or“intermediate”risks.

关键词： Tyrosine kinase inhibitor Metastatic renal cell carcinoma Overall survival Progression-free survival

Vomiting-induced pharyngeal perforation during bowel preparation for colonoscopy:A case report

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World Journal of Clinical Cases 2024年第18期12卷 3615-3621页

作者： Geonhee Kim Won Hyuk Lee Seokin Kang jung Rock Moon Yoon Suk Lee Jun Hyuk Son Nam-Hoon Kim Jong wook Kim Department of Internal Medicine Ilsan Paik HospitalInje University College of MedicineGoyang 10380South Korea

BACKGROUND Effective bowel cleansing is essential for a successful ***,such as polyethylene glycol,are commonly used for bowel *** is a frequent complication during bowel preparation,and forceful vomiting can potentially lead to esophageal perforation,as reported in several previous ***,pharyngeal perforation during bowel preparation has not been previously ***,we present a case of pharyngeal perforation induced by forceful vomiting during bowel *** SUMMARY A 38-year-old man with a history of hypertension,dyslipidemia,diabetes mellitus,and end-stage renal disease on hemodialysis was admitted for evaluation of recurrent abdominal *** patient complained of sudden pain in the neck,throat,and anterior chest following forceful vomiting during bowel *** examination revealed crepitus under the skin of the neck and anterior chest on palpation,and upper gastrointestinal endoscopy revealed pharyngeal *** perforation site was located above the upper esophageal sphincter,which distinguished it from Boerhaave’s *** medical management was chosen after consultation with a thoracic surgeon and an otolaryngologist,considering the patient's mild symptoms,stable vital signs,and the small size of the lesion;the perforation resolved without endoscopic or surgical *** patient was discharged from hospital two weeks after the *** Despite its rarity,pharyngeal perforation should be considered a potential complication of bowel preparation for colonoscopy.

关键词： Colonoscopy Pharynx Polyethylene glycols Spontaneous perforation Case report

Non-metallic inclusions in electroslag remelting:a review

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Journal of Iron and Steel Research International 2021年第12期28卷 1483-1503页

作者： Cheng-bin Shi Shi-jun Wang Jing Li jung-wook cho Institute of Advanced Steel State Key Laboratory of Advanced MetallurgyUniversity of Science and Technology Beijing(USTB)Beijing100083China Graduate Institute of Ferrous and Energy Materials Technology Pohang University of Science and Technology(POSTECH)Pohang790-784Republic of Korea

Non-metallic inclusion in electroslag remelting is a constant topic that has been studied for *** results and conclusions are obtained on some of the subjects from these previous *** differences originate in part from different experimental conditions,including original inclusion chemistries in consumable electrode,slag composition,oxygen level,liquid metal compositions,deoxidation schemes,and melting rates of electroslag *** advances in the operating practices of inclusion control in electroslag remelting production are *** evolution during the electroslag remelting and related processing parameters are also reviewed and *** role of the reoxidation of liquid steel during electroslag remelting on oxide inclusion composition is *** generation of inclusions in remelted ingot is critically *** and remaining issues are noted.

关键词： Non-metallic inclusion Electroslag remelting Inclusion removal Reoxidation

Fluoride evaporation and crystallization behavior of CaF_2–CaO–Al_2O_3–(TiO_2) slag for electroslag remelting of Ti-containing steels

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International Journal of Minerals,Metallurgy and Materials 2016年第6期23卷 627-636页

作者： Cheng-bin Shi jung-wook cho Ding-li Zheng Jing Li State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Graduate Institute of Ferrous Technology Pohang University of Science and Technology

To elucidate the behavior of slag films in an electroslag remelting process, the fluoride evaporation and crystallization of CaF2–CaO–Al2O3–（TiO2） slags were studied using the single hot thermocouple technique. The crystallization mechanism of TiO2-bearing slag was identified based on kinetic analysis. The fluoride evaporation and incubation time of crystallization in TiO2-free slag are found to considerably decrease with decreasing isothermal temperature down to 1503 K. Fish-bone and flower-like CaO crystals precipitate in TiO2-free slag melt, which is accompanied by CaF2 evaporation from slag melt above 1503 K. Below 1503 K, only near-spherical CaF2 crystals form with an incubation time of less than 1 s, and the crystallization is completed within 1 s. The addition of 8.1wt% TiO2 largely prevents the fluoride evaporation from slag melt and promotes the slag crystallization. TiO2 addition leads to the precipitation of needle-like perovskite（CaTiO3） crystals instead of CaO crystals in the slag. The crystallization of perovskite（CaTiO3） occurs by bulk nucleation and diffusion-controlled one-dimensional growth.

关键词： electroslag remelting slag crystallization crystallization kinetics fluorides evaporation

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Effect of SiO2 substitution with Al2O3 during high-Al TRIP steel casting on crystallization and structure of low-basicity CaO–SiO2-based mold flux

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Journal of Iron and Steel Research International 2020年第1期27卷 33-41页

作者： Ding-li Zheng Cheng-bin Shi Zhi-jun Li Jing Li jung-wook cho State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Division of Steelmaking Shougang Qian’an Iron and Steel Co.Ltd.Qian’an 064404HebeiChina Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohang 790-784Republic of Korea

The crystallization and structure of non-conventional lime-silica-based mold fluxes after undergoing slag-steel interaction in casting high-AI transformation induced plasticity(TRIP)steel were *** results showed that the crystallization temperatures of the mold fluxes decreased with decreasing the SiO2/Al2O3 ratio,and CaO/MnO2 ratio had an opposite effect on the crystallization *** crystalline phases precipitated in the mold flux were Ca4Si2O7F2 and *** SiO2/Al2O3 ratio and increasing CaO/MnO2 ratio in the mold fluxes have no influence on the types of crystalline *** dominant crystalline phase precipitated in each mold flux was Ca4Si2O7F2 with dendritic morphology,except for part of that with globular morphology in the mold flux without MnO2 ***4 crystals are distributed in the space among Ca4Si2O7F2 *** size of Ca4Si2O7F2 crystals in the slag with higher S1O2/AI2O3 ratio is smaller,which is attributed to the polymerization degree of the mold flux with increasing SiO2/Al2O3 ratio.[SiO4]-tetrahedral,[AlO4]-tetrahedral and T-O-T bending(T denotes Si or Al)depolymerized gradually with decreasing SiO2/Al2O3 ratio,and an opposite trend was observed for the case with increasing CaO/MnO2 *** polymerization degree of the mold fluxes decreased,which would result in the decrease in the viscosity of the mold fluxes.

关键词： Mold flux Crystallization Structure Continuous casting High-AI steel