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肺表面活化蛋白A相似分子在炎症肠道疾病组织中的过量表达(英文)

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中南大学学报（医学版） 2008年第11期33卷 979-986页

作者：罗俊铭刘昭前 chin y.eugene 肾脏研究所堪萨斯大学医学院中南大学临床药理研究所遗传药理学湖南省重点实验室外科学研究室布朗大学医学院

目的:阐明炎症肠道疾病(inlammatory bowel disease,IBD)中肺表面活化蛋白A(pulmonary surfactant protein A,SP-A)相似分子的分布特征和CD68阳性巨噬细胞的免疫反应。方法:外科手术获得的结肠组织标本来自布朗大学医学院罗得岛医院病理... 详细信息

目的:阐明炎症肠道疾病(inlammatory bowel disease,IBD)中肺表面活化蛋白A(pulmonary surfactant protein A,SP-A)相似分子的分布特征和CD68阳性巨噬细胞的免疫反应。方法:外科手术获得的结肠组织标本来自布朗大学医学院罗得岛医院病理科,应用免疫组织化学方法检测IBD患者肠道组织中SP-A相似分子的表达。结果:SP-A相似分子分布在肠道上皮、肠道绒毛表面,连接组织血管和某些炎症细胞。具有SP-A相似分子和CD68阳性表达的巨噬细胞数量炎症区域明显增加,高于正常组织。而免疫荧光双标记实验显示,一些CD68阳性巨噬细胞可以表达SP-A相似分子免疫反应。结论:SP-A是肺脏一种重要的宿主防御因子。

关键词：炎症肠道疾病肺表面活化蛋白A相似分子 CD68 免疫组织化学

Apolipoprotein E elicits targetdirected miRNA degradation to maintain neuronal integrity

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Neural Regeneration Research 2025年第9期20卷 2577-2578页

作者： Jiazi Tan chin-Tong Ong Temasek Life Sciences Laboratory National University of SingaporeSingapore Department of Biological Sciences National University of SingaporeSingapore

Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous *** are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.

关键词： metabolism glycoprotein maintain

PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression

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中国民康医学 2015年第14期 142-142页

作者： Wan Junhu Zhan Jun Li Shuai Ma Ji Xu Weizhi Liu Chang Xue Xiaowei Xie yuping Fang Weigang chin y.eugene Zhang Hongquan Key Laboratory of Carcinogenesis and Translational Research Ministry of Educationand State Key Laboratory of Natural andBiomimetic DrugsPeking University Health Science Center Laboratory of Molecular Cell Biology and Tumor Biology Department of AnatomyHistology and EmbryologyPeking University Health Science Center School of Life Sciences Tsinghua University Department of Pathology Peking University Health Science Center Institute of Health Sciences Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai Jiaotong University School of Medicine

Enhancer of zeste homolog 2(EZH2)is a key epigenetic regulator that catalyzes the trimethylation of H3K27 and is modulated by post-translational modifications(PTMs).However,the precise regulation of EZH2 PTMs remains ***,herein,report that EZH2 is acetylated by acetyltransferase P300/CBP-associated factor(PCAF)and is deacetylated by deacetylase *** identified that PCAF interacts with and acetylates EZH2 mainly at lysine 348(K348).Mechanistically,K348 acetylation decreases EZH2 phosphorylation at T345 and T487 and increases EZH2 stability without disrupting the formation of polycomb repressive complex 2(PRC2).Functionally,EZH2 K348 acetylation enhances its capacity in suppression of the target genes and promotes lung cancer cell migration and ***,elevated EZH2 K348 acetylation in lung adenocarcinoma patients predicts a poor *** findings define a new mechanism underlying EZH2 modulation by linking EZH2 acetylation to its phosphorylation that stabilizes EZH2 and promotes lung adenocarcinoma progression.

关键词： lung PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression

Reversible acetylation modulates dishevelled-2 puncta formation in canonical Wnt signaling activation

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1437-1440页

作者： Jinhong Shen Lin Hu Li yang Mengshi Zhang Weihong Sun Xiaomei Lu Gufa Lin Chao Huang Xiaoren Zhang y.eugene chin CAS Key Laboratory of Tissue Microenvironment and Tumor Institute of Health SciencesShanghai Jiao Tong University School of Medicine&Shanghai Institutes for Biological SciencesChinese Academy of SciencesUniversity of Chinese Academy of Sciences200031 ShanghaiChina Institutes of Biology and Medical Sciences Soochow University Medical College215000 SuzhouJiangsuChina Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopaedic Department of Tongji HospitalSchool of Life Sciences and TechnologyTongji University200065 ShanghaiChina Clinical Medical Research Institute First Affiliated Hospital of Xinjiang Medical University830054 UrumuqiXinjiangChina

Dear Editor,Dishevelled-2(DVL2)is a central adaptor protein that propagates signals from upstream receptors to downstream effectorβ-catenin in canonical Wnt *** high local concentration,DVL2 assembles into signalosomes through DIX domain-mediated homo-polymerization to provide a docking platform for the recruitment of signaling components,which is critical for Wnt signaling transduction and activation;1 however,the exact underlying mechanism remains *** the roles of phosphorylation and ubiquitination in DVL2-puncta formation have been discussed before,2 the impact of lysine acetylation of DVL2 on this process remains *** we investigated the effect of acetylation on DVL2-puncta formation.

关键词： activation canonical upstream

m TOR and post-translational modifications rely on mitochondrion as the arsenal for cellular metabolism regulation

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Science china(Life Sciences) 2015年第8期58卷 810-812页

作者： ZHUGE ChunChun J CHEN Si J chin y.eugene Shanghai Chest Hospital Shanghai Jiaotong University Institute of Health Sciences Chinese Academy of Sciences School of Medicine Shanghai Jiaotong University

Mitochondrion is considered as the"powerhouse of the cell"almost immediately since its *** carries less than 1,000 proteins and some nucleotides as well as *** is also discovered as the"lung of the cell"for its role i... 详细信息

关键词：细胞器线粒体翻译后修饰代谢调节 mTOR 呼吸作用代谢过程核苷酸

Microplastic and nanoplastic exposure and risk of diabetes mellitus

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World Journal of Clinical Cases 2025年第3期13卷 24-29页

作者： Hui-yi Hsiao Chung-yi Nien Ruei-Feng Shiu Wei-Chun chin Tzung-Hai yen Department of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina Center for Tissue Engineering Chang Gung Memorial HospitalLinkouTaoyuan 33305TaiwanChina Department of Life Sciences National Central UniversityZhongli 320317TaoyuanTaiwanChina Center of Excellence for The Oceans Taiwan Ocean UniversityKeelung 20224TaiwanChina Institute of Marine Environment and Ecology Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Chemical and Materials Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalLinkou 33305TaoyuanTaiwanChina School of Traditional chinese Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

The issue of plastic pollutants has become a growing *** microplastics(MPs)(particle size<5 mm)and nanoplastics(NPs)(particle size<1μm)can cause DNA damage,cytotoxicity,and oxidative stress in various *** primary kno... 详细信息

The issue of plastic pollutants has become a growing *** microplastics(MPs)(particle sizeytotoxicity,and oxidative stress in various *** primary known impacts of microplastic/nanoplastic are observed in the liver and respiratory system,leading to hepatotoxicity and chronic obstructive pulmonary *** research on the effects of MPs and NPs on diabetes is still in its early stages,there are potential *** editorial highlights the risk to diabetics from co-exposure to contaminants and MPs/NPs,supported by evidence from animal studies and the various chemical compositions of MPs/NPs.

关键词： Microplastics Nanoplastics Plastic pollution,Diabetes mellitus Insulin resistance

Hybrid therapy for Helicobacter pylori infection:A systemic review and meta-analysis

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World Journal of Gastroenterology 2015年第45期21卷 12954-12962页

作者： Ping-I Hsu Pei-chin Lin David y Graham Division of Gastroenterology Department of Internal Medicine Kaohsiung Veterans General Hospital and National Yang-Ming University Department of Pharmacy Kaohsiung Veterans General Hospital College of Pharmacy Kaohsiung Medical University Department of Medicine/Gastroenterology Michael E. De Bakey Veterans Affairs Medical Center and Baylor College of Medicine Houston

AIM: To compare the effectiveness of hybrid therapy with other recommended regimens using ***: Bibliographical searches for randomized trials comparing hybrid and other therapies were performed in Pubmed, the Cochrane Library and relevant congresses up to February 2015 using the following keywords(all fields and/or me SH):("Helicobacter pylori " or "H. pylori") and("hybrid therapy" or "sequential-concomitant therapy"). metaanalyses were performed with Cochrane Review manager 5.1. The random effect model proposed by Der Simonian and Laird and the mantel-Haenszel method were used to estimate the pooled relative risk and 95%CI of the efficacy outcomes between hybrid therapy and other eradication therapies. RESULTS: Eight studies(2516 subjects) met entry criteria. The antimicrobial resistance in the study groups ranged from 6.9% to 23.5%. The mean cure rates of hybrid therapy by intention-to-treat(ITT) and perprotocol analyses were 88.5%(n = 1207; range: 80.0% to 97.4%) and 93.3%(n = 1109; range: 85.7% to99.1%), respectively. meta-analysis showed there was no significant difference in ITT eradication rate between hybrid and sequential therapy(relative risk: 1.01; 95%CI: 0.92-1.11). Subgroup analysis revealed hybrid therapy was more effective than sequential therapy in the non-Italian populations(95%CI: 1.01-1.18) and was only less effective in one, Italian population(95%CI: 0.83-0.98). There was no significant difference in eradication rate between hybrid therapy and concomitant therapy(95%CI: 0.93-1.02). No head-tohead comparisons of hybrid therapy and standard triple therapy or bismuth quadruple therapy were found. However, a multicenter, randomized trial showed that reverse hybrid therapy was superior to standard triple therapy(95.5% vs 88.6% ITT; P = 0.011).CONCLUSION: Hybrid therapy appears to be an effective, safe, and well-tolerated treatment for H. pylori infection in the era of increasing antibiotic resistance.

关键词： Helicobacter pylori Concomitant therapy Hybrid the

β-arrestin在肾间质纤维化中的作用及机制

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β-arrestin在肾间质纤维化中的作用及机制

Ultracold atomic gases going strong

中国生理学会肾脏生理专业委员会第二届学术年会

作者：赵莉芹王艳道 y.eugene chin 余晨同济大学附属同济医院肾脏科中国科学院健康所

目的:肾素—血管紧张素系统(RAS)过度激活是促进肾脏纤维化的关键之一,长期肾间质纤维化最终发展成肾功能衰竭。近年对RAS认识有重要突破:当血管紧张素II(AngII)激活1型受体(ATlR)后,其下游信号通路除了传统认识的G蛋白偶联通路,还有一...

目的:肾素—血管紧张素系统(RAS)过度激活是促进肾脏纤维化的关键之一,长期肾间质纤维化最终发展成肾功能衰竭。近年对RAS认识有重要突破:当血管紧张素II(AngII)激活1型受体(ATlR)后,其下游信号通路除了传统认识的G蛋白偶联通路,还有一条新认识的β-arrestin依赖性信号通路,两条通路各自独立,具有不同生物学效应。

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National Science Review 2016年第2期3卷 168-170页

作者： Cheng chin James Franck Institute Enrico Fermi InstituteUniversity of Chicago

The year 2015 marks the 20th anniversary of the achievement of Bose-Einstein condensation(BEC)in atomic *** BEC,realized by Eric Cornell,Carl Wieman and Wolfgang Ketterle in1995,commenced an exciting wave to explore quantum few-and many-body *** from solid state matter and helium superfluids,atomic condensates in the gas phase come with

关键词： body BEC Ultracold atomic gases going strong length