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英语画刊（高三·社会综合版） 2012年第11期 25-25页

作者： perri O. Blumberg

专家建议成年女性每日最多摄取6茶匙的添加糖，而成年男性每日的添加糖摄取不得超过9茶匙。看看以下食物的含糖量，你的糖分摄取是否超标了呢？

关键词：高中英语课外阅读阅读材料

Oxidative stress:New insights on the association of nonalcoholic fatty liver disease and atherosclerosis

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World Journal of Hepatology 2015年第10期7卷 1325-1336页

作者： Licia Polimeni Maria Del Ben Francesco Baratta Ludovica perri Fabiana Albanese Daniele Pastori Francesco Violi Francesco Angelico Department of Public Health and Infectious Diseases Sapienza University of Rome Department of Internal Medicine and Medical Specialties Sapienza University of Rome

Non-alcoholic fatty liver disease(NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseasesranging from simple fatty liver to non-alcoholic steatohepatitis(NASH),which may progress to fibrosis and more severe liver complications such as cirrhosis,hepatocellular carcinoma and liver mortality. NAFLD is strongly associated with obesity,insulin resistance,hypertension,and dyslipidaemia,and is now regarded as the liver manifestation of the metabolic syndrome. The increased mortality of patients with NAFLD is primarily a result of cardiovascular disease and,to a lesser extent,to liver related diseases. Increased oxidative stress has been reported in both patients with NAFLD and patient with cardiovascular risk factors. Thus,oxidative stress represents a shared pathophysiological disorder between the two conditions. Several therapeutic strategies targeting oxidative stress reduction in patients with NAFLD have been proposed,with conflicting results. In particular,vitamin E supplementation has been suggested for the treatment of non-diabetic,non-cirrhotic adults with active NASH,although this recommendation is based only on the results of a single randomized controlled trial. Other antioxidant treatments suggested are resveratrol,silybin,L-carnitine and pentoxiphylline. No trial so far,has evaluated the cardiovascular effects of antioxidant treatment in patients with NAFLD. New,large-scale studies including as end-point also the assessment of the atherosclerosis markers are needed.

关键词： Cardiovascular disease Oxidative stress Non-alcoholic fatty liver disease Atherosclerosis Nonalcoholicsteatohepatitis

Early onset versus late onset in Alzheimer’s disease: What is the reliable cut-off?

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Advances in Alzheimer's Disease 2013年第1期2卷 40-47页

作者： Gianfranco Spalletta Vincenzo De Luca Alessandro Padovani Luca Rozzini Roberta perri Amalia Bruni Vincenzo Canonico Alberto Trequattrini Giuseppe Bellelli Carla Pettenati Floriana Pazzelli Carlo Caltagirone Maria Donata Orfei Azienda Sanitaria Locale Città di Castello Perugia Italy Centro Regionale Alzheimer Azienda Ospedaliera Guido Salvini Passirana Italy Centro Regionale Di Neurogenetica Azienda Sanitaria Provinciale Catanzaro Lamezia Terme Italy Department of Clinical and Behavioral Neurology IRCCS Santa Lucia Foundation Rome Italy Department of Geriatrics University of Naples Naples Italy Department of Neurology University of Brescia Brescia Italy Department of Neuroscience Tor Vergata University of Rome Rome Italy Department of Prevention and Clinical Medicine University of Milano-Bicocca Monza Italy Department of Psychiatry University of Toronto Toronto Canada NESMOS Department Sapienza University of Rome Rome Italy

Objective: As the literature on conventional criteria for discriminating early-onset (EO) from late-onset (LO) Alzheimer’s disease (AD) is sparse and controversial, the aim of this study was to establish a precise age at onset (AAO) criterion, by using a specific statistical procedure, and to describe the clinical characteristics of the two sub-groups. Methods: Admixture analysis was performed to establish the AAO cut-off in a multi-center study including 2000 AD patients consecutively recruited in eight Italian Memory Clinics. None of the patients were taking acetylcholinesterase inhibitors, antipsychoticor anti-depressant drugs. At the first diagnosticvisit, they were administered the Mini Mental StateExamination, the Basic and Instrumental Activities of Daily Living and the Neuropsychiatric Inventorytoassess clinical phenomenology. Results: Using a specific statistical procedure, we established that AAO that discriminated EO-from LO-AD was 66. Compared with the LO-AD group, the EO-AD group showed longer duration of illness and a higher educational level as well as less severe functional impairment and delusions. Conclusions: Differences in sociodemographic and clinical characteristics, such as duration of illness, education and delusion severity, suggested the involvement of different pathogenic processes. Additional studies are needed to further investigate the mechanisms underlying the disorder in the two sub-groups of AD patients.

关键词： Alzheimer’s Disease Onset Neuropsychiatric Symptoms Admixture Analysis Pathogenesis Cognitive Reserve

阿尔茨海默病与额叶型额颞痴呆:一组认知功能和行为特征的简短测验

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 34-35页

作者： perri R. Koch G. Carlesimo G.A. 李一明 Fondazione IRCCS Santa Lucia Via Ardeatina 306 00179 Roma Italy

The aim of this study was to investigate whether a brief neuropsychological battery consisting of a limited number of cognitive tests and an evaluation of the behavioural domains intended to discriminate between frontotemporal dementia (fv-FTD) and Alzheimer's disease (AD), constitutes a useful instrument for making a differential clinical diagnosis between these two pathologies. Nineteen fv-FTD and 39 AD patients were compared on cognitive tasks (assessing memory, executive functions, language and constructional praxis) and on the NPI behavioural assessment. A stepwise discriminant analysis was performed to identify the linear combination of cognitive and behavioural measures able to best discriminate between the two groups. One test for each of the investigated cognitive domains (Delayed Prose Recall, FAS verbal fluency, Boston naming test, Rey's Figure A Copy) and the four subscales of the Neuropsychiatry Inventory (NPI) which best differentiated between fv-FTD and AD patients (apathy, disinhi bition, euphoria, aberrant motor behaviour) were used. The analysis selected Rey's Figure A Copy, FAS verbal fluency and NPI apathy subscale as the best discri minants between fv-FTD and AD patients. The final equation assigned 73.7%of th e fv-FTD patients and 94.7%of the AD patients to the correct diagnostic group. A validation study conducted on a new independent sample of 11 fv-FTD and 22 A D patients confirmed the high sensitivity (82.6 %) and specificity (81.8%) of the diagnostic equation in assigning fv-FTD and AD patients to the correct deme ntia group. Although both cognitive and behavioural differences exist between FT D and AD, previous studies have aimed at differentiating the two pathologies by considering the two aspects separately and discriminant analyses were focused on ly on neuropsychological or neuropsychiatric evaluations. The present results em phasise the importance of rating both cognitive and behavioural clinical feature s of the two syndromes as obj

关键词：额颞痴呆 FTD AD 患者认知功能阿尔茨海默病

意大利Bulla剖面二叠纪-三叠纪之交分子化石的特征及意义

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意大利Bulla剖面二叠纪-三叠纪之交分子化石的特征及意义

Anaplastic thyroid carcinoma:A comprehensive review of current and future therapeutic options

中国古生物学会第十次全国会员代表大会暨第25届学术年会——纪念中国古生物学会成立80周年

作者：贾成玲陈林谢树成黄俊华 FARABEGOLI Enzo perri M Cristina 中国地质大学生物地质与环境地质教育部重点实验室中国地质大学地质过程与矿产资源国家重点实验室 Dipartimento di Scienze della Terra e Geologico-Ambientali Bologna University Via Zamboni 67 40126 Bologna Italy

二叠纪-三叠纪界线(PTB)集群绝灭是显生宙以来海洋生物界发生的规模最大的一次灾变事件。意大利Bulla剖面是二叠系与三叠系分界的重要剖面,保存有一套良好的分子化石记录,为PTB事件的研究提供分子尺度的证据。Bulla剖面2-甲基藿烷在界线... 详细信息

二叠纪-三叠纪界线(PTB)集群绝灭是显生宙以来海洋生物界发生的规模最大的一次灾变事件。意大利Bulla剖面是二叠系与三叠系分界的重要剖面,保存有一套良好的分子化石记录,为PTB事件的研究提供分子尺度的证据。Bulla剖面2-甲基藿烷在界线(第12B层)附近以及上部第25层附近出现两个峰值,与煤山剖面的

关键词： 2-甲基藿烷多环芳烃蓝细菌陆地风化意大利Bulla

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World Journal of Clinical Oncology 2011年第3期2卷 150-157页

作者： Francesco perri Giuseppe Di Lorenzo Giuseppina Della Vittoria Scarpati Carlo Buonerba Department of Skin Musculoskeletal System and Head-neckINT Foundation G.PascaleNapoli 80131Italy Department of Endocrinology and Medical Oncology Genitourinary Cancer SectionUniversity Federico IINapoli 80131Italy

Anaplastic thyroid carcinoma(ATC)is the rarest,but deadliest histologic type among thyroid malignancies,with a dismal median survival of 3-9 *** though ATC accounts for less than 2%of all thyroid tumors,it is responsible for 14%-39%of thyroid carcinoma-related *** clinically presents as a rapidly growing mass in the neck,associated with dyspnoea,dysphagia and vocal cord *** is usually locally advanced and often metastatic at initial *** operable diseases,the combination of radical surgery with adjuvant radiotherapy or chemotherapy,using agents such as doxorubicin and cisplatin,is the best treatment *** drugs for advanced/metastatic ATC are poorly *** the other hand,targeted agents might represent a viable therapeutic ***,combretastatin A4,sorafenib and imatinib have been tested in small clinical trials of ATC,with a promising disease control rate ranging from 33%to 75%.Other clinical trials of targeted therapy for thyroid carcinoma are currently *** agents that are under investigation include pazopanib,gefitinib and *** the very limited therapeutic armamentarium available at the present time,targeted therapy constitutes an exciting new horizon for *** future,biological agents will probably represent the standard of care for this aggressive malignancy,in the same fashion as it has recently occurred for other chemo-refractory tumors,such as kidney and hepatic cancer.

关键词： Anaplastic thyroid cancer Targeted agents

Measuring consciousness in coma and related states

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World Journal of Radiology 2014年第8期6卷 589-597页

作者： Carol Di perri Aurore Thibaut Lizette Heine Andrea Soddu Athena Demertzi Steven Laureys Neuroradiology National Neurological Institute C Mondino 27100 Pavia Italy Cyclotron Research Center and Neu-rology Department Coma Science Group University of Liège Physics and Astrono-my Department Western University London Ontario N6A 3K7 Canada

Consciousness is a prismatic and ambiguous concept that still eludes any universal definition. Severe acquired brain injuries resulting in a disorder of con-sciousness(DOC) provide a model from which insights into consciousness can be drawn. A number of recent studies highlight the difficulty in making a diagnosis in patients with DOC based only on behavioral assessments. Here we aim to provide an overview of how neuroimaging techniques can help assess patients with DOC. Such techniques are expected to facilitate a more accurate understanding of brain function in states of unconsciousness and to improve the evaluation of thepatient's cognitive abilities by providing both diagnostic and prognostic indicators.

关键词： Disorders of consciousness Neuroimaging Magnetic resonance imaging Transcranial magnetic stimulation/electroencephalography Minimally conscious state Vegetative state/unresponsive wakefulness syndrome

Locally advanced nasopharyngeal carcinoma:Current and emerging treatment strategies

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World Journal of Clinical Oncology 2011年第12期2卷 377-383页

作者： Francesco perri Davide Bosso Carlo Buonerba Giuseppe Di Lorenzo Giuseppina Della Vittoria Scarpati Oncology Division Division INT Fondazione“G.Pascale”80131 NaplesItaly Oncology and Rare Cancer Center FedericoⅡUniversity80131 NaplesItaly

Although nasopharyngeal carcinoma(NPC)is a widespread malignant tumor,it is particularly frequent in Southeast *** T1 tumors can be effectively controlled with exclusive radiotherapy,this treatment modality is insufficient for most NPC patients,who present with locally advanced disease at *** fact,for stages ranging from T2b N0 to T4 N3,definitive scientific evidence supports the use of concurrent platinum-based chemotherapy with standard external beam *** treatment approach has shown a statistically significant advantage in terms of overall survival,with respect to radiotherapy *** trials have also investigated the use of neoadjuvant and adjuvant chemotherapy in combination with radiotherapy or *** compounds,anthracyclines and taxanes are among the chemotherapy agents *** review focuses on the clinical results obtained in the field of adjuvant/concurrent/neoadjuvant chemotherapy for locally advanced NPC,for which exclusive concurrent chemo-radiotherapy currently represents the standard treatment approach.

关键词： Chemotherapy Nasopharyngeal carcinoma Radiotherapy Treatment

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保持健康的早晨习惯（英文）

英语画刊(高中版) 2022年第6期 9-9页

作者： perri Ormont Blumberg

一日之计在于晨，养成良好的早晨习惯可以说是健康生活的开始。Drink *** bodies tend to get dehydrated while we are ***, starting your day off with two to three cups is aneasy way to increase your overall water intake befo...

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令人震惊的健康新闻:为何水能令你发胖

英语画刊(高中版) 2013年第10期 2-2页

作者： perri O.Blumberg

在我们的观念里,有这样一类人的存在:他们认为自己喝水也会胖。许多人会对此一笑了之,并报以同情的目光。然而,从某种角度来说,他们是对的。

关键词：水能震惊新闻