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Nomogram prediction of vessels encapsulating tumor clusters in small hepatocellular carcinoma≤3 cm based on enhanced magnetic resonance imaging

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1808-1820页

作者： hui-Lin Chen Rui-Lin He Meng-Ting Gu Xing-Yu Zhao Kai-Rong Song Wen-Jie Zou Ning-Yang Jia Wan-min Liu School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Radiology The Third Affiliated Hospital of Shanghai Naval Military Medical UniversityShanghai 200438China Department of Radiology Tongji University Affiliated Tongji HospitalShanghai 200065China

BACKGROUND Vessels encapsulating tumor clusters(VETC)represent a recently discovered vascular pattern associated with novel metastasis mechanisms in hepatocellular carcinoma(HCC).However,it seems that no one have focused on predicting VETC status in small HCC(sHCC).This study aimed to develop a new nomogram for predicting VETC positivity using preoperative clinical data and image features in sHCC(≤3 cm)*** To construct a nomogram that combines preoperative clinical parameters and image features to predict patterns of VETC and evaluate the prognosis of sHCC *** A total of 309 patients with sHCC,who underwent segmental resection and had their VETC status confirmed,were included in the *** patients were recruited from three different hospitals:Hospital 1 contributed 177 patients for the training set,Hospital 2 provided 78 patients for the test set,and Hospital 3 provided 54 patients for the validation *** predictors of VETC were identified through univariate and multivariate logistic *** independent predictors were then used to construct a VETC prediction model for *** model’s performance was evaluated using the area under the curve(AUC),calibration curve,and clinical decision ***,Kaplan-Meier survival analysis was performed to confirm whether the predicted VETC status by the model is associated with early recurrence,just as it is with the actual VETC status and early *** Alpha-fetoprotein_lg10,carbohydrate antigen 199,irregular shape,non-smooth margin,and arterial peritumoral enhancement were identified as independent predictors of *** model incorporating these predictors demonstrated strong predictive *** AUC was 0.811 for the training set,0.800 for the test set,and 0.791 for the validation *** calibration curve indicated that the predicted probability was consistent with the actual VETC status in all three ***,the decision curve analysis demonstr

关键词： Small hepatocellular carcinoma Vessels encapsulating tumor clusters Nomogram Magnetic resonance imaging Multicenter

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Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling

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Protein & Cell 2024年第6期15卷 441-459页

作者： Feifei Liu Yi Lu Xuebao Wang Shuhui Sun huize Pan min Wang Zehua Wang Weiqi Zhang Shuai Ma Guoqiang Sun Qun Chu Si Wang Jing Qu Guang-hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Sports Medicine Department Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Division of Life Sciences and Medicine School of Life SciencesUniversity of Science and Technology of ChinaHefei 230001China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China The Fifth People’s Hospital of Chongqing Chongqing 400062China Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China

The synovium,a thin layer of tissue that is adjacent to the joints and secretes synovial fluid,undergoes changes in aging that contribute to intense shoulder pain and other joint ***,the mechanism underlying human synovial aging remains poorly ***,we generated a comprehensive transcriptomic profile of synovial cells present in the subacromial synovium from young and aged *** delineating aging-related transcriptomic changes across different cell types and their associated regulatory networks,we identified two subsets of mesenchymal stromal cells(MSCs)in human synovium,which are lining and sublining MSCs,and found that angiogenesis and fibrosis-associated genes were upregulated whereas genes associated with cell adhesion and cartilage development were downregulated in aged ***,the specific cell-cell communications in aged synovium mirrors that of aging-related inflammation and tissue remodeling,including vascular hyperplasia and tissue *** particular,we identified forkhead box O1(FOXO1)as one of the major regulons for aging differentially expressed genes(DEGs)in synovial MSCs,and validated its downregulation in both lining and sublining MSC populations of the aged *** human FOXO1-depleted MSCs derived from human embryonic stem cells,we recapitulated the senescent phenotype observed in the subacromial synovium of aged *** data indicate an important role of FOXO1 in the regulation of human synovial ***,our study improves our understanding of synovial aging during joint degeneration,thereby informing the development of novel intervention strategies aimed at rejuvenating the aged joint.

关键词： FOXO1 degeneration inflammation

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视觉提示学习综述

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计算机学报 2024年第4期47卷 790-820页

作者：廖宁曹敏严骏驰上海交通大学人工智能教育部重点实验室上海200240 苏州大学计算机科学与技术学院江苏苏州215021

近年来,随着提示学习方法在自然语言处理领域被提出,其日益受到研究人员广泛关注,它通过将各类下游任务重构成预训练任务的形式,以参数高效和数据高效的方式将大规模预训练模型应用在各类自然语言相关下游任务中.其中以GPT系列为代表的... 详细信息

近年来,随着提示学习方法在自然语言处理领域被提出,其日益受到研究人员广泛关注,它通过将各类下游任务重构成预训练任务的形式,以参数高效和数据高效的方式将大规模预训练模型应用在各类自然语言相关下游任务中.其中以GPT系列为代表的模型通过提示学习在对话生成和多模态图文理解等任务上取得了巨大的成功.然而,这类模型及方法还不能解决视觉中的稠密任务.受此启发,一些研究人员逐渐将提示学习广泛应用到视觉相关的各类任务当中,如图像识别、目标检测、图像分割、领域适应、持续学习等.由于目前还没有提示学习应用在视觉相关领域中的综述,本文将对视觉单模态领域以及视觉语言多模态领域的提示学习方法展开全面论述和分析.作为回顾,我们首先简要介绍自然语言处理领域的预训练模型,并对提示学习的基本概念、下游应用形式以及提示模板类型进行阐述和分类.其次,我们分别介绍视觉单模态领域以及视觉语言多模态领域里提示学习方法适配的预训练模型和任务.再次,我们分别介绍视觉单模态领域以及视觉语言多模态领域的提示学习方法.在自然语言处理领域,提示学习方法以继承预训练形式实现多任务统一为主要目的;与此不同,在视觉相关领域,提示学习方法侧重于面向特定下游任务进行设计.为此,我们将从方法设计上进行简单分类,然后从应用任务角度详细介绍视觉单模态提示学习和视觉语言多模态提示学习方法.最后,我们对比分析了自然语言处理领域和视觉相关领域提示学习研究的进展,并对未来研究路线给出了展望。

关键词：大规模预训练模型自然语言处理视觉单模态提示学习视觉语言多模态提示学习

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Fermi Rubik's Cube in High-Pressure Induced Chlorine-Rich Compounds

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chinese Physics Letters 2024年第10期41卷 78-83页

作者： Jun Kong Lei Su Haixu Cui Hairui Ding Jingyu Hou Chunxia chi Shiyang Liu Xiang-Feng Zhou hui-Tian Wang Xiao Dong Key Laboratory of Weak-Light Nonlinear Photonics and School of Physics Nankai UniversityTianjin 300071China Center for High Pressure Science and Technology Advanced Research Beijing 100093China Key Laboratory of Photochemistry Institute of ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100190China College of Physics and Materials Science Tianjin Normal UniversityTianjin 300387China Center for High Pressure Science State Key Laboratory of Metastable Materials Science and TechnologySchool of ScienceYanshan UniversityQinhuangdao 066004China National Laboratory of Solid State Microstructures School of Physicsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

In the quasi-free electron model,the Fermi surface spreads into a sphere in the Brillouin zone,i.e.,the Fermi *** Fermi sphere exists widely in metal systems,no matter whether the crystal is in a body-center cubic,face-center cubic,or hexagonal close-packed ***,we report a class of compounds stabilized at high pressure with Rubik’s cubic Fermi surface.

关键词： surface. Fermi cubic

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清代商州方志中李白商州诗探析

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商洛学院学报 2017年第5期31卷 6-10,32页

作者：任梦池刘慧敏商洛学院人文学院陕西商洛726000

天宝四载,李白在朝廷遭受排挤,不得不离开长安东去,路过商州。据清代商州方志中记载,李白与商州有关的诗歌有十余首,这些与《李太白全集》中收录李白在商州时创作的诗歌,部分有所不同。清代商州方志中李白的商州诗,一方面吟咏秀美的自... 详细信息

天宝四载,李白在朝廷遭受排挤,不得不离开长安东去,路过商州。据清代商州方志中记载,李白与商州有关的诗歌有十余首,这些与《李太白全集》中收录李白在商州时创作的诗歌,部分有所不同。清代商州方志中李白的商州诗,一方面吟咏秀美的自然风光,一方面记述厚重的人文景观。在政治上受挫的李白,在诗中抒发了自己怀才不遇的感慨、不屈其志的节操及仕与隐的矛盾心理。研究清代商州方志中所收录的李白诗歌,对全面了解李白有着较为重要的作用。

关键词：李白清代商州方志《李太白全集》商州诗歌情感

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Research status and hotspots of tight junctions and colorectal cancer:A bibliometric and visualization analysis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3705-3715页

作者： hui-min Li Yin Liu Meng-Di Hao Xiao-Qing Liang Da-Jin Yuan Wen-Bin Huang Wen-Jie Li Lei Ding Department of Gastrointestinal Oncology Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND Colorectal cancer(CRC)is the third most common cancer worldwide and the second leading cause of cancer-related *** the past two decades,numerous researchers have provided important evidence regarding the role of tight junction(TJ)proteins in the occurrence and progression of *** causal relationship between the presence of specific TJ proteins and the development of CRC has also been *** the large number of publications in this field,a bibliometric study to review the current state of research and highlight the research trends and hotspots in this field has not yet been *** To analyze research on TJs and CRC,summarize the field’s history and current status,and predict future research *** We searched the Science Citation Index Expanded database for all literature on CRC and TJs from *** used bibliometrics to analyze the data of these papers,such as the authors,countries,institutions,and ***-authorship,co-citation,and co-occurrence analyses were the main methods of *** and VOSviewer were used to visualize the *** A total of 205 studies were ultimately *** number of publications on this topic has steadily increased since *** and the United States have made the largest contributions to this *** Research was the most prolific journal,publishing 8 articles,while the journal Oncogene had the highest average citation rate(68.33).Professor Dhawan P was the most prolific and cited author in this ***-occurrence analysis of keywords revealed that“tight junction protein expression”,“colorectal cancer”,“intestinal microbiota”,and“inflammatory bowel disease”had the highest frequency of occurrence,revealing the research hotspots and trends in this *** This bibliometric analysis evaluated the scope and trends of TJ proteins in CRC,providing valuable research perspectives and future directions for studying the connection between th

关键词： Colorectal cancer Tight junctions Bibliometric analysis Research trends Hot spots

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Effect of artificial natural light on the development of myopia among primary school-age children in china:a three-year longitudinal study

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 924-931页

作者： hui-min Cai Meng-Yan Li Yi Cao Yu-Lin Wu ming Liang Yu-Shi Chen Bi-Kun Xian Yu-Juan Huang Xiang-Bin Kong Department of Ophthalmology the Second People’s Hospital of FoshanAffiliated Foshan Hospital of Southern Medical UniversityFoshan 528000Guangdong ProvinceChina Guangdong Medical University Zhanjiang 524023Guangdong ProvinceChina Guangdong Cosio Lighting Corporation Foshan 528000Guangdong ProvinceChina

AIM:To assess the efficacy of artificial natural light in preventing incident myopia in primary school-age ***:This is a prospective,randomized control,intervention study.A total of 1840 students from 39 classes in 4 primary schools in Foshan participated in this *** whole randomization method was adopted to include classes as a group according to 1:1 randomized *** in the control group were illuminated by usual light,and classrooms in the intervention group were illuminated by artificial natural *** students received uncorrected visual acuity and best-corrected visual acuity measurement,non-cycloplegic autorefraction,ocular biometric examination,slit lamp and strabismus ***-year follow-up,the students underwent same *** was defined as spherical equivalent refraction≤-0.50 D and uncorrected visual acuity<20/***:There were 894 students in the control group and 946 students in the intervention group with a mean±SD age of 7.50±*** three-year cumulative incidence rate of myopia was 26.4%(207 incident cases among 784 eligible participants at baseline)in the control group and 21.2%(164 incident cases among 774 eligible participants at baseline)in the intervention group[difference of 5.2%(95%CI,3.7%to 10.1%);P=0.035].There was also a significant difference in the three-year change in spherical equivalent refraction for the control group(-0.81 D)compared with the intervention group[-0.63 D;difference of 0.18 D(95%CI,0.08 to 0.28 D);P<0.001].Elongation of axial length was significantly different between in the control group(0.77 mm)and the intervention group[0.72 mm;difference of 0.05 mm(95%CI,0.01 to 0.09 mm);P=0.003].CONCLUSION:Artificial natural light in the classroom of primary schools can result in reducing incidence rate of myopia during a period of three years.

关键词： myopia artificial natural light school-age children efficacy

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METTL14 downregulation drives S100A4^(+)monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2176-2192页

作者： Yue-fan Wang Wen-li Zhang Zhi-xuan Li Yue Liu Jian Tan Hao-zan Yin Zhi-chao Zhang Xian-jie Piao min-hao Ruan Zhi-hui Dai Si-jie Wang Chen-yang Mu Ji-hang Yuan Shu-han Sun hui Liu Fu Yang The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University200438 ShanghaiChina The Department of Medical Genetics Naval Medical University200433 ShanghaiChina Translational Medicine Research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital100048 BeijingChina The Department of Pharmaceutical Analysis School of PharmacyNaval Medical University200433 ShanghaiChina Key Laboratory of Biosafety Defense Ministry of Education200433 ShanghaiChina Shanghai Key Laboratory of Medical Biodefense 200433 ShanghaiChina

Without intervention,a considerable proportion of patients with metabolism‐associated fatty liver disease(MAFLD)will progress from simple steatosis to metabolism‐associated steatohepatitis(MASH),liver fibrosis,and even hepatocellular ***,the molecular mechanisms that control progressive MAFLD have yet to be fully ***,we unraveled that the expression of the N6-methyladenosine(m6A)methyltransferase METTL14 is remarkably downregulated in the livers of both patients and several murine models of MAFLD,whereas hepatocyte-specific depletion of this methyltransferase aggravated lipid accumulation,liver injury,and ***,hepatic Mettl14 overexpression alleviated the above pathophysiological changes in mice fed on a high-fat diet(HFD).Notably,in vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner,which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1^(+)Ccr2^(+)monocyte-derived macrophages(Mo-macs).In detail,Cx3cr1^(+)Ccr2^(+)Mo-macs can be categorized into M1-like macrophages and S100A4-positive macrophages and then further activate hepatic stellate cells(HSCs)to promote liver *** experiments revealed that CX3CR1 can activate the transcription of S100A4 via CX3CR1/MyD88/NF-κB signaling pathway in Cx3cr1^(+)Ccr2^(+)*** of METTL14 or GLS2,or interfering with this signal transduction pathway such as inhibiting MyD88 could ameliorate liver injuries and *** together,these findings indicate potential therapies for the treatment of MAFLD progression.

关键词： S100A4 MyD88 metabolism

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兴衰有道:清代北商的砖茶贸易

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史学集刊 2024年第2期 21-39页

作者：赖惠敏王惠敏 “中研院”近代史研究所中国台湾台北11529 陕西师范大学中国西部边疆研究院陕西西安710062

茶叶是清代国内外贸易的大宗物资,也是销往边疆民族地区具有战略意义的特殊商品。砖茶对清廷维护边疆统治秩序极其重要。借助康雍乾三朝对准噶尔部的军事行动所带来的商业契机,北商贩售砖茶至蒙古地区的经济活动在清中前期边疆贸易领域... 详细信息

茶叶是清代国内外贸易的大宗物资,也是销往边疆民族地区具有战略意义的特殊商品。砖茶对清廷维护边疆统治秩序极其重要。借助康雍乾三朝对准噶尔部的军事行动所带来的商业契机,北商贩售砖茶至蒙古地区的经济活动在清中前期边疆贸易领域写就了壮丽篇章,促进了商贸线路、物资交易网络和商业市镇的形成。砖茶自产茶区流向万里之外的蒙古地区,成为当地居民的日常必需品和广泛流通的“货币”,并且终清之世位列输入品首位。咸丰十年《中俄北京条约》签订后,经恰克图与俄国贸易的北商群体严重受挫,遂将视野转向蒙古地区,并改变经营策略。清末,北商在蒙古地区的商业活动基本得以撑持,砖茶贸易仍保持一定的优势,但盈利情况一落千丈。由是观之,清代北商的砖茶贸易兴衰之道与清朝国力的盛衰走向高度契合。

关键词：清代北商蒙古地区恰克图砖茶

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Influence of oxygen-rich hot air composite gas medium on sintering performance and function mechanism

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Journal of Iron and Steel Research International 2024年第5期31卷 1071-1081页

作者： min Gan Hao-xiang Zheng Xiao-hui Fan Zhi-yun Ji Qiang Li ming Wu Yi-fan Wang Xiao-long Wang Yu-feng Wu Xu-ling Chen Zeng-qing Sun Xiao-xian Huang School of minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Shanxi Taigang Stainless Steel Co. Ltd.Taiyuan030003ShanxiChina

Hot air sintering technology is used to improve the quality and production efficiency of sintered ***,the current thick layer condition highlights the disadvantage of the low oxygen potential of the hot air sintering ***,it is considered to use oxygen enrichment sintering to improve the environment of hot air *** sintering,hot air sintering,and oxygen-rich hot air sintering were compared through sintering cup experiments,and the influence of hot air and oxygen-rich hot air on sintering indexes was *** air reduced the vertical sintering velocity,while improved the yield and tumbler ***-rich hot air sintering contributed to improving the vertical sintering velocity while ensuring the quality of sintered ore,thus comprehensively improving production *** the action of hot air,the highest temperature of the sintering layer increased and the high-temperature holding time was *** oxygen enrichment,the combustion efficiency of fuels in the upper layer of materials was promoted,which optimized heat distribution in the middle and lower layers of materials and increased the content of calcium ferrite in the sintered ore,thus strengthening the sintering process.

关键词： Iron ore sintering Hot air sintering Oxygen enrichment Function mechanism

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