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Food Science and Human Wellness 2024年第5期13卷 2629-2641页

作者： Xinyi Liu Yukun Song shasha cheng Mingqian Tan School of Food Science and Technology Dalian Polytechnic UniversityDalian 116034China National Engineering Research Center of Seafood Dalian 116034China

The aim of this study is to investigate the feasibility of Maillard reaction products of Haematococcus pluvialis protein and galactose(HPP-GAL)for improving the bioactivities of curcumin(CUR)for alleviating alcoholic liver *** was embedded into HPP-GAL nanoparticles by the self-assembly of hydrogen bonding and hydrophobic interaction with the particle size around 200 ***-GAL enhanced the encapsulation efficiency and loading amount of CUR with the value of(89.21±0.33)%and(0.500±0.004)%,*** stabilities of CUR under strong acid,salt ion stability and ultraviolet irradiation conditions were improved by the ***-GAL-CUR nanoparticles exhibited excellent concentration-dependent in vitro antioxidant activities including DPPH and ABTS scavenging rates,and better protective effect on CUR against gastric acid environment as well as longer release of CUR in simulated intestinal *** addition,the HPPGAL-CUR delivery system possessed liver targeting property due to the existence of GAL,which could effectively alleviate the alcohol-induced liver damage and the inflammation indexes by inhibiting the oxidative ***,HPP-GAL-CUR nanoparticles might be a potential candidate system for the prevention of alcoholic liver damage in the future.

关键词： Haematococcus pluvialis protein Galactose Curcumin nanocarrier Maillard reaction Alcoholic liver damage Liver targeting

Lactobacillus plantarum J26 alleviates alcohol-induced oxidative liver injury by regulating the Nrf2 signaling pathway

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Food Science and Human Wellness 2024年第4期13卷 2068-2078页

作者： Hongxuan Li shasha cheng Yuhong Wang Yilin Sun Jiaxin Zhang Mingshuang Sun Chaoxin Man Yu Zhang Yujun Jiang Key Laboratory of Dairy Science Ministry of EducationCollege of Food Science and EngineeringNortheast Agricultural UniversityHarbin 150030China

Oxidative stress is one of the main ways to cause alcohol-induced liver injury,and alcoholic liver disease(ALD)has been a common health problem *** acid bacteria(LAB)is also considered as a potential treatment to alleviate alcohol-induced liver *** plantarum J26 is a LAB isolated from Chinese traditional fermented dairy products with excellent probiotic *** study aimed to establish a mice model of alcoholic liver injury through acute-on-chronic alcohol feeding and to study the alleviating effect of pre-intake of *** J26 on alcohol-induced oxidative liver injury and focus on its potential mechanism of alleviating *** results showed that pre-intake of *** J26 could improve liver pathological changes,reduce lipid accumulation,increase mitochondrial ATP and mitochondrial(mtDNA)levels,and alleviate liver *** addition,pre-intake *** J26 can improve the level of short-chain fatty acids(SCFAs)in the intestines in mice,short chain fatty acids can be used as a signaling molecule activation of nuclear factor E2-related factor 2(Nrf2)signaling pathway to alleviate liver oxidative stress,and maintain mitochondrial homeostasis by regulating the expression of genes related to mitochondrial dynamics and autophagy,thereby reducing cell apoptosis to alleviate alcohol-induced oxidative liver injury.

关键词： Alcoholic liver disease Probiotics Nuclear factor E2-related factor 2(Nrf2) Oxidative stress Short-chain fatty acids

地方高职院校创新创业教育与专业教育融合路径研究——以广西建设职业技术学院建设工程管理专业为例

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科教文汇 2024年第16期 164-168页

作者：程沙沙广西建设职业技术学院广西南宁530007

高职院校创新创业教育对提高教育教学质量、促进学生全面发展、推动毕业生创业就业发挥了重要作用。创新创业教育与专业教育融合发展,是市场竞争加剧和产业升级的必然要求。文章以广西建设职业技术学院建设工程管理专业为例,以促进专创... 详细信息

高职院校创新创业教育对提高教育教学质量、促进学生全面发展、推动毕业生创业就业发挥了重要作用。创新创业教育与专业教育融合发展,是市场竞争加剧和产业升级的必然要求。文章以广西建设职业技术学院建设工程管理专业为例,以促进专创融合为目标,深入研究高职院校创新创业教育与专业教育融合现状,分析专创融合过程中存在的问题,并提出相应的路径对策,为促进创新创业教育与专业教育融合发展提供借鉴。

关键词：高职院校创新创业专业教育融合路径

京广大通道航空流流动韧性研究——基于原始网络与优化网络的比较

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地理研究 2024年第10期43卷 2602-2615页

作者：张一诺路紫成莎莎康佩瑶河北师范大学地理科学学院石家庄050024 河北省环境演变与生态建设实验室石家庄050024

京广大通道是中国民航“十三五”规划的重要工程,旨在宏观尺度上调整空域结构并释放空域承载容量,预期将提升航空流流动韧性。本文构建了一个组合的航空流流动韧性评估框架,使用航迹延迟数据分析京广大通道开通前后航空流流动韧性的变... 详细信息

京广大通道是中国民航“十三五”规划的重要工程,旨在宏观尺度上调整空域结构并释放空域承载容量,预期将提升航空流流动韧性。本文构建了一个组合的航空流流动韧性评估框架,使用航迹延迟数据分析京广大通道开通前后航空流流动韧性的变化进而揭示其内在机制。对比原始网络与优化网络发现:原始网络中脆弱节点和脆弱航段从沿线中心机场及其关联航段转移到外围参与机场及其关联航段,优化网络中延迟传播依赖路径数量减少、范围缩小且延迟传播依赖链得到疏解,延迟依赖风险空间结构趋向于多源-网络模式,减轻了航空流网络极化状态,加强了均衡性,致使原有的沿线中心机场延迟风险的“轴带”模式得以改善。优化后的京广大通道航空流流动韧性得到明显提升。检验不同航空流配置策略的增益效果还发现,新辟路径释放闲置空域资源和阻滞延迟传播所产生的增益效果显著。京广大通道在打造航路航线集群系统的同时,实现了空域系统功能转换和空域资源充分开发利用。航空流流动韧性研究将为空域资源优化配置提供理论参考。

关键词：流动韧性航班延迟依赖链航空流配置京广大通道

Bug localization based on syntactical and semantic information of source code

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Journal of Systems Engineering and Electronics 2023年第1期34卷 236-246页

作者： YAN Xuefeng cheng shasha GUO Liqin College of Computer Science Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Collaborative Innovation Center of Novel Software Technology and Industrialization Nanjing 211106China State Key Laboratory of Intelligent Manufacturing System Technology Beijing Institute of Electronic System EngineeringBeijing 100854China

The existing software bug localization models treat the source file as natural language, which leads to the loss of syntactical and structure information of the source file. A bug localization model based on syntactical and semantic information of source code is proposed. Firstly, abstract syntax tree(AST) is divided based on node category to obtain statement sequence. The statement tree is encoded into vectors to capture lexical and syntactical knowledge at the statement ***, the source code is transformed into vector representation by the sequence naturalness of the statement. Therefore,the problem of gradient vanishing and explosion caused by a large AST size is obviated when using AST to the represent source code. Finally, the correlation between bug reports and source files are comprehensively analyzed from three aspects of syntax, semantics and text to locate the buggy code. Experiments show that compared with other standard models, the proposed model improves the performance of bug localization, and it has good advantages in mean reciprocal rank(MRR), mean average precision(MAP) and Top N Rank.

关键词： bug report abstract syntax tree code representation software bug localization

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植物乳杆菌J26对蓝莓酒品质的影响

中国食品学报 2024年第8期24卷 259-267页

作者：梁雅琪程莎莎丁弋芯苏悦鲁杏茹张宇满朝新姜毓君东北农业大学食品学院、乳品科学教育部重点实验室哈尔滨150030

以蓝莓汁为原料,接种植物乳杆菌J26(原植物乳杆菌NDC75017、TD109、LJ26)预发酵后,利用酿酒酵母发酵蓝莓酒,采用pH计法、直接测定法、分光光度法和高效液相色谱法分析植物乳杆菌+酵母发酵组、酵母发酵组和市售蓝莓酒的pH值、总酸、糖度... 详细信息

以蓝莓汁为原料,接种植物乳杆菌J26(原植物乳杆菌NDC75017、TD109、LJ26)预发酵后,利用酿酒酵母发酵蓝莓酒,采用pH计法、直接测定法、分光光度法和高效液相色谱法分析植物乳杆菌+酵母发酵组、酵母发酵组和市售蓝莓酒的pH值、总酸、糖度、酒精度、总酚以及花青素含量,确定添加益生菌预发酵对蓝莓酒品质的影响。结果表明,添加益生菌预发酵后的蓝莓酒,pH值、总酸、糖度和酒精度均在国家标准规范围。在25 d的发酵时间里,其总酚含量下降至8010.21 mg/L,显著高于酵母发酵组;植物乳杆菌+酵母组的花青素在发酵时期含量保持稳定,发酵末期花青素含量显著高于酵母发酵组(7200.65 mg/kg)。在后发酵结束后,植物乳杆菌+酵母发酵组蓝莓酒中J26活菌数可达9.3×106 CFU/mL。本研究通过添加益生菌预发酵得到的蓝莓酒总酚、花青素含量丰富,且具有一定数量的益生菌,可赋予蓝莓酒一定的益生功能,有助于提高蓝莓酒的品质。

关键词：植物乳杆菌J26 发酵蓝莓酒功能成分品质

Influence of Spatial-Temporal and Environmental Factors on Larimichthys polyactis, Octopus variabilis, and Species Aggregated Set-Net CPUEs in Haizhou Bay, China

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Journal of Ocean University of China 2018年第4期17卷 973-982页

作者： TANG Yanli MA Shuyang LIU Changdong WANG Xinmeng cheng shasha Fisheries Technology Laboratory College of Fisheries Ocean University of China

Set-nets are common alongshore fishing gear used in Haizhou Bay, which rely on flow to catch fish. The catch per unit effort(CPUE) of set-net is affected by spatial-temporal and environmental factors but no research has been conducted on this subject. In this study, we used generalized additive models(GAMs) to explore the influence of spatial-temporal and environmental factors on CPUEs of species aggregated, small yellow croaker(Larimichthys polyactis), and octopus(Octopus variabilis) based on logbooks investigations conducted at 4 stations in an alongshore area of Haizhou Bay from 2011 to 2012. The results showed that all CPUEs exhibited significant spatial-temporal differences at various scales. Aggregated CPUE was high when the sea surface temperature(SST) was 15-18℃ and 20-23℃, which was mainly determined by life history traits of the octopus and small yellow croaker(optimal SSTs 14-17℃ and 19-24℃, respectively). Chlorophyll-a concentration had significant influences on the aggregated, small yellow croaker and octopus CPUEs at optimal ranges of 3.8-6.2 mg m^(-3), 4.2-4.8 mg m^(-3) and 4.5-5.5 mg m^(-3), respectively. Flow through the net had positive relationships with CPUEs. The approximate logarithmic trends in regression curves had a critical point of 2.5 Mm^3 d^(-1), which was the dividing point that differentiated whether the major factor affecting CPUEs was the flow velocity or the fishery resource. Our results from this study will help guide fishery production and improve catch rate of set-net fishing in Haizhou Bay.

关键词： spatial-temporal environmental factors set-net small yellow croaker octopus generalized additive models Haizhou Bay

Recent research progress of bimetallic phosphides-based nanomaterials as cocatalyst for photocatalytic hydrogen evolution

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Chinese Chemical Letters 2022年第3期33卷 1141-1153页

作者： Chunmei Li Daqiang Zhu shasha cheng Yan Zuo Yun Wang Changchang Ma Hongjun Dong Advanced Chemical Engineering Laboratory of Green Materials and Energy of Jiangsu Province Institute of Green Chemistry and Chemical TechnologySchool of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013China Department of Chemistry Dongguk UniversitySeoul 04620Republic of Korea

Hydrogen energy(H_(2)) has been considered as the most possible consummate candidates for replacing the traditional fossil fuels because of its higher combustion heat value and lower environmental *** hydrogen evolution(PHE) from water splitting based on semiconductors is a promising technology towards converting solar energy into sustainable H_(2)fuel evolution. Developing high-activity and abundant source semiconductor materials is particularly important to realize highly efficient hydrogen evolution as for photocatalysis technology. However, unmodified pristine photocatalysts are often unable to overcome the weakness of low performance due to their limitations. In recent years, transition metal phosphides(TMPs) were used as valid co-catalysts to replace the classic precious metal materials in the process of photocatalytic reaction owing to their lower cost and higher combustion heat *** is more, bimetallic phosphides have been also caused widespread concern in H_(2)evolution reaction owing to its much lower overpotential, more superior conductivity, and weaker charge carriers transfer impedance in comparison to those of single metal phosphides. In this minireview, we concluded the latest developments of bimetallic phosphides for a series of photocatalytic reactions. Firstly, we briefly summarize the present loading methods of bimetallic phosphides(BMPs) anchored on the photocatalyst. After that, the H;evolution efficiency based on BMPs as cocatalyst is also studied in detail. Besides, the application of BMPs-based host photocatalyst for H_(2)evolution under dye sensitization effect has also been discussed. At last, the current development prospects and prospective challenges in many ways of BMPs are proposed. We sincerely hope this minireview has certain reference value for great developments of BMPs in the future research.

关键词： Bimetallic Phosphides Cocatalyst Photocatalysis Hydrogen evolution Dye Sensitization Effect

Artificial intelligence-aided discovery of prolyl hydroxylase 2 inhibitors to stabilize hypoxia inducible factor-1α and promote angiogenesis

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中国化学快报：英文版 2023年第2期34卷 412-415页

作者： Jianzhong Zhu cheng Chen Jie Dong shasha cheng Guodong Li Chunming Wang Defang Ouyang Chung-Hang Leung Ligen Lin State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Xiangya School of Pharmaceutical Science Central South UniversityChangsha 410083China

From ZINC database with a total of 1.8 million small molecules, four compounds are identified as prolyl hydroxylase 2 inhibitors through a virtual screening workflow that sequentially incorporates machine learning, molecular docking, and molecular dynamics. Among them, compound 103,(E)-5-(5-((2-(1Htetrazol-5-yl)hydrazineylidene)methyl)furan-2-yl)isoindoline-1,3-dione, promotes the migration and capillary tube formation capacity of human umbilical vein endothelial cells through enhancing the stability of hypoxia inducible factor-1α and increasing the level of vascular endothelial growth factor.

关键词： Machine learning Virtual screening PHD2 Angiogenesis Wound healing

Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 proteineprotein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells

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Genes & Diseases 2022年第6期9卷 1674-1688页

作者： shasha cheng Guan-Jun Yang Wanhe Wang Dik-Lung Ma Chung-Hang Leung State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao SARPR China Department of Chemistry Hong Kong Baptist UniversityKowloon TongHong Kong SARPR China Institute of Medical Research Northwestern Polytechnical UniversityXi’anShaanxi 710072PR China Department of Biomedical Sciences Faculty of Health SciencesUniversity of MacaoMacao SARPR China

Triple-negative breast cancer(TNBC)is a highly aggressive and metastasizing cancer that has the worst prognosis out of all breast cancer *** epithelial emesenchymal transition(EMT)and cancer stem cells(CSCs)have been proposed as important mechanisms underlying TNBC ***9 is highly expressed in breast cancer,including TNBC,where it promotes EMT and induces cancer cell *** this study,we have identified a tetrahydroisoquinoline derivative(compound 1)as a potent and selective CDK9-cyclin T1 inhibitor via virtual ***,by targeting the ATP binding site,compound 1 not only inhibited CDK9 activity but also disrupted the CDK9-cyclin T1 proteineprotein interaction(PPI).Mechanistically,compound 1 reversed EMT and reduced the ratio of CSCs by blocking the CDK9-cyclin T1 interaction,leading to reduced TNBC cell proliferation and *** date,compound 1 is the first reported tetrahydroisoquinoline-based CDK9-cyclin T1 ATP-competitive inhibitor that also interferes with the interaction between CDK9 and cyclin *** 1 may serve as a promising scaffold for developing more selective and potent anti-TNBC *** work also provides insight into the role of the CDK9-cyclin T1 PPI on EMT and CSCs and highlights the feasibility and significance of targeting CDK9 for the treatment of TNBC.

关键词： Cancer stem cells CDK9-cyclin T1 Epithelial mesenchymal transition Proteineprotein interaction(PPI) Triple-negative breast cancer(TNBC)