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Autophagy-targeting modulation to promote peripheral nerve regeneration

Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan chen Hongxia Deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

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Covalent organic frameworks doped with manganese-metal organic framework for peroxymonosulfate activation

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Chinese Chemical Letters 2024年第4期35卷 199-203页

作者： Yinyin Xu Yuanyuan Li Jingbo Feng chen Wang Yan Zhang Yukun Wang Xiuwen cheng Key Laboratory for Environmental Pollution Prediction and Control College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Key Laboratory of Pollutant Chemistry and Environmental Treatment College of Chemistry and Environmental ScienceYili Normal UniversityYining 835000China

A novel N, O modified Mn_(3)O_(4)@porous carbon catalyst(NOC-Mn_(3)O_(4)) was prepared by direct carbonization using the manganese-metal organic framework(Mn-MOF) and covalent organic framework(COF) as precursors to activate peroxymonosulfate(PMS) for the degradation of bisphenol A(BPA) and rhodamine B(Rh B). Benefiting from the N and O co-doping of COF, larger specific surface area, faster electron transfer and Mn cycling, the optimum 1NOC-Mn_(3)O_(4)could significantly improve the degradation performance of BPA and Rh B(92.1% and 96.9% within 30 min) as compared to C-Mn_(3)O_(4)without COF doping. In addition, 1NOC-Mn_(3)O_(4) showed good reusability and strong anti-interference ability. Radical quenching experiments, X-ray photoelectron spectroscopy(XPS), Electron paramagnetic resonance spectrometer(EPR) and electrochemical tests showed that the 1NOC-Mn_(3)O_(4)/PMS system degraded BPA and Rh B by both radical and non-radical pathways. Moreover, the possible degradation pathways of BPA and Rh B were proposed by liquid chromatography-mass spectrometry(LC-MS). Except for that, the toxicity of BPA, Rh B and their intermediates were evaluated. This study opens up a new prospect for the design of COF-doped PMS catalysts.

关键词： Peroxymonosulfate Covalent organic framework Mn-metal organic framework Organic pollutant Degradation

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B and Fe co-doped Co_(2)P hollow nanocubes for nitrate electroreduction to ammonia

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Chinese Chemical Letters 2024年第2期35卷 278-282页

作者： Jing Miao Qingling Hong Liping Liang Guomin Li Zhihong Liu Shibin Yin Yu chen School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China School of Materials Science and Engineering Shaanxi Normal UniversityXi'an 710062China School of Chemistry and Chemical Engineering Shaanxi Normal UniversityXi'an 710062China Guangxi Key Laboratory of Electrochemical Energy Materials School of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China

Nitrate(NO_(3)^(−))electroreduction reaction(NO_(3)^(−)RR)provides an attractive and sustainable route for NO_(3)^(−)pollution mitigation or energy-saved ammonia(NH3)*** this work,high-quality B and Fe co-doped Co_(2) P hollow nanocubes(B/Fe-Co_(2) P HNCs)are successfully synthesized though simultaneous boronation-phosphorization treatment,which reveal outstanding selectivity,activity,stability for the NO_(3)^(−)to NH_(3) conversion in neutral electrolyte because of big surface area,fast mass transport,superhydrophilic surface,and optimized electronic structure.B/Fe-Co_(2) P HNCs can achieve the high NH3 yield rate(22.67 mg h^(−1) mg_(cat)^(−1))as well as Faradaic efficiency(97.54%)for NO_(3)^(−)RR,greatly outperforming most of non-precious metal based NO_(3)^(−)RR electrocatalysts.

关键词： Nitrate electroreduction reaction Ammonia synthesis Transition metal phosphides Hollow nanocubes

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Long-term in vivo chimeric cells tracking in non-human primate

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Protein & Cell 2024年第3期15卷 207-222页

作者： Junmo Wu Yu Kang Xiang Luo Shaoxing Dai Yuxi Shi Zhuoyao Li Zengli Tang Zhenzhen chen Ran Zhu Pengpeng Yang Zifan Li Hong Wang Xinglong chen Ziyi Zhao Weizhi ji Yuyu Niu State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China Yunnan Key Laboratory of Primate Biomedical Research Kunming 650500China Faculty of Life Science and Technology Kunming University of Science and TechnologyKunming 650500China

Non-human primates(NHPs)are increasingly used in preclinical trials to test the safety and efficacy of biotech-nology ***,given the ethical issues and costs associated with this model,it would be highly advantageous to use NHP cellular models in clinical ***,developing and maintaining the naive state of primate pluripotent stem cells(PSCs)remains difficult as does in vivo detection of PSCs,thus limiting biotech-nology application in the cynomolgus ***,we report a chemically defined,xeno-free culture system for culturing and deriving monkey PSCs in *** cells display global gene expression and genome-wide hypometh-ylation patterns distinct from monkey-primed *** also found expression of signaling pathways components that may increase the potential for chimera *** for biomedical applications,we were also able to integrate bioluminescent reporter genes into monkey PsCs and track them in chimeric embryos in vivo and in *** engineered cells retained embryonic and extra-embryonic developmental ***,we generated a chimeric monkey carrying bioluminescent cells,which were able to track chimeric cells for more than 2 years in living *** study could have broad utility in primate stem cell engineering and in utilizing chimeric monkey models forclinical studies.

关键词： pluripotent stem cells bioluminescence imaging non-human primates

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中深层煤炭地下气化的气化腔安全宽度计算方法

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煤炭科学技术 2024年第2期52卷 183-193页

作者：东振任博陈艳鹏赵宇峰陈浩陈姗姗薛俊杰张梦媛易海洋吴瀚琦中国石油勘探开发研究院北京100083 中国矿业大学深部岩土力学与地下工程国家重点实验室江苏徐州221116 华北科技学院建筑工程学院河北廊坊065201 中国石油天然气股份有限公司储气库分公司北京100101

煤炭地下气化是目前温度最高(超过1200℃)的化石能源非常规开发方式,中深层(本文指埋深800~1500 m)煤炭地下气化在提高气化压力、降低地质安全风险方面优势明显,科学预测气化腔安全宽度对保障气化稳定运行十分重要,由于目前基于可控注... 详细信息

煤炭地下气化是目前温度最高(超过1200℃)的化石能源非常规开发方式,中深层(本文指埋深800~1500 m)煤炭地下气化在提高气化压力、降低地质安全风险方面优势明显,科学预测气化腔安全宽度对保障气化稳定运行十分重要,由于目前基于可控注入点后退(CRIP)工艺的气化腔安全宽度计算方法尚未建立,为保证现场试验顺利实施,需要开展针对性研究。气化腔顶板“裸露”在气化腔后会受到高温影响,通过数值模拟方法研究了压应力约束条件下岩石内部热应力产生位置以及颗粒、基质热膨胀系数差异对热应力大小的影响规律,结合高温处理后的岩石电镜扫描结果,查明了高温下岩石热损伤机理。根据CRIP气化工艺造腔特点,建立了考虑高温影响的气化腔顶板薄板模型,结合“关键层”理论提出了气化腔安全宽度计算方法。研究表明:岩石热损伤是岩石物理化学反应与热应力互相促进、共同作用的结果,高温下岩石发生不规则变形,岩石热损伤引起的微观结构变化是导致岩石力学性质、物理性质变化的根本原因。岩石的最大拉张热应力出现在颗粒界面或热膨胀系数较小的颗粒中,颗粒与基质热膨胀系数比值在[0.01~1)时,最大拉张热应力随颗粒热膨胀系数减小而快速增加。泥岩加热到200℃时开始出现微裂隙;加热到400℃时裂隙发育更加明显,主要是沿颗粒边缘破裂;加热到600~800℃时,裂隙数量增多、尺寸变大;加热到1000℃时,除出现较大裂隙外,还产生了大量孔隙;1200℃时裂隙连通性明显增加,气孔发育较大。由于高温的影响,薄板模型的步距准数不再是定值,需要根据气化腔顶板热破坏范围与顶板硬岩层的空间位置关系确定具体数值。气化腔安全宽度受温度影响,在研究算例中,砂岩顶板在35、1000℃时安全宽度计算结果分别为34.3 m和14.1 m,相差达58.9%,泥岩顶板在35、1000℃时安全宽度计算结果分别为16.7 m和15.9 m,相差4.8%。最后从降低顶板垮落风险、有利于气化控制角度,提出了煤层纵向靶区位置的确定方法,当煤层厚度超过气化腔安全宽度一半时,建议将水平井纵向靶区设计在距离煤顶不超过气化腔安全宽度一半的位置。

关键词：煤炭地下气化可控注入点后退工艺气化腔热应力热损伤薄板模型步距准数安全宽度

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Physiological and Biochemical Responses of Perennial Ryegrass Mixed Planting with Legumes under Heavy Metal Pollution

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1749-1765页

作者： Yi Xi Li Zhang Yanhong Xu Wei cheng Chao chen College of Animal Science Guizhou UniversityGuiyang550025China

In artiﬁcially controlled pot experiments,perennial ryegrass was mixed with other leguminous plants(white clo-ver and alfalfa)and treated with lead,zinc and cadmium(337 mg·kg^(-1),648 mg·kg^(-1),and 9 mg·kg^(-1),respectively)to simulate compound pollution *** results showed that the concentrations of heavy metals,trans-port factors,and bioconcentration factors in mixed planting of ryegrass decreased compared with those in *** of whether heavy metal pollution was introduced,mixed planting increased the aboveground and underground biomasses of *** different mixed planting treatments had no signiﬁcant impact on the chlorophyll concentration of *** mowing time,mixed planting treatment,and heavy metal treatment had impacts on antioxidant and osmotic adjustment substances,and there were some *** mixed planting treatment did not signiﬁcantly affect glutathione concentration,cysteine concentration,or nonprotein *** planting generally increased the nitrogen and phosphorus concentrations of ryegrass while reducing the stoichiometric ratio of carbon,nitrogen,and *** results suggest that the mixed planting of ryegrass with legumes promotes the growth of ryegrass in the presence of high concentrations of heavy metal ***,it does not enhance the ability of ryegrass to remediate heavy metal pollution in the soil.

关键词： Perennial ryegrass mixed planting phytoremediation lead zinc and cadmium soil pollution

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无麸质饮食营养改善生物策略:乳酸菌发酵

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中国粮油学报 2024年第8期39卷 35-41页

作者：付文慧王睿粲谢强陈晨王硕薛文通南开大学医学院天津300071 中国农业大学食品科学与营养工程学院北京100037

长期严格无麸质饮食是麸质相关疾病患者的唯一治疗方式,大量研究指出无麸质饮食目前存在营养不均衡、麸质意外暴露等风险。乳酸菌发酵作为传统且安全的食品加工方式,正被应用于无麸质食品的制作,研究表明乳酸菌能通过体外发酵及体内定... 详细信息

长期严格无麸质饮食是麸质相关疾病患者的唯一治疗方式,大量研究指出无麸质饮食目前存在营养不均衡、麸质意外暴露等风险。乳酸菌发酵作为传统且安全的食品加工方式,正被应用于无麸质食品的制作,研究表明乳酸菌能通过体外发酵及体内定植的方式改善无麸质食品的营养品质。文章从乳酸菌发酵提升无麸质食品营养及其对麸质相关疾病患者的体内益生作用2个方面展开综述,拟为建立乳酸菌干预的无麸质饮食营养改善生物策略提供支撑。

关键词：无麸质营养乳酸菌发酵

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山东省地市级疾控人员工作偏好研究:基于离散选择实验

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中国卫生政策研究 2024年第1期17卷 60-67页

作者：妥泽贵陈思思陈亦萱严豪石学峰北京中医药大学管理学院北京102488

目的:探讨地市级疾病预防控制中心人员的工作偏好,为制定有效的激励机制提供依据。方法:本研究采用分层抽样和立意抽样相结合的方法,线上调研山东省6个地市级疾控机构的455名工作人员,利用混合Logit模型和潜在类别模型分析数据,并计算... 详细信息

目的:探讨地市级疾病预防控制中心人员的工作偏好,为制定有效的激励机制提供依据。方法:本研究采用分层抽样和立意抽样相结合的方法,线上调研山东省6个地市级疾控机构的455名工作人员,利用混合Logit模型和潜在类别模型分析数据,并计算支付意愿和相对重要性。结果:混合Logit模型中,收入、福利水平、编制、工作量、群众的认可与尊重、个人职业发展机会和培训机会均对疾控人员的工作偏好有显著影响(P<0.05),其中编制(β=2.636)和收入(β=0.083)等保健因素较激励因素影响程度大。潜在类别模型显示,相对年轻、月收入较低的疾控人群更重视收入;年龄较大、月收入较高的疾控人群更重视编制。结论:地市级疾控人员偏好有编制、收入较高、福利水平很好、群众认可且尊重、工作量少、个人职业发展机会较多和培训机会丰富的工作。建议合理控制并动态调整编制总量,平衡编制内外工作条件的差异;增加对疾控的财政投入,改善薪酬绩效体系;同时重视保健因素和激励因素,多种手段共同激励疾控人员发展;对不同类别的疾控人员采用差异化的激励措施。

关键词：疾控人员偏好研究离散选择实验

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Mutation Studies of 31 Highly Mutated Y-chromosomal Short Tandem Repeat Systems in the Han Population of Northern China

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Journal of Forensic Science and Medicine 2024年第2期10卷 155-162页

作者： Shicheng Hao Jinghan chen Hang He Li Yuan Key Laboratory of Evidence Science Ministry of EducationChina University of Political Science and LawBeijingChina Shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of JusticeAcademy of Forensic ScienceShanghaiChina

A six-color fluorescent multiplex amplification system for 31 Y-chromosomal short tandem repeats(Y-STRs)(DYS19,DYS390,DYS391,DYF399S1,DYF404S1,DYS439,DYS444,DYS449,DYS452,DYS456,DYS458,DYS460,DYS481,DYS508,DYS513,DYS516,DYS518,DYS543,DYS547,DYS549,DYS552,DYS557,DYS570,DYS576,DYS612,DYS622,DYS626,DYS627,DYS630,DYS635,and Y-GATA-A10)was developed for investigating the mutation rates of 31 highly mutated Y-STR genes in the Han population of northern *** mutation rates of the 31 highly mutated Y-STRs were calculated using the father-son pair study method after typing 526 Northern Han father-son pairs with this ***,148 Y-STR mutations were found,with mutation rates ranging from 0(95%confidence interval[CI]0 to 9.0×10^(−3),DYS622)to 7.0×10^(−2)(95%CI 5.1×10^(−2)to 9.7×10^(−2),DYF399S1).Out of these,126 father-son pairs were successfully identified,with a distinction rate of 24.0%(95%CI 20.4%-27.9%).The ability of the 31 highly mutated Y-STRs to distinguish closely related males from the same paternal lineage in the Northern Han population is extremely valuable for criminal investigations and other purposes.

关键词： Forensic genetics mutation rate rapidly mutating Y-chromosomal short tandem repeat

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碳汇视角下海洋生态效率的时空差异及影响因素研究——以环渤海地级市为例

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海洋与湖沼 2024年第2期55卷 409-418页

作者：狄乾斌邵春雪陈小龙张洁梁晨露辽宁师范大学海洋可持续发展研究院辽宁大连116029 辽宁师范大学地理科学学院辽宁大连116029

为了推进海洋高质量发展,建设海洋强国,基于2011~2020年环渤海16个地级市的面板数据,运用非期望产出超效率SBM模型和Tobit模型测度环渤海地级市的海洋生态效率、时空演化特征并实证分析其影响因素。结果表明:(1)从时序演化看,2011~2020... 详细信息

为了推进海洋高质量发展,建设海洋强国,基于2011~2020年环渤海16个地级市的面板数据,运用非期望产出超效率SBM模型和Tobit模型测度环渤海地级市的海洋生态效率、时空演化特征并实证分析其影响因素。结果表明:(1)从时序演化看,2011~2020年环渤海地级市海洋生态效率均值呈波动上升趋势,仍有较大进步空间。(2)从空间差异看,环渤海地级市海洋生态效率空间分布格局由2011年高低生态效率水平相间分布的无序状态向2020年两个较高生态效率区空间上集聚的有序化发展倾向转变,但并未出现区域协同化发展趋势。(3)Malmquist生产率指数分解表明,研究前期纯技术效率作为效率增长的单一推动力存在动力不足问题;研究后期2016~2020年,技术进步、规模效率双驱动,保证了海洋生态效率的提升。(4)地区经济发展水平、碳减排水平对环渤海地级市海洋生态效率具有显著正向影响;环境规制、海洋产业结构呈显著负相关;海洋科技水平正向影响但未通过显著性检验。未来要注重海洋科技发展、推进绿色低碳转型以及加强地区间合作,提升海洋发展基础以促进环渤海地区海洋高质量发展。

关键词：海洋生态效率非期望产出环渤海地级市 Tobit回归模型海洋碳汇

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