检索结果-南通市图书馆

Association between DNA mismatch repair gene polymorphisms and platinum-based chemotherapy toxicity in non-small cell lung cancer patients

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2017年第6期36卷 267-273页

作者： Jun-Yan Liu chen-Yue Qian Yuan-Feng Gao Juan chen Hong-Hao Zhou Ji-Ye Yin Xiangya School of Medicine Central South University Department of Clinical Pharmacology Xiangya HospitalCentral South University Institute of Clinical Pharmacology Hunan Key Laboratory of PharmacogeneticsCentral South University Hunan Province Cooperation Innovation Center for Molecular Target New Drug Study

Background:Chemotherapy toxicity is a serious problem from which non-small cell lung cancer(NSCLC) patients *** mismatch repair(MMR) system is associated with platinum-based chemotherapy toxicity in NSCLC *** this study,we aimed to investigate the relationship between genetic polymorphisms in the MMR pathway and platinum-based chemotherapy toxicity in NSCLC ***:A total of 220 Chinese lung cancer patients who received at least two cycles of platinum-based chemotherapy were recruited for this *** was evaluated in each patient after two cycles of chemotherapy.A total of 44 single nucleotide polymorphisms were selected to investigate their associations with platinum-based chemotherapy ***:MutS homolog 2[MSH2) rs6544991[odds ratio(OR) 2.98,95%confidence interval(ci) 1.20-7.40,P = 0.019]was associated with gastrointestinal toxicity in the dominant model;MSH3 rs6151627(OR 2.38,95%ci 1.23-4.60,P = 0.010),rs6151670(OR 2.05,95%ci 1.07-3.93,P = 0.031),and rs7709909(OR 2.38,95%ci 1.23-4.64,P = 0.010)were associated with hematologic toxicity in the dominant ***,MSH5 rs805304 was significantly associated with overall toxicity(OR 2.21,95%ci 1.19-4.09,P = 0.012),and M5H5 rs707939 was significantly associated with both overall toxicity(OR 0.42,95%ci 0.23-0.76,P = 0.004) and gastrointestinal toxicity(OR 0.44,95%ci 0.20-0.96,P = 0.038) in the dominant ***:Genetic polymorphisms in the MMR pathway are potential clinical markers for predicting chemotherapy toxicity in NSCLC patients.

关键词：非小细胞肺癌药物毒性基因多态性错配修复化疗患者 DNA 单核苷酸多态性

两性霉素B脂质体治疗侵袭性真菌感染病人发生急性肾损伤危险因素分析

在线全文

学校读者我要写书评

暂无评论

安徽医药 2024年第6期28卷 1263-1268页

作者：陈丽娟朱蕻潮吴晓丽杨康群秦海艳王昕雯南京医科大学附属淮安第一医院药学部江苏淮安223300 南京医科大学附属淮安第一医院核医学科江苏淮安223300

目的研究两性霉素B脂质体(L-AMB)治疗侵袭性真菌感染病人发生急性肾损伤(AKI)的危险因素。方法回顾性分析南京医科大学附属淮安第一医院2018年1月至2021年12月61例两性霉素B脂质体治疗侵袭性真菌感染病人的临床资料,根据是否发生两性霉... 详细信息

目的研究两性霉素B脂质体(L-AMB)治疗侵袭性真菌感染病人发生急性肾损伤(AKI)的危险因素。方法回顾性分析南京医科大学附属淮安第一医院2018年1月至2021年12月61例两性霉素B脂质体治疗侵袭性真菌感染病人的临床资料,根据是否发生两性霉素B脂质体相关AKI分为AKI组23例(37.7%),非AKI组38例(62.3%)。采用单因素分析法比较两组临床资料,logistic回归分析两性霉素B脂质体(L-AMB)治疗侵袭性真菌感染病人发生AKI的危险因素,应用受试者操作特征曲线(ROC曲线)评价L-AMB使用累积剂量及治疗前血清钾水平在诊断AKI方面的能力。结果有23例病人在使用L-AMB治疗过程中发生AKI,AKI发生率为37.7%。L-AMB疗程、累积剂量、日剂量,L-AMB治疗前血钾水平在AKI及非AKI两组病人比较中均差异有统计学意义(均Pci:(1.08,1.98),P=0.014];在L-AMB治疗前低血钾水平是发生L-AMB相关AKI的另一个独立危险因素[OR=0.05,95%ci:(0.01,0.43),P=0.007]。累积剂量和治疗前血钾水平曲线下面积(AUC)及其95%ci分别为0.88(0.79,0.98)、0.88(0.79,0.96),灵敏度分别为86.9%、81.5%,特异度分别为89.4%、86.9%。结论L-AMB累积剂量及治疗前低血钾水平均是L-AMB相关AKI的独立危险因素,两者在L-AMB相关AKI的诊断中均有一定的预测价值,而且累积剂量的诊断价值大于治疗前低血钾水平。

关键词：两性霉素B脂质体侵袭性真菌感染急性肾损伤药物毒性危险因素

在线全文

学校读者我要写书评

暂无评论

俄罗斯管道投产技术标准先进性研究

全面腐蚀控制 2014年第2期28卷 29-33,43页

作者：何坤陈喆杜娟颜辞敬辉阳中国石化管道储运分公司荆门输油处湖北荆门448002 中油管道物资装备总公司河北廊坊065000 中国石油管道研究中心河北廊坊065000 中石油山东输油有限公司山东日照276826 中国石油天然气管道工程有限公司天津滨海分公司天津300450

为保障中俄原油管道安全运行,全面梳理了俄罗斯管道投产技术标准,从管道清管、试压、投产试运技术和站场工艺检测等方面,深入研究了中国和俄罗斯管道标准的差异。系统阐述了俄罗斯标准的先进性,例如清管周期、紧急清管、清管器跟踪监测... 详细信息

为保障中俄原油管道安全运行,全面梳理了俄罗斯管道投产技术标准,从管道清管、试压、投产试运技术和站场工艺检测等方面,深入研究了中国和俄罗斯管道标准的差异。系统阐述了俄罗斯标准的先进性,例如清管周期、紧急清管、清管器跟踪监测设置地点、高强度液体试压、试压介质泄漏监测、零度以下管道试压技术、管道投产延迟条件下重新试压、运行管道强制性试压准则、输油站紧急停输准则、管道运行参数记录分析和站场工艺管道检测周期等。最后,针对借鉴俄罗斯标准,提高我国管道投产标准水平以及加强标准制修订工作,提出了建议。

关键词：管道标准清管试压投产

颅内动脉粥样硬化性狭窄的药物涂层球囊安全性评估:前循环与后循环的比较

在线全文

学校读者我要写书评

暂无评论

中国体视学与图像分析 2024年第1期29卷 64-73页

作者：罗继昌黄凯勋宫昊志王韬焦力群陈赛安张桃红首都医科大学宣武医院神经外科北京100053 中国国际神经外科研究所北京100053 首都医科大学宣武医院介人放射科北京100053 中山大学第八附属医院深圳518033 北京科技大学计算机与通信工程学院北京100083

目的药物涂层球囊(DCB)血管成形术是治疗颅内动脉粥样硬化性狭窄(ICAS)患者的一种潜在方法。由于前、后循环的血管解剖结构不同,围手术期的并发症也各不相同。本研究旨在比较DCB血管成形术治疗前、后循环ICAS的疗效和安全性。方法这项... 详细信息

目的药物涂层球囊(DCB)血管成形术是治疗颅内动脉粥样硬化性狭窄(ICAS)患者的一种潜在方法。由于前、后循环的血管解剖结构不同,围手术期的并发症也各不相同。本研究旨在比较DCB血管成形术治疗前、后循环ICAS的疗效和安全性。方法这项研究将纳入在首都医科大学宣武医院接受DCB血管成形术的症状性重度ICAS患者。根据责任病变的位置,参与者被分为两组,前循环(Ac)组和后循环(Pc)组。两组患者的基线人口统计学、斑块特征和临床结果进行了比较。结果共有94名符合条件的患者被纳入本次分析(Ac组53例,Pc组41例)。两组患者围手术期的卒中或死亡风险无明显差异(Ac:Ac:5.7%[3/53]vs:Pc:4.9%2/41);OR2.91,95%置信区间[ci]0.33~25.99。经多因素分析校正后,Ac组发生医源性动脉夹层(Ac:45.3%[24/53]***:12.2%[5/41];a0R4.72,95%ci1.49~14.90)和补救性支架植入(Ac:26.4%[14/53]***:2.4%[1/41];a0R14.71,95%ci1.61~134.37)的风险明显高于Pc组。结论DCB血管成形术治疗前循环和后循环ICAS的安全性相当。但前循环中的DCB可能会导致更多的动脉夹层和支架补救治疗。为进一步证实ICAS治疗策略,有必要进行长期随访和进一步研究。

关键词：颅内动脉粥样硬化药物涂层球囊高分辨率磁共振成像卒中

A poor performance in comprehensive geriatric assessment is associated with increased fall risk in elders with hypertension： a cross-sectional study

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2015年第2期12卷 113-118页

作者： Jiao-Jiao CHU Xu-Jiao chen Shan-Shan SHEN Xue-Feng ZHANG Ling-Yan chen Jing-Mei ZHANG Jing HE Jun-Feng ZHAO Department of Geriatrics Zhejiang Hospital Hangzhou 310013 Zhefiang Province China Fuyuan Hospital of Yiwu Yiwu 322000 Zhejiang Province China Department of Emergency Zhejiang Hospital Hangzhou 310013 Zhejiang Province China

Background Fall and serious fall injuries have become a major health concern for elders. Many factors including blood pressure and anti-hypertensive medication application were reported as hazards of fall. The purpose of this study was to determine if age related systemic functional decline related with increased fall risks in elderly patients with hypertension. Methods A total of 342 elderly hypertension patients （age 79.5 ＋ 6.7 years, male 63.8%） were recruited to the study. Comprehensive geriatric assessment （CGA）, including measurements about activity of daily living （ADL）, nutrition, cognition, depression, numbers of prescription medication and number of clinical diagnosis, was conducted to evaluate the physical and mental status of each participants. Fall risk was evaluated by Morse fall scale, Tinetti perform- ance oriented mobility assessment （POMA） and history of fall in the recent years. Participants were grouped into tertiles according to CGA score. Correlation between CGA and fall risk was analyzed through SPSS 18.0. Results Participants with higher CGA score were likely to be older, had a lower body mass index （BMI）, and a higher prevalence of cardiovascular disease, chronic obstructive pulmonary disease （COPD）, cerebrovascular disease and osteoarthropathia. Participants in higher tertile of CGA score got increased prevalence of fall risk than those in lower tertile （P 〈 0.01 T3 vs. T1, P 〈 0.01 T3 vs. T2）. Correlation analysis and regression analysis showed significant association between CGA and Morse fall scale （P 〈 0.001）, as well as CGA and POMA （P 〈 0.001）. Meanwhile, CGA components also showed co-relationships with increase fall risks. After adjusting age, BMI, benzodiazepine use, cardiovascular disease, cerebrovascular disease, COPD and osteoarthropathia, both history of fall in the recent year and rising Morse fall scale were significantly associated with ADL im- pairment （OR： 2.748, 95%ci： 1.598-4.725）, （OR： 3.310, 95%ci： 1.893-5.788）. Decreas

关键词： Comprehensive geriatric assessment Elderly patient Fall risk Hypertension

机械制造工人职业性噪声接触与动脉硬化的关联性研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国职业医学 2024年第2期51卷 150-155页

作者：陈兆敏黄雪赞陶月情张淏喆李文祯王冬明华中科技大学同济医学院公共卫生学院教育部环境与健康重点实验室湖北武汉430030 香港中文大学赛马会公共卫生及基层医疗学院中国香港999077

目的探讨机械制造工人职业性噪声与动脉硬化之间的关联。方法采用判断抽样方法,选择某机械制造企业453名员工为研究对象。测量其工作场所噪声接触水平,结合工种-噪声暴露矩阵和职业病危害接触史评估其累积噪声暴露量(CNE)。对研究对象... 详细信息

目的探讨机械制造工人职业性噪声与动脉硬化之间的关联。方法采用判断抽样方法,选择某机械制造企业453名员工为研究对象。测量其工作场所噪声接触水平,结合工种-噪声暴露矩阵和职业病危害接触史评估其累积噪声暴露量(CNE)。对研究对象进行纯音听力测试,测量其肱-踝脉搏波传导速度(baPWV)。结果研究对象CNE为(91±11)dB(A)·年,baPWV中位数为1278.0 cm/s。广义线性回归模型分析结果显示,CNE每增加1 dB(A)·年,总人群baPWV增加0.20%[95%置信区间(ci)为0.10%~0.30%,Pci为0.06%~0.28%,Pci为0.07%~0.49%,Pci为2.42%~11.87%,Pci分别为3.07%~17.07%和2.13%~11.11%,P值均0.05)。结论职业性噪声接触可能会增加动脉硬化的风险。

关键词：职业性噪声动脉硬化肱-踝脉搏波传导速度听力损失关联性

Characteristics of homologous recombination repair pathway genes mutation in ovarian cancers

在线全文

学校读者我要写书评

暂无评论

Cancer Innovation 2022年第3期1卷 220-228页

作者： Zongbi Yi Min chen Shaoxing Sun Chunxu Yang Zijie Mei Hui Yang Qingming Xiang Hui Qiu Department of Radiation and Medical Oncology Hubei Key Laboratory of Tumour Biological BehaviorsHubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhanChina

Background:Few studies have investigated the characteristics of non‐BRCA homologous recombination repair(HRR)pathway somatic mutations,and the impact of these mutations on efficacy of treatment in ovarian cancer patients is not ***,we conducted this study to analyze the frequency and spectrum of somatic mutations in HRR pathway genes in patients with ovarian cancer and to examine the relationships between somatic mutations in HRR pathway genes and their effects on the efficacy of platinum‐based ***:We performed targeted sequencing of 688 genes related to the occurrence,development,treatment,and prognosis of solid *** mutations were identified by paired analysis of tumor tissue and germline DNA in blood ***:A total of 38 patients with ovarian cancer were included in the study,and 35(92.1%)patients were diagnosed with high‐grade serous *** patients exhibited somatic mutations in the tumor tissue *** commonly mutated genes were TP53(73.7%),BRCA2(55.3%),NF1(52.6%),BRCA1(47.4%),and CDH1(47.4%).Overall,71.1%of the patients exhibited mutation in at least one HRR pathway *** most frequently altered HRR genes were BRCA2(55.3%),followed by BRCA1(47.4%),ATM(44.7%),BARD1(42.1%),and CHEK1(36.8%).The median progression‐free survival(PFS)in patients with HRR pathway mutation was 36.0 months compared with 13.6 months in patients with no HRR pathway mutation(hazard ratio[HR],0.25;95%confidence interval[ci],0.08–0.77;p=0.016).Patients harboring BRCA1/2 and/or CDK12 mutations displayed a longer PFS(median,36.0 months)compared with patients with no BRCA1/2 or CDK12 mutation(median,13.6 months;HR,0.21;95%ci,0.07–0.61;p=0.004).In multivariate analysis Cox proportional hazards models,after adjustment for tumor stage at diagnosis and histology of initial diagnosis,patients with HRR pathway mutation had a longer PFS than patients with HRR wild‐type genes(p=0.006).Conclusions:HRR pathway somatic mutations are common in

关键词： ovarian cancer genetic testing somatic mutation homologous recombination repair platinum-based therapy

固定式与支架式宫内节育器的有效性、安全性和续用率比较

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国计划生育学杂志 2024年第2期32卷 282-287页

作者：滕英陈星岳茗肖武冰雪黄蔚丁璟秦明车焱张妍广西壮族自治区计划生育药具和医疗器械管理服务中心南宁530028 上海市生物医药技术研究院国家卫生健康委员会计划生育药具重点实验室复旦大学

目的:观察固定式宫内节育器(IUD)在育龄女性中的安全性、有效性和续用情况。方法:以2022年1-6月使用国家免费IUD的育龄妇女为研究对象,随访置入后1、3个月的IUD避孕效果、不良反应和续用情况。多因素logistic回归分析有宫颈松弛、宫颈... 详细信息

目的:观察固定式宫内节育器(IUD)在育龄女性中的安全性、有效性和续用情况。方法:以2022年1-6月使用国家免费IUD的育龄妇女为研究对象,随访置入后1、3个月的IUD避孕效果、不良反应和续用情况。多因素logistic回归分析有宫颈松弛、宫颈宽大、既往IUD脱落史、分娩后或人工流产后即时放置IUD等特征的“特殊人群”使用不同类型IUD对随访结局的影响。结果:纳入使用固定式或支架式IUD者分别为1060人和1589人,固定式IUD组中特殊人群535例(占50.5%),支架式式IUD组中特殊人群288例(占18.1%)。放置后3个月特殊人群中固定式IUD月经改变和白带异常的发生率较支架式IUD组低(16.8%比18.8%,3.0%比3.5%,均Pci0.45~0.85);放置后3个月固定式IUD组发生白带异常的风险均较低(一般人群OR=0.50,95%ci0.29~0.80;特殊人群OR=0.43,95%ci0.24~0.72);发生IUD脱落/异位的风险增加无统计学意义(一般人群OR=1.41,95%ci0.52~3.53;特殊人群OR=1.57,95%ci0.61~3.83)。结论:固定式IUD在白带异常和月经改变方面的表现较优于传统的支架式IUD;在一般人群和特殊人群中,固定式IUD均为一种安全有效的避孕方式。

关键词：宫内节育器月经改变白带异常腰腹疼痛

维普期刊数据库博看期刊

High Spicy Food Intake and Risk of Cancer： A Meta-analysis of Case-control Studies

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第18期130卷 2241-2250页

作者： Yu-Heng chen Xiao-Nong Zou Tong-Zhang Zheng Qi Zhou Hui Qiu Yuan-Li chen Mei He Jia Du Hai-Ke Lei Ping Zhao Cancer Foundation of China National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021 China National Office for Cancer Prevention and Control National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China Department of Epidemiology School of Public Health Brown University Providence RI 02912 USA Office for Cancer Prevention and Control Chongqing Cancer Hospital Chongqing 400030 China

Background：Studies on the association between spicy food intake and cancer risk have reported inconsistent *** quantitatively assessed this association by conducting a meta-analysis based on evidence from case-control ***：PubMed,EMBASE,and the Cochrane Library were searched for eligible *** odds ratios （ORs） with their 95% confidence interval （ci） were calculated using a random-or fixed-effects *** methodological quality of the included articles was assessed using the Newcastle-Ottawa scale （NOS）.All data were analyzed using STATA 1 1.0 software （version 11.0;StataCorp.,College Station,TX,USA）.Subgroup analyses were also performed with stratification by region,sex,number of cases,cancer subtype,source of the control group,and NOS ***：A total 39 studies from 28 articles fulfilled the inclusion criteria for the meta-analysis （7884 patients with cancer and 10,142 controls）.Comparison of the highest versus lowest exposure category in each study revealed a significant OR of 1.76 （95% ci =1.35-2.29） in spite of significant heterogeneity （P 〈 0.00l）.In the subgroup analyses,this positive correlation was still found for gastric cancer,different regions,different numbers of cases,different sources of the control group,and high-quality articles （NOS score of≥ 7）.However,no statistically significant association was observed for women,esophageal cancer,gallbladder cancer,or low-quality articles （NOS score of〈7）.No evidence of publication bias was ***：Evidence from case-control studies suggested that a higher level of spicy food intake may be associated with an increased incidence of cancer despite significant *** studies are warranted to clarify our understanding of the association between high spicy food intake and the risk of cancer.

关键词： Cancer Incidence: Case control Studies Meta-analysis Spicy Food