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Multi-element analysis by ArF laser excited atomic fluorescence of laser ablated plumes： Mechanism and applications

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Frontiers of physics 2012年第6期7卷 670-678页

作者： Yue Cai Po-chun Chu Sut Kam ho Nai-ho cheung Department of Physics Hong Kong Baptist University Kowloon Tong Hong Kong China Faculty of Science and Technology University of Macao Macao China

A new multi-element analysis technique based on laser-excited atomic fluorescence was reviewed. however, the one-wavelength-one-transition constraint was overcome. Numerous elements were induced to fluoresce at a single excitation wavelength of 193 nm. This was possible provided that the analytes were imbedded in dense plumes, such as those produced by pulsed laser ablation. The underlying mechanism of the technique was explained and corroborated. Analytical applications to metals, plastics, ceramics and their composites were discribed. Detection limits in the ng/g range and mass limits of atto moles were demonstrated. Several real-world problems, including the analysis of paint coating for trace lead, the non-destructive analysis of potteries and ink, the chemical profiling of electrode plastic interfaces, and the analysis of ingestible lead colloids were discussed.

关键词： laser-excited atomic fluorescence (LEAF) argon fluoride laser laser plume spectroscopy multi-element analysis

Elafibranor:A promising therapeutic approach for liver fibrosis and gut barrier dysfunction in alcohol-associated liver disease

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World Journal of Gastroenterology 2025年第3期31卷 123-126页

作者： chun-Han Cheng Wen-Rui Hao Tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This article discusses the recent study written by Koizumi et ***-associated liver disease(ALD)is a major cause of liver-related morbidity and mortality,which is driven by complex mechanisms,including lipid accumulation,apoptosis,and inflammatory responses exacerbated by gut barrier *** study explored the therapeutic potential of elafibranor,a dual peroxisome proliferatoractivated receptor alpha/delta *** clinical trials,elafibranor has shown promise for the treatment of other liver conditions;however,its effects on ALD remain *** authors’findings indicate that elafibranor significantly reduced liver fibrosis and enhanced gut barrier integrity in patients with *** positive effects of elafibranor are mediated through multiple *** promotes lipid metabolism,reduces oxidative stress,and inhibits inflammatory responses by restoring gut barrier ***,it improves hepatocyte function by enhancing autophagic and antioxidant capacity,and it mitigates inflammation by suppressing the lipopolysaccharide/toll-like receptor 4/nuclear factor kappa B signaling *** findings indicate that elafibranor has promising clinical *** addition,the study highlights elafibranor’s potential as a therapeutic agent for liver diseases,particularly *** article underscores the importance of understanding the mechanistic pathways underlying ALD and suggests directions for future research aimed at elucidating the benefits and limitations of elafibranor.

关键词： Elafibranor Liver fibrosis Gut barrier function Alcohol-associated liver disease Peroxisome proliferatoractivated receptor agonists

Fanlian Huazhuo formula:A promising therapeutic approach for metabolic associated steatotic liver disease

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World Journal of Gastroenterology 2025年第1期31卷 167-171页

作者： chun-Han Cheng Wen-Rui Hao Tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This article reviews the study,“Fanlian huazhuo formula alleviates high-fat-dietinduced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway”published in the World Journal of *** study explores the therapeutic potential of Fanlian Huazhuo formula(FLHZF)in treating metabolic-associated steatotic liver disease(MASLD),demonstrating that FLHZF reduces lipid accumulation,oxidative stress,and liver injury in MASLD models by modulating key signaling pathways involved in lipid metabolism and *** editorial emphasizes the potential of FLHZF as a treatment for MASLD and calls for further research to verify its clinical efficacy.

关键词： Fanlian Huazhuo formula Metabolic associated steatotic liver disease Autophagy Lipid metabolism Oxidative stress

Advancing treatment strategies:Insights from network meta-analysis of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 252-255页

作者： chun-Han Cheng Wen-Rui Hao Tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan City 33305TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung City 404328TaiwanChina

This study examines the pivotal findings of the network meta-analysis of Zhou et al,which evaluated the efficacy of hepatic arterial infusion chemotherapy and combination therapies for advanced hepatocellular carcinoma(HCC).This meta-analysis suggests that therapeutic combinations have greater efficacy than do standard *** article highlights the key insights that have the potential to shift current clinical practice and enhance outcomes for patients with advanced ***,this article discusses further research that can be conducted to optimize these treatments and achieve personalized care for patients with HCC.

关键词： Hepatic arterial infusion chemotherapy Advanced hepatocellular carcinoma Combination therapy Network meta-analysis Treatment efficacy

An Investigation of Effect of Stand-Off Distance on the Material Removal Characteristics and Surface Generation in Fluid Jet Polishing

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Nanomanufacturing and Metrology 2020年第2期3卷 112-122页

作者： chun Jin Wang Chi Fai cheung Lai Ting ho Yee Man Loh State Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Fluid jet polishing(FJP)is a versatile polishing process that has many advantages compared to other polishing ***-off distance(SOD)is one of the key parameters in flu id jet polishi ***,relatively little research work has been carried out to investigate its effect of SOD on material removal characteristics and surface generation in *** this paper,a systematic investigation of the effect of SOD on the tool influence function and surface topography in FJP was *** were designed for FJP two kinds of materials corresponding to ductile and brittle *** are nickel copper(NiCu)alloy and BK7 optical glass,*** this study,the SOD was varied from 2 to 35 *** and discussions were made on its effect on the shape of TIF,material removal rate,and surface *** is interesting to note that the TIF shape becomes a Gaussian-like shape with large SOD both on NiCu and BK7,which provides a novel way to optimize the TIF in *** variation of the material removal rate and surface roughness versus SOD on NiCu and BK7 were also determined from the experimental ***,the surface topography of NiCu and BK7 were characterized from the results measured from the white light interferometer and scan electron *** outcome of the study provides a better understanding of the material removal characteristics and surface generation mechanism in FJP.

关键词： Fluid jet polishing Material removal characteristics Stand-off distance Tool influence function Surface generation Ultra-precision machining

Self-synchronization of reinjected droplets for highefficiency droplet pairing and merging

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Microsystems & Nanoengineering 2023年第2期9卷 181-192页

作者： Lang Nan Tianjiao Mao ho cheung Shum Advanced Biomedical Instrumentation Centre Hong Kong Science ParkShatinNew TerritoriesHong KongChina Department of Mechanical Engineering The University of Hong KongPokfulam RoadHong KongChina

Droplet merging serves as a powerful tool to add reagents to moving droplets for biological and chemical ***,unsynchronized droplet pairing impedes high-effciency ***,we develop a microfluidic design for the self-synchronization of reinjected droplets.A periodic increase in the hydrodynamic resistance caused by droplet blocking a T-junction enables automatic pairing of *** inducing spacing,the paired droplets merge downstream under an electric *** blockage-based design can achieve a 100%synchronization efficiency even when the mismatch rate of droplet frequencies reaches 10%.Over 98%of the droplets can still be synchronized at nonuniform droplet sizes and fluctuating reinjection flow ***,the droplet pairing ratio can be adjusted flexibly for on-demand sample *** this system,we merge two groups of droplets encapsulating enzyme/substrate,demonstrating its capacity to conduct multi-step *** also combine droplet sorting and merging to coencapsulate single cells and single beads,providing a basis for high-efficiency single-cell *** expect that this system can be integrated with other droplet manipulation systems for a broad range of chemical and biological applications.

关键词： field merge spacing

A Versatile Flow-Profile Engineering Method in the Stokes Flow Regime for Complex-Shaped Flows

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Engineering 2021年第5期7卷 655-662页

作者： Zhenyu Yang Lang Nan ho cheung Shum Department of Mechanical Engineering The University of Hong KongHong Kong 999077China

Flow profiles are frequently engineered in microfluidic channels for enhanced mixing,reaction control,and material ***,flow profiles are engineered by inducing inertial secondary flow to redistribute the streams,which can hardly be reproduced in microfluidic environments with negligible inertial *** employed symmetric channel structures also limit the variety of achievable flow ***,each of the flow profiles specifically corresponds to a strictly defined flow condition and cannot be generalized to other flow *** address these issues,we present a systematic method to engineer the flow profile using inertialess secondary *** flow is manipulated in the Stokes regime by deploying a cascaded series of microsteps with various morphologies inside a microchannel to shape the flow *** tuning the shapes of the microsteps,arbitrary outflow profiles can be customized.A numerical profile-transformation program is developed for rapid prediction of the output profiles of arbitrary sequences of predefined *** proposed method allows the engineering of stable flow profiles,including asymmetric ones,over a wide range of flow conditions for complex microfluidic environmental prediction and design.

关键词： Microfluidics Flow profile Stokes flow Hydrodynamic focusing Flow shaping

Novel biomarkers GEP/ABCB5 regulate response to adjuvant transarterial chemoembolization after curative hepatectomy for hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 524-530页

作者： Charing Ching-Ning Chong Siu Tim cheung Yue-Sun cheung Anthony Wing-Hung Chan Stephen Lam Chan Simon chun-ho Yu Paul Bo-San Lai Department of Surgery Prince of Wales HospitalThe Chinese University of Hong Kong4/F Clinical Science Building30-32 Ngan Shing StreetShatinHong KongChina Department of Anatomical and Cellular Pathology State Key Laboratory in Oncology in South ChinaPrince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina Department of Clinical Oncology Prince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina Department of Imaging and Interventional Radiology Prince of Wales HospitalThe Chinese University of Hong Kong30-32 Ngan Shing StreetShatinHong KongChina

Background: Transarterial chemoembolization(TACE) is the most commonly used adjuvant therapy for hepatocellular carcinoma(HCC) after curative resection. Responses to TACE are variable due to tumor and patient heterogeneity. We had previously demonstrated that expression of Granulin-epithelin precursor(GEP) and ATP-dependent binding cassette(ABC)B5 in liver cancer stem cells was associated with chemoresistance. The present study aimed to evaluate the association between GEP/ABCB5 expression and response to adjuvant TACE after curative resection for HCC. Methods: Patients received adjuvant TACE after curative resection for HCC and patients received curative resection alone were identified from a prospectively collected database. Clinical samples were retrieved for biomarker analysis. Patients were categorized into 3 risk groups according to their GEP/ABCB5 status for survival analysis: low(GEP-/ABCB5-), intermediate(either GEP +/ABCB5-or GEP-/ABCB5 +) and high(GEP +/ABCB5 +). Early recurrence(recurrence within 2 years after resection) and disease-free survival were analyzed. Results: Clinical samples from 44 patients who had followed-up for more than 2 years were retrieved for further biomarker analysis. Among them, 18 received adjuvant TACE and 26 received surgery alone. Patients with adjuvant TACE in the intermediate risk group was associated with significantly better overall survival and 2-year disease-free survival than those who had surgery alone( P = 0.036 and P = 0.011, respectively). Adjuvant TACE did not offer any significant differences in the early recurrence rate, 2-year disease-free survival and overall survival for patients in low and high risk groups. Conclusions: Adjuvant TACE can only provide survival benefits for patients in the intermediate risk group(either GEP +/ABCB5-or GEP-/ABCB5 +). A larger clinical study is warranted to confirm its role in patient selection for adjuvant TACE.

关键词： Adjuvant therapy Hepatocellular carcinoma Drug transporter Transarterial chemoembolisation Granulin-epithelin precursor

Examining patterns of traditional chinese medicine use in pediatric oncology: A systematic review, meta-analysis and data-mining study

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Journal of Integrative Medicine 2022年第5期20卷 402-415页

作者： chun Sing Lam Li Wen Peng Lok Sum Yang ho Wing Janessa Chou Chi-Kong Li Zhong Zuo ho-Kee Koon Yin Ting cheung School of Pharmacy Faculty of Medicinethe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of Medicinethe Chinese University of Hong KongHong KongChina hong Kong Hub of Paediatric Excellence the Chinese University of Hong KongHong KongChina Department of Paediatrics&Adolescent Medicine Hong Kong Children’s HospitalHong KongChina School of Chinese Medicine Faculty of Medicinethe Chinese University of Hong KongHong KongChina

Background Traditional Chinese medicine(TCM)is becoming a popular complementary approach in pediatric ***,few or no meta-analyses have focused on clinical studies of the use of TCM in pediatric *** We explored the patterns of TCM use and its efficacy in children with cancer,using a systematic review,meta-analysis and data mining *** strategy We conducted a search of five English(Allied and Complementary Medicine Database,Embase,PubMed,Cochrane Central Register of Controlled Trials,and ***)and four Chinese databases(Wanfang Data,China National Knowledge Infrastructure,Chinese Biomedical Literature Database,and VIP Chinese Science and Technology Periodicals Database)for clinical studies published before October 2021,using keywords related to“pediatric,”“cancer,”and“TCM.”Inclusion criteria We included studies which were randomized controlled trials(RCTs)or observational clinical studies,focused on patients agedho had been diagnosed with cancer,and included at least one group of subjects receiving TCM *** extraction and analysis The methodological quality of RCTs and observational studies was assessed using the six-item Jadad scale and the Effective Public Healthcare Panacea Project Quality Assessment Tool,***-analysis was used to evaluate the efficacy of combining TCM with *** outcomes included the treatment response rate and occurrence of cancer-related *** rule mining(ARM)was used to investigate the associations among medicinal herbs and patient *** The fifty-four studies included in this analysis were comprised of RCTs(63.0%)and observational studies(37.0%).Most RCTs focused on hematological malignancies(41.2%).The study outcomes included chemotherapy-induced toxicities(76.5%),infection rate(35.3%),and response,survival or relapse rate(23.5%).The methodological quality of most of the RCTs(82.4%)and observational studies(80.0%)was r

关键词： Traditional Chinese Medicine Herbal medicine Pediatric oncology Data mining Associate rule mining Chemotherapy