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Assessment of the Benefits of Targeted Interventions for Pandemic Control in China Based on Machine Learning Method and Web Service for COVID-19 Policy Simulation

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Biomedical and Environmental Sciences 2022年第5期35卷 412-418页

作者： WU Jie Wen JIAO Xiao Kang DU Xin Hui JIAO Zeng Tao LIANG Zuo Ru PANG Ming Fan JI Han Ran cheng zhi da CAI Kang Ning QI Xiao Peng Center for Global Public Health Chinese Center for Disease Control and PreventionBeijing 102206China Yidu Cloud(Beijing)Technology Co. Ltd.Beijing 100083China

Taking the Chinese city of Xiamen as an example,simulation and quantitative analysis were performed on the transmissions of the Coronavirus Disease 2019(COVID-19)and the influence of intervention combinations to assist policymakers in the preparation of targeted response measures.A machine learning model was built to estimate the effectiveness of interventions and simulate transmission in different *** comparison was conducted between simulated and real cases in Xiamen.A web interface with adjustable parameters,including choice of intervention measures,intervention weights,vaccination,and viral variants,was designed for users to run the *** total case number was set as the *** cumulative number was 4,614,641 without restrictions and 78 under the strictest intervention *** with the parameters closest to the real situation of the Xiamen outbreak was performed to verify the accuracy and reliability of the *** simulation model generated a duration of 52 days before the daily cases dropped to zero and the final cumulative case number of 200,which were 25 more days and 36 fewer cases than the real situation,*** interventions could benefit the prevention and control of COVID-19 outbreak while safeguarding public health and mitigating impacts on people’s livelihood.

关键词： COVID-19 Intervention policy simulation Machine learning Compartment model

面心立方单晶镍纳米线稳定性及磁性的第一性原理计算

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物理学报 2011年第3期60卷 672-676页

作者：程志达朱静孙铁昱清华大学材料科学与工程系北京100084 北京电子显微镜中心北京100084

本文采用第一性原理方法,研究了轴向为低指数晶向的面心立方(fcc)单晶镍纳米线的稳定性和磁性.计算表明,[110]是fcc镍纳米线最容易出现的取向,[111]取向次之,而[001]取向则很难出现,这一结果与实验事实符合.镍纳米线按照原子位置和磁性... 详细信息

本文采用第一性原理方法,研究了轴向为低指数晶向的面心立方(fcc)单晶镍纳米线的稳定性和磁性.计算表明,[110]是fcc镍纳米线最容易出现的取向,[111]取向次之,而[001]取向则很难出现,这一结果与实验事实符合.镍纳米线按照原子位置和磁性强弱的不同,可以分成简单的芯-壳结构,在纳米线芯部,原子的磁矩大小与块体基本一致.在纳米线表面,镍原子的磁矩比芯部原子有所增加.表面原子磁矩与轴向的取向相关,[110]为轴向的纳米线表面原子磁矩最低,而[001]为轴向的纳米线表面原子磁矩最高.

关键词：镍纳米线第一性原理原子磁矩

Oxcarbazepine monotherapy in children with benign epilepsy with centrotemporal spikes improves quality of life

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Chinese Medical Journal 2020年第14期133卷 1649-1654页

作者： Wan-Ting Liu Xiu-Xian Yan da-zhi cheng Han-Zi Zhang Ning Ding Ke-Ming Xu Xin-Lin Zhou Qian Chen Department of Neurology Capital Institute of PediatricsBeijing 100020China National Key Laboratory of Cognitive Neuroscience and Learning Institute of Cognitive Neuroscience and LearningBeijing Normal UniversityBeijing 100020China

Background:Benign epilepsy with centrotemporal spikes(BECTS)is the most common type of childhood idiopathic focal *** is associated with pervasive cognitive deficits and behavior *** seizures can be easily controlled,it is crucial to select anti-epileptic drugs that do not impair cognition,do not cause psychosocial effects,and improve the quality of *** studies showed effects of oxcarbazepine(OXC)monotherapy on the cognitive and psychosocial profiles of patients with ***,we studied the effects of OXC monotherapy on the neuropsychologic profiles and quality of life in patients with BECTS in ***:Thirty-one patients aged 6 to 12 years newly diagnosed with BECTS were recruited.A psychometric assessment was performed before and during the follow-up of OXC monotherapy with Cognitive Computerized Task Battery,Depression SelfRating Scale for children,Screen for Child Anxiety Related Emotional Disorders,and Quality of Life in Epilepsy-31(QOLIE-31).The results of the assessments were compared to explore the effect of OXC monotherapy in patients with ***:Thirty children with BECTS completed the *** of ten cognitive test scores improved after treatment via OXC monotherapy,including visual tracing(F=14.480,Pdata concerning the quality of life,statistically significant improvements were observed in emotion(F=4.946,P<0.05),QOLIE-social(F=5.912,P<0.05),and QOLIE-total(F=14.161,P<0.001).Conclusions:OXC is safe and does not impair neuropsychologic functions,with no obvious mood burden on children with *** importantly,OXC has positive impacts on children’s perception of quality of life,especially in terms of happiness and life satisfaction.

关键词： Epilepsy Cognition Psychosocial difficulties Cognitive function Benign epilepsy with centro-temporal spikes

基于脑科学的儿童神经认知发育障碍评估与干预

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中国实用儿科杂志 2017年第4期32卷 275-279页

作者：程大志陈倩首都儿科研究所附属儿童医院神经内科北京100020

儿童神经认知发育障碍主要包括发展性阅读障碍、发展性计算障碍、注意缺陷多动障碍和孤独症谱系障碍,是儿童神经系统疾病的高发共患病。神经认知发育障碍严重影响患儿的学业表现和社交能力,对长期的社会预后提出巨大挑战。目前,对于儿... 详细信息

儿童神经认知发育障碍主要包括发展性阅读障碍、发展性计算障碍、注意缺陷多动障碍和孤独症谱系障碍,是儿童神经系统疾病的高发共患病。神经认知发育障碍严重影响患儿的学业表现和社交能力,对长期的社会预后提出巨大挑战。目前,对于儿童神经认知发育的诊疗,临床尚缺乏客观有效的工具。近些年,脑科学技术的发展为儿童神经认知发育障碍的机制及其干预提供了新的途径。文章从认知行为、脑神经机制和干预的角度,阐述儿童神经认知发育障碍脑科学研究成果。这些证据表明,儿童神经认知发育障碍存在特定的核心认知障碍和脑区的结构或功能异常,其干预以认知行为训练为主,脑刺激的效果有待进一步确认。

关键词：儿童神经认知发育障碍脑科学神经机制

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联觉的认知神经机制

心理科学进展 2009年第5期17卷 944-950页

作者：程大志隋光远陈春萍浙江师范大学心理系金华321004

联觉是指由一种感官刺激引起其他感官体验的心理过程。近年来的研究将行为实验和脑成像技术结合,发现了联觉的认知神经基础。本文总结了最受关注的字形-颜色联觉的研究成果,认为联觉发生在视知觉加工的早期阶段,与知觉在本质上有许多共... 详细信息

联觉是指由一种感官刺激引起其他感官体验的心理过程。近年来的研究将行为实验和脑成像技术结合,发现了联觉的认知神经基础。本文总结了最受关注的字形-颜色联觉的研究成果,认为联觉发生在视知觉加工的早期阶段,与知觉在本质上有许多共同特征,其脑区涉及梭状回(V4)和顶叶。未来联觉的研究将通过综合运用各种方法,进一步拓宽研究范围。

关键词：字形-颜色联觉神经基础梭状回(V4) 顶叶

中小学教师感知使命感对践行使命感的作用机制研究

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教师教育研究 2022年第4期34卷 45-52页

作者：王乃弋肖金昕马瑾程大志北京师范大学教育学部北京100875 成都市温江区教育局四川成都611130 首都儿科研究所神经内科北京100020

在鼓励教师不忘教育初心、牢记育人使命的新时代,研究教师职业使命感的形成机制尤为重要。教师职业使命感包含感知使命感和践行使命感两种状态,从使命感知到使命践行中间可能存在断层。本研究以518名中小学教师为调查对象,探讨教师感知... 详细信息

在鼓励教师不忘教育初心、牢记育人使命的新时代,研究教师职业使命感的形成机制尤为重要。教师职业使命感包含感知使命感和践行使命感两种状态,从使命感知到使命践行中间可能存在断层。本研究以518名中小学教师为调查对象,探讨教师感知使命感对践行使命感的作用机制。结果表明:教师感知使命感显著正向影响践行使命感;工作意义在二者之间起中介作用,职业承诺在二者之间的中介作用不显著;组织支持感负向调节工作意义中介效应的前半路径:当组织支持感较低时,感知使命感通过工作意义对践行使命感的影响较强,反之影响较弱。上述结果提示可以通过提升感知使命感、工作意义感,以及提供合理的组织支持等途径提高教师的践行使命感。

关键词：中小学教师感知使命感践行使命感有调节的中介

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen Li Hui Ye Xue-zhi Zhang Jian-Xiang Liu Hong cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu Zi-Yun Yuan zhi-Yuan Liu Zi-Zhu Liu zhi-Cong Xiao Jing-Hui Li cheng-zhi Huang Jun-Jiang Wang Xue-Qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type II diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage III CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage III CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage III CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis Type II diabetes mellitus

Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa Shen Chang cheng Yu-Han Wang Wen-Chao cheng De-zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report