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Absence of metallicity and bias-dependent resistivity in low-carrier-density EuCd_(2)As_(2)

Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 119-125页

作者： Yuxiang Wang Jianwen Ma Jian Yuan Wenbin Wu yong Zhang Yicheng Mou Jiaming Gu Peihong cheng Wu Shi xiang Yuan Jinglei Zhang Yanfeng Guo cheng Zhang State Key Laboratory of Surface Physics and Institute for Nanoelectronic Devices and Quantum Computing Fudan UniversityShanghai 200433China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field Laboratory of the Chinese Academy of SciencesHefei 230031China School of Physics and Electronic Science East China Normal UniversityShanghai 200241China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China ShanghaiTech Laboratory for Topological Physics Shanghai 201210China

EuCd_(2)As_(2)was theoretically predicted to be a minimal model of Weyl semimetals with a single pair of Weyl points in the ferromagnet ***,the heavily p-doped Eu Cd_(2)As_(2)crystals in previous experiments prevent direct identification of the semimetal ***,we present a comprehensive magneto-transport study of high-quality Eu Cd_(2)As_(2)crystals with ultralow bulk carrier density(10^(13)cm^(-3)).In contrast to the general expectation of a Weyl semimetal phase,Eu Cd_(2)As_(2)shows insulating behavior in both antiferromagnetic and ferromagnetic states as well as surface-dominated conduction from band ***,the application of a dc bias current can dramatically modulate the resistance by over one order of magnitude,and induce a periodic resistance oscillation due to the geometric *** nonlinear transport results from the high nonequilibrium state induced by an electrical field near the band *** results suggest an insulating phase in Eu Cd_(2)As_(2)and put a strong constraint on the underlying mechanism of anomalous transport properties in this system.

关键词： magnetic Weyl semimetal quantum transport Hall effect nonlinear resistivity

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A compact route for efficient production of high-purityβ-Ga_(2)O_(3) powder

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Rare Metals 2024年第9期43卷 4573-4584页

作者： xiao-Wei Zhou Gao-Jie Chen Liang Xu Zhi-Jun Shao cheng Yang yong-Pan Tian Zhuo Zhao School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243032China Low-Carbon Research Institute Anhui University of TechnologyMa'anshan 243032China

The present study has proposed a compact process for the production of high-purityβ-Ga_(2)O_(3)powder by simply using gallium metal and water as the raw *** process basically consists of two essential steps including hydrothermal synthesis of Ga OOH and calcination of Ga OOH for the production of the target product ofβ-Ga_(2)O_(3).Thermodynamic evaluation and systematic experiments were conducted for process parameter optimization.X-ray diffractometer(XRD),scanning electron microscopy(SEM),thermogravimetryDdifferential scanning calorimetry(TG-DSC)and X-ray photoelectron spectroscopy(XPS)were utilized to clarify the reaction mechanisms of the hydrothermal synthesis and transformation of Ga OOH toβ-Ga_(2)O_(3)by *** analysis of the final product ofβ-Ga_(2)O_(3)obtained under the optimal conditions was carried out with inductively coupled plasma mass spectrometry(ICP-MS),and the results showed that the contents of the representative impurities such as Ni,Cu,In,Mn,Co,Zn and Cr are obviously lower than the requirement of 5Nβ-Ga_(2)O_(3)standard,exhibiting excellent application prospect of the proposed process to produce high-purityβ-Ga_(2)O_(3).

关键词： β-Ga_(2)O_(3) Hydrothermal synthesis Calcination Purity Reaction mechanism

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The BEL1-like transcription factor GhBLH5-A05 participates in cotton response to drought stress

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The Crop Journal 2024年第1期12卷 177-187页

作者： Jing-Bo Zhang Yao Wang Shi-Peng Zhang Fan cheng yong Zheng Yang Li Xue-Bao Li Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhan 430079HubeiChina College of Life Sciences Xinjiang Normal UniversityUrumqi 830017XinjiangChina

Drought stress impairs crop growth and ***1-like family transcription factors may be involved in plant response to drought stress,but little is known of the molecular mechanism by which these proteins regulate plant response and defense to drought *** we show that the BEL1-like transcription factor GhBLH5-A05 functions in cotton(Gossypium hirsutum)response and defense to drought *** of GhBLH5-A05 in cotton was induced by drought *** of GhBLH5-A05 in both Arabidopsis and cotton increased drought tolerance,whereas silencing GhBLH5-A05 in cotton resulted in elevated sensitivity to drought ***5-A05 binds to cis elements in the promoters of GhRD20-A09 and GhDREB2C-D05 to activate the expression of these ***5-A05 interacted with the KNOX transcription factor ***-expression of GhBLH5-A05 and GhKNAT6-A03 increased the transcription of GhRD20-A09 and *** conclude that GhBLH5-A05 acts as a regulatory factor with GhKNAT6-A03 functioning in cotton response to drought stress by activating the expression of the drought-responsive genes GhRD20-A09 and GhDREB2C-D05.

关键词： Cotton(Gossypium hirsutum) BEL1-like transcription factor Drought stress Transcriptional regulation Drought tolerance

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HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6

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Science Bulletin 2024年第2期69卷 173-178页

作者： Siyuan Jiang xiaoqi Han Tihui Liu Ying He Zidong Zhao Tongfeng Liu Shuwen cheng Jihang Zhang Liqiang Duan Yajuan Liu Tianyou cheng yong Liu Qinong Ye Shan Gao Zhongda Hospital Medical SchoolAdvanced Institute for Life and HealthSoutheast UniversityNanjing 20096China Medical School of Guizhou University Guiyang 550025China Shanxi Academy of Advanced Research and Innovation Taiyuan 030032China Zhongda Hospital School of Life Sciences and TechnologyAdvanced Institute for Life and HealthSoutheast UniversityNanjing 210096China Nanjing University Medical School Nanjing 210046China Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesWuhan UniversityWuhan 430072China Department of Medical Molecular Biology Beijing Institute of BiotechnologyCollaborative Innovation Center for Cancer MedicineBeijing 100850China

Endocytosis is a crucial cellular process that takes up cargos by enclosing them in membrane-bound vesicles,and transports cargos to different parts of the cell,such as the lysosomes[1].Endocytosis is classified into several mechanistically and morphologically pathways,including clathrin-mediated endocytosis(CME)and caveolae-mediated endocytosis(CavME)[1,2].

关键词： endocytosis cargo uptake

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Photoluminescent nickel(Ⅱ)carbene complexes with ligand-to-ligand charge-transfer excited states

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Chinese Chemical Letters 2024年第1期35卷 357-360页

作者： Chun-Liang Hou Jia-xi Song xiaoyong Chang yong Chen Key Laboratory of Photochemical Conversion and Optoelectronic Materials&CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

While nickel(II)complexes have been widely used as catalysts for carbon-carbon coupling reactions,the exploration of their photophysical and photochemical properties is still in the ***,a series of square-planar Ni(II)complexes[(diNHC)NiX2]bearing chelating benzimidazole-based bis(N-heterocyclic carbene)ligands and varying anionic coligands(1,X=Cl;2,X=Br;3,X=I)are synthesized and structurally *** solid state,both 1 and 2 exhibit orange-red photoluminescence under ambient *** photophysical and electrochemical measurements along with density functional theory(DFT)calculations reveal that the low-energy emissions can be attributed to singlet excited states with ligand-to-ligand charge-transfer(LLCT)*** work suggests that strong-field N-heterocyclic carbene ligands play a crucial role to achieve the luminescence of Ni(II)complexes.

关键词： Nickel(II)complexes N-Heterocyclic carbene Luminescence Ligand-to-ligand charge-transfer character Low-lying d-d excited states

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Epigenetic regulation of SARS-Cov-2 spike protein modulates cellular viability and nascent RNA transcription in neuronal cells

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Genes & Diseases 2024年第2期11卷 535-538页

作者： xi Kong Peng Lu Jinyue Zhang Zheng Bao chenghao Kuang Bingqing xie Jianhua Peng Ning Ma yong Jiang Shigang Yin Laboratory of Neurological Diseases and Brain Function The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Institute of Epigenetics and Brain Science Southwest Medical UniversityLuzhouSichuan 646000China Department of Neurosurgery The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China Inflammation and Allergic Diseases Research Unit The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan 646000China

SARS-CoV-2 has been demonstrated to be highly susceptible to neuron-and glial-like cells,1 but there is no consensus regarding how the virus affects neurons following *** is therefore unknown if and how SARS-CoV-2 maintains the homeostasis of neuronal ***,we revealed that the receptor-binding domain(RBD)of the SARS-CoV-2 spike protein acted as an extracellular remodeling component to undermine epigenetic regulation,perturbnascentRNA(nsRNA)transcription,promote mitochondrial biogenesis,and increase cellular viability in SH-SY5Y cells.

关键词： invasion homeostasis maintain

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Single-Cell Mapping of Brain Myeloid Cell Subsets Reveals Key Transcriptomic Changes Favoring Neuroplasticity after Ischemic Stroke

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Neuroscience Bulletin 2024年第1期40卷 65-78页

作者： Fangxi Liu xi cheng Chuansheng Zhao xiaoqian Zhang Chang Liu Shanshan Zhong Zhouyang Liu xinyu Lin Wei Qiu xiuchun Zhang Department of Neurology.The First Affiliated Hospital of China Medical University Shenyang 110001China Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Stroke Center The First Affiliated Hospital of China Medical UniversityShenyang 110001China

Interactions between brain-resident and periph-eral infiltrated immune cells are thought to contribute to neuroplasticity after cerebral ***,con-ventional bulk sequencing makes it challenging to depict this complex immune *** single-cell RNA sequencing,we mapped compositional and transcriptional features of peri-infarct immune *** were the predominant cell type in the peri-infarct region,displaying a more diverse activation pattern than the typical pro-and anti-inflammatory state,with axon tract-associated micro-glia(ATMs)being associated with neuronal *** inference suggested that infiltrated monocyte-derived macrophages(MDMs)exhibited a gradual fate trajectory transition to activated ***-cellular crosstalk between MDMs and microglia orchestrated anti-inflammatory and repair-promoting microglia phenotypes and promoted post-stroke neurogenesis,with SOX2 and related Akt/CREB signaling as the underlying *** description of the brain's immune landscape and its relationship with neurogenesis provides new insight into promoting neural repair by regulating neuroinflammatory responses.

关键词： Ischemic stroke Monocyte-derived macrophage Microglia Neurogenesis Single-cell sequencing

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Human bone marrow mesenchymal stem cell-derived exosomes loaded with gemcitabine inhibit pancreatic cancer cell proliferation by enhancing apoptosis

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 4006-4013页

作者： Zu-Gui Tang Tie-Mei Chen Yi Lu Zhe Wang xi-cheng Wang Yi Kong Department of Oncology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080Guangdong ProvinceChina Faculty of Pharmaceutical Sciences Shenzhen University of Advanced TechnologyShenzhen 518000Guangdong ProvinceChina Guangdong Pharmaceutical University Guangzhou 510006Guangdong ProvinceChina

BACKGROUND Pancreatic cancer remains one of the most lethal malignancies,and has limited effective ***(GEM),a chemotherapeutic agent,is commonly used for clinical treatment of pancreatic cancer,but it has characteristics of low drug delivery efficiency and significant side *** study tested the hypothesis that human bone marrow mesenchymal stem cell(MSC)-derived exosomes loaded with GEM(Exo-GEM)would have a higher cytotoxicity against human pancreatic cancer cells by enhancing their *** To investigate the cytotoxicity of MSC-derived Exo-GEM against pancreatic cancer cells in *** Exosomes were isolated from MSCs and characterized by transmission electron microscopy and nanoparticle tracking ***-GEM through electroporation,sonication,or incubation,and the loading efficiency was *** cytotoxicity of Exo-GEM or GEM alone against human pancreatic cancer Panc-1 and MiaPaca-2 cells was assessed by MTT and flow cytometry *** The isolated exosomes had an average size of 76.7 *** encapsulation efficacy and loading efficiency of GEM by electroporation and sonication were similar and significantly better than *** cytotoxicity of Exo-GEM against pancreatic cancer cells was stronger than free GEM and treatment with 0.02μM Exo-GEM significantly reduced the viability of both Panc-1 and MiaPaca-2 ***,Exo-GEM enhanced the frequency of GEMinduced apoptosis in both cell *** Human bone marrow MSC-derived Exo-GEM have a potent cytotoxicity against human pancreatic cancer cells by enhancing their apoptosis,offering a promising drug delivery system for improving therapeutic outcomes.

关键词： Mesenchymal stem cells Exosomes Extracellular vesicles Gemcitabine Pancreatic cancer Drug delivery

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Mendelian randomization analysis of causal relationship between cheese intake and diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1905-1910页

作者： cheng-Ye Tang Dong-yong Tang Ying-Qin Yang Yu-Bing Liang Hao Liang Department of Ophthalmology the First Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Ophthalmology the Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina Department of Anesthesiology Guangxi Medical University Cancer HospitalNanning 530000Guangxi Zhuang Autonomous RegionChina

AIM:To assess whether there is a possible causal link between the intake of cheese and the risk of diabetic retinopathy(DR)utilizing a two-sample Mendelian randomization(MR)***:The research data were obtained from summary statistics of genome-wide association studies(GWAS).Genetic loci closely related to cheese intake were extracted as instrumental variables(IVs),and DR was the outcome *** data were extracted from individuals of European *** data of cheese intake consisted of 451486 samples with 9851867 single nucleotide polymorphisms(SNPs),while the DR data consisted of 206234 samples with 16380446 ***-one genetic loci closely related to cheese intake were selected as *** analysis was performed by inverse-variance weighted(IVW)method and MR-Egger regression *** causal relationship between cheese intake and DR was evaluated using odds ratios(ORs)and 95%confidence intervals(CIs).Egger-intercept test was used to test horizontal pleiotropy and sensitivity analysis was performed by leave-one-out ***:The P value of the IVW method was less than 0.05,indicating a significant negative correlation between cheese intake and ***-Egger regression showed that the intercept was 0.01 with a standard error of 0.022,and a P-value of 0.634,indicating no evidence of horizontal pleiotropy affecting the IVs related to the exposure ***,heterogeneity tests confirmed the absence of heterogeneity,and the“leave-one-out”sensitivity analysis demonstrated that the results were ***:Cheese intake is causally negatively correlated with the occurrence of DR,and cheese intake could reduce the risk of DR.

关键词： cheese intake diabetic retinopathy Mendelian randomization analysis

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Immune remodulation in pediatric inherited metabolic liver diseases

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World Journal of Hepatology 2024年第9期16卷 1258-1268页

作者： Yi-Chi Wu Xue-Lin xiang June-Kong yong Meng Li Lin-Man Li Zi-cheng Lv Yi Zhou xi-cheng Sun Zi-Jie Zhang Huan Tong xiao-Ying He Qiang xia Hao Feng Department of Liver Surgery Renji Hospital(Punan Branch)School of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Liver Surgery Renji Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai Institute of TransplantationShanghai Engineering Research Center of Transplantation and ImmunologyShanghai 200127China Department of Gynecology Shanghai First Maternity and Infant HospitalShanghai 200012China

Inherited metabolic liver diseases arise from genetic mutations that lead to dis-ruptions in liver metabolic pathways and are predominantly observed in pedia-tric *** spectrum of genetic metabolic liver disorders is diverse,encompassing a range of conditions associated with aberrations in iron,copper,carbohydrate,lipid,protein,and amino acid ***,research in the domain of genetic metabolic liver diseases has predominantly concentrated on hepatic parenchymal cell ***,emerging studies suggest that inherited metabolic liver diseases exert significant influences on the immune microenvironment,both within the liver and *** review endeavors to encapsulate the immunological features of genetic metabolic liver diseases,aiming to expand the horizons of researchers in this discipline,and to elucidate the underlying pathophysiological mechanisms pertinent to hereditary metabolic liver diseases and to propose innovative therapeutic approaches.

关键词： Liver transplantation Inherited metabolic liver diseases Immune microen-vironment Genetic metabolic liver diseases Immunotherapy

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