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Effect of trichostatin A and paclitaxel on the proliferation and apoptosis of lung adenocarcinoma cells

Chinese Medical Journal 2013年第1期126卷 129-134页

作者： ZHANG Song ZHANG Qun-cheng JIANG shu-juan Department of Respiratory Diseases Provincial Hospital Affiliatedto Shandong University Jinan Shandong 250021 China

Background Histone deacetylase inhibitors can regulate gene expression through modulation of the degree of acetylation of histone and non-histone, thus affecting cell proliferation, survival and chemosensitivity. Histone deacetylase inhibitors combined with paclitaxel may enhance the inhibitory effect of drugs on lung cancer cells. This study aimed to observe the effect of trichostatin A （TSA）/paclitaxel on the proliferation and apoptosis in human A549 lung adenocarcinoma cells, and to investigate its mechanism. Methods A549 cells were cultured in Dulbecco modified Eagle＇s medium （DMEM） in the presence of paclitaxel and the histone deacetylase inhibitor TSA, and the growth curve was obtained by trypan-blue exclusion assay and cell count. Apoptosis was assessed using Hoechst 33258 staining and flow cytometry analysis, and cell cycle was detected by flow cytometry analysis. The proteins poly ADP-ribose polymerase （PARP）, caspase-3, survivin, and tubulin acetylation were detected by Western blotting. Results A significant reduction of proliferation was observed in A549 lung adenocarcinoma cells treated by paclitaxel or TSA. Combined treatment with TSA/paclitaxel caused the greatest inhibition of cell proliferation. The combined treatment with TSA and paclitaxel induced more severe apoptosis, and significantly more cells were arrested in G2/M phase （P 〈0.05） then with a single drug. Using Western blotting, we demonstrated that treatment with TSNpaclitaxel led to synergistic increase in acetylated tubulin, PARP, caspase-3, and reduced the expression of survivin. Conclusion TSA and paclitaxel have a synergistic activity that can inhibit cell growth and induce apoptosis.

关键词： trichostatin A paclitaxel caspase-3 survivin

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论国家所有权的客体——以作为集合物的“国有财产”为中心的思考

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西北大学学报（哲学社会科学版） 2011年第1期41卷 95-100页

作者：程淑娟西北政法大学民商法学院陕西西安710063

《物权法》将物权的客体规定为动产和不动产,但是却将国家所有权的客体规定为"国有财产",而没有简单地以"动产和不动产"来指代。国有财产是集合物,它作为国家所有权客体的必要性,也体现了罗马法中集合物这个概念的现代意义。集合物具有... 详细信息

《物权法》将物权的客体规定为动产和不动产,但是却将国家所有权的客体规定为"国有财产",而没有简单地以"动产和不动产"来指代。国有财产是集合物,它作为国家所有权客体的必要性,也体现了罗马法中集合物这个概念的现代意义。集合物具有独立性和整体性,应当适用同一法律关系,包括成立以确权或归属为目的的所有权法律关系。因此,将"国有财产"作为国家所有权的客体能实现民法对国家所有权的确权保护,维护国有财产发挥公共利益的功能。

关键词：国有财产民法保护集合物

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商法理念的司法实现

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西北大学学报（哲学社会科学版） 2012年第4期42卷 129-134页

作者：程淑娟西北政法大学民商法学院陕西西安710063

商法理念是商法自身的目标,包括基本理念和特有理念两个层次,商法的基本理念以商法作为特别私法为依据,商法的特有理念即适用商法应遵循的商法特色。司法实现商法理念的核心是公平。通过司法来实现商法理念有助于正确理解和适用复杂的商... 详细信息

商法理念是商法自身的目标,包括基本理念和特有理念两个层次,商法的基本理念以商法作为特别私法为依据,商法的特有理念即适用商法应遵循的商法特色。司法实现商法理念的核心是公平。通过司法来实现商法理念有助于正确理解和适用复杂的商法,突出商事审判的特质并发展商法。商法的基本理念包括公平和诚实信用理念,商法的特有理念包括维持商事营业、信赖保护和保护交易安全的理念。

关键词：商法理念特别私法商法特色

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论民法中的集合物及其现代应用

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河北法学 2008年第9期26卷 34-39页

作者：程淑娟西北政法大学陕西西安710063

我国《物权法》以不动产和动产作为物权的客体缺乏普适性。作为物权客体的物,应有多种法定的分类,集合物就是相当必要和重要的一种物的类型。国有财产、集体财产和私人财产以及企业,都符合集合物的构成要求;它们之所以能作为物权的客体... 详细信息

我国《物权法》以不动产和动产作为物权的客体缺乏普适性。作为物权客体的物,应有多种法定的分类,集合物就是相当必要和重要的一种物的类型。国有财产、集体财产和私人财产以及企业,都符合集合物的构成要求;它们之所以能作为物权的客体,是要适用统一的法律关系。上述几种集合物可以依法成立归属意义的所有权法律关系和担保法律关系。集合物的这种意义能够起到民法上的确权和保护作用。建立多样化的物的分类体系应当成为我国未来的立法趋势。

关键词：物权客体物的分类集合物财产企业

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确信与限制——国家所有权主体的法哲学思考

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河北法学 2009年第5期27卷 37-41页

作者：程淑娟西北政法大学民商法学院陕西西安710063

公共财产的所有权主体之一是国家,公共所有权与私人所有权共同组成了所有权的谱系,国家所有权是公共所有权的类型之一。我国对于所有权类型研究的方法论值得深刻反思。国家作为国家所有权的主体应当得到确信,全民所有是国家所有权的价... 详细信息

公共财产的所有权主体之一是国家,公共所有权与私人所有权共同组成了所有权的谱系,国家所有权是公共所有权的类型之一。我国对于所有权类型研究的方法论值得深刻反思。国家作为国家所有权的主体应当得到确信,全民所有是国家所有权的价值定位和合法性依据。民法中的国家,作为一个特种的社团,自古和率先被承认具有独立人格。国家作为所有权主体的人格应当与其公法人格相区分,并且受到公共利益的严格限制。

关键词：国家所有权公共所有权所有权主体国家法人格

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B2-CuZr reinforced amorphous alloy matrix composites:A review

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China Foundry 2025年第1期22卷 1-11页

作者： Wei Guo Run-hua Huang Zhen Zhang Mi Zhao Jin-cheng Wang Yan-qiang Qiao shu-lin Lü shu-sen Wu State Key Lab of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China School of Aerospace Engineering Huazhong University of Science and TechnologyWuhan 430074China Research Institute of Huazhong University of Science and Technology in Shenzhen Shenzhen 518057GuangdongChina

B2-CuZr phase reinforced amorphous alloy matrix composites has become one of the research hotspots in the field of materials science due to the“transformation-induced plasticity”phenomenon,which makes the composites show better macroscopic plastic deformability and obvious work-hardening behavior compared to the conventional amorphous alloy matrix composites reinforced with ductile ***,the in-situ metastable B2-CuZr phase tends to undergo eutectoid decomposition during solidification,and the volume fraction,size,and distribution of B2-CuZr phase are difficult to control,which limits the development and application of these *** date,much efforts have been made to solve the above problems through composition optimization,casting parameter tailoring,and post-processing *** this study,a review was given based on relevant studies,focusing on the predictive approach,reinforcing mechanism,and microstructure tailoring methods of B2-CuZr phase reinforced amorphous alloy matrix *** research focus and future prospects were also given for the future development of the present composite system.

关键词： amorphous alloy matrix composite B2-CuZr phase plasticity microstructure tailoring

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Is it necessary to stent renal artery stenosis patients before cardiopulmonary bypass procedures？

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Chinese Medical Journal 2011年第10期124卷 1453-1457页

作者： ZHENG Bin YAN Hong-bing LIU Rui-fang cheng shu-juan WANG Jian ZHAO Han-jun SONG Li Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background Acute kidney injury （AKI） is associated with poor prognosis after cardiopulmonary bypass. The aim of this retrospective study was to investigate whether stent implantation before cardiopulmonary bypass has beneficial effect on development of AKI in renal artery stenosis （RAS） *** In this retrospective study, patients with abnormal baseline serum creatinine （SCr, 〉106 μmol/L） were not included. Included patients （n=69） were divided into two groups. Group 1 included 31 RAS patients receiving no stent implantation before cardiopulmonary bypass. Group 2 included 38 RAS patients having received stent implantation just before cardiopulmonary bypass. To assess AKI after cardiopulmonary bypass, serum urea nitrogen, SCr and creatinine clearance were recorded at baseline, at the end of operation, during the first and second postoperative 24 *** Baseline characteristics were similar between groups. Serum urea nitrogen, SCr, creatinine clearance before and after cardiopulmonary bypass were also similar class groups. Incidence of AKI in group 1 was not significantly different from group 2. In group 1, AKI defined by RIFLE between occurred in 7 （22.6%） patients： 5 （16.1%） with RIFLE-R,2 （6.5%） with RIFLE-I, and no patients with RIFLE-F. In group 2, 10 patients （26.3%） had an episode of AKI during hospitalization： 6 （15.8%） had RIFLE-R, 4 （10.5%） had RIFLE-I, and no patients had *** There are no data suggesting that it is necessary to stent RAS patients with normal SCr before cardiopulmonary bypass. However, it cannot be concluded that RAS is not associated with AKI after cardiopulmonary bypass

关键词： renal insufficiency cardiopulmonary bypass peripheral vascular disease renal artery

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经济转型时期物权立法的一面镜子——以俄罗斯的国家所有权立法为鉴

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现代法学 2006年第5期28卷 173-181页

作者：余能斌程淑娟武汉大学法学院湖北武汉430072

俄罗斯对国家所有权的规定体现了其社会转型的特点。它赋予国家所有权与其他种类所有权平等的法律地位,实现了国家所有权主体和客体的多元化。在国家所有权的实现方式上采用了两种不同的权利安排:一是对国有单一制企业和机构保留国家的... 详细信息

俄罗斯对国家所有权的规定体现了其社会转型的特点。它赋予国家所有权与其他种类所有权平等的法律地位,实现了国家所有权主体和客体的多元化。在国家所有权的实现方式上采用了两种不同的权利安排:一是对国有单一制企业和机构保留国家的所有权,该单一制企业和机构本身享有他物权性质的经营权和业务管理权;二是通过法人所有权作为一种中介性概念实现国家所有权。此外,俄罗斯国家所有权的取得方式、消灭和保护也都有自己的特点。我国要坚持社会主义方向,国家所有权的意义自然与俄罗斯不同,但物权法也应设计出最适合自己国情的国家所有权制度。

关键词：国家所有权俄罗斯联邦民法典物权法

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Protection Effect of Exogenous Fibroblast Growth Factor 21 on the Kidney Injury in Vascular Calcification Rats

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Chinese Medical Journal 2018年第5期131卷 532-538页

作者： Yu-Chen Shi Wei-Wei Lu Yue-Long Hou Kun Fu Feng Gan shu-juan cheng Shao-Ping Wang Yong-Fen Qi Jing-Hua Liu Department of Cardiology Beijing Anzhen Hospital Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing 100029 China Department of Physiology Xuzhou Medical University Xuzhou Jiangsu 221004 China Department of Pharmacology and Nutritional Sciences University of Kentucky Lexington Kentucky USA Key Laboratory of Molecular Cardiovascular Science Ministry of Education Peking University Health Science Center Beijing 100191 China Department of Cardiology Beijing Aerospace General Hospital Beijing 100076 China

Background： Chronic kidney disease （CKD） is closely related to the cardiovascular events in vascular calcification （VC）. However, little has known about the characteristics of kidney injury caused by VC. Fibroblast growth factor 21 （FGF21 ） is an endocrine thctor, which takes part in various metabolic actions with the potential to alleviate metabolic disorder diseases, Even FGF21 has been regarded as a biomarker in CKD, the role of FGF21 in CKD remains unclear. Therefore, in this study, we evaluate the FGF21 on the kidney injury in VC rats. Methods： The male Sprague-Dawley rats were divided into three groups：（ 1 ） control group, （2） Vitamin D3 plus nicotine （VDN）-induced VC group, （3） FGF21-treated VDN group. After 4 weeks, the rats were killed and the blood was collected for serum creatinine, urea nitrogen, calcium, and phosphate measurement. Moreover, the renal tissues were homogenized for alkaline phosphatases （ALPs） activity and calcium content. The levels of FGF21 protein were measured by radioimmunoassay. The levels of β-Klotho and FGF receptor 1 （FGFR1） protein were measured by enzyme-linked immunosorbent assay （EL1SA）. The structural damage and calcifications in aortas were stained by Alizarin-red S. Moreover, the structure of kidney was observed by hematoxylin and eosin staining. Results： The renal lhnction impairment caused by VDN modeling was ameliorated by FGF21 treatment, inhibited the elevated serum creatinine and urea level by 20.5% （34.750 ± 4.334 pmol/L vs. 27.630± 2.387pamol/L） and 4.0% （7.038 ± 0.590 mmol/L vs. 6.763 ±0.374 mmol/L; P 〈 0.01 ）, respectively, together with the structural damages of glomerular atrophy and renal interstitial fibrosis. FGF21 treatment downregulated the ALP activity, calcium content in the kidney of VC rats by 42.1% （P 〈 0.01 ） and 11.7% （P 〈 0.05） as well as ameliorated the aortic injury and calcification as compared with VDN treatment alone group, indicating an ameliorative effect on VC. EL1SA assays showed that the

关键词： Chronic Fibroblast Growth Factor 21 Renal Insufficiency Vascular Calcification β-Klotho

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Recent advances in semi-heterogenous photocatalysis in organic synthesis

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Chinese Chemical Letters 2025年第2期36卷 94-117页

作者： Jia-cheng Hou Wei Cai Hong-Tao Ji Li-juan Ou Wei-Min He School of Chemistry and Chemical Engineering University of South China School of Pharmaceutical Sciences Hunan University of Medicine School of Materials Science and Engineering Hunan Institute of Technology

Semi-heterogeneous photocatalysis has emerged as a powerful and productive platform in organic chemistry, which provides mild and eco-friendly conditions for a diverse range of bond-forming *** synergy of homogeneous catalysts and heterogeneous catalysts inherits their main advantages, such as higher activities, easy separation and superior recyclability. In this review, we summarize the recent advances in recyclable semi-heterogenous protocols for the light promoted bond-forming reactions and identify directions for future research according to the different photocatalysts/metal/redox catalysts involved. Notably, this review is not a comprehensive description of reported literature but aim to highlight and illustrate key concepts, strategies, reaction model, reaction conditions and mechanisms.

关键词： Bond-forming Organic synthesis Photocatalysis Recyclable Semi-heterogeneous

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