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Simultaneous quantification of chlorogenic acid and taurocholic acid in human plasma by LC-MS/MS and its application to a pharmacokinetic study after oral administration of Shuanghua Baihe tablets

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Chinese Journal of Natural Medicines 2016年第4期14卷 313-320页

作者： GU Pan LIU Rui-Juan cheng min-lu WU Yao ZHENG lu LIU Yu-Jie MA Peng-cheng DING Li Department of Pharmaceutical Analysis China Pharmaceutical UniversityNanjing 210009China Nanjing Clinical Tech laboratories Inc. Nanjing 211000China Yangtze River Pharmaceutical Group Taizhou 225321China Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjing 210042China

An LC-MS/MS method was developed and validated for the simultaneous quantification of chlorogenic acid(CGA) and taurocholic acid(TCA) in human plasma using hydrochlorothiazide as the internal standard. The chromatographic separation was achieved on a Hedera ODS-2 column with a gradient elution using 10 mmol·L^(-1) of ammonium acetate buffer solution containing 0.5% of formic acid- acetonitrile as mobile phase at a flow rate of 300 μL·min-1. The detection was performed on a triple quadrupole tandem mass spectrometer by multiple reaction monitoring in negative ESI mode. The method was fully validated over the concentration ranges of 0.1–10 ng·m L^(-1) for CGA and 2–150 ng·m L^(-1) for TCA. It was successfully applied to a pharmacokinetic study of CGA and TCA in healthy Chinese volunteers after oral administration of Shuanghua Baihe tablets(SBTs). In the single-dose study, the maximum plasma concentration(C_(max)), time to reach C_(max)(T_(max)) and elimination half-life(t_(1/2)) of CGA were(0.763 8 ± 0.542 0) ng·m L^(-1),(1.0 ± 0.5) h, and(1.3 ± 0.6) h, respectively. In the multiple-dose study, the C_(max), T_(max) and t_(1/2) of CGA were(0.663 7 ± 0.583 3) ng·m L^(-1),(1.1 ± 0.5) h, and(1.4 ± 0.7) h, respectively. For TCA, no significant characteristic increasing plasma TCA concentration-time curve was found in the volunteers after oral administration of SBTs, indicating its complicated process in vivo as an endogenous ingredient.

关键词： Chlorogenic acid Taurocholic acid Shuanghua Baihe tablets Pharmacokinetics LC-MS/MS

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Matrix metalloproteinase 2 degrades collagen I to regulate ovarian development by association with an insulin-like peptide

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Insect Science 2024年第4期31卷 1090-1106页

作者： Yi Wei Xiao-Lin Zhou Peng Chen Tai-Hang Liu cheng lu min-Hui Pan State Key Laboratory of Silkworm Genome Biology Southwest UniversityChongqingChina Key Laboratory for Sericulture Functional Genomics and Biotechnology of Agricultural ministry Southwest UniversityChongqingChina Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang ProvinceChina

The ovary generally undergoes tissue remodeling during larval to pupal transition,which includes membrane degeneration and ovariole *** the same time,the hormones produced by insects significantly change during ***,the regulatory mechanism for ovarian development and hormones is not fully understood in ***,we found that matrix metalloproteinase 2(MMP2)was highly expressed in the ovarian capsules and ovarioles,and the development was abnormal after knocking out MMP2 in Bombyx *** process of abnormal degradation of collagen I due to MMP2 deletion,which resulted in abnormal development of ovarioles and eggs,was analyzed in *** proteomics of ovaries in the MMP2-knock out and wild type strains showed a critically significant difference in the expression of a protein,insulin-like peptide(ILP).Additional analysis revealed significant alteration of ILP during ovarian development,and abnormal expression of ILP significantly affected ovarian development in vivo and MMP2 expression in vitro and in *** results showed that MMP2 regulation of ovarian tissue remodeling is closely related to ILP *** study provides new insights into the regulatory mechanism of MMP2 and ovarian development in ***.

关键词： Bombyx mori collagen I insulin-like peptide matrix metalloproteinase ovarian development

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Compound Product of Hypermatrices

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Journal of Systems Science & Complexity 2024年第1期37卷 169-183页

作者： cheng Daizhan MENG min ZHANG Xiao JI Zhengping Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China Department of Control Science and Engineering School of Electronics and Information EngineeringTongji UniversityShanghai 201210China National Center for Mathematics and Interdisciplinary Sciences Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100149China.

The semi-tensor product(STP)of matrices is generalized to multidimensional arrays,called the compound product of *** product is first defined for three-dimensional hypermatrices with compatible orders and then extended to general *** different types of hyperdeterminants are introduced and certain properties are *** Lie groups and Lie algebras corresponding to the hypermatrix products are ***,these results are applied to dynamical systems.

关键词： Compound semi-tensor product hyperdeterminants hypereigenvalues and hypereigenvectors hypergeneral linear groups hypermatrices.

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A Reliable Iteration Algorithm for One-Bit Compressive Sensing on the Unit Sphere

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 801-822页

作者： Yan-cheng lu Ning BI An-hua WAN School of Mathematics Sun Yat-sen UniversityGuangzhou 510275China

The one-bit compressed sensing problem is of fundamental importance in many areas,such as wireless communication,statistics,and so ***,the optimization of one-bit problem coustrained on the unit sphere lacks an algorithm with rigorous mathematical proof of convergence and *** this paper,an iteration algorithm is established based on difference-of-convex algorithm for the one-bit compressed sensing problem constrained on the unit sphere,with iterating formula■,where C is the convex cone generated by the one-bit measurements andη_(1)>η_(2)>1/*** new algorithm is proved to converge as long as the initial point is on the unit sphere and accords with the measurements,and the convergence to the global minimum point of the l_(1)norm is discussed.

关键词： one-bit compressed sensing difference of convex algorithm iteration algorithm ■1-minimization

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Achieving a superior Na storage performance of Fe-based Prussian blue cathode by coating perylene tetracarboxylic dianhydride amine

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Carbon Energy 2024年第5期6卷 53-64页

作者： Xin-Yuan Fu lu-lu Zhang Zhao-Yao Chen Yunkai Xu Junxiu Wu cheng-cheng Wang Xiao-Kai Ding Xue-Lin Yang Jun lu Hubei Provincial Collaborative Innovation Center for New Energy Microgrid College of Electrical Engineering&New EnergyChina Three Gorges UniversityYichangHubeiChina College of Materials and Chemical Engineering China Three Gorges UniversityYichangHubeiChina College of Chemical and Biological Engineering Zhejiang UniversityHangzhouChina

Fe-based Prussian blue(Fe-PB)cathode material shows great application potential in sodium(Na)-ion batteries due to its high theoretical capacity,long cycle life,low cost,and simple preparation ***,the crystalline water and vacancies of Fe-PB lattice,the low electrical conductivity,and the dissolution of metal ions lead to limited capacity and poor cycling *** this work,a perylene tetracarboxylic dianhydride amine(PTCDA)coating layer is successfully fabricated on the surface of Fe-PB by a liquid-phase *** aminated PTCDA(PTCA)coating not only increases the specific surface area and electronic conductivity but also effectively reduces the crystalline water and vacancies,which avoids the erosion of Fe-PB by ***,the PTCA layer reduces the charge transfer resistance,enhances the Na-ion diffusion coefficient,and improves the structure *** PTCA-coated Fe-PB exhibits superior Na storage performance with a first discharge capacity of 145.2 mAh g^(−1) at 100 mA g^(−1).Long cycling tests exhibit minimal capacity decay of 0.027%per cycle over 1000 cycles at 1 A g^(−1).Therefore,this PTCA coating strategy has shown promising competence in enhancing the electrochemical performance of Fe-PB,which can potentially serve as a universal electrode coating strategy for Na-ion batteries.

关键词： cathode material coating Fe-based Prussian blue Na-ion batteries perylene tetracarboxylic dianhydride amine

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Compliance motion control of the hydraulic dual-arm manipulator with adaptive mass estimation of unknown object

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Frontiers of Mechanical Engineering 2024年第1期19卷 35-52页

作者： Bolin SUN min cheng Ruqi DING Bing XU State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China Key Laboratory of Conveyance and Equipment(ministry of Education) East China Jiaotong UniversityNanchang 330013China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

Given the limited operating ability of a single robotic arm,dual-arm collaborative operations have become increasingly *** with the electrically driven dual-arm manipulator,due to the unknown heavy load,difficulty in measuring contact forces,and control complexity during the closed-chain object transportation task,the hydraulic dual-arm manipulator(HDM)faces more difficulty in accurately tracking the desired motion trajectory,which may cause object deformation or even *** overcome this problem,a compliance motion control method is proposed in this paper for the *** mass parameter of the unknown object is obtained by using an adaptive method based on velocity *** to the difficulty in obtaining the actual internal force of the object,the pressure signal from the pressure sensor of the hydraulic system is used to estimate the contact force at the end-effector(EE)of two hydraulic manipulators(HMs).Further,the estimated contact force is used to calculate the actual internal force on the ***,a compliance motion controller is designed for HDM closed-chain *** position and internal force errors of the object are reduced by the feedback of the position,velocity,and internal force errors of the object to achieve the effect of the compliance motion of the HDM,i.e.,to reduce the motion error and internal force of the *** required velocity and force at the EE of the two HMs,including the position and internal force errors of the object,are inputted into separate position *** addition,the position controllers of the two individual HMs are designed to enable precise motion control by using the virtual decomposition control ***,comparative experiments are carried out on a hydraulic dual-arm test *** proposed method is validated by the experimental results,which demonstrate improved object position accuracy and reduced internal force.

关键词： hydraulic dual-arm manipulator compliance motion control unknown object adaptive mass estimation nonlinear control

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Jellyfish bio-inspired Fe@CNT@CuNC derived from ZIF-8 for cathodic oxygen reduction

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Nano Research 2024年第4期17卷 2352-2359页

作者： Kai cheng Zequan Liu Demin Jiang min Song Yuqiao Wang Research Center for Nano Photoelectrochemistry and Devices School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China Yangtze River Delta Carbon Neutrality Strategy Development Institute Southeast UniversityNanjing 210096China School of Energy and Environment Southeast UniversityNanjing 210096China

Biomimetics provides guidance to design and synthesize advanced catalysts for oxygen reduction reaction in microbial fuel cells(MFCs).Herein,jellyfish-inspired Fe clusters on carbon nanotubes connected with CuNC(Fe@CNT@CuNC)were designed and prepared by using zeolitic imidazolate framework(ZIF)-8 precursors to imitate the organic texture and function of *** antibacterial effect of Cu^(+)ions depressed the growth of cathode biofilm to ensure rapid mass *** clusters and CuNC connected by CNTs accelerated the electron transfer from Fe to *** optimization of oxygen adsorption was caused by electron redistribution between sites of Fe and ***-like catalysts achieved a half-wave potential of 0.86 V and onset potential of 0.95 V *** hydrogen electrode(RHE).MFCs gained the maximum power density of 1600 mW·m^(-2) after 500 h *** work provides insights into the special design of advanced catalysts based on bio-inspiration and biomimetics.

关键词： bio-inspiration oxygen reduction reaction antibacterial ability microbial fuel cells density functional theory(DFT)rational design

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Strengthened and toughened SiHfBCN-based hightemperature resistant adhesive with SiC NWs

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Chinese Journal of Aeronautics 2024年第7期37卷 539-549页

作者： Xingang luAN Xiyue ZHU Xichao DONG min LI Laifei cheng Science and Technology on Thermostructural Composite Materials Laboratory Northwestern Polytechnical UniversityXi’an 710072China

To further improve the performance of binders,a SiHfBCN-based high-temperature resistant adhesive was successfully synthesized by Polymer-Derived Ceramics(PDC)route using TiB2,Polysiloxane(PSO)and short SiC nanowires as *** effect of short SiC nanowires on the adhesive strength at room temperature and high temperature,as well as the reinforcing mechanism was *** with the adhesive without SiC nanowires,after curing(at 170℃)and pyrolysis(at 1000℃)in air,the appropriate adding of SiC nanowires upgrades the room temperature and high temperature(at 1000℃ in air)adhesive strength to(12.50±0.67)MPa(up by about 32%)and(13.11±0.79)MPa(up by about 106%),***,under the synergistic impact of the nanowire bridging,nanowire breaking,nanowire drawing and crack deflection,the optimized adhesive exhibits multi-stage fracture,causing the increscent fracture displacement.

关键词： High-temperature resistant adhesive SiHfBCN SiC NWs Strengthening Toughening

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Linguistic landscape and its impacts on place-making in mountain destination:A case of Mogan Mountain Town of Huzhou City,China

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Journal of Mountain Science 2024年第5期21卷 1613-1629页

作者： LI Chenyan lu Song LONG cheng ZHU Jiaheng School of Tourism Shanghai Normal UniversityShanghai 200034China School of Environmental and Geographical Sciences Shanghai Normal UniversityShanghai 200034China

The place and placeness are believed to be a crucial perspective for comprehending the transformative dynamics of tourist destinations in the context of globalization and the rapid development of the tourism *** the material carrier of language,linguistic landscape is an intermediary for people to endow emotions and personalities into the place,becoming an effective path for exploring the place-making in a certain *** Mountain is a famous national tourist resort,which is located in Mogan Mountain Town,Deqing County,Huzhou City,*** is a good case area for studying the relationship between linguistic landscape and placemaking in tourist *** are two theories that form the theoretical foundation of the study,namely the place and the ***,the results showed the overall style of the linguistic *** labelling(52.7%),official signs(55.3%),and standardized Chinese characters predominantly shaped the linguistic landscape,with English and other languages being ***,from the perspective of three dimensions of the geosemiotics framework,such as inscription,language preference,and placement position,we conduct a comprehensive semiotic analysis of the linguistic landscape,which encompasses diverse facets such as fonts,materials,shifts in state,text vectors,and symmetrical ***,we explore the influence of linguistic landscapes on the place-making of Mogan Mountain through the dimensions of location,locale,and sense of *** information on linguistic landscapes indicates the geographical *** linguistic landscapes play an important role in constructing the language order,nostalgic atmosphere,exotic atmosphere,and elegant and tasteful lifestyle of the public space in Mogan *** of linguistic landscapes,including tourists and residents,generate and identify with the unique sense of place in Mogan *** linguistic landscapes construct the destinati

关键词： Linguistic landscape Place-making Tourist destination Geosemiotics Place theory Place branding Mogan Mountain Town China

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Random gradient-free method for online distributed optimization with strongly pseudoconvex cost functions

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Control Theory and Technology 2024年第1期22卷 14-24页

作者： Xiaoxi Yan cheng Li Kaihong lu Hang Xu School of Electrical and Information Engineering Jiangsu UniversityZhenjiang212013JiangsuChina College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao266590ShandongChina

This paper focuses on the online distributed optimization problem based on multi-agent systems. In this problem, each agent can only access its own cost function and a convex set, and can only exchange local state information with its current neighbors through a time-varying digraph. In addition, the agents do not have access to the information about the current cost functions until decisions are made. Different from most existing works on online distributed optimization, here we consider the case where the cost functions are strongly pseudoconvex and real gradients of the cost functions are not available. To handle this problem, a random gradient-free online distributed algorithm involving the multi-point gradient estimator is proposed. Of particular interest is that under the proposed algorithm, each agent only uses the estimation information of gradients instead of the real gradient information to make decisions. The dynamic regret is employed to measure the proposed algorithm. We prove that if the cumulative deviation of the minimizer sequence grows within a certain rate, then the expectation of dynamic regret increases sublinearly. Finally, a simulation example is given to corroborate the validity of our results.

关键词： Multi-agent system Online distributed optimization Pseudoconvex optimization Random gradient-free method

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