检索结果-南通市图书馆

基于ADAMS的PUMA560机器人运动学研究

在线全文

学校读者我要写书评

暂无评论

唐山师范学院学报 2024年第3期46卷 73-77页

作者：王宁国石宝玉程茂胜安徽莱恩电泵有限公司技术部安徽宁国242300 安徽工业大学机械工程学院安徽马鞍山243032

在建立PUMA560机器人模型的基础上,通过D-H坐标系对模型进行运动学理论分析,推导出相关公式,并将关节角度代入以得到末端姿态的理论值。以世界上著名的机械系统仿真软件ADAMS作为分析平台,通过在ADAMS中导入模型并进行相关仿真并得到仿... 详细信息

在建立PUMA560机器人模型的基础上,通过D-H坐标系对模型进行运动学理论分析,推导出相关公式,并将关节角度代入以得到末端姿态的理论值。以世界上著名的机械系统仿真软件ADAMS作为分析平台,通过在ADAMS中导入模型并进行相关仿真并得到仿真数据,将其与理论值相比较。通过数据处理可以得知,PUMA560机器人的运动学误差相对较小,机器人可以达到预期的动作效果。

关键词：机器人仿真运动学 ADMAS

Syntheses and Antibacterial Activities of Novel Erythromycin O-Alkylamidoximes

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2005年第5期21卷 540-544页

作者： ZHANG Zhan-tao WU Cai-ling ZHAO Yan-fang cheng mao-sheng GONG Ping School of Pharmacetical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China

Nine novel erythromycin O-alkylamidoxime derivatives were prepared in excellent yields via the condensation of different O-alkylhydroxylamines with erythromycin imino ether. The structures of all the compounds prepared were confirmed by ^1 H NMR, 13C NMR, IR and MS, and their in vtiro antibacterial activities were tested. Among the compounds, two of them showed good antibacterial aetivities.

关键词： Erythromycin O-Alkylamidoxime derivative Condensation Characterization Antibacterial activities

Protein tyrosine phosphatase 1B inhibitory activities of ursane-type triterpenes from Chinese raspberry, fruits of Rubus chingii

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2019年第1期17卷 15-21页

作者： ZHANG Xiang-Yu LI Wei WANG Jian LI Ning cheng mao-sheng KOIKE Kazuo Key Laboratory of Structure-Based Drug Design&Discovery Ministry of EducationShenyang Pharmaceutical University School of Pharmaceutical Engineering Shenyang Pharmaceutical University Faculty of Pharmaceutical Sciences Toho University

Protein tyrosine phosphatase 1 B(PTP1 B) has led to an intense interest in developing its inhibitors as anti-diabetes, anti-obesity and anti-cancer agents. The fruits of Rubus chingii(Chinese raspberry) were used as a kind of dietary traditional Chinese medicine. The methanolic extract of R. chingii fruits exhibited significant PTP1 B inhibitory activity. Further bioactivity-guided fractionation resulted in the isolation of three PTP1 B inhibitory ursane-type triterpenes: ursolic acid(1), 2-oxopomolic acid(2), and 2α, 19α-dihydroxy-3-oxo-urs-12-en-28-oic acid(3). Kinetics analyses revealed that 1 was a non-competitive PTP1 B inhibitor, and 2 and 3 were mixed type PTP1 B inhibitors. Compounds 1-3 and structurally related triterpenes(4-8) were further analyzed the structure-activity relationship, and were evaluated the inhibitory selectivity against four homologous protein tyrosine phosphatases(TCPTP, VHR, SHP-1 and SHP-2). Molecular docking simulations were also carried out, and the result indicated that 1, 3-acetoxyurs-12-ene-28-oic acid(5), and pomolic acid-3β-acetate(6) bound at the allosteric site including α3, α6, and α7 helix of PTP1 B.

关键词： Protein tyrosine phosphatase 1B Raspberry Rubus chingii Triterpene Ursane

靶向胰高血糖素样肽-1/胰高血糖素/葡萄糖依赖性促胰岛素多肽受体的肥胖症新型治疗药物——retatrutide

在线全文

学校读者我要写书评

暂无评论

临床药物治疗杂志 2024年第4期22卷 17-20页

作者：王文轩冯东梅程卯生刘洋沈阳药科大学制药工程学院基于靶点的药物设计与研究教育部重点实验室沈阳110016

肥胖症是一种由遗传、环境等因素引起的以脂肪过多为特征的复杂疾病。retatrutide(研发代号:LY3437943)作为一种胰高血糖素样肽-1/胰高血糖素/葡萄糖依赖性促胰岛素多肽受体激动剂,在肥胖症及心血管疾病治疗中显示出长期有效性。Ⅰ、Ⅱ... 详细信息

肥胖症是一种由遗传、环境等因素引起的以脂肪过多为特征的复杂疾病。retatrutide(研发代号:LY3437943)作为一种胰高血糖素样肽-1/胰高血糖素/葡萄糖依赖性促胰岛素多肽受体激动剂,在肥胖症及心血管疾病治疗中显示出长期有效性。Ⅰ、Ⅱ期临床试验结果表明,retatrutide具有良好的有效性和安全性。该药物目前正在处于Ⅲ期临床试验的招募阶段。本文主要对该药物的基本信息、作用机制、临床前研究及临床研究等方面进行概述。

关键词： retatrutide 肥胖症 2型糖尿病奥利司他

Influences of shale microstructure on mechanical properties and bedding fractures distribution

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第3期21卷 1944-1954页

作者： Ming-Zhe Gu mao sheng Shi-Zhong cheng Fan-Hao Gong Gen-sheng Li State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing2249China College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China Shenyang Center of China Geological Survey ShenyangLiaoning110034China

The difference in microstructure leads to the diversity of shale mechanical properties and bedding fractures distribution *** this paper,the microstructure and mechanical properties of Longmaxi marine shale and Qingshankou continental shale were studied by X-ray diffractometer(XRD),field emission scanning electron microscope(FE-SEM)with mineral analysis system,and ***,the typical bedding layers area was properly stratified using Focused Ion Beam(FIB),and the effects of microstructure and mechanical properties on the distribution patterns of bedding fractures were *** results show that the Longmaxi marine shale sample contains more clay mineral grains,while the Qingshankou continental shale sample contains more hard brittle mineral grains such as *** Longmaxi marine shale sample,hard brittle minerals with grain sizes larger than 20μm is18.24%and those with grain sizes smaller than 20μm is 16.22%.For Qingshankou continental shale sample,hard brittle minerals with grain sizes larger than 20μm is 40.7%and those with grain sizes smaller than 20μm is 11.82%.In comparison to the Qingshankou continental shale sample,the Longmaxi marine shale sample has a lower modulus,hardness,and *** shales are formed by alternating coarse-grained and fine-grained layers during *** average single-layer thickness of Longmaxi marine shale sample is greater than Qingshankou continental shale *** two types of shale have similar bedding fractures distribution patterns and fractures tend to occur in the transition zone from coarse-grained to fine-grained *** orientation of the fracture is usually parallel to the bedding plane and detour occurs in the presence of hard brittle *** fracture distribution density of the Longmaxi marine shale sample is lower than that of the Qingshankou continental shale sample due to the strong heterogeneity of the Qingshankou continental *** current resea

关键词： Shale Nanoindentation Microstructure Mechanical property Fracture

Design, Synthesis, and Activities of Novel Derivativesof Isophthalamide and Benzene-1,3-disulfonamide

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2006年第3期22卷 356-359页

作者： LIU Xiu-jie WANG Song-qing ZHANG jing ZHANG Feng-xia LI Gui-zhu WANG Bao-jie SHAO Ying-lu ZHANG Li-guang FANG Lin cheng mao-sheng The College of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P.R. China The College of Pharmaceutical and Biotechnology Tianjin University Tianjin 300072 P. R. China The School of Biology and Chemistry Tianjin University of Technology Tianjin 300191 P. R. China

Based on the antiplatelet aggregation mechanism and the bioisosterism principle of the reference drug picotamide, thirteen novel derivatives of arylamide and arylsulfonamide were designed and prepared. The biological activities of these derivatives were investigated. The chemical structures of the target compounds were confirmed by ^1H NMR and IR. The in vitro activities of antiplatelet aggregation of the thirteen target compounds were assessed by Bore＇s method. Compounds 2b and 8h have significant antiplatelet aggregation activities, which are superior to the corresponding activity of Picotamide.

关键词： Thromboxane Antiplatelet Isophthalamide Disulfonamide Synthesis

Elastic wave insulation and propagation control based on the programmable curved-beam periodic structure

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第10期45卷 1791-1806页

作者： Jiajia mao Hong cheng Tianxue MA Beijing Key Laboratory of Nonlinear Vibrations and Strength of Mechanical Structures Department of MechanicsSchool of MathematicsStatistics and MechanicsBeijing University of TechnologyBeijing 100124China Department of Mechanics School of Physical Science and EngineeringBeijing Jiaotong UniversityBeijing 100044China

Curved-beams can be used to design modular multistable metamaterials(MMMs)with reprogrammable material properties,i.e.,programmable curved-beam periodic structure(PCBPS),which is promising for controlling the elastic wave *** PCBPS is theoretically equivalent to a spring-oscillator system to investigate the mechanism of bandgap,analyze the wave propagation mechanisms,and further form its geometrical and physical criteria for tuning the elastic wave *** the equivalent model,we calculate the analytical solutions of the dispersion relations to demonstrate its adjustability,and investigate the wave propagation characteristics through the *** validate the equivalent system,the finite element method(FEM)is *** is revealed that the bandgaps of the PCBPS can be turned on-and-off and shifted by varying its physical and geometrical *** findings are highly promising for advancing the practical application of periodic structures in wave insulation and propagation control.

关键词： curved-beam based periodic structure equivalent stiffness spring-oscillator system dispersion relation wave propagation

Modelling the formation and dissolution behavior of alumina agglomerate in the cryolite

在线全文

学校读者我要写书评

暂无评论

Particuology 2024年第3期86卷 211-222页

作者： Jiaqi Wang mao Li Benjun cheng Hesong Li School of Energy Science and Engineering Central South UniversityChangsha410083China

The presence of alumina agglomerates seriously affects the current efficiency of the aluminum electrolysis *** the dynamic dissolution process of agglomerates is essential to improve the current efficiency of aluminum electrolysis.A mathematical model is proposed to describe the different phenomena from the formation until complete dissolution of *** permeation and solidification processes of cryolite,a semi-analytical mathematical model is developed to formulate the formation,melting and dissolution processes of agglomerates,and the time duration for each stage is *** and heat mass transfer of agglomerates are explored based on the packing theory and mechanism of heat mass transfer in wet porous *** approach is applied to investigate the main factors affecting the dissolution stages and porosity of *** results show that the superheat has a great influence on the formation and melting stage,the diameter of agglomerates can reach 14.93 mm for 200 particles *** density decreases with the increase of agglomerated particle number,which varies in the range of 2.27-2.28 g/cm^(3).The average dissolution rate of agglomerates is about 1.83×10^(-5)-2.95×10^(-5) kg/s within the range of alumina concentration in this study.

关键词： Mathematical model Alumina agglomerate Porous media Packing theory Heatand mass transfer

The influences of perforating phase and bedding planes on the fracture deflection in laminated shale

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 1221-1230页

作者： Ming-Zhe Gu mao sheng Xiao-Ying Zhuang Xin-Yi Li Gen-sheng Li National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China College of Petroleum Engineering China University of PetroleumBeijing102249China College of Civil Engineering Tongji UniversityShanghai200092China

The perforating phase leads to complex and diverse hydraulic fracture propagation behaviors in laminated shale formations. In this paper, a 2D high-speed imaging scheme which can capture the interaction between perforating phase and natural shale bedding planes was proposed. The phase field method was used to simulate the same conditions as in the experiment for verification and hydraulic fracture propagation mechanism under the competition of perforating phase and bedding planes was *** results indicate that the bedding planes appear to be no influence on fracture propagation while the perforating phase is perpendicular to the bedding planes, and the fracture propagates along the perforating phase without deflection. When the perforating phase algins with the bedding planes, the fracture initiation pressure reserves the lowest value, and no deflection occurs during fracture propagation. When the perforating phase is the angle 45°, 60°and 75°of bedding planes, the bedding planes begin to play a key role on the fracture deflection. The maximum deflection degree is reached at the perforating phase of75°. Numerical simulation provides evidence that the existence of shale bedding planes is not exactly equivalent to anisotropy for fracture propagation and the difference of mechanical properties between different shale layers is the fundamental reason for fracture deflection. The findings help to understand the intrinsic characteristics of shale and provide a theoretical basis for the optimization design of field perforation parameters.

关键词： Shale Propagation Perforating Bedding Structure