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Balancing act:The dilemma of rapid hyperglycemia correction in diabetes management

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World Journal of Diabetes 2024年第2期15卷 129-132页

作者： Ke-Xin Zhang cheng-Xia kan Xiao-Dong Sun Department of Endocrinology and Metabolism Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina

The global diabetes surge poses a critical public health challenge,emphasizing the need for effective glycemic ***,rapid correction of chronic hyperglycemia can unexpectedly trigger microvascular complications,necessitating a reevaluation of the speed and intensity of glycemic *** suggest swift blood sugar reductions may cause inflammation,oxidative stress,and neurovascular changes,resulting in *** providers should cautiously approach aggressive glycemic control,especially in long-standing,poorly controlled *** and managing these complications requires a personalized,comprehensive approach with education,monitoring,and interdisciplinary *** management must balance short and longterm goals,prioritizing overall *** editorial underscores the need for a personalized,nuanced approach,focusing on equilibrium between glycemic control and avoiding overcorrection.

关键词： Diabetes Hyperglycemia correction Management Microvascular complications Glucose control

Elucidating the cardioprotective mechanisms of sodium-glucose cotransporter-2 inhibitors beyond glycemic control

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World Journal of Diabetes 2024年第2期15卷 137-141页

作者： Ke-Xin Zhang cheng-Xia kan Fang Han Jing-Wen Zhang Xiao-Dong Sun Department of Endocrinology and Metabolism Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina

Sodium-glucose cotransporter-2(SGLT2)inhibitors have emerged as a pivotal intervention in diabetes management,offering significant cardiovascular ***,in particular,has demonstrated cardioprotective effects beyond its glucose-lowering action,reducing heart failure hospitalizations and improving cardiac *** note,the cardioprotective mechanisms appear to be independent of glucose lowering,possibly mediated through several mechanisms involving shifts in cardiac metabolism and anti-fibrotic,anti-inflammatory,and anti-oxidative *** editorial summarizes the multifaceted cardiovascular advantages of SGLT2 inhibitors,highlighting the need for further research to elucidate their full therapeutic potential in cardiac care.

关键词： Diabetes Sodium-glucose cotransporter-2 Cardiovascular diseases Empagliflozin

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项目驱动:建筑物理实验教学改革的方向

林区教学 2024年第8期 76-79页

作者：成侃湖北工程学院建筑学院湖北孝感432100

项目式实验教学有助于重构学生对客观世界的认识方式、提升学生的合作探究能力和自主探究能力。当前一些高校的建筑物理实验教学面临着实验基础设施不足、实验教学手段传统等问题。将项目式实验教学纳入建筑物理实验教学中,能够克服传... 详细信息

项目式实验教学有助于重构学生对客观世界的认识方式、提升学生的合作探究能力和自主探究能力。当前一些高校的建筑物理实验教学面临着实验基础设施不足、实验教学手段传统等问题。将项目式实验教学纳入建筑物理实验教学中,能够克服传统建筑物理实验教学的不足,调动学生参与建筑物理实验教学积极性,促进教师在实施建筑物理实验教学中不断提升自我,并通过实验准备、实验组织、实验实施、实验结果展示与评价推动建筑物理项目式实验教学的具体实践。

关键词：项目式教学建筑物理实验教学改革

Preparation and properties of thermoexpandable polymeric microspheres

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Chinese Chemical Letters 2014年第9期25卷 1279-1281页

作者： Zhao-Sheng Hou cheng-You kan College of Chemistry Chemical Engineering and Materials ScienceCollaborative Innovation Center of Functionalized Probes for Chemical ImagingKey Laboratory of Molecular and Nano ProbesMinistry of EducationShandong Normal University Department of Chemical Engineering Tsinghua University

In this paper, thermoexpandable polymeric microspheres were prepared by suspension polymerization with acrylonitrile （AN） and methyl methacrylate （MMA） as monomers and/-butane as a blowing agent. The micromorphology and thermal stability were researched by polarized microscopy and TGA. The diameter of the expandable microspheres increased from about 20μm （unexpanded） to 40-80 μm （expanded） upon heating. The maximum expansion volume was higher than 22 times of the original volume and the density of the expanded microspheres was about 16.7 kg/m3. The blowing agent content in microspheres was about 20 wt% and To.e., Tm.e. and To.s. were 80℃, 120-130℃ and 140-145℃, respectively.

关键词： Expandable microspheres Suspension polymerization Methyl methacrylate Properties

Effects of Shell Composition, Dosage and Alkali Type on the Morphology of Polymer Hollow Microspheres

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Chinese Journal of Polymer Science 2018年第1期36卷 43-48页

作者： Wei Deng Hua-Chao Guo Wei-Li Yu cheng-You kan Key Laboratory of Engineering Dielectrics and Its Application Ministry of Education School of Material Science and Engineering Harbin University of Science and Technology Department of Chemical Engineering Key Laboratory of Advanced Materials of Ministry of Education Tsinghua University

Polymer hollow microspheres were prepared by performing alkali treatment on the multilayer core/shell polymer latex particles containing carboxyl groups. Effects of the shell composition and dosage as well as alkali type on the morphology of the microspheres were investigated. Results showed that in comparison with acrylonitrile（AN） and methacrylic acid（MAA）, using butyl acrylate（BA） as the shell co-monomer decreased the glass transition temperature（T_g） of shell effectively and was beneficial to the formation of uniform and big hollow structure. Along with the increase of the shell dosage, the alkali-treated microspheres sequentially presented porous and hollow morphology, and the size of microspheres increased, while the hollow diameter increased first and then decreased, and the maximum hollow ratio reached 39.5%. Furthermore, the multilayer core/shell microspheres had better tolerance to NH_3·H_2O than to NaOH. When the molar ratio of alkali to methacrylic acid（MR_（alkali/acid）） for Na OH ranged from 1.15 to 1.30 or MRalkali/acid for NH_3·H_2O ranged from 1.30 to 2.00, the regular polymer hollow microspheres could be obtained.

关键词： Hollow microspheres Core-Shell polymer Alkali treatment Morphology

Fabrication of polymeric-Laponite composite hollow microspheres via LBL assembly

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Chinese Chemical Letters 2017年第2期28卷 367-371页

作者： Wei Deng Hua-Chao Guo Guo-An Li cheng-You kan Key Laboratory of Engineering Dielectrics and Its Application Ministry of Education School of Material Science and Engineering Harbin University of Science and Technology Key Laboratory of Advanced Materials of Ministry of Education Department of Chemical Engineering Tsinghua University

Hollow structure microspheres with composite polymeric-Laponite shells were prepared by electrostatic self-assembly of Laponite on the polymeric hollow microspheres in this *** multilayer hydrophilic core/hydrophobic shell polymer latex particles containing carboxyl groups inside were first synthesized via seeded emulsion polymerization,followed by alkali treatment,generating polymeric hollow ***,polyethyleneimine（PEI） and Laponite were alternately electrostatic adsorbed on the prepared polymeric hollow microspheres to form polymeric-Laponite composite hollow *** was indicated that the morphology of alkali-treated microspheres could be tuned through simply altering the dosage of alkali used in the post-treatment *** with the increasing of the coating layers,the zeta potential of microspheres absorbed PEI or Laponite approximately tended to be constant respectively,and the thickness of Laponite layer around the hollow microspheres increased clearly,getting more uniform and ***,the corresponding polymeric-Laponite hollow microspheres showed high pressure resistance ability compared to the polymeric hollow microspheres.

关键词： Composite microspheres Hollow structure Laponite Osmotic swelling LBL assembly

A global analysis searching for neutrinos associated with black hole merger gravitational wave events

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Research in Astronomy and Astrophysics 2018年第11期18卷 11-16页

作者： Yu-Zi Yang Jia-Jie Ling Wei Wang Zhao-kan cheng School of Physics Sun Yat-sen University School of Science Harbin Institute of Technology

Several neutrino observatories have searched for coincident neutrino signals associated with gravitational waves induced by the merging of two black holes. No statistically significant neutrino signal in excess of the background level was observed. These experiments use different neutrino detection technologies and are sensitive to various neutrino types. A combined analysis was performed on the KamLAND, Super-Kamiokande and Borexino experimental data with a frequentist statistical approach to achieve a global picture of the associated neutrino fluence. Both monochromatic and Fermi-Dirac neutrino spectra were assumed in the calculation. The final results are consistent with null neutrino signals associated with the process of a binary black hole merger. The derived 90% confidence level upper limits on the fluence and luminosity of various neutrino types are presented for neutrino energy less than110 MeV.

关键词： gravitational wave black hole merger neutrino fluence global analysis

Interspecific hybridization between Bursaphelenchus xylophilus and Bursaphelenchus mucronatus

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Journal of Forestry Research 2019年第2期30卷 699-707页

作者： kan-cheng Liu Ailing Ben Zhengmin Han Ye Guo Dongxia Cao College of Forestry Nanjing Forestry University Nanjing Xiaozhuang University

Bursaphelenchus xylophilus is the pathogen that causes pine wilt disease, which has greatly damaged forests and ecosystems in countries of East Asia and *** mucronatus is closely related to B. xylophilus in morphology and host plant specificity. A longrunning debate has existed regarding whether these two species can successfully produce hybrid offspring. In the present study, we performed in the laboratory, hybridization of two B. xylophilus nematode isolates from China and Japan and three B. mucronatus isolates from China, Japan and France. Nematode isolates of B. xylophilus were successfully crossed with B. mucronatus isolates, and the rate of hybridization was relatively high; however, some hybrid offspring died. Successful hybridization occurred between B. xylophilus and B. mucronatus isolates from China, and 22 generations of hybrids were produced. All F1 hybrids could be backcrossed with their parents and produce offspring. Variation in mucro length among the hybrid offspring and their parents was observed. The hybrid offspring and their parents were inoculated into 3-months-old black pine(Pinus tunbergii) seedlings. Weaker pathogenicity of hybrid offspring was observed compared with that of their parents, and significantly fewer offspring nematodes than parents were reisolated from pines. Therefore, the offspring of B. xylophilus and B. mucronatus may exist in the forest and could influence disease epidemics.

关键词： Bursaphelenchus xylophilus Bursaphelenchus mucronatus Interspecific hybridization Variation

Influences of Electrolytes on the Soap-free Emulsion Copolymerization of St-MMA-AA

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Chinese Chemical Letters 2006年第11期17卷 1503-1506页

作者： Rong Long LI cheng You kan Yi DU Ze Ping LI Department of Chemical Engineering and Key Laboratory of Advanced Materials of Ministry of Education Tsinghua University Beijing 100084

Monodisperse functional polymer microspheres with different particle size and with clean surface were prepared by batch soap-free emulsion polymerization of styrene, methyl methacrylate and acrylic acid in the presence of salts, and the influences of type and amount of electrolytes on polymerization process and particle morphology were investigated. Results showed that there was a critical concentration for different electrolyte to make polymerization process and the resultant emulsion stable, and the particle size increased with the increase of electrolyte concentration. The effect of metal ions was Ca^2＋〉〉K^＋〉Na^＋〉Li^＋, and the effect of haloids was Br〉Cl〉F. Keywords： Electrolyte, soap-free emulsion polymerization, polystyrene, latex particle morphology.

关键词： Electrolyte soap-free emulsion polymerization polystyrene latex particle morphology.