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Syntheses of amphiphilic biodegradable copolymers of poly(ethyl ethylene phosphate) and poly(3.hydroxybutyrate) for drug delivery

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science China Chemistry 2009年第7期52卷 961-968页

作者： cheng jing1 & wang jun2 1 department of polymer science and engineering, university of science and{3. of China, hefei 2.002., China 2 hefei National Laboratory for Physical sciences at Microscale, School of Life sciences, university of science and{3. of China, hefei 2.002., China department of polymer science and{3. University of Science and Technology of China Hefei 230026 China hefei National Laboratory for Physical sciences at Microscale School of Life Sciences University of Science and Technology of China Hefei 230027 China

Biodegradable and amphiphilic triblock copolymers poly(ethyl ethylene phosphate)-poly(3.hydroxybutyrate)-poly(ethyl ethylene phosphate) (PEEP-b-PHB-b-PEEP) have been successfully synthesized through ring-opening polymerization. The structures are confirmed by gel permeation chromatography and NMR analyses. Crystallization investigated by X-ray diffraction reveals that the block copolymer with higher content of poly(ethyl ethylene phosphate) (PEEP) is more amorphous, showing decreased crystallizability. The obtained copolymers self-assemble into biodegradable nanoparticles with a coreshell micellar structure in aqueous solution, verified by the probe-based fluorescence measurements and transmission electronic microscopy (TEM) observation. The hydrophobic poly(3.hydroxybutyrate) (PHB) block serves as the core of the micelles and the micelles are stabilized by the hydrophilic PEEP block. The size and size distribution are related to the compositions of the copolymers. Paclitaxel (PTX) has been encapsulated into the micelles as a model drug and a sustained drug release from the micelles is observed. MTT assay also demonstrates that the block copolymers are biocompatible, rendering these copolymers attractive for drug delivery.

关键词： poly(3.hydroxybutyrate) polyphosphoester drug delivery polymeric nanoparticles

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Enriched electrophilic oxygen species facilitate acidic oxygen evolution on Ru-Mo binary oxide catalysts

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Nano Research 2024年第3期17卷 1165-1172页

作者： Yaya wang Yunzhou Wen Yumeng cheng Xinhong Chen Mengjiao Zhuansun Tongbao wang {3. Li Debora Meira Huarui Sun {3. Wei Jia Zhou Yuhang wang Sisi He Shenzhen Key Laboratory of Flexible Printed Electronics technology Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China School of science Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory of Advanced Negative Carbon TechnologiesSoochow UniversitySuzhou 215123China Frontiers science Center for Transformative Molecules Shanghai Jiao Tong UniversityShanghai 200240China science Division Canadian Light SourceSaskatoonSKS7N 2V3Canada Photon science Division Argonne National LaboratoryLemontIL60439USA School of Materials science and engineering Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China

The polymer electrolyte membrane(PEM)electrolyzers are burdened with costly iridium(Ir)-based catalysts and high operation overpotentials for the oxygen evolution reaction(OER).The development of earth-abundant,highly active,and durable electrocatalysts to replace Ir is a critical step in reducing the cost of green hydrogen *** we develop a Ru5Mo4Ox binary oxide catalyst that exhibits high activity and stability in acidic *** electron-withdrawing property of Mo enriches the electrophilic surface oxygen species,which promotes acidic OER to proceed via the adsorbate evolution *** a result,we achieve a 189 mV overpotential at 10 mA·cm^(-2) and a Tafel slope of 48.8 mV·dec^(-1).Our catalyst demonstrates a substantial 18-fold increase in intrinsic activity,as evaluated by turnover frequency,compared to commercially available RuO_(2) and IrO_(2) ***,we report a stable OER operation at 10 mA·cm^(-2) for 100 h with a low degradation rate of 2.05 mV·h^(-1).

关键词： electrocatalysis oxygen evolution reaction(OER) ruthenium(Ru)-based oxide molybdenum electrophilic oxygen

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Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK-STAT pathway

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2554-2566页

作者： jingyi Tan Jiayu Zhang cheng Hu Gongwei wang Qianyao Ren Chaoqun wang Jia Dan Zexin Zeng jun Hu Wenbo Zhu Jiankai Liang jing Cai Ying Liu Guangmei Yan Yuan Lin department of Pharmacology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510655China department of Urology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Advanced Medical technology Center the First Affiliated Hospital-Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Human Microbiome and Elderly Chronic Diseases Ministry of EducationGuangzhou 510655China department of Infectious Diseases the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Oncolytic viruses(OVs),a group of replication-competent viruses that can selectively infect and kill cancer cells while leaving healthy cells intact,are emerging as promising living anticancer *** traditional drugs composed of non-replicating compounds or biomolecules,the replicative nature of viruses confer unique pharmacokinetic properties that require further *** some pharmacokinetics studies of OVs,mechanistic insights into the connection between OV pharmacokinetics and antitumor efficacy remain ***,we characterized the pharmacokinetic profile of oncolytic virus M1(OVM)in immunocompetent mouse tumor models and identified the JAK-STAT pathway as a key modulator of OVM *** suppressing the JAK-STAT pathway,early OVM pharmacokinetics are ameliorated,leading to enhanced tumor-specific viral accumulation,increased AUC and Cmax,and improved antitumor *** than compromising antitumor immunity after JAK-STAT inhibition,the improved pharmacokinetics of OVM promotes T cell recruitment and activation in the tumor microenvironment,providing an optimal opportunity for the therapeutic outcome of immune checkpoint blockade,such as *** together,this study advances our understanding of the pharmacokinetic-pharmacodynamic relationship in OV therapy.

关键词： Pharmacokinetics Oncolytic virus JAK-STAT Anticancer

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Sciadopitysin exerts anticancer effects on HepG2 hepatocellular carcinoma cells by regulating reactive oxygen species-mediated signaling pathways

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BIOCELL 2024年第7期48卷 1055-1069页

作者： YAN-NAN LI YUN-HONG XIU YAN-jun TANG jing-LONG CAO WEN-SHUANG HOU AN-QI wang TIAN-ZHU LI {3.-HAO JIN department of Biochemistry and Molecular Biology Heilongjiang Bayi Agricultural UniversityDaqingChina Hemodialysis Center Daqing Oilfield General HospitalDaqingChina department of Food science and engineering Heilongjiang Bayi Agricultural UniversityDaqingChina department of Molecular Biology Chifeng UniversityChifengChina National Coarse Cereals engineering Research Center DaqingChina

Objectives:Sciadopitysin(SP)is aﬂavonoid in Ginkgo biloba that exhibits various pharmacological *** study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma(HCC)***:Network pharmacology was used for target prediction *** Counting Kit-8(CCK-8)assay was used to test the cell *** cytometry was used to test the cell cycle distribution,apoptosis status,and reactive oxygen species(ROS)*** and wound-healing assay was used to test the migration effect of SP on HepG2 *** Blot assay was used to test the expression levels of ***:Network pharmacology analysis results showed that the mitogen-activated protein kinase(MAPK)and other signaling pathways are involved in the SP anti-HCC biological ***-8 assay results demonstrated that SP showed an obvious killing effect on three types of HCC cells and low cytotoxic effect on normal *** Blot andﬂow cytometry results showed that SP regulated MAPK/signal transducer and activator of transcription 3.STAT3./nuclear factor kappa-B(NF-κB)signaling pathway to induce mitochondrion-dependent apoptosis in HepG2 ***,SP can arrest the G0/G1 phase cell cycle via the protein kinase B(AKT)/p21/p27/cyclin-dependent kinase(CDK)/Cyclin signaling *** healing and transwell assays showed that SP inhibited cell motility and invasion through the AKT/glycogen synthase kinase3.(GSK-3.)/vimentin/β-catenin signaling ***:Theseﬁndings demonstrated that SP induced mitochondrion-dependent apoptosis,arrested cell cycle in the G0/G1 phase,and inhibited cell migration by regulating the ROS-mediated signaling pathway in HepG2 ***,SP could serve as a therapeutic agent for the treatment of human HCC.

关键词： Sciadopitysin Hepatocellular carcinoma Apoptosis Cell cycle Cell migration

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Structural Properties of Ions and Polyelectrolytes in Aqueous Solutions under External Electric Fields:The Sign Effect

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Chinese Journal of polymer science 2024年第9期42卷 1341-1352,I0007页

作者： cheng-Jiang Lin jun-jun {3. Yuan Jiang Shu-Li Chen Hong-Fei Li Wen-Han Zhao Qing-Rong Huang Chang-Ru Rong Xiao-Zheng Duan State Key Laboratory of polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and engineering University of Science and Technology of ChinaHefei230026China National Key Laboratory of Advanced Vehicle Integration and Control China FAW Group Co.Ltd.Changchun130013China State Key Laboratory of Molecular engineering of polymers Department of Macromolecular ScienceFudan UniversityShanghai200438China department of Food science Rutgers University65 Dudley RoadNew BrunswickNew Jersey08901USA

We utilize molecular dynamics simulations to investigate the microstructures of ions and polyelectrolytes in aqueous solutions under external electric *** focusing on the multi-body interactions between ionic components and H_(2)O molecules,as well as their responses to the external electric fields,we clarify several nontrivial molecular features of the ionic and polyelectrolyte solutions,such as the solvations of cations and anions,clustering of the ions,and dispersions/aggregations of polyelectrolyte chains,as well as the corresponding responses of H_(2)O molecules in these *** simulations illustrate the variations in structures of ionic solutions caused by reversing the charge sign of the ions,and elucidate the disparity in structures between anionic and cationic polyelectrolyte solutions in the presence of the external electric *** work clarifies the mechanism for the alternations in complex multi-body interactions in aqueous solutions caused by the application electric field,which can contribute to the fundamental understanding of the physical and chemical natures of ion-containing and charged polymeric systems.

关键词： Polyelectrolyte Ions Aqueous solutions External electric fields Asymmetric dipole

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Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 81-92页

作者： Zitian Huo Yaqi Duan Dongdong Zhan Xizhen Xu Nairen Zheng jing Cai Ruifang Sun Jianping wang Fang cheng Zhan Gao Caixia Xu Wanlin Liu Yuting Dong Sailong Ma Qian Zhang Yiyun Zheng Liping Lou Dong Kuang Qian Chu {3. Qin Guoping wang Yi wang Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of Pathology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Health Commission Key Laboratory of Respiratory Diseases Tongji HosptialTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Beijing Pineal Diagnostics Co. Ltd.Beijing 102206China department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China Institution of Pathology The First Affiliated Hospital of Henan UniversityKaifeng 475001China department of Tumor Biobank Shanxi Cancer HospitalTaiyuan 030013China Chongqing Key Laboratory of Big Data for Bio Intelligence School of BioinformationChongqing University of Posts and TelecommunicationsChongqing 400065China

Small cell lung cancer(SCLC)is a highly malignant and heterogeneous cancer with limited therapeutic options and prognosis prediction ***,we analyzed formalin-fixed,paraffin-embedded(FFPE)samples of surgical resections by proteomic profiling,and stratified SCLC into three proteomic subtypes(S-I,S-II,and S-III)with distinct clinical outcomes and chemotherapy *** proteomic subtyping was an independent prognostic factor and performed better than current tumor–node–metastasis or Veterans Administration Lung Study Group staging *** subtyping results could be further validated using FFPE biopsy samples from an independent cohort,extending the analysis to both surgical and biopsy *** signatures of the S-II subtype in particular suggested potential benefits from *** overexpressed proteins in S-III,the worst prognostic subtype,allowed us to nominate potential therapeutic targets,indicating that patient selection may bring new hope for previously failed clinical ***,analysis of an independent cohort of SCLC patients who had received immunotherapy validated the prediction that the S-II patients had better progression-free survival and overall survival after first-line ***,our study provides the rationale for future clinical investigations to validate the current findings for more accurate prognosis prediction and precise treatments.

关键词： Small cell lung cancer Proteomics Prognosis Chemotherapy response Immunotherapy

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polymer electrolytes for flexible zinc-air batteries:Recent progress and future directions

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Nano Research 2024年第7期17卷 6058-6079页

作者： jing Wu Wen-Ya Wu Suxi wang Dan Kai Enyi Ye Warintorn Thitsartarn Janet Beng Hoon Tan Jianwei Xu Qingyu Yan Qiang Zhu Xian jun Loh Institute of Sustainability for Chemicals Energy and Environment(ISCE2)Agency for ScienceTechnology and Research(A*STAR)1 Pesek RoadJurong IslandSingapore 627833Singapore Institute of Materials Research and engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)2 Fusionopolis WayInnovis#08-03Singapore 138634Singapore School of Materials science and engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological University21 Nanyang LinkSingapore 637371Singapore department of Material science and engineering National University of Singapore9 Engineering Drive 1#03-09 EASingapore 117575Singapore

This review article delves into the development of electrolytes for flexible zinc-air batteries(FZABs),a critical component driving the advancement of flexible *** started by surveying the current advancements in electrolyte technologies,including solid-state and gel-based types,and their contributions to enhance the flexibility,efficiency,and durability of ***,we explored the challenges in this domain,focusing on maintaining electrolyte stability under mechanical stress,ensuring compatibility with flexible substrates,optimizing ion conductivity,and under harsh environmental ***,the key issues regarding interface details between electrolyte and the electrodes are covered as *** then discussed the future of electrolyte development in FZABs,highlighting potential avenues such as materials development,sustainability,in-situ studies,and battery *** review offers an in-depth overview of the advancements,challenges,and potential breakthroughs in creating electrolytes for FZABs over the past five *** serves as a guide for both researchers and industry professionals in this dynamic area.

关键词： flexible zinc-air batteries electrolyte polymer hydrogel electrolyte-electrode interface

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Advances in the function of traditional medicine for vitiligo treatment

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Traditional Medicine Research 2024年第3期9卷 43-51页

作者： jun Liu Jia-Yi Li jing-jing Xu Ling-jun Li wang cheng Sheng-Tao Yuan Wei Zhang Hong-Yang Li Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjing 210042China Jiangsu Center for Pharmacodynamics Research and Evaluation China Pharmaceutical UniversityNanjing 210009China School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjing 210042China department of Dermatology Zhongda Hospital Southeast UniversityNanjing 210009China

Vitiligo has a significant impact on a substantial number of individuals *** Chinese medicine has a long history of serving as a therapeutic treatment for ***,given the increasing volume of research on the utilization of traditional Chinese medicine for vitiligo treatment,it is imperative to conduct a comprehensive review that elucidates the efficacy of Chinese traditional medicine and other active ingredients in the treatment of *** paper presents a comprehensive overview of the clinical preparations used to treat vitiligo,while also highlighting the potential monomers and extracts derived from traditional Chinese medicine for vitiligo treatment.A thorough analysis of the pharmacological effects of traditional Chinese medicine on vitiligo treatment will provide valuable insights and reliable information for the development of new treatment strategies.

关键词： vitiligo traditional Chinese medicine melanogenesis

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准二维电荷密度波导体钾紫青铜K_xMo_6O_(17)单晶样品的制备

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物理学报 2004年第3期53卷 895-899页

作者：王俊峰熊锐余恒李慧汤五丰余祖新石兢田德诚田明亮张裕恒武汉大学物理科学与技术学院武汉430072 中国科学技术大学结构分析中心合肥230026

采用碳酸盐替代高钼酸盐电解还原的方法成功制备出了准二维电荷密度波导体钾紫青铜单晶 .通过x射线衍射、透射电子显微术等方法对单晶进行结构分析表明 :晶胞参数a =b =0 5 5 4 0nm ,c =1 3. 0 8nm ,单晶为三角晶系 ,对称群为P3. .电... 详细信息

采用碳酸盐替代高钼酸盐电解还原的方法成功制备出了准二维电荷密度波导体钾紫青铜单晶 .通过x射线衍射、透射电子显微术等方法对单晶进行结构分析表明 :晶胞参数a =b =0 5 5 4 0nm ,c =1 3. 0 8nm ,单晶为三角晶系 ,对称群为P3. .电阻温度关系曲线的测量显示 :钾紫青铜KxMo6 O1 7单晶在

关键词：钾紫青铜电荷密度波 Peierls相变钼酸钾单晶 X射线衍射结构分析晶胞参数

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Crystallization behavior and hydrophilicity of PVDF/PMMA/PVP blend via in-situ polymerization method

Crystallization behavior and hydrophilicity of PVDF/PMMA/PVP...

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2011年全国高分子学术论文报告会

作者： jing cheng 1,Shuangjun Chen 1,jun Zhang 1,Xiaolin wang 2 1 College of Materials science and engineering,Nanjing {3. of technology,Nanjing,210009 2 department of Chemical engineering,Tsinghua {3.,Beijing 100084

＜正＞In this work,methyl methacrylate （MMA） and N-vinyl-2-pyrrolidone （VP） as polymeric monomers are used to improve the hydrophilicity of poly （vinylidene fluoride）（PVDF）

关键词： PVDF PMMA PVP In-situ polymerization Hydrophilicity

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