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A new approach for identification of medicinal almonds by fourier transform infrared spectroscopy and systematic clustering of characteristic peaks

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Chinese Journal of Natural Medicines 2017年第9期15卷 703-709页

作者： cheng chun-song WANG Can-Jian LIANG Jie LAO Chi-Chou ZHOU Hua ZHANG Zhi-Feng State Key Laboratory of Quality Research in Chinese Medicine (Macao University of Science and Technology) Macao 999078China Faculty of Chinese Medicine Macao University of Science and Technology Macao 999078 China Macao Institute for Applied Research in Medicine and Health Macao 999078 China

Medicinal almonds have been used for over 2 000 years and its clinical efficacy includes relieving cough and asthma. The domestic market in China is flooded with different kinds of dried almonds, such as bitter almond(Armeniacae Semen Amarum, AAS),sweet almond(Armeniacae Semen Dulce, ADS), salted almond(Armeniacae Semen Salsa, ASS), and their sulfur-fumigating products(Armeniacae Semen Sulphur Fumabat, ASFS). Wide varieties of almonds may lead to uncertain efficacy, aberrant quality, and even increased safety risk. However, the authentication method for medicinal almonds has not been reported, although imposters may lead to ineffective medical response. In the present study, Fourier transform infrared spectroscopy(FTIR) and the 2-dimensional infrared(2 D-IR) spectroscopy were used to identify different almonds, which were extracted with different solvents including water, methanol, ethanol, chloroform and ethyl acetate, respectively. A new simple FTIR method was developed in the present study. According to the gradient solvent polarity, a new 2 D IR method was first developed, and the commodities of almonds in China were analyzed by using the FTIR spectroscopy supported by hierarchical clustering of characteristic peaks. Moreover, 5-hydroxymethyl-2-furfural could be used as a detection index and control target in the quality control of medicinal almonds.

关键词： FTIR Almonds Xingren Sulfur-fumigation

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Novel SNP markers on ginsenosides biosynthesis functional gene for authentication of ginseng herbs and commercial products

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Chinese Journal of Natural Medicines 2020年第10期18卷 770-778页

作者： WU Wen-Ru cheng chun-song cheng Qi-Qing LAO Chi-Chou CUI Hao TANG Zi-Yu OUYANG Yue LIU Liang ZHOU Hua State Key Laboratory of Quality Research in Chinese Medicine Faculty of Chinese MedicineMacao University o f Science and TechnologyMacao 999078China School of Chinese Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China Macao University of Science and TechnologyMacao 999078China

Panax ginseng and Panax quinquefolius have similar bioactive components and morphological characteristics, but they are known to have different medicinal values, high-sensitive and accurate method is expected to identify the sources of ginseng products and evaluate the quality, but with a huge challenge. Our established UHPLC-TOF/MS method coupled with orthogonal partial least squares discriminant analysis(OPLS-DA) model based on 18 ginsenosides was applied to discriminate the sources of raw medicinal materials in ginseng products, and nested PCR strategy was used to discover 6 novel single nucleotide polymorphism(SNP)sites in functional dammarenediol synthase(DS) gene for genetic authentication of P. ginseng and P. quinquefolius for the first ***-DA model could identify the sources of raw ginseng materials are real or not. SNP markers were applied to identify ginseng fresh samples as well as commercial products, and proved to be successful. This established molecular method can tell exact source information of adulterants, and it was highly sensitive and specific even when total DNA amount was only 0.1 ng and the adulteration was as low as 1%. Therefore, this study made an attempt at the exploration of new type SNP marker for variety authentication and function regulation at the same time, and the combination of chemical and molecular discrimination methods provided the comprehensive evaluation and authentication for the sources of ginseng herbs and products.

关键词： Panax ginseng Panax quinquefolius UHPLC-TOF/MS Dammarenediol synthase Nested PCR SNP

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Discovery of differential sequences for improving breeding and yield of cultivated Ophiocordyceps sinensis through ITS sequencing and phylogenetic analysis

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Chinese Journal of Natural Medicines 2018年第10期16卷 749-755页

作者： cheng Qi-Qing cheng chun-song OUYANG Yue LAO Chi-Chou CUI Hao XIAN Yu JIANG Zhi-Hong LI Wen-Jia ZHOU Hua State Key Laboratory of Quality Research in Chinese Medicine(Macao University of Science and Technology) Avenida WailongTaipaMacao Special Administrative RegionChina Macao Institute for Applied Research in Medicine and Health Avenida WailongTaipaMacao Special Administrative RegionChina Faculty of Chinese Medicine Macao University of Science and TechnologyAvenida WailongTaipaMacao Special Administrative RegionChina Sunshine Lake Pharma Co. Ltd.Dongguan 523808China

To accelerate the breeding process of cultivated Ophiocordyceps sinensis and increase its yield,it is important to identify molecular fingerprint of dominant *** the present study,we collected 3 batches of industrially cultivated *** product with higher yield than the others and compared their internal transcribed spacer(ITS)sequences with the wild and the *** ITS sequence was obtained by bidirectional sequencing and analyzed with molecular systematics as a DNA barcode for rapid and accurate identification of wild and cultivated *** *** ITS sequences of *** with detailed collection loci on NCBI were downloaded to construct a phylogenetic tree together with the sequences obtained from the present study by using neighbor-joining method based on their evolution *** information on collection loci was analyzed with ArcGIS 10.2 to demonstrate the geographic distribution of these samples and thus to determine the origin of the dominant *** results showed that all wild and cultivated samples were identified as *** and all sequences were divided into seven phylogenetic groups in the *** groups were precisely distributed on the map and the process of their system evolution was clearly *** three cultivated samples were clustered into two dominant groups,showing the correlation between the industrially cultivated samples and the dominant wild samples,which can provide references for its optimized breeding in the future.

关键词： Ophiocordyceps sinensis ITS Phylogenetic relationship Artificial cultivation Evolution process

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English Grammar Teaching for Advanced ESL Learners in China

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Sino-US English Teaching 2014年第4期11卷 277-282页

作者： cheng chun-song Quzhou University Quzhou China

English majors usually have learned English for at least six years at middle school, but there are still many grammatical errors in their writing and speaking. Such errors even still remain after four-year English learning at university. Such problem has troubled many teachers teaching English Grammar. Therefore, the paper attempts to study the ways of improving English majors＇ grammatical competence. It is concluded that reform of grammar test should be carried out to guide grammar teaching and learning, error analysis should be conducted to decide what to teach, and an output-oriented approach should be employed to meet the requirements of leamers＇ future profession.

关键词： English Grammar teaching English majors reform of grammar test error analysis output-orientedapproach

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基于网络药理学和实验验证分析鸡血藤治疗卵巢癌的分子机制

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中国中药杂志 2022年第3期47卷 786-795页

作者：朱时纯蔡俊吴承玉程春松南京中医药大学中医学院-中西医结合学院江苏南京210023 中国科学院庐山植物园资源植物研究中心江西九江332900 澳门科技大学中药质量研究国家重点实验室中国澳门999078

通过网络药理学和分子对接及体外细胞实验,对鸡血藤Spatholobi Caulis治疗卵巢癌(ovarian cancer,OC)的主要活性成分及其潜在的作用机制进行探讨。运用中药药理学数据库与分析平台(TCMSP)获取鸡血藤的主要活性成分及其预测靶点,通过Gene... 详细信息

通过网络药理学和分子对接及体外细胞实验,对鸡血藤Spatholobi Caulis治疗卵巢癌(ovarian cancer,OC)的主要活性成分及其潜在的作用机制进行探讨。运用中药药理学数据库与分析平台(TCMSP)获取鸡血藤的主要活性成分及其预测靶点,通过GeneCards、OMIM、PharmGkb、TTD、DrugBank数据库检索获得疾病基因。将疾病及药物预测靶点进行交集处理,筛选出共同的潜在治疗靶点。运用Cytoscape 3.7.1软件构建"药物-成分-疾病-靶点"相互作用网络图;运用STRING数据库构建蛋白相互作用的PPI网络。运用R 4.0.5进行GO与KEGG功能富集分析。分析对接虚拟筛选的处理和优化由Schr9dinger Maestro软件完成。该研究筛选出鸡血藤23个活性成分,涉及75个卵巢癌靶点及178个相关信号通路;网络分析结果表明鸡血藤可能通过作用于GSK-3β、Bcl-2、Bax等关键靶点,发挥抗卵巢癌作用;分子对接结果显示GSK-3β与活性成分樱黄素结合活性较好。最后体外实验将筛选出的鸡血藤活性成分樱黄素对人卵巢癌细胞SKOV3进行核心靶点和通路的初步验证。采用CCK-8法检测细胞增殖情况,使用流式细胞仪检测樱黄素对人卵巢癌细胞SKOV3凋亡的影响。运用Western blot法检测樱黄素靶点及相关调控蛋白的表达。体外细胞实验证明,樱黄素对卵巢癌细胞的增殖有明显的抑制作用,并且樱黄素对SKOV3有诱导凋亡的作用。Western blot实验结果表明,樱黄素可以通过抑制GSK-3β磷酸化的发生,调控下游Bcl-2、Bax蛋白的表达,诱导SKOV3细胞凋亡的发生。该研究揭示了网络药理学预测并指导实验设计的科学性,证实樱黄素可通过阻断GSK-3β/Bcl-2/Bax细胞信号转导通路治疗卵巢癌,为鸡血藤治疗卵巢癌的机制研究提供依据。

关键词：网络药理学分子对接鸡血藤樱黄素卵巢癌

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Ideal Bi-Based Hybrid Anode Material for Ultrafast Charging of Sodium-Ion Batteries at Extremely Low Temperatures

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NANO-MICRO LETTERS 2025年第1期17卷 1-16页

作者： Bai, Jie Jia, Jian Hui Wang, Yu Yang, chun cheng Jiang, Qing Jilin Univ Key Lab Automobile Mat Sch Mat Sci & Engn Minist Educ Changchun 130022 Peoples R China

Metallic nanoparticles with excellent size controllability and high loading rate are obtained via ultrafast high temperature shock *** Bi/CNRs-15 electrode exhibits an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, while the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C.A novel strategy of high-rate activation is proposed to obtain high capacity and superior stability at low temperature by creating new active sites for interfacial reaction. Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at - 20 degrees C or lower. However, the key capability of ultrafast charging at ultralow temperature for SIBs is rarely reported. Herein, a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue, which is synthesized via a high temperature shock method. Such a hybrid shows an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, outperforming all reported SIB anode materials. Coupled with a Na3V2(PO4)3 cathode, the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C. Based on this work, a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

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中国英语学习者增强语副词使用情况的调查研究

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湖南工程学院学报（社会科学版） 2008年第3期18卷 65-69页

作者：程春松浙江工业大学浙西分校外语系浙江衢州324000

利用语料库对中国英语学习者的增强语副词使用情况进行调查研究。研究发现中国英语学习者对该类词既有使用过多又有使用过少的现象,但从总体上看,他们过多使用了增强语副词,而且过多使用的词主要集中在more,very,much和too四个词上。这... 详细信息

利用语料库对中国英语学习者的增强语副词使用情况进行调查研究。研究发现中国英语学习者对该类词既有使用过多又有使用过少的现象,但从总体上看,他们过多使用了增强语副词,而且过多使用的词主要集中在more,very,much和too四个词上。这种现象主要是由于学习者的词汇量较小和母语负迁移而造成的。此外,中国英语学习者使用增强语副词的能力随英语水平的提高而提高,高水平学习者所使用的增强语副词范围更广,使用增强语副词的能力更接近于本族语者。

关键词：中国英语学习者增强语副词语料库

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Improving postoperative outcomes in patients with pancreatic cancer:Inflammatory and nutritional biomarkers

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World Journal of Clinical Oncology 2025年第1期16卷 59-64页

作者： chun-Han cheng Wen-Rui Hao Tzu-Hurng cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This editorial assesses the prognostic value of preoperative inflammatory and nutritional biomarkers in patients undergoing surgical resection for pancreatic *** et al evaluated the ability of seven biomarkers to predict postoperative recovery and long-term *** biomarkers were albumin-to-globulin ratio,prognostic nutritional index(PNI),systemic immune-inflammation index,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,nutritional risk index,and geriatric nutritional risk *** PNI was found to be a strong predictor of both overall and recurrence-free survival,underscoring its clinical relevance in managing patients with pancreatic cancer.

关键词： Pancreatic cancer Prognostic nutritional index Systemic immune-inflammation index Postoperative recovery Prognosis

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从植物引种驯化史轨迹探讨野生果树驯化与育种

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植物遗传资源学报 2021年第6期22卷 1463-1473页

作者：黄宏文邹帅宇程春松中国科学院庐山植物园九江332900 中国科学院华南植物园广州510650

纵观千百年来人类驯化成功的作物,不论是驯化栽培历史较为久远的如小麦、玉米、水稻、苹果、李、葡萄等,还是驯化栽培史较近的如猕猴桃、蓝莓、草莓等,均经历了人类长期不断的选择和栽培实践。本文以史为鉴,概要梳理并分析了植物驯化改... 详细信息

纵观千百年来人类驯化成功的作物,不论是驯化栽培历史较为久远的如小麦、玉米、水稻、苹果、李、葡萄等,还是驯化栽培史较近的如猕猴桃、蓝莓、草莓等,均经历了人类长期不断的选择和栽培实践。本文以史为鉴,概要梳理并分析了植物驯化改良的历程,并重点以20世纪百年的果树驯化案例,探讨了本世纪野生果树植物驯化的思考和路径。

关键词：植物驯化果树植物育种改良农耕文明 21世纪新水果

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黄芩炭对早孕流产大鼠子宫出血保护作用及机制研究

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中国中药杂志 2019年第21期44卷 4691-4697页

作者：黄琪李丽丽程春松张村金传山安徽中医药大学药学院安徽合肥230012 中国中医科学院中药研究所北京100700 澳门科技大学澳门999078 中药饮片制造新技术安徽省重点实验室安徽合肥230012

研究黄芩炭对早孕流产大鼠子宫出血保护作用及其机制。取未怀孕的雌性大鼠8只作为正常组,同一天受孕的雌性大鼠40只,以米非司酮(11. 4 mg·kg-1)和米索前列醇(125μg·kg-1)建立大鼠早孕不完全流产模型,将流产模型大鼠分为模型组,黄芩... 详细信息

研究黄芩炭对早孕流产大鼠子宫出血保护作用及其机制。取未怀孕的雌性大鼠8只作为正常组,同一天受孕的雌性大鼠40只,以米非司酮(11. 4 mg·kg-1)和米索前列醇(125μg·kg-1)建立大鼠早孕不完全流产模型,将流产模型大鼠分为模型组,黄芩炭水提液低(0. 55 g·kg-1)、中(1. 10 g·kg-1)、高(2. 20 g·kg-1)剂量组及阳性药断血流片(0. 45 g·kg-1)组。紫外分光光度法测定大鼠子宫出血量,HE染色法观察子宫内膜病理变化,ELISA法测定血浆中IL-1β,IL-6和TNF-α水平,RT-PCR法检测子宫组织中IL-1β,IL-6和TNF-αmRNA水平,Western blot法检测子宫组织中VEGF,MMP-2,MMP-9蛋白表达量。结果显示,与正常组相比,模型组大鼠子宫出血量显著增加,病理评分显著升高,微血管密度明显减少,血浆中TNF-α和IL-1β含量均显著升高,IL-6含量显著降低,TNF-α和IL-1βmRNA表达显著升高,IL-6 mRNA表达显著降低,大鼠子宫VEGF,MMP-2,MMP-9表达量显著升高;与模型组相比,黄芩炭中、高剂量组可显著降低流产大鼠子宫出血量,促进子宫内膜修复及升高子宫内膜组织微血管密度,降低大鼠子宫内TNF-α和IL-1β的含量及mRNA表达量,升高IL-6的含量及mRNA表达量,降低大鼠子宫VEGF,MMP-2,MMP-9等蛋白的表达。表明黄芩炭具有止血作用,其止血机制可能与修复子宫内膜、抑制炎症反应有关。

关键词：黄芩炭子宫出血止血作用炎症反应子宫内膜修复

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