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Identification and validation of novel prognostic fatty acid metabolic gene signatures in colon adenocarcinoma through systematic approaches

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Oncology Research 2024年第2期32卷 297-308页

作者： HENG ZHANG wenjing cheng HAIBO ZHAO WEIDONG CHEN QIUJIE ZHANG QING-QING YU Department of Laboratory Shandong Daizhuang HospitalJining272051China Jining No.1 People’s Hospital Shandong First Medical UniversityJining272000China

Colorectal cancer(CRC)belongs to the class of significantly malignant tumors found in ***,dysregulated fatty acid metabolism(FAM)has been a topic of attention due to its modulation in cancer,specifically ***,the regulatory FAM pathways in CRC require comprehensive ***:The clinical and gene expression data of 175 fatty acid metabolic genes(FAMGs)linked with colon adenocarcinoma(COAD)and normal cornerstone genes were gathered through The Cancer Genome Atlas(TCGA)-COAD corroborating with the Molecular Signature Database v7.2(MSigDB).Initially,crucial prognostic genes were selected by uni-and multi-variate Cox proportional regression analyses;then,depending upon these identified signature genes and clinical variables,a nomogram was ***,to assess tumor immune characteristics,concomitant evaluation of tumor immune evasion/risk scoring were ***:A 8-gene signature,including ACBD4,ACOX1,CD36,CPT2,ELOVL3,ELOVL6,ENO3,and SUCLG2,was generated,and depending upon this,CRC patients were categorized within high-risk(H-R)and low-risk(L-R)***,risk and age-based nomograms indicated moderate discrimination and good *** data confirmed that the 8-gene model efficiently predicted CRC patients’***,according to the conjoint analysis of tumor immune evasion and the risk scorings,the H-R cohort had an immunosuppressive tumor microenvironment,which caused a substandard ***:This investigation established a FAMGs-based prognostic model with substantially high predictive value,providing the possibility for improved individualized treatment for CRC individuals.

关键词： Fatty acid metabolism Colorectal cancer Gene signatures Machine learning

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胫骨平台骨折术后后倾角对膝关节功能的影响

安徽医科大学学报 2024年第9期59卷 1659-1663页

作者：吴兴净陶周善程文静皖南医学院弋矶山医院骨科芜湖241000

目的探讨胫骨平台骨折术后后倾角的改变以及其与膝关节功能的关系。方法收集83例行-胫骨平台骨折手术的病例,测出患者健侧、术后患侧及最后一次随访患侧胫骨平台后倾角(PTS),评价并记录Lysholm、HSS及Rasmussen等三种系统的膝关节评分数... 详细信息

目的探讨胫骨平台骨折术后后倾角的改变以及其与膝关节功能的关系。方法收集83例行-胫骨平台骨折手术的病例,测出患者健侧、术后患侧及最后一次随访患侧胫骨平台后倾角(PTS),评价并记录Lysholm、HSS及Rasmussen等三种系统的膝关节评分数据,根据术后PTS角度将患者分为PTS<9°组和PTS≥9°组。将两组三种膝关节功能评分均数行统计学分析,同时也将术后与最后随访PTS均数进行统计学处理。计算最后随访与健侧PTS的差值,将差值与最后一次随访膝关节功能数据进行相关性分析。结果两组患者一般情况方面未见明显差异。PTS<9°组膝关节Lysholm、HSS、Rasmussen评分数据均明显高于PTS≥9°组(P<0.05)。两组患者术后PTS与最后一次随访PTS相比,差异有统计学意义(P<0.05)。最后一次随访与健侧PTS之间的差值(b)与Lysholm、HSS及Rasmussen膝关节评分数据均具有相关性(P<0.05)。结论术后康复锻炼导致PTS角度发生改变。PTS<9°组患者膝关节功能好于术后PTS≥9°组患者,最后一次随访PTS与健侧PTS的差值与膝关节功能有相关性。因此手术中尽可能恢复平台骨折的解剖对位或控制术后PTS<9°。

关键词：胫骨平台后倾角胫骨平台骨折术后骨折塌陷膝关节功能评分相关性

Agricultural Vulnerability to Drought in China's Agro-pastoral Ecotone:A Case Study of Yulin City,Shaanxi Province

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中国地理科学:英文版 2023年第5期33卷 934-945页

作者： LI Yuheng cheng wenjing ZUO Wenjie ZHANG Lingyue Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China College of Resources and Environment University of the Chinese Academy of SciencesBeijing 100049China College of Public Administration and Law Northeast Agricultural UniversityHarbin 150030China College of Economics and Management Northwest A&F UniversityYangling 712100China

Agro-pastoral ecotone of northern China is the prominent area for agricultural production,but it is also the most typical ecological fragile area with frequent drought *** Yulin City at Shaanxi Province in China as the case area,the paper aims to investigate the spatio-temporal changes of agricultural vulnerability to drought in China’s agro-pastoral ecotone in the period 2000 *** results show that:1)the agricultural vulnerability to drought in Yulin City has shifted from high vulnerability in the period2000–2010 to low vulnerability in the period 2011–2020.2)There exist obvious spatio-temporal differences of the agricultural vulnerability to drought in Yulin City during the research period.3)Four sensitive events and 14 resilient events were identified in the research and the crops of Yulin had become more resilient to ***,the paper put forward with policy implications to make adaptive strategies of agriculture to climate change in China’s agro-pastoral ecotone in the future,e.g.,carrying out agricultural zoning based on agricultural production conditions,intensifying the construction of disaster prevention and relief system,and integrating with modern agricultural technology to develop new type agriculture.

关键词： climate change agricultural vulnerability drought agro-pastoral ecotone Yulin City,China

不同覆盖方式对桃园土壤性状及果实产量品质的影响

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中国南方果树 2024年第5期53卷 124-129页

作者：成文竞张琴佘为为许太白张微微上海农林职业技术学院上海201699

连续2年在上海市12年生蟠桃园将修剪枝条粉碎后翻埋还田,并将此措施与碎枝覆盖、果园生草或反光地布覆盖相结合,探索桃园碎枝利用及复合覆盖的适宜形式。结果表明,相对于对照(不做任何处理),翻埋粉碎树枝、翻埋粉碎树枝+覆盖粉碎树枝、... 详细信息

连续2年在上海市12年生蟠桃园将修剪枝条粉碎后翻埋还田,并将此措施与碎枝覆盖、果园生草或反光地布覆盖相结合,探索桃园碎枝利用及复合覆盖的适宜形式。结果表明,相对于对照(不做任何处理),翻埋粉碎树枝、翻埋粉碎树枝+覆盖粉碎树枝、翻埋粉碎树枝+人工生草、翻埋粉碎树枝+铺设反光地布4种措施能使蟠桃单果质量提升13.8%~35.0%,增产16.0%~36.9%,其中以碎枝覆盖结合翻埋的增产提质效果最佳。连续2年的碎枝覆盖结合翻埋,使得0~30 cm土层土壤有机质、全氮、有效磷和速效钾含量比对照显著高出82.1%、52.0%、48.5%和47.7%,0~10 cm土层土壤容重比对照显著降低12.0%,0~20 cm土层土壤平均含水量比对照显著高出10.0%,且在土壤含水量偏低时的保水作用更显著。蟠桃单果质量和产量与土壤含水量、孔隙度、有机质、全氮、有效磷、速效钾含量等土壤理化指标表现出极显著或显著正相关关系。碎枝翻埋和覆盖相结合是适宜华东地区的桃园废弃物就地利用的良好方式。

关键词：桃枝条还田果园覆盖土壤肥力土壤理化性状相关性分析果实品质

弧形改良切口与传统“L” 形切口治疗粉碎性跟骨骨折疗效比较

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皖南医学院学报 2024年第4期43卷 342-345页

作者：吴兴净陶周善程文静皖南医学院第一附属医院弋矶山医院骨科安徽芜湖241001

目的:比较弧形改良切口和传统“L”形切口治疗粉碎性跟骨骨折的临床效果。方法:收集2020年1月~2022年10月在弋矶山医院手术的43例粉碎性跟骨骨折患者作为研究对象。23例采用弧形改良切口治疗(改良组),20例采用“L”形切口治疗(对照组)... 详细信息

目的:比较弧形改良切口和传统“L”形切口治疗粉碎性跟骨骨折的临床效果。方法:收集2020年1月~2022年10月在弋矶山医院手术的43例粉碎性跟骨骨折患者作为研究对象。23例采用弧形改良切口治疗(改良组),20例采用“L”形切口治疗(对照组)。根据影像学资料测量跟骨骨折手术前后Gissane角、Bohler角、宽度和高度数值,对两组手术前后组内、诅间各项影像学指标进行比较。将两组手术时间、切口缝合时间、术后并发症以及美国足与踝关节协会(AOFAS)评分进行比较。结果:两组患者随访时间为10~16个月,中位随访时间12.62个月。两组患者术后跟骨宽度、高度、Gissane角及Bohler角均较术前改善(P0.05)。两组患者手术时间和切口缝合时间方面差异均无统计学意义(P>0.05)。改良组术后并发症发生率(0.0%)低于对照组(30.0%),P<0.05。改良组患者AOFAS评分(87.56±4.73)优于对照组(73.95±4.38),P<0.001。结论:弧形改良切口治疗粉碎性跟骨骨折具有切口并发症少、疗效显著的优点,值得推广。

关键词：跟骨骨折疗效对比弧形改良切口 “L”形切口粉碎性

Synthesis of Submicrometer-sized Sn-MCM-41 Particles and Their Catalytic Performance in Baeyer-ViUiger Oxidation

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Chemical Research in Chinese Universities 2015年第1期31卷 138-143页

作者： CHEN Na JIANG Yanqiu cheng wenjing LIN Kaifeng XU Xianzhu State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology Harbin 150090 P. R. China Academy of Fundamental and Interdisciplinary Sciences Harbin Institute of Technology Harbin 150080 P. R. China

Submicrometer-sized tin-containing MCM-41 particles with a size of several hundred nanometers（Sn-MCM-41/SMPs） were rapidly prepared with tin chloride as tin source and tetraethyl orthosilicate as silicon source via a dilute solution route in sodium hydroxide medium at room temperature. The characterization results show the highly ordered hexagonal mesopores and tetrahedral Sn species in Sn-MCM-41/SMPs. The material proved to be active and selective for Baeyer-Villiger oxidation of adamantanone with aqueous H2O2. Notably, Sn-MCM-41/ SMPs displayed a higher initial reaction rate and turnover number（TON） than common micrometer-sized Sn-MCM-41 large particles（Sn-MCM-41/LPs）, mainly attributed to the accelerated diffusion of the reactants and enhanced accessibility to the catalytic Sn species via shorter mesopore channels in Sn-MCM-41/SMPs. Furthermore, Sn-MCM-41/SMPs could be reused without the loss of activity after five runs, indicating that Sn active sites in the submicrometer-sized particles are remarkably stable. The study shows that decreasing particle size of Sn-MCM-41 in submicrometer scale is an effective way to achieve catalysts for Baeyer-Villiger oxidations with improved catalytic performance.

关键词： Sn-MCM-41 Submicrometer-sized particle Shorter mesopore channel Baeyer-Villiger oxidation

Mesoporous TiO_2/Carbon Beads: One-Pot Preparation and Their Application in Visible-Light-Induced Photodegradation

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Nano-Micro Letters 2015年第3期7卷 243-254页

作者： Xiaowei Li Yanqiu Jiang wenjing cheng Yudong Li Xianzhu Xu Kaifeng Lin Academy of Fundamental and Interdisciplinary Sciences Harbin Institute of Technology

Mesoporous Ti O2/Carbon beads have been prepared via a facile impregnation-carbonization approach, in which a porous anion-exchange resin and K2 Ti O(C2O4)2were used as hard carbon and titanium source, *** results reveal that the self-assembled composites have disordered mesostructure, uniform mesopores,large pore volumes, and high surface areas. The mesopore walls are composed of amorphous carbon, well-dispersed and confined anatase or rutile nanoparticles. Some anatase phase of Ti O2 was transformed to rutile phase via an increase of carbonization temperature or repeated impregnation of the resin with Ti O(C2O4)22-species. X-ray photoelectron spectroscopy, carbon, hydrogen, and nitrogen element analysis, and thermal gravity analysis results indicate the doping of carbon into the Ti O2 lattice and strong interaction between carbon and Ti O2 nanoparticles. A synergy effect by carbon and Ti O2 in the composites has been discussed herein on the degradation of methyl orange under visible light. The dye removal process involves adsorption of the dye from water by the mesopores in the composites, followed by photodegradation on the separated dye-loaded catalysts. Mesopores allow full access of the dye molecules to the surface of Ti O2 ***, the bead format of such composite enables their straightforward separation from the reaction mixture in their application as a liquid-phase heterogeneous photodegradation catalyst.

关键词： Ti O2nanoparticles Mesoporous carbon Composite bead Visible light Easy separation

化妆品使用植物功效成分抑制痤疮的研究及相关专利分析

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中华中医药杂志 2024年第1期39卷 336-341页

作者：李璐瑶程文静狄飞倩张佳婵王昌涛安全石秀芹北京工商大学北京植物资源研究开发重点实验室北京100048 云南白药股份有限公司昆明650000

痤疮是一种慢性炎症性皮肤表现,其影响因素复杂多样。《已使用化妆品原料目录(2021年版)》规定了祛痘植物原料在化妆品领域的可使用范围。基于此,笔者从痤疮发生机制入手,详细阐述痤疮相关生物学变化;在调研文献资料的基础上,对未收录... 详细信息

痤疮是一种慢性炎症性皮肤表现,其影响因素复杂多样。《已使用化妆品原料目录(2021年版)》规定了祛痘植物原料在化妆品领域的可使用范围。基于此,笔者从痤疮发生机制入手,详细阐述痤疮相关生物学变化;在调研文献资料的基础上,对未收录其中的10种祛痘功效植物成分的作用机制进行了更新和综述;最后,对2002年至2022年已授权祛痘相关专利进行分析,探索祛痘产品的研究现状和发展趋势,为祛痘类产品的研发提供新思路。

关键词：痤疮痤疮发生机制植物活性成分化妆品 SOOPAT专利分析

Paraventricular Nucleus P2X7 Receptors Aggravate Acute Myocardial Infarction Injury via ROS-Induced Vasopressin-V1b Activation in Rats

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Neuroscience Bulletin 2021年第5期37卷 641-656页

作者： wenjing cheng Yinggang Sun Qin Wu Kokwin Ooi Yi Feng Chunmei Xia Danian Zhu Department of Physiology and Pathophysiology School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Cardiovascular Diseases Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Medical Technology Jiangsu Vocational College of MedicineYancheng 224005China Department of Integrative Medicine and Neurobiology School of Basic Medical SciencesFudan UniversityShanghai 200032China

The present study was designed to investigate the mechanisms by which P2X7 receptors(P2X7Rs)mediate the activation of vasopressinergic neurons thereby increasing sympathetic hyperactivity in the paraventricular nucleus(PVN) of the hypothalamus of rats with acute myocardial ischemia(AMI). The left anterior descending branch of the coronary artery was ligated to induce AMI in rats. The rats were pretreated with BBG(brilliant blue G, a P2X7R antagonist), nelivaptan(a vasopressin V1b receptor antagonist), or diphenyleneiodonium(DPI) [an nicotinamide adenine dinucleotide phosphate(NADPH)oxidase inhibitor]. Hemodynamic parameters of the heart were monitored. Myocardial injury and cardiomyocyte apoptosis were assessed. In the PVN of AMI rats, P2X7R mediated microglial activation, while reactive oxygen species(ROS) and NADPH oxidase 2(NOX2) were higher than in the sham group. Intraperitoneal injection of BBG effectively reduced ROS production and vasopressin expression in the PVN of AMI rats. Moreover, both BBG and DPI pretreatment effectively reduced sympathetic hyperactivity and ameliorated AMI injury, as represented by reduced inflammation and apoptosis of ***, microinjection of nelivaptan into the PVN improved cardiac function and reduced the norepinephrine(AE) levels in AMI rats. Collectively, the results suggest that, within the PVN of AMI rats, P2X7R upregulation mediates microglial activation and the overproduction of ROS, which in turn activates vasopressinergic neuron V1b receptors and sympathetic hyperactivity, hence aggravating myocardial injury in the AMI setting.

关键词： PVN P2X7 receptor Vasopressin Reactive oxygen species c-fos Myocardial ischemia