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卡瑞利珠单抗联合TACE对伴微血管侵犯肝细胞癌患者肿瘤标志物、血管生成因子和血清PD-1、PD-L1的影响

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现代生物医学进展 2024年第9期24卷 1678-1681页

作者：汪景洲王宇鹏刘航成梁峰赵清涛中国人民解放军联勤保障部队第九八〇医院肝胆胰脾科河北石家庄050000 中国人民解放军联勤保障部队第九八〇医院肿瘤科河北石家庄050000

目的:观察卡瑞利珠单抗联合肝动脉化疗栓塞术(TACE)对伴微血管侵犯肝细胞癌(HCC)患者肿瘤标志物、血管生成因子和血清程序性细胞死亡蛋白-1(PD-1)、程序性死亡配体-1(PD-L1)的影响。方法:根据随机数字表法将2021年6月~2023年7月期间我... 详细信息

目的:观察卡瑞利珠单抗联合肝动脉化疗栓塞术(TACE)对伴微血管侵犯肝细胞癌(HCC)患者肿瘤标志物、血管生成因子和血清程序性细胞死亡蛋白-1(PD-1)、程序性死亡配体-1(PD-L1)的影响。方法:根据随机数字表法将2021年6月~2023年7月期间我院收治的121例伴微血管侵犯HCC患者分为对照组(n=60,接受肝癌根治术和TACE治疗)和研究组(n=61,对照组的基础上接受卡瑞利珠单抗治疗)。对比两组疗效、血清肿瘤标志物水平[甲胎蛋白(AFP)、癌胚抗原(CEA)、异常凝血酶原(PIVKA-Ⅱ)、糖类抗原199(CA199)]、血管生成因子水平[血管内皮生长因子受体2(VEGF-R2)、血管生成素-2(Ang-2)、血管内皮生长因子(VEGF)]、血清PD-1、PD-L1水平、不良反应。结果:与对照组相比,研究组的临床总有效率更高(P0.05)。结论:卡瑞利珠单抗联合TACE治疗伴微血管侵犯HCC患者,可改善血清肿瘤标志物,可抑制血管生成和降低血清PD-1、PD-L1水平,有效控制疾病进展。

关键词：卡瑞利珠单抗 TACE 微血管侵犯肝细胞癌肿瘤标志物血管生成因子 PD-1 PD-L1

Single transition-metal atoms anchored on a novel Diracdispersiveπ-πconjugated holey graphitic carbon nitride substrate:computational screening toward efficient bifunctional OER/ORR electrocatalysts

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Rare Metals 2024年第8期43卷 3819-3832页

作者： Chun-Yao Fang Xi-hang Zhang Qiang Zhang Di Liu Xiao-Meng Cui Jing-cheng Xu cheng-Long Shi Meng-Yu Yang College of Science University of Shanghai for Science and TechnologyShanghai 200093China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China

Nonprecious-metal-group single-metal-atom catalysts with bifunctional catalytic capabilities toward the oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)are highly sought after in energy-conversion and storage ***,producing renewable and sustainable energy sources remains ***,single-transition metal atoms anchored onπ-πconjugated two-dimensional(2D)graphitic carbon nitride substrates formπ-d conjugated conductive channels that enhance the overall electrocatalytic ***,firstprinciples calculations were carried out to design and demonstrate a novel macropore graphitic carbon nitride(gC_(10)N_(3))as a promising 2D electrocatalyst substrate to support single-transition metal(TM,from Sc to Au).The"donation-acceptance"charge interaction in the TM-N_(2)moiety effectively balances the adsorption strength of oxygenated intermediates in Ni@g-C_(10)N_(3)and Rh@gC_(10)N_3,making them effective bifunctional OER/ORR electrocatalysts with IrO_(2)/Pt-beyond overpotentials being as low as 0.39/0.38 V and 0.54/0.44 V,***,they possess high stability and conductivity and are less susceptible to oxidation and corrosion under working *** guarantees high activity under ambient ***,the origin of the OER/ORR activity of TM@g-C_(10)N_(3) is explained using multilevel descriptors:intrinsic(p,Bader charge,integral crystal orbital Hamilton population(ICOHP),bond length,and d-band center(εd).In particular,for optimal Ni@g-C_(10)N_(3),the clear hybridization between the Ni-d orbital and surface O-p orbital causes the paired electrons to occupy the bonding *** enables OH~*to be adsorbed on the Ni@g-C_(10)N_(3),thereby achieving the highest catalytic performance.

关键词： First-principles calculation Oxygen evolution reaction Oxygen reduction reaction Bifunctional electrocatalysts Single-metal-atom electrocatalysts

Hollow glass microspheres/silicone rubber composite materials toward materials for high performance deep in-situ temperaturepreserved coring

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Petroleum Science 2022年第1期19卷 309-320页

作者： Jian-Ping Yang Ling Chen Xiao-Bin Gu Zhi-Yu Zhao cheng-hang Fu Dong-Sheng Yang Dong-Zhuang Tian Zhi-Sheng Chen He-Ping Xie College of Polymer Science and Engineering Sichuan UniversityChengdu610065China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060China School of Mechanical Engineering Sichuan UniversityChengdu610065China Jinshi Drilltech Company Limited Tangshan063004Hebei Institute of New Energy and Low-Carbon Technology Sichuan UniversityChengdu610065China College of Water Resource&Hydropower Sichuan UniversityChengdu610065China Xi'an Research Institute China Coal Technology&Engineering Group CorpXi'an710077China

Deep petroleum resources are stored under high temperature and pressure conditions,with the temperature having a significant influence on the properties of *** in-situ temperature-preserved coring(ITP-coring)devices were developed to assess deep petroleum reserves ***,hollow glass microspheres(HGMs)/silicone rubber(SR)composites that exhibit excellent thermal insulation properties were prepared as thermal insulation materials for deep ITP-coring *** mechanism and process of heat transfer in the composites were explored,as well as their other *** results show that the HGMs exhibit good compatibility with the SR *** the volume fraction of the HGMs is increased to 50%,the density of the HGMs/SR composites is reduced from 0.97 to 0.56 g/cm^(3).The HGMs filler introduces large voids into the composites,reducing their thermal conductivity to 0.11 W/m·*** addition of HGMs into the composites further enhances the thermal stability of the SR,wherein the higher the HGMs filler content,the better the thermal stability of the *** significantly enhance the mechanical strength of the *** increase the compressive strength of the composites by 828%and the tensile strength by 164%.Overall,HGMs improve the thermal insulation,pressure resistance,and thermal stability of HGMs/SR composites.

关键词： In-situ temperature-preserved coring(ITP-coring) Deep in-situ conditions Thermal insulation materials HGMs/SR composites

心肌梗死病史对同期行外科主动脉瓣置换术和冠状动脉旁路移植术患者预后的影响

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中华实用诊断与治疗杂志 2024年第6期38卷 601-606页

作者：王志华赵泽原胡俊龙程行孙俊杰刘运彪李建朝程兆云阜外华中心血管病医院郑州大学华中阜外医院心外科河南郑州451464 阜外华中心血管病医院郑州大学华中阜外医院体外循环科河南郑州451464

目的分析有心肌梗死(MI)病史的主动脉瓣狭窄合并冠心病患者同期行外科主动脉瓣置换术(SAVR)和冠状动脉旁路移植术(CABG)的手术及随访情况,探讨MI病史对患者预后的影响。方法 2018年1月—2023年7月阜外华中心血管病医院诊治同期行SAVR和... 详细信息

目的分析有心肌梗死(MI)病史的主动脉瓣狭窄合并冠心病患者同期行外科主动脉瓣置换术(SAVR)和冠状动脉旁路移植术(CABG)的手术及随访情况,探讨MI病史对患者预后的影响。方法 2018年1月—2023年7月阜外华中心血管病医院诊治同期行SAVR和CABG的主动脉瓣狭窄合并冠心病患者225例,根据有无MI病史分为MI组74例和非MI组151例。采用1∶1倾向性评分匹配,协变量包括性别、年龄、体质量指数、吸烟史、基础疾病等临床资料,匹配后比较2组冠状动脉病变血管数量和部位、欧洲心血管手术危险因素评分(EuroSCORE)等MI病史相关指标,术后24、48 h血清心肌损伤标志物,手术情况及术后并发症发生情况。随访3~67个月,比较2组术后3个月时左室射血分数、左心室舒张末期内径及死亡、再入院发生率。结果经1∶1倾向性评分匹配后,MI组和非MI组各69例,2组年龄、体质量指数及男性、吸烟、高血压、糖尿病、高脂血症、心房颤动、脑血管疾病、慢性阻塞性肺疾病、肾功能不全比率比较差异均无统计学意义(P>0.05)。MI组3支病变血管、左回旋支病变比率(62.3%、68.1%)及EuroSCORE评分[(7.1±2.0)分]均高于非MI组[34.8%、47.8%、(5.6±2.0)分](P0.05)。MI组术后24 h血清N末端脑钠肽前体水平[2 016.0(1 210.0,4 023.8)ng/L]高于非MI组[1 315.5(856.6,2 272.8)ng/L](Z=-2.603,P=0.009),术后48 h血清N末端脑钠肽前体及术后24、48 h血清肌钙蛋白T、肌红蛋白、肌酸激酶同工酶水平与非MI组比较差异均无统计学意义(P>0.05)。MI组搭桥数量[(2.8±1.2)支]多于非MI组[(2.3±1.2)支](t=2.707,P=0.008),体外循环时间[(209.3±98.5)min]、手术时间[(441.5±115.5)min]、机械通气时间[39.0(21.5, 73.0)h]、ICU停留时间[4.0(2.5, 6.0)d]均长于非MI组[(175.5±57.5)min、(401.1±93.5)min、28.0(16.0,59.5)h、3.0(2.0,4.5)d](P0.05)。2组术后新发MI、低心排血量综合征、心房颤动、心室颤动、急性肾损伤、消化道出血、切口愈合不良、院内死亡发生率比较差异均无统计学意义(P>0.05)。2组术后3个月时左室射血分数、左心室舒张末期内径及死亡、再入院发生率比较差异均无统计学意义(P>0.05)。结论对同期行SAVR和CABG的主动脉瓣狭窄合并冠心病患者,MI病史可能延长手术时间及术后监护时间,但不增加术后心肌损伤、严重并发症和近中期死亡的发生风险。

关键词：主动脉瓣狭窄冠心病心肌梗死外科主动脉瓣置换术冠状动脉旁路移植术

Role of micro-Ca/In alloying in tailoring the microstructural characteristics and discharge performance of dilute Mg-Bi-Sn-based alloys as anodes for Mg-air batteries

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Journal of Magnesium and Alloys 2024年第1期12卷 251-266页

作者： Fei-er Shangguan Wei-li cheng Yu-hang Chen Ze-qin Cui Hui Yu Hong-xia Wang Li-fei Wang hang Li Hua Hou School of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Hebei University of TechnologyTianjin 300132China School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

The influence of micro-Ca/In alloying on the microstructural charac teristics,electrochemical behaviors and discharge properties of extruded dilute Mg-0.5Bi-0.5Sn-based(wt.%)alloys as anodes for Mg-air batteries are *** grain size and texture intensity of the Mg-Bi-Sn-based alloys are significantly decreased after the Ca/In alloying,particularly for the In-containing *** that,in addition to nanoscale Mg_(3)Bi_(2)phase,a new microscale Mg_(2)Bi_(2)Ca phase forms in the Ca-containing *** electrochemical test results demonstrate that Ca/In micro-alloying can enhance the electrochemical *** In to alloy the Mg-Bi-Sn-based alloy is effective in restricting the cathodic hydrogen evolution(CHE)kinetics,leading to a low self-corrosion rate,while severe CHE occurred after Ca *** micro-alloying of Ca/In to Mg-Bi-Sn-based alloy strongly deteriorates the compactness of discharge products film and mitigates the"chunk effect"(CE),hence the cell voltage,anodic efficiency as well as discharge capacity are greatly *** In-containing alloy exhibits outstanding discharge performance under the combined effect of the modified microstructure and discharge products,thus making it a potential anode material for primary Mg-air battery.

关键词： Mg-air batteries Mg-Bi-Sn based alloys Electrochemical behaviors Discharge properties

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某电机印制板组件用三防胶选用不当案例分析

电子质量 2024年第5期 75-80页

作者：刘子莲程航梁俊豪张莹洁徐焕翔顾家宝工业和信息化部电子第五研究所广东广州511370

三防胶质量的好坏直接影响印刷电路板组件的防护效果和产品的可靠性,因此,科学有效地选用合适的三防胶就显得尤为重要。从失效案例入手,首先,通过外观观察和SEM&EDS分析对三防胶的外观及元素成分进行了分析;随后,通过FT-IR分析、TGA分析... 详细信息

三防胶质量的好坏直接影响印刷电路板组件的防护效果和产品的可靠性,因此,科学有效地选用合适的三防胶就显得尤为重要。从失效案例入手,首先,通过外观观察和SEM&EDS分析对三防胶的外观及元素成分进行了分析;随后,通过FT-IR分析、TGA分析和DSC分析对三防胶的材质进行了分析;最后,通过离子色谱分析测试了三防胶的离子含量,深入分析了某产品印制板组件因三防胶引起短路打火导致电机失效的问题,并对电路板上三防胶的失效原因和机理进行了详细的阐述,同时提出了切实可行的解决方法与改善建议,对于三防胶的合理选用具有一定的参考意义。

关键词：印制板组件三防胶失效分析短路选用

基于国际原子能机构277和381报告对直线加速器双模式光子线和电子线输出量校准研究

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中国医学装备 2024年第1期21卷 29-33页

作者：景周陈幼芬程杭蔡佳彬张磊康德华余姚市人民医院放疗技术科宁波315400 浙江省肿瘤医院放射物理科杭州310022 中山大学肿瘤防治中心放疗科广州510060

目的:基于国际原子能机构(IAEA)TRS 277和TRS 381《高能电子束和光子束中使用平行电离室的国际剂量测定操作规范》报告,校准加速器配置的不同档能量射线水中的吸收剂量,确保临床放疗中直线加速器输出剂量的精确性。方法:采用Elekta Infi... 详细信息

目的:基于国际原子能机构(IAEA)TRS 277和TRS 381《高能电子束和光子束中使用平行电离室的国际剂量测定操作规范》报告,校准加速器配置的不同档能量射线水中的吸收剂量,确保临床放疗中直线加速器输出剂量的精确性。方法:采用Elekta Infinity直线加速器,光子线能量6 MV分别为均整(FF)模式和非均整(FFF)模式;电子线能量分别为4、6、8、10、12和15 MeV。根据IAEATRS277和TRS381报告,使用PTW剂量仪、PTW30013指型电离室和PTW34001平行板电离室分别进行光子线和电子线水中输出剂量的校准,对各步骤的误差进行分析,对比采用不同标准对直线加速器的输出量水中校准的准确性。结果:6 MV的FF模式和FFF模式光子线在水中最大剂量点处的输出量分别为1.003和1.008 cGy/MU;4、6、8、10、12和15 MeV的电子线每档能量在水中最大剂量点处的输出量分别为1.003、1.002、0.998、0.999、1.000和1.003 cGy/MU。每档能量的射线在水中最大剂量点处的输出量校准为1 MU对应1 cCy,误差<1%。结论:根据IAEA TRS277号和TRS381号报告对直线加速器的输出剂量在水中进行校准,可以保证直线加速器的输出剂量的准确性。

关键词：输出量校准国际原子能机构(IAEA)TRS277和TRS381报告电子线光子线均整模式非均整模式

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Study of Changing Features of Precipitation from 1900-2010 Years in Africa-Asia Arid and Semi-Arid Area

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Journal of Geoscience and Environment Protection 2017年第1期5卷 62-72页

作者： Xiangkun cheng hang cheng Guowu Sun Xiaomeng Shi Jinzhou District Meteorological Bureau of Dalian Dalian China Dalian Meteorological Bureau Dalian China Institute of Arid Meteorology China Meteorological Administration Lanzhou China Qingdao Meteorological Bureau Qingdao China

The relationship between time-space variation characteristics and the variation of the general atmospheric circulation of rainfall occurred in Asia, Africa through North Africa-Middle East-Western Middle Asia-Eastern Middle Asia, Northwest China-Eastern Northwest China-North China and Northeast China is studied based on the analysis of GPCC rainfall data from 1901 to 2010 and annual precipitation in relevant cities of China from 1901 to 2010, and the data of NCEP of surface pressure as well as 500 Hpa potential high from 1950 to 2010. The result shows that the total precipitation presents a decreasing trend in north Africa to the northeast of China in recent 100 years. It has a mutation in 1950s. The precipitation presented a decreasing trend in North Africa and Middle East, in recent 100 years;it presented a further decreasing trend after 1950s. It presented a decreasing trend before 1950s and an increasing trend after 1950s in Middle Asia and Northwest china. It also presented a decreasing trend before 1950s and an increasing trend between 1950s to 1990s, and decreased later in Eastern Northwest China, North China and Northeast China which also presented in a more or less period in different areas from North Africa to Northeast China. The beginning of less precipitation years and less period occurred after it presented less period in north Africa in time and space. After it moved to the east areas as the year past, at last, the SLPA fields which presented more or less precipitations of years from North Africa to Northeast China were analyzed. It also shows that the SLPA fields which presented more were beneficial to the precipitations and presented negative effects of precipitations in the polar, high and mid- and lower latitudes.

关键词： Asia-Africa Arid and Semi-Arid Region Rainfall above or below the Normal Precipitation Sea Lever Pressure Anomalies

Differential Innervation of Secretory Coils and Ducts in Human Eccrine Sweat Glands

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Chinese Medical Journal 2018年第16期131卷 1964-1968页

作者： Zhan Ouyang Hai-Hong Li Ming-Jun Zhang Si-Tian Xie Liu-hang-hang cheng Department of Burn and Plastic Surgery The Second Affiliated Hospital Shantou University Medical College Shantou Guangdong 515041 China

Background： Previous studies demonstrate that eccrine sweat glands are innervated by both cholinergic and adrenergic nerves. However, it is still unknown whether the secretory coils and ducts ofeccrine sweat glands are equally innervated by the sympathetic nerve fibers. To welt understand the mechanisms on sweat secretion and reabsorption, the differential innervation of secretory coils and ducts in human eccrine sweat glands was investigated in the study. Methods： From June 2016 to June 2017, six human skins were fixed, paraffin-embedded, and cut into 5 μm-thick sections, followed by costaining for nerve fiber markers protein gene product 9.5 （PGP 9.5）, tyrosine hydroxylase （TH） and vasoactive intestinal peptide （VIP）, and eccrine sweat gland markers K7, S100P, and K14 by combining standard immunofluorescence with tyramide signal amplification （IF-TSA）. Stained sections were observed under the microscope, photographed, and analyzed. Results： The fluorescent signals of PGP 9.5, TH, and VIP were easily visualized, by 1F-TSA, as circular patterns surrounding eccrine sweat glands, but only PGP 9.5 could be observed by standard IF. The IF-TSA method is more sensitivity than standard IF in detecting antigens expressed at low levels. PGP 9.5, TH, and VIP appeared primarily surrounding the secretory coils and sparsely surrounding the sweat ducts. Conclusion： Sweat secretion is mainly controlled by autonomic nerves whereas sweat reabsorption is less affected by nerve activity.

关键词： Duct Eccrine Sweat Glands Innervation Nerve Fibers Secretory Coil Tyramide Signal Amplification