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Energy-Efficient Framework for Virtual Machine Consolidation in Cloud Data Centers

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China Communications 2017年第10期14卷 192-201页

作者： Kejing He Zhibo Li Dongyan Deng yanhua chen School of Computer Science and Engineering South China University of Technology Guangzhou 510641 China

With the advent of the era of cloud computing, the high energy consumption of cloud computing data centers has become a prominent problem, and how to reduce the energy consumption of cloud computing data center and improve the efficiency of data center has become the research focus of researchers all the world. In a cloud environment, virtual machine consolidation(VMC) is an effective strategy that can improve the energy efficiency. However, at the same time, in the process of virtual machine consolidation, we need to deal with the tradeoff between energy consumption and excellent service performance to meet service level agreement(SLA). In this paper, we propose a new virtual machine consolidation framework for achieving better energy efficiency-Improved Underloaded Decision(IUD) algorithm and Minimum Average Utilization Difference(MAUD) algorithm. Finally, based on real workload data on Planet Lab, experiments have been done with the cloud simulation platform Cloud Sim. The experimental result shows that the proposed algorithm can reduce the energy consumption and SLA violation of data centers compared with existing algorithms, improving the energy efficiency of data centers.

关键词： cloud computing virtual machine consolidation energy efficiency virtual machine migration

Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment

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Genes & Diseases 2023年第6期10卷 2414-2424页

作者： Qianqian Zhou yanhua chen Ruolei Wang Fengjing Jia Feng He Fuwen Yuan Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China

The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in over 570 million infections and 6 million deaths worldwide. Early detection and quarantine are essential to arrest the spread of the highly contagious COVID-19. High-risk groups, such as older adults and individuals with comorbidities, can present severe symptoms, including pyrexia, pertussis, and acute respiratory distress syndrome, on SARS-CoV-2 infection that can prove fatal, demonstrating a clear need for high-throughput and sensitive platforms to detect and eliminate SARS-CoV-2. CRISPR-Cas13, an emerging CRISPR system targeting RNA with high specificity and efficiency, has recently drawn much attention for COVID-19 diagnosis and treatment. Here, we summarized the current research progress on CRISPR-Cas13 in COVID-19 diagnosis and treatment and highlight the challenges and future research directions of CRISPR-Cas13 for effectively counteracting COVID-19.

关键词： COVID-19 CRISPR-Cas13 Diagnosis SARS-CoV-2 Treatment

Brassinosteroids Mediate Endogenous Phytohormone Metabolism to Alleviate High Temperature Injury at Panicle Initiation Stage in Rice

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Rice science 2023年第1期30卷 70-86页

作者： chen yanhua WANG Yaliang chen Huizhe XIANG Jing ZHANG Yikai WANG Zhigang ZHU Defeng ZHANG Yuping National Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 310006China

High temperatures cause physiological and biochemical changes and significantly affect young panicle development of rice(Oryza sativa L.).Brassinosteroids play important roles in enhancing crop stress *** this study,we subjected rice cultivars Huanghuazhan(heat-resistant)and IR36(heat-sensitive)to high temperature(HT,40 oC)or normal temperature(NT,33 oC)for 7 d at the panicle initiation stage,in conjunction with application of 24-epibrassinolide[EBR,a synthetic brassinolide(BR)]or brassinazole(BRZ,a BR biosynthesis inhibitor)at the beginning of the *** exacerbated spikelet degeneration and inhibited young panicle growth,which were partially prevented by EBR application,while BRZ application aggravated the reduction in spikelet *** decreased the contents of BR,active cytokinins(aCTK),active gibberellins(aGA)and indole-3-acetic acid(IAA),but increased the content of abscisic acid(ABA)in young *** activities of key enzymes involved in sucrose hydrolysis,glycolysis and the tricarboxylic acid cycle in young panicles were decreased with the change of endogenous hormone levels under *** addition,the contents of H2O2 and malondialdehyde(MDA)were increased and the activities of antioxidant enzymes were decreased in young *** application of EBR induced the expression of phytohormone biosynthesis-related genes and down-regulated the expression of phytohormone catabolism-related genes to increase the contents of endogenous BR,aCTK,aGA and ABA,thus promoting the decomposition and utilization of sucrose in young panicles,enhancing the activities of superoxide dismutase,catalase and peroxidase,and reducing the accumulation of H2O2 and MDA in young panicles,whereas application of BRZ had the opposite physiological *** results showed that brassinosteroids mediate endogenous phytohormone metabolism to alleviate HT injury at the panicle initiation stage in rice.

关键词： rice high temperature panicle initiation stage phytohormone metabolism physiological and biochemical indices

Synthesis of hyperbranched copolymers by combining enzymatic ring-opening polymerization and ATRP from a novel bifunctional initiator

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Chinese Science Bulletin 2006年第22期51卷 2706-2709页

作者： AI Peng chen Liang HU Dehua chen yanhua LU Dongshuang ZHANG Bao SHA Ke WANG Jingyuan Alan G. MacDiarmid Institute of Jilin University Changchun 130012 China First Hospital of Jilin University Changchun 130021 China College of Chemistry Jilin University Changchun 130012 China

亢奋的分叉的脂肪族的聚酯 P (epsilon -CL) 借助于 BHB 的催化 Novozyme435 的戒指洞聚合(ROP ) 被综合(2， 2 二度(hydroxymethyl ) 奶油的酸) 。以 P ( epsilon-CL )的氢氧根结束的链被 esteriflcation ofa-bromopropionyl 溴化物... 详细信息

亢奋的分叉的脂肪族的聚酯 P (epsilon -CL) 借助于 BHB 的催化 Novozyme435 的戒指洞聚合(ROP ) 被综合(2， 2 二度(hydroxymethyl ) 奶油的酸) 。以 P ( epsilon-CL )的氢氧根结束的链被 esteriflcation ofa-bromopropionyl 溴化物修改获得亢奋的分叉的 difunctional 宏开始者，它在圣库克尔姆泰塔的 theATRP 被使用在 ATRP 的反应被用作催化剂系统 polystyrene-block-poly 获得 thehyperbranched 共聚物(2,2二度( hydroxymethyl )奶油的酸)。共聚物被 NMR 和 GPC 证实。

关键词： ATRP 酶开环聚合作用共聚物生物化学

The role of maize root size in phosphorus uptake and productivity of maize/faba bean and maize/wheat intercropping systems

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Science China(Life Sciences) 2012年第11期55卷 993-1001页

作者： ZHANG YiKai chen FanJun LI Long chen yanhua LIU BingRan ZHOU YuLing YUAN LiXing ZHANG FuSuo MI GuoHua Key Laboratory of Plant-Soil Interactions Ministry of EducationCenter for ResourcesEnvironment and Food SecurityCollege of Resources and Environmental ScienceChina Agricultural UniversityBeijing 100193China

Interspecific root/rhizosphere interactions affect phosphorus (P) uptake and the productivity of maize/faba bean and maize/wheat intercropping systems. The aim of these experiments was to determine whether manipulation of maize root growth could improve the productivity of the two intercropping systems. Two near isogenic maize hybrids (the larger-rooted T149 and smaller-rooted T222) were intercropped with faba bean and wheat, under conditions of high- and low-P availability. The larger-rooted T149 showed greater competitive ability than the smaller-rooted T222 in both maize/faba bean and maize/wheat intercropping systems. The higher competitive ability of T149 improved the productivity of the maize/faba bean intercropping system in P-sufficient conditions. In maize/wheat intercropping systems, root growth, shoot biomass, and P uptake of maize were inhibited by wheat, regardless of the P-supply. Compared with T222, the larger-rooted T149 suffered less in the intercropping systems. The total biomass of the maize/wheat intercropping system was higher for wheat/T149 than for wheat/T222 under low-P conditions. These data suggested that genetic improvement of maize root size could enhance maize growth and its ability to compete for P resources in maize/faba bean and maize/wheat intercropping systems. In addition, depending on the P availability, larger maize roots could increase the productivity of intercropping systems.

关键词： faba bean intercropping maize phosphorus uptake root growth wheat

Decrement of Sugar Consumption in Rice Young Panicle Under High Temperature Aggravates Spikelet Number Reduction

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Rice science 2020年第1期27卷 44-55页

作者： WANG Yaliang ZHANG Yikai SHI Qinghua chen Huizhe XIANG Jing HU Guohui chen yanhua WANG Xiaodan WANG Junke YI Zihao ZHU Defeng ZHANG Yuping China National Rice Research Institute/State Key Laboratory of Rice Biology Hangzhou 310006China College of Agronomy Jiangxi Agricultural University/Key Laboratory of Crop PhysiologyEcology and Genetics BreedingMinistry of EducationNanchang 330045China

Two rice genotypes Huanghuazhan(HHZ, heat-resistant) and IR36(heat-susceptible) were subjected to high-temperature(HT, 40℃) and normal-temperature(NT, 32℃) treatments at the spikelet differentiation stage. HT treatment inhibited spikelet differentiation, aggravated spikelet degeneration, reduced spikelet size, and disordered carbohydrate allocation. Meanwhile, HT treatment increased nonstructural carbohydrate content in leaves, but decreased that in stems and young panicles, and the same tendencies of sucrose and starch contents were observed in leaves and stem. However, HT treatment significantly increased the sucrose content and sharply decreased the glucose and fructose contents in young panicles. Lower activity levels of soluble acid invertase(EC3.***.1.26) and sucrose synthase(EC2.***.1.13) were observed under HT treatment. Moreover, HT treatment reduced the activities of key enzymes associated with glycolysis and the tricarboxylic acid cycle, which indicated sucrose consumption was inhibited in young panicles under HT treatment. Exogenous glucose and fructose applied under HT treatment increased the spikelet number more than exogenous sucrose. In conclusion, the results demonstrated that the reduction of spikelet number under high temperature was more affected by the decrease in sugar consumption than the blocking of sucrose transport. The impairment of sucrose hydrolysis was the main reason for the inhibition of sugar utilization.

关键词： rice high temperature panicle development spikelet number carbohydrate allocation sugar consumption

Identification of A Novel SBF2 Frameshift Mutation in Charcot–Marie–Tooth Disease Type 4B2 Using Whole-exome Sequencing

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Genomics, Proteomics & Bioinformatics 2014年第5期12卷 221-227页

作者： Meiyan chen Jing Wu Ning Liang Lihui Tang yanhua chen Huishuang chen Wei Wei Tianying Wei Hui Huang Xin Yi Ming Qi BGI-Shenzhen School of Life Sciences The Chinese University of Hong Kong NT Center for Genetic and Genomic Medicine Zhejiang University School of Medicine First Affiliated Hospital and James D. Watson Institute of Genome Sciences Department of Pathology University of Rochester Medical Center

Abstract Charcot-Marie-Tooth disease type 4B2 with early-onset glaucoma （CMT4B2, OMIM 604563） is a genetically-heterogeneous childhood-onset neuromuscular disorder. Here, we report the case of a 15-year-old male adolescent with lower extremity weakness, gait abnormalities, foot deformities and early-onset glaucoma. Since clinical diagnosis alone was insufficient for providing pathogenetic evidence to indicate that the condition belonged to a consanguineous family, we applied whole-exome sequencing to samples from the patient, his parents and his younger brother, assuming that the patient＇s condition is transmitted in an autosomal recessive pattern. A frame-shift mutation, c.4571delG （***1524Glufs＊42）, was revealed in the CMT4B2-related gene SBF2 （also known as MTMR13, MIM 607697）, and this mutation was found to be homozygous in the proband and heterozygous in his parents and younger brother. Together with the results of clinical diagnosis, this case was diagnosed as CMT4B2. Our finding further demonstrates the use of whole-exome sequencing in the diagnosis and treatment of rare diseases.

关键词： Whole-exome sequencing Charcot-Marie--Toothdisease Early-onset glaucoma SBF2

Exploring the Role of Narrative Medicine in the Cultivation of Humanistic Spirit among Respiratory Medicine Interns

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Journal of Clinical and Nursing Research 2024年第10期8卷 250-255页

作者： yanhua chen Bing Zhang Hao Ming Department of Respiratory and Critical Care Medicine The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou 225300Jiangsu ProvinceChina

Objective:To explore the role of narrative medicine in cultivating the humanistic spirit of respiratory medicine ***:Thirty interns were selected,all of whom were received by the respiratory department of our hospital from September 2023 to June 2024 and underwent narrative medicine *** on narrative medicine knowledge,empathy ability,humanistic care ability,and teaching recognition were compared before and after the ***:Compared to before the internship,the interns’scores on narrative medicine knowledge were significantly higher after the internship,as were their empathy and humanistic care scores(P<0.05).Among the 30 interns,25 expressed interest in narrative medicine,and 29 were willing to continue with the narrative medicine teaching ***:The application of narrative medicine in respiratory medicine internship teaching is highly *** cultivates the humanistic spirit of interns,improves their empathy and humanistic care abilities,and is worthy of wider implementation.

关键词： Narrative medicine Respiratory medicine Interns Cultivation of humanistic spirit

Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging

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Acta Pharmaceutica Sinica B 2021年第11期11卷 3665-3677页

作者： Zhonghua Wang Wenqing Fu Meiling Huo Bingshu He Yaqi Liu Lu Tian Wanfang Li Zhi Zhou Baili Wang Jianzhen Xia yanhua chen Jinfeng Wei Zeper Abliz Key Laboratory of Mass Spectrometry Imaging and Metabolomics(Minzu University of China) National Ethnic Affairs CommissionBeijing 100081China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China New Drug Safety Evaluation Center Institute of Materia MedicaPeking Union Medical CollegeBeijing 100050China School Hospital Minzu University of ChinaBeijing 100081China Key Laboratory of Ethnomedicine of Ministry of Education School of PharmacyMinzu University of ChinaBeijing 100081China

Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy(DN)is vital for more accurate understanding the molecular pathological signature and developing novel therapeutic *** the present study,a spatial-resolved metabolomics approach based on air flowassisted desorption electrospray ionization(AFADESI)and matrix-assisted laser desorption ionization(MALDI)integrated mass spectrometry imaging(MSI)was proposed to investigate tissue-specific metabolic alterations in the kidneys of high-fat diet-fed and streptozotocin(STZ)-treated DN rats and the therapeutic effect of astragalosideⅣ,a potential anti-diabetic drug,against *** a result,a wide range of functional metabolites including sugars,amino acids,nucleotides and their derivatives,fatty acids,phospholipids,sphingolipids,glycerides,carnitine and its derivatives,vitamins,peptides,and metal ions associated with DN were identified and their unique distribution patterns in the rat kidney were visualized with high chemical specificity and high spatial *** region-specific metabolic disturbances were ameliorated by repeated oral administration of astragaloside Ⅳ(100 mg/kg)for 12 *** study provided more comprehensive and detailed information about the tissue-specific metabolic reprogramming and molecular pathological signature in the kidney of diabetic *** findings highlighted the promising potential of AFADESI and MALDI integrated MSI based metabolomics approach for application in metabolic kidney diseases.

关键词： Spatial-resolved metabolomics Mass spectrometry imaging Diabetic nephropathy Metabolic reprogramming AstragalosideⅣ