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危险化学品全生命周期管理的研究

广州化工 2024年第6期52卷 226-228页

作者：江欣欣陈燕清谢雅丽广东石油化工学院实验室与设备管理处广东茂名525000

在化工类高校的实验室危化品安全管理方面进行积极探索和实践做总结,如何更好地开展高校实验室管制类危化品全生命周期的管理工作,通过物联网、互联网、云计算、大数据分析和二维码等信息技术,对化学品全生命周期进行智能管控,解决实验... 详细信息

在化工类高校的实验室危化品安全管理方面进行积极探索和实践做总结,如何更好地开展高校实验室管制类危化品全生命周期的管理工作,通过物联网、互联网、云计算、大数据分析和二维码等信息技术,对化学品全生命周期进行智能管控,解决实验室危化品管控问题,实现了对管制类化学品的入库、出库、使用、处置等环节全流程的实时管控,药品数据库信息的实时更新。

关键词：危化品管理化学品全生命周期管理实验室安全管理

经阴道三维超声联合超声弹性成像在多囊卵巢综合征诊断中的应用价值

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川北医学院学报 2024年第7期39卷 957-959,973页

作者：陈艳青张松秦颢诚于明徐州医科大学附属连云港医院超声科江苏连云港222000 连云港市妇幼保健院超声医学科江苏连云港222000

目的:探讨经阴道三维超声(3D-TVS)联合超声弹性成像(UE)在多囊卵巢综合征(PCOS)诊断中的应用价值。方法:选取106例PCOS患者为研究组;同期106名体检健康女性为对照组,均于月经周期第7天行3D-TVS联合UE检查。比较两组对象卵泡数量及大小... 详细信息

目的:探讨经阴道三维超声(3D-TVS)联合超声弹性成像(UE)在多囊卵巢综合征(PCOS)诊断中的应用价值。方法:选取106例PCOS患者为研究组;同期106名体检健康女性为对照组,均于月经周期第7天行3D-TVS联合UE检查。比较两组对象卵泡数量及大小、卵巢体积、最大峰值血流速度、舒张末期血流速度和阻力指数;Logistic回归分析影响PCOS发生的因素;ROC曲线分析3D-TVS联合UE检查各参数对PCOS的诊断价值。结果:与对照组相比,研究组患者阻力指数更小,其他卵巢形态学及血流动力学参数更大,差异均有统计学意义(P<0.05)。回归分析显示,卵泡数量、卵巢体积、最大峰值血流速度和舒张末期血流速度过大均是PCOS发生的影响因素(P<0.05)。ROC曲线分析结果显示,卵泡数量(AUC=0.764)、卵巢体积(AUC=0.782)、最大峰值血流速度(AUC=0.693)和舒张末期血流速度(AUC=0.754)对PCOS均具有诊断价值,且联合检测(AUC=0.849)的诊断价值更高(P<0.05)。结论:月经周期第7天,3D-TVS联合UE检查的卵泡数量、卵巢体积、最大峰值血流速度和舒张末期血流速度水平对PCOS患者诊断有良好价值。

关键词：经阴道三维超声超声弹性成像多囊卵巢综合征联合检测

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Model Parameters Identification and Backstepping Control of Lower Limb Exoskeleton Based on Enhanced Whale Algorithm

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 100-114页

作者： yan Shi Jiange Kou Zhenlei chen Yixuan Wang qing Guo School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Aeronautics and Astronautics University of Electronic Science and Technology of ChinaChengdu 611731China

Exoskeletons generally require accurate dynamic models to design the model-based controller conveniently under the human-robot interaction ***,due to unknown model parameters such as the mass,moment of inertia and mechanical size,the dynamic model of exoskeletons is difficult to ***,an enhanced whale optimization algorithm(EWOA)is proposed to identify the exoskeleton model ***,the periodic excitation trajectories are designed by finite Fourier series to input the desired position demand of exoskeletons with mechanical physical *** a backstepping controller based on the identified model is adopted to improve the human-robot wearable comfortable performance under cooperative ***,the proposed Model parameters identification and control are verified by a two-DOF exoskeletons *** knee joint motion achieves a steady-state response after 0.5 ***,the position error of hip joint response is less than 0.03 rad after 0.9 *** addition,the steady-state human-robot interaction torque of the two joints is constrained within 15 N·*** research proposes a whale optimization algorithm to optimize the excitation trajectory and identify model ***,an enhanced mutation strategy is adopted to avoid whale evolution’s unsatisfactory local optimal value.

关键词： Parameter identification Enhanced whale optimization algorithm(EWOA) Backstepping Human-robot interaction Lower limb exoskeleton

Feasibility of using 6F angiographic catheters for primary percutaneous coronary intervention in patients with acute myocardial infarction

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Chinese Medical Journal 2010年第10期123卷 1345-1346页

作者： chen yan-qing HOU Lei WEI Yi-dong LI Wei-ming XU Ya-wei Department of Emergency Tenth People's Hospital Tongji University Shanghai 200072 China Tenth People's Hospital Tongji University Shanghai 200072 China Department of Cardiology

The transradial access has been used for percutaneous coronary intervention （PCI） for more than 10 years. Many studies have confirmed several advantages of a radial route over the traditional transfemoral approach, some of which include a decreased incidence of access site complications, an earlier ambulation after the procedure which helps make patients more comfortable after the procedure.4-SHowever, the radial artery is easier to spasm as it is smaller than the femoral artery. This kind of phenomenon often happens when shifting from angiographic catheters to guiding catheters.

关键词： transradial percutaneous coronary intervention acute myocardial infarction

Initial experience with circumferential pulmonary vein isolation guided~ by Overlay Ref and CartoMerge in the treatment of paroxysmal atrial fibrillation

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Chinese Medical Journal 2010年第10期123卷 1269-1272页

作者： TANG Kai ZHAO Dong-dong ZHANG Jing-ying chen yan-qing XU Ya-wei Department of Cardiology Shanghai Tenth People's Hospital Tong Ji University Shanghai 200072 China

Background CartoMerge has been widely used in guiding circumferential pulmonary vein isolation （CPVI） for the treatment of paroxysmal atrial fibrillation （PAF）. However, the procedure of landmarks selection varies among operators according to their experience. Techniques have to be established to standardize this procedure. We propose that Overlay Ref could facilitate this procedure. This paper aimed to report our initial experience with CPVI guided by Overlay Ref and CartoMerge for the treatment of PAF. Methods Fifty-nine patients with PAF were enrolled in this study. Using Overlay Ref technique, a reference image （inverted） was faded into the live fluoroscopic image. Landmarks of CartoMerge were selected from anatomic points of the top of superior pulmonary veins （PVs） and the bottom of inferior PVs guided by Overlay Ref image. Overlay Ref images were also used to guide the ablation procedure combining with CartoMerge. Results All patients were successfully mapped by CartoMerge guided by Overlay Ref. The distance between the mapping points and the CT surfaces was （1.42±0.67） mm for the patients as a whole. This led to a successful rate of 96% for isolation of pulmonary veins. Duration of ablation procedure was （92±17） minutes. And the total duration of procedure was （139±32） minutes. CartoMerge could also be performed just with 3 paries to 4 paries selected landmarks guided by Overlay Ref without a full anatomic model constructed by Carto. Then, the total duration of procedure could be shortened to （115±38） minutes. Conclusions Overlay Ref technique can facilitate the catheter ablation of PAF and can help to standardize the procedure of landmarks selection.

关键词： circumferential pulmonary vein isolation Overlay Ref technique computed tomography three-dimensional electroanatomic mapping atrial fibrillation

Diazoxide preconditioning plus subsequent hypothermia increased resistance of rat cultured hippocampal neurons against hypoxia-reoxygenation injury

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Chinese Medical Journal 2006年第11期119卷 887-893页

作者： LIU Rong-guo WANG Wei-jian S0NG Na chen yan-qing LI Li-huan Department of Anesthesiology Fujian Provincial Hospital Fuzhou 350001 China Department of Anesthesiology First Affiliated Hospital of Wenzhou Medical College Wenzhou 325000China Department of Anesthesiology Cardiovascular Institute Fuwai Hospital Peking Union Medical college and Chinese Academy of Medical Sciences Beijing 100037 China

Background Cerebral ischemia-reperfusion/hypoxia-reoxygenation insult triggers lots of pathophysiological and biochemical events that separately affect the evolution of cerebral damage. Accordingly, all known effective neuroprotective measures should be taken to get the optimal efficacy of therapy. This study was undertaken to investigate whether diazoxide （DZ） preconditioning combined with the following hypothermia could contribute to synergistic neuroprotection compared with either hypothermia or DZ preconditioning alone. Methods Cultured for 9-10 days in vitro, the hippocampal neurons of SD rats were preconditioned with DZ 0 pmol/L or DZ 250 pmol/L for 1 hour per day and this treatment lasted for 3 days. Subsequently, neurons were subjected to deprivation of oxygen for 4 hours at 37°0, 34°C, 30℃ and 22℃, respectively. This experiment consisted of 8 groups （4 temperature groups and 4 combination groups） and each group contained 12-well or 2-dish cells. Survival rate, expression of Bcl-2, fluorescence magnitude of intracellular calcium, and concentration of malondialdehyde （MDA） were determined at 24 hours after reoxygenation. Results The survival rate and expression of Bcl-2 were both increased in individually hypothermic conditions compared with those at 370G （P〈0.05）, whereas intracellular calcium and MDA did the opposite exhibition simultaneously （P〈0.05）. 22℃ contributed to a higher survival rate and greater expression of Bcl-2 in comparison with other hypothermia （P〈0.05）. Preceding administration of 250 pmol/L DZ took the similar effects on the neurons like hypothermia. Moreover, compared with individual hypothermia or DZ preconditioning, the neuronal survival rate and expression of Bcl-2 in the combination group were increased significantly （P〈0.05）, whereas the calcium fluorescence density and concentration of MDA were reduced further （P〈0.05）. 250 Iamol/L DZ preconditioning combined with 22℃ provided a maximal neuroprotection. Conclusions Compared with ei

关键词： diazoxide hypothermia proto-oncogene protein c-bcl-2 calcium malondialdehyde

Flexible assistance strategy of lower limb rehabilitation exoskeleton based on admittance model

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Science China(Technological Sciences) 2024年第3期67卷 823-834页

作者： KOU JianGe WANG YiXuan chen ZhenLei SHI yan GUO qing XU Meng School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Aeronautics and Astronautics University of Electronic Science and Technology of ChinaChengdu 611731China Department of Musculoskeletal Tumor Senior Department of Orthopedicsthe Fourth Medical Centerof PLA GeneralHospitalBeijing 100853China

Exercise training based on exoskeleton is an effective rehabilitation method for stroke patients. However, some rehabilitation exoskeletons still have poor wearable performance and obvious human-robot impedance during training, which easily cause secondary injuries to the patients. In this study, a variable admittance control strategy is proposed to improve the operator's wearable comfort, which can adapt to different operators by regulating admittance parameters. The admittance controller has two feedback loops: the position inner-loop and the admittance outer-loop. Meanwhile, the exoskeleton Lagrange model is constructed with unknown friction disturbance. By using Lyapunov technique and backstepping with state observer, the joint position error of exoskeleton is convergence into a zero neighborhood. The effectiveness of the proposed admittance controller is verified by both simulation and experiment. The tracking error of hip and knee joint is less than 4 degrees while the human-robot interaction torque is constrained in a tolerable range of the operator.

关键词： human-robot interaction exoskeleton backstepping admittance control

Screening of Serum Biomarkers for Distinguishing between Latent and Active Tuberculosis Using Proteome Microarray

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Biomedical and Environmental Sciences 2018年第7期31卷 515-526页

作者： CAO Shu Hui chen yan qing SUN Yong LIU yang ZHENG Su Hua ZHANG Zhi Guo LI Chuan You Department of Bacteriology and Immunology Beijing Key Laboratory on Drug-Resistant Tuberculosis Research Beijing Tuberculosis and Thoracic Tumor Research Institute/Beijing Chest Hospital Capital Medical University. Beijing 101149 China Department of Laboratory Center Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing 100045 China Department of Clinical Laboratory Beijing Tuberculosis and Thoracic Tumour Research Institute/Beijing Chest Hospital Capital Medical University Beijing 101149 China Department of Epidemiological Research Beijing Tuberculosis and Thoracic Tumour Research lnstitute/Beijing Chest Hospital Capital Medical University Beijing 101149 China Institute of Tuberculosis Prevention and Control of District Changping Beijing 102200 China

Objective To identify potential serum biomarkers for distinguishing between latent tuberculosis infection（LTBI） and active tuberculosis（TB）. Methods A proteome microarray containing 4,262 antigens was used for screening serum biomarkers of 40 serum samples from patients with LTBI and active TB at the systems level. The interaction network and functional classification of differentially expressed antigens were analyzed using STRING 10.0 and the TB database, respectively. Enzyme-linked immunosorbent assays（ELISA） were used to validate candidate antigens further using 279 samples. The diagnostic performances of candidate antigens were evaluated by receiver operating characteristic curve（ROC） analysis. Both antigen combination and logistic regression analysis were used to improve diagnostic ability. Results Microarray results showed that levels of 152 Mycobacterium tuberculosis（Mtb）-antigenspecific IgG were significantly higher in active TB patients than in LTBI patients（P 〈 0.05）, and these differentially expressed antigens showed stronger associations with each other and were involved in various biological processes. Eleven candidate antigens were further validated using ELISA and showed consistent results in microarray analysis. ROC analysis showed that antigens Rv2031 c, Rv1408, and Rv2421 c had higher areas under the curve（AUCs） of 0.8520, 0.8152, and 0.7970, respectively. In addition, both antigen combination and logistic regression analysis improved the diagnostic ability. Conclusion Several antigens have the potential to serve as serum biomarkers for discrimination between LTBI and active TB.

关键词： LTBI Active TB Proteome microarray Serum biomarkers

Cobalt-loaded carbon nanotubes boosted aerobic ciprofloxacin transformation driven by sulfide:A comprehensive mechanism investigation

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Chinese Chemical Letters 2024年第3期35卷 127-134页

作者： Han-qing Zhao Peili Lu Fei chen chen-Xuan Li Rui yan yang Mu State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China CAS Key Laboratory of Urban Pollutant Conversion Department of Environmental Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment College of Environment and EcologyChongqing UniversityChongqing 400045China College of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China

Sulfide oxidation under aerobic conditions can produce active oxygen for the transformation of organic pollutants in aquatic ***,the catalytic performance of transition metal-supported carbon material on this process is poor *** study found that Co-loaded carbon nanotubes(CNTs)was able to realize the efficient aerobic transformation of antibiotic ciprofloxacin(CIP)by sulfide,with the pseudo-first order reaction rate constant improved from 0.013 h^(-1)without catalyst to 0.44–0.71 h^(-1)with 100 mg/L Co-loaded *** oxygen(^(1)O_(2))was the main active specie playing key roles in the process of CIP aerobic transformation with presence of Co-loaded *** studies indicated that the excellent electron transfer ability of Co-loaded CNTs might play an important role to promote the electron transfer and facilitate the formation of intermediate H_(2)O_(2)and^(1)O_(2).Additionally,the Co-loaded CNTs/sulfide system effectively reduced the acute toxicity of organic pollutant,and Co-loaded CNTs showed remarkable cycling stability and negligible *** study gives a better understanding for the Co-loaded CNTs mediated aerobic antibiotics transformation by sulfide,and provide a reference for the application of Co-loaded carbon materials on organics aerobic transformation by sulfide.

关键词： Ciprofloxacin Aerobic transformation Co-loaded carbon nanotubes Sulfide Singlet oxygen