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非结核分枝杆菌病临床特征及临床分离株的菌种分布及耐药性

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中华医院感染学杂志 2024年第1期34卷 41-44页

作者：储美萍钱静娟程亮毛昕妍郭丹丹无锡市第五人民医院呼吸与危重症科江苏无锡214007 无锡市第五人民医院感染管理科江苏无锡214007 江南大学医学系江苏无锡214000 东北塘街道社区卫生服务中心呼吸科江苏无锡214000

目的探讨非结核分枝杆菌病患者临床特征及临床分离株菌种分布和耐药情况。方法回顾性选取2020年5月-2023年2月无锡市第五人民医院收治的104例非结核分枝杆菌病患者为研究对象,分析患者基本情况、临床特征及临床分离株菌种分布和耐药情... 详细信息

目的探讨非结核分枝杆菌病患者临床特征及临床分离株菌种分布和耐药情况。方法回顾性选取2020年5月-2023年2月无锡市第五人民医院收治的104例非结核分枝杆菌病患者为研究对象,分析患者基本情况、临床特征及临床分离株菌种分布和耐药情况。结果非结核分枝杆菌病患者咳嗽咳痰、发热占比较高,分别为77.88%、27.88%;伴有肺气肿、支气管扩张占比较高,分别为31.73%、23.08%;有斑片结条索、支气管扩张改变、空洞占比较高,分别为100.00%、81.73%、51.92%;104株非结核分枝杆菌临床分离菌株中胞内分枝杆菌、龟脓肿分枝杆菌、鸟分枝杆菌及堪萨斯分枝杆菌的占比较高,分别为44.23%、25.00%、12.50%及10.58%;主要非结核分枝杆菌对异烟肼、链霉素、阿米卡星和对氨基水杨酸的耐药率均为100.00%。结论临床可通过病原菌培养、临床症状、合并症及影像学特征等对非结核分枝杆菌病及时诊断,且非结核分枝杆菌中胞内分枝杆菌、龟脓肿分枝杆菌、鸟分枝杆菌及堪萨斯分枝杆菌占比较高,临床可根据药敏结果及时给予针对性的抗菌治疗。

关键词：非结核分枝杆菌分布非结核分枝杆菌病临床特征耐药性

Significantly enhanced charge transfer efficiency and surface reaction on NiP_(2)/g-C_(3)N_(4) heterojunction for photocatalytic hydrogen evolution

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Chinese Journal of Chemical Engineering 2022年第3期35卷 31-39页

作者： Xiaoqing yan Hua An Zihao chen Guidong yang XJTU-Oxford International Joint Laboratory for Catalysis School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an 710049China

In this work,a novel NiP_(2)/g-C_(3)N_(4)heterojunction via homogeneous precipitation method assisted by thermal phosphorization reaction was designed and constructed,and the optimized sample showed the excellent photocatalytic H_(2)evolution activity under visible-light irradiation,which was nearly 112 times higher than that of pristine g-C_(3)N_(4)*** characterizations and DFT calculations demonstrated that the NiP_(2)nanoparticles covered on the g-C_(3)N_(4)surface can form a built-in electric field at the interface to accelerate the transfer of photoexcited electrons from g-C_(3)N_(4)to NiP_(2),crucial for hindering the recombination of electron-hole ***,the energy barrier of hydrogen evolution reaction can also vastly reduce when combined NiP_(2)and g-C_(3)N_(4)to construct NiP_(2)/g-C_(3)N_(4)*** work represents a method through combing experimental and theoretical tools to thoroughly investigate the mechanism of photocatalytic process.

关键词： Carbon neutrality Charge transfer Internal electric field Photocatalytic H_(2)generation

利用TALEN技术创建RPE65基因编辑犬

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农业生物技术学报 2024年第6期32卷 1452-1461页

作者：徐铮李振诚赖威仲许博钱雨玉陈晨王晶张勇冯冲魏彦明甘肃农业大学动物医学院甘肃省动物生殖生理及繁殖调控重点实验室苏州启辰生物科技有限公司

视网膜色素上皮65 (retinal pigment epithelium 65, RPE65)基因在视循环中起重要作用，当RPE65基因发生突变时，视锥、视杆细胞功能丧失，严重的患者会视力丧失。为构建RPE65基因突变动物疾病模型，本研究利用转录激活因子样效应物核酸... 详细信息

视网膜色素上皮65 (retinal pigment epithelium 65, RPE65)基因在视循环中起重要作用，当RPE65基因发生突变时，视锥、视杆细胞功能丧失，严重的患者会视力丧失。为构建RPE65基因突变动物疾病模型，本研究利用转录激活因子样效应物核酸酶(transcription activator-like effector nucleases,TALENs)基因编辑技术，以比格犬(Canis lupus familiaris)为实验动物，针对RPE65基因第3号和第7号外显子构建表达载体，结合显微操作创建RPE65基因编辑犬。通过临床观察、常规眼科检查、眼底照相(fundus photography, FP)、光学相干断层扫描(optical coherence tomography, OCT)和全视野视网膜电图(electroretinography, ERG)对幼犬视功能进行表型分析检测。T7E1酶切和基因测序结果显示，最终获得2只RPE65基因编辑雄性幼犬。眼科表型分析表明，RPE65基因编辑幼犬眼底血管稀疏纤细；ERG结果显示，光感受器细胞的电位活动a波、b波振幅降低，峰时延长，提示视网膜功能受损。本研究利用TALEN基因编辑技术构建的RPE65基因编辑幼犬存在视功能障碍，可为RPE65基因突变诱导的视网膜疾病及相关研究提供参考，还为治疗手段的开发、临床药物的筛选提供良好的动物疾病模型。

关键词：比格犬转录激活因子样效应物核酸酶(TALEN) 视网膜色素上皮65(RPE65) 基因编辑视网膜

Allyl-containing Poly(aryl ether sulfone): Synthesis and Crosslinking

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Chemical Research in Chinese Universities 2011年第3期27卷 520-523页

作者： YU Yun-wu XING yan GUO mei-mei LIU Bai-jun JIANG Zhen-hua Alan G. MacDiarmid Institute College of Chemistry JiJin University Changehun 130012 R R. China

A novel type of crosslinkable poly（aryl ether sulfone）（PAES） bearing an allyl pendant（PES-OAllyl） was synthesized by a grafting reaction of hydrophenyl-containing PAES（PES-OH） and allyl bromide. PES-OH was prepared by a demethylation reaction of a methoxyphenylated PAES（PES-OCH3） in the presence of pyridine/hydrochlo- ride. The PES-OCH3 was synthesized by an aromatic nucleophilic substitution of bis（4-chlorophenyl）sulfone and （p-methoxy）phenylhydroquinone. Both DSC and solubility investigation were used to study the crosslinking behavior of PES-OAllyl. After heat treatment, the glass transition temperature（Tg） value of PES-OAllyl sharply increased from 165 ℃ to 227 ℃. Meanwhile, PES-OAllyl changed from a soluble polymer to an insoluble thermoset. In addition, TGA（thermogravimetric analysis） result suggests that the thermal stability of the crosslinked product was improved. All the data prove that the crosslinked PES-OAllyl could be a potential solvent-resistance high-performance material.

关键词： Crosslinkable Grafting reaction Poly(aryl ether sulfone)

不同饲料对星康吉鳗幼鱼生长、体成分和消化酶活性的影响

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大连海洋大学学报 2024年第3期39卷 420-428页

作者：杨浩史宝王成刚张代强李静赵新宇晏科文陈彦中国水产科学研究院黄海水产研究所海水养殖生物育种与可持续产出全国重点实验室农业农村部海洋渔业与可持续发展重点实验室崂山实验室海洋渔业科学与食物产出过程功能实验室山东青岛266071 内蒙古民族大学动物科学技术学院内蒙古通辽028000 海阳市黄海水产有限公司山东烟台265100

为了研制星康吉鳗(Conger myriaster)配合饲料,进行了不同饲料对星康吉鳗(体质量为53.98 g±1.23 g)生长性能、体成分和消化酶活性的影响试验,设置日本鳗鲡(Anguilla japonica)配合饲料处理组(饲料1,添加了3%虾糠和14%鱼粉)、日本鳗鲡... 详细信息

为了研制星康吉鳗(Conger myriaster)配合饲料,进行了不同饲料对星康吉鳗(体质量为53.98 g±1.23 g)生长性能、体成分和消化酶活性的影响试验,设置日本鳗鲡(Anguilla japonica)配合饲料处理组(饲料1,添加了3%虾糠和14%鱼粉)、日本鳗鲡配合饲料(饲料2)、玉筋鱼(Ammodytes personatus)(饲料3)、方氏云鳚(Enedras fangi)(饲料4)、玉筋鱼+方氏云鳚混合料(饲料5)5种试验饲料组,每种饲料组设置3个平行,每个平行放置26尾鱼,养殖试验共进行40 d。结果表明:饲料1、2组星康吉鳗的特定生长率与增重率显著低于饲料3、5组(P<0.05),饲料系数显著高于饲料3、4、5组(P<0.05),干物质及粗蛋白质、粗脂肪表观消化率也显著低于饲料3、4、5组(P<0.05);随着饲料中粗脂肪、总糖水平的升高,鱼体的粗脂肪、总糖含量呈上升趋势,其中,饲料1、2组的鱼体粗脂肪含量显著低于饲料3、5组(P<0.05),总糖含量显著高于饲料4、5组(P<0.05);饲料1、2组星康吉鳗胃、前肠、中肠和后肠的胰蛋白酶活性显著低于饲料4组(P<0.05),前肠和中肠的脂肪酶活性显著低于饲料3、5组(P<0.05),胃、前肠、中肠和后肠的淀粉酶活性显著高于饲料3、4、5组(P<0.05)。研究表明,饲喂玉筋鱼、方氏云鳚、玉筋鱼+方氏云鳚混合料组的星康吉鳗,其生长性能、饲料系数、饲料表观消化率(干物质、粗蛋白质、粗脂肪),以及胰蛋白酶和脂肪酶活性均优于饲喂日本鳗鲡配合饲料处理组和日本鳗鲡配合饲料组,其中饲喂玉筋鱼组的投喂效果最佳,建议参考玉筋鱼的营养成分组成,开发星康吉鳗的商品饲料配方。

关键词：星康吉鳗不同饲料营养成分生长性能消化酶活性

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A one-pot stereoselective synthesis of 1,4-dienyl selenides by hydrostannylation-Stille tandem reaction of acetylenic selenides with Bu_3SnH and allylic bromides

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Chinese Chemical Letters 2008年第9期19卷 1047-1050页

作者： La mei Yu Wen yan Hao Ming Zhong Cai Department of Chemistry Jiangxi Normal University Nanchang 330022 China

1,4-Dienyl selenides can be stereoselectively synthesized in one pot under mild conditions in good yields by the palladiumcatalyzed hydrostannylation of acetylenic selenides, followed by Stille coupling with allylic b... 详细信息

关键词： Acetylenic selenide Hydrostannylation Stille coupling 1,4-Dienyl selenide Stereoselective synthesis

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桂枝饮片质量评价和分级标准探讨

中国中药杂志 2024年第11期49卷 2920-2929页

作者：谢彬李龙妹陈蒙关宇欧阳罗丹葛菲肖苏萍徐艳琴孙马马杜杰王继永江西中医药大学药学院江西南昌330004 中国中药有限公司北京100195 北京大学未来技术学院北京100871 北京城市学院北京100094 国药集团北京华邈药业有限公司北京102600

探究桂枝饮片外观性状与内在成分之间的关联,以期为桂枝饮片质量评价和等级标准制定提供参考依据。测定核心产区广西和广东两地41批桂枝饮片外观性状和指标成分含量,并建立其HPLC特征图谱方法。以饮片质量、横切面最窄直径和横切面最宽... 详细信息

探究桂枝饮片外观性状与内在成分之间的关联,以期为桂枝饮片质量评价和等级标准制定提供参考依据。测定核心产区广西和广东两地41批桂枝饮片外观性状和指标成分含量,并建立其HPLC特征图谱方法。以饮片质量、横切面最窄直径和横切面最宽直径为外观性状指标;运用已建立的含量测定方法测定指标成分(肉桂酸和桂皮醛)含量;特征图谱测定采用Waters XBridgeC_(18)色谱柱(4.6 mm×250 mm,5μm),流动相为0.1%磷酸水-乙腈,梯度洗脱,流速1 mL·min^(-1),柱温30℃,检测波长254nm。采用聚类分析和主成分分析等化学计量学手段,对饮片外观性状和指标/特征成分进行相关性分析,比较不同批次和产地桂枝饮片质量差异。结果表明桂枝饮片质量、横切面最窄直径和横切面最宽直径越大,各主要指标/特征成分含量越低,且不同成分之间具有协同降低趋势。广西和广东两地桂枝饮片整体质量相近,但不同产地之间、同产地不同批次间仍存在差异。基于外观性状和指标/特征成分,对桂枝饮片进行质量评价和分级标准制定科学可行,研究为桂枝质量控制评价和标准制定提供了更为科学、全面的依据和基础。

关键词：桂枝饮片外观性状含量测定特征图谱相关性质量评价分级标准

Risks of maternal prepregnancy overweight/obesity, excessive gestational weight gain, and bottle-feeding in infancy rapid weight gain: evidence from a cohort study in China

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Science China(Life Sciences) 2019年第12期62卷 1580-1589页

作者： Shaoping yang Hong mei Hui mei yan yang Na Li Yafei Tan Yiming Zhang Dan Zhang yan Zhang An’na Peng Bin Zhang Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital) Tongji Medical College Huazhong University of Science & Technology

Rapid weight gain(RWG) in infants is associated with numerous health problems, and its risk factors are still unclear. We assessed 98,097 maternal-infant pairs from a population-based cohort study and followed up with them until the infants were6 months old. We assessed the associations between maternal prepregnancy weight status;gestational weight gain;feeding pattern;and infants’ RWG at 0–1, 0–3, 1–3, and 3–6 months using multivariate unconditional logistic regression models, with controlled confounders. We found that maternal prepregnancy weight status, gestational weight gain, and feeding pattern at the1 st, 3 rd, and 6 th months had significant impacts on the infants’ RWG at each time period(P<0.05). Infants with overweight/obese mothers had a higher risk of RWG after birth, whereas those of mothers who experienced excessive gestational weight gain had higher risks of RWG from birth than the other groups(P<0.01). Infants who were formula-fed had a higher risk of RWG than breastfed infants at the same time point(P<0.01). In conclusion, maternal prepregnancy obesity, excessive gestational weight gain, and formula-feeding were risk factors for infants’ RWG during the first 6 months of life.

关键词： rapid weight gain body mass index gestational weight gain breastfeeding influencing factor

Optimization of sampling frequency for routine river water quality monitoring

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Science China Chemistry 2014年第5期57卷 772-778页

作者： LIU yan ZHENG BingHui WANG mei XU yanXue QIN yanWen State Key Laboratory of Environmental Criteria and Risk Assessment & State Environmental Protection Key Laboratory of Drinking Water Source Protection Chinese Research Academy of Environmental Sciences

Sampling frequency is an important factor to be considered during the design of a water monitoring network,and the cost-effective selection of possible ways and means for the optimization of sampling frequency is still *** paper introduces water pollution index deviation ratio comparison(WPI DRC),a procedure for the optimization of sampling frequency for a routine river water quality monitoring *** frequency optimized using WPI DRC at monitoring station X5 in the mainstream of Xiangjiang River is compared with that established using the traditional Statistical Algorithm *** result of comparison indicates that WPI DRC is more feasible than the traditional *** then,the sampling frequencies for other 16 monitoring stations also have been optimized,and the results show the sampling frequencies of all the stations except that X4 are reduced,and there is no unacceptable difference between water quality evaluation results at 17 stations before and after the ***,it is concluded that WPI DRC is an effective optimization process with operable results,which can be used to fulfill the requirement of practical monitoring work.

关键词： optimization of sampling frequency routine river water quality monitoring water pollution index deviation ratiocomparison