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Chinese Journal of Chemical Engineering 2024年第5期69卷 238-249页

作者： yuehua yao fan Wang yinguang Xu Zishuai Xu Lizhen chen Jianlong Wang School of Chemistry and Chemical Engineering North University of ChinaTaiyuan 030051China Gansu yinguang Chemical Industry Group Co.Ltd. Baiyin 730900China

In order to remove hexahydro-1,3,5-trinitro-1,3,5-triazine(RDX),the main impurity,in process of polymorphic transformation of octrahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine(HMX),the solubility ofβ-HMX and RDX in acetonitrile(ACN)+water in the temperature range of 288.15-333.15 K and in nitric acid(HNO_(3))+water in the temperature range of 298.15-333.15 K were measured by laser dynamic *** results showed that the solubility of bothβ-HMX and RDX in binary mixed solvents increased monotonously as the temperature increase at a given solvent composition or with increasing of mole fraction of solvent(ACN and nitric acid).Solubility data were well correlated by the modified Apelblat equation,Jouyban-Acree model,yaws equation and van't Hoff equation,and the yaws equation achieved the best fitting results according to the relative error and the mean square error ***,the solubility ofβ-HMX and RDX in binary mixed solvent was compared,based on the solubility difference and the solvent's own properties,the best separation degree ofβ-HMX and RDX was found when the mole fraction of nitric acid was 0.22 at room temperature,which provided data support for HMX crystallization in mixed *** solubility differences between RDX andβ-HMX in mixed solvents were explained from the formation of intermolecular and intramolecular hydrogen bonds.

关键词： Solubility Octrahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine Hexahydro-1,3,5-trinitro-1,3,5-triazine Separation Model Hydrogen bond

Enhancing metformin-induced tumor metabolism destruction by glucose oxidase for triple-combination therapy

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Journal of Pharmaceutical Analysis 2024年第3期14卷 321-334页

作者： Rangrang fan Linrui Cai Hao Liu Hongxu chen Caili chen Gang Guo Jianguo Xu Department of Neurosurgery and Institute of Neurosurgery Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China NMPA Key Laboratory for Technical Research on Drug Products in Vitro and in Vivo Correlation Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOENational Drug Clinical-Trial InstitutionWest China Second HospitalSichuan UniversityChengdu610041China Department of Immunology School of Basic Medical SciencesXinxiang Medical UniversityXinxiangHenan453000China

Despite decades of laboratory and clinical trials,breast cancer remains the main cause of cancer-related disease burden in *** the metabolism destruction effect of metformin(Met)and cancer cell starvation induced by glucose oxidase(GOx),after their efficient delivery to tumor sites,GOx and Met may consume a large amount of glucose and produce sufficient hydrogen peroxide in ***,a pH-responsive epigallocatechin gallate(EGCG)-conjugated low-molecular-weight chitosan(LC-EGCG,LE)nanoparticle(Met–GOx/Fe@LE NPs)was *** coordination between iron ions(Fe3+)and EGCG in this nanoplatform can enhance the efficacy of chemodynamic therapy via the Fenton ***–GOx/Fe@LE NPs allow GOx to retain its enzymatic activity while simultaneously improving its ***,this pH-responsive nanoplatform presents controllable drug release *** in vivo biodistribution study showed that the intracranial accumulation of GOx delivered by this nanoplatform was 3.6-fold higher than that of the free *** in vivo anticancer results indicated that this metabolism destruction/starvation/chemodynamic triple-combination therapy could induce increased apoptosis/death of tumor cells and reduce their *** triple-combination therapy approach is promising for efficient and targeted cancer treatment.

关键词： Metformin Glucose oxidase Metabolism disruption Tumor starvation Combination cancer therapy

Miniature tunable Airy beam optical meta-device

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Opto-Electronic Advances 2024年第2期7卷 5-12页

作者： Jing cheng Zhang Mu Ku chen yubin fan Qinmiao chen Shufan chen Jin yao Xiaoyuan Liu Shumin Xiao Din Ping Tsai Department of Electrical Engineering City University of Hong KongKowloonHong Kong SAR 999077China State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong Kong SAR 999077China Centre for Biosystems Neuroscienceand NanotechnologyCity University of Hong KongKowloonHong Kong SAR 999077China Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic SystemsHarbin Institute of TechnologyShenzhen 518055China

Tunable Airy beams with controllable propagation trajectories have sparked interest in various fields,such as optical manipulation and laser *** research approaches encounter challenges related to insufficient compactness and integration feasibility,or they require enhanced tunability to enable real-time dynamic manipulation of the propagation *** this work,we present a novel method that utilizes a dual metasurface system to surpass these limitations,significantly enhancing the practical potential of the Airy *** approach involves encoding a cubic phase profile and two off-axis Fresnel lens phase profiles across the two *** validity of the proposed strategy has been confirmed through simulation and experimental *** proposed meta-device addresses the existing limitations and lays the foundation for broadening the applicability of Airy beams across diverse domains,encompassing light-sheet microscopy,laser fabrication,optical tweezers,etc.

关键词： metasurface miniature device tunable Airy beam tunable meta-device

Integrated schedule of order picking and delivery for instant delivery

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Journal of Management Science and Engineering 2024年第1期9卷 88-100页

作者： Qiuchen Gu Tijun fan Jingyi chen School of Business East China University of Science and TechnologyShanghai200237China Research Center for Operations and Supply Chain Management East China University of Science and TechnologyShanghai200237China Economics and Management School Minjiang UniversityFuzhou350108China

In this study,we introduce an integrated schedule of order picking and delivery for instant *** picking,including order batching and picking sequencing,is scheduled online under real-time order arrival,which integrates order delivery by depicting order location dispersion in an online order picking *** delivery,including delivery person assignment and route planning,is modeled to minimize the total duration of order fulfillment by considering the influence of the order picking completion time.A rule-based online order picking strategy is established,and a customized ant colony optimization(ACO)algorithm is proposed to optimize order *** on 16 simulated instances of different scales demonstrate that our online order picking schedule considering order delivery outperforms existing approaches and that the customized ACO algorithm for order delivery is effective.

关键词： Online scheduling Order picking Delivery routing Integrated order picking and delivery Instant delivery

CPL-active hybrid copper(Ⅰ)halides enabled by cation inclusion with chiral crown-ether

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Science China Chemistry 2024年第10期67卷 3283-3290页

作者： Peng fan Li-Xuan Cai Xiao-fang Duan fan yin chen-chen Li Zhong-Hua Deng Xiao-Zhen Li Qing-Fu Sun College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Strait Institute of Flexible Electronics(Future Technologies) Fujian Key Laboratory of Flexible ElectronicsFujian Normal University and Strait Laboratory of Flexible ElectronicsFuzhou 350117China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian College University of Chinese Academy of SciencesFuzhou 350002China

Chiral hybrid metal halides with high photoluminescence quantum yield(PLQy)and superior dissymmetry factor(g_(lum))are promising candidates for circularly polarized luminescence(CPL)emitting ***,it is a great challenge to achieve both high g_(lum)and large ***,we report a new supramolecular strategy to fabricate chiral hybrid Cu(Ⅰ)-halides with nearunity quantum yields and intense CPL *** dissymmetry factor can be dramatically modulated by tuning the hostguest *** to the chirality and variable conformations of the host-guest complexes,a series of chiral[G@L^(R/S)]_(2)Cu_(4)I_(6)have been *** incorporation of different cations within the chiral L^(R/S)hosts leads to variations of packing modes along the c-axis and different extent of distortions in the[Cu_(4)I_(6)]_(2)-*** them,[H_(3)O@L^(R/S)]+cations are stacked based on Van der Waals interactions and hierarchically self-assemble into a right/left-handed helix in[H_(3)O@L^(R/S)]_(2)Cu_(4)I_(6),which results in a high g_(lum)of-7×10^(-3)and a large PLQy of 96.92%.Notably,[G@L^(R/S)]_(2)Cu_(4)I_(6)shows promising applications in single-component white light emitting diodes(WLEDs),exhibiting a maximum dissymmetry factor of-1.2×10^(-3).The effective host-guest complexation and oriented hierarchical self-assembly provide an effective strategy for the development of high-performance CPL materials.

关键词： host-guest interaction circularly polarized luminescence copper iodide cluster hierarchical self-assembly chirality

Photocatalytic applications and modification methods of two-dimensional nanomaterials:a review

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Tungsten 2024年第1期6卷 77-113页

作者： fan yang Ping Hu fan yang Xing-Jiang Hua Bo chen Lili Gao Kuai-She Wang School of Metallurgy Engineering Xi’an University of Architecture and TechnologyXi’an 710055China National and Local Joint Engineering Research Center for Functional Materials Processing Xi’an University of Architecture and TechnologyXi’an 710055China

Due to its unique electronic structure and special size effect,two-dimensional(2D)nanomaterials have shown great potential far beyond bulk materials in the field of *** to deeply explore the photocatalytic mechanism of 2D nanomaterials and design more efficient 2D semiconductor photocatalysts are research *** review provides a comprehensive introduction to typical 2D nanomaterials and discusses their current application status in the field of *** effects of material properties such as band structure,morphology,crystal face structure,crystal structure and surface defects on the photocatalytic process are *** main modification methods are highlighted,including doping,noble metal deposition,heterojunction,thickness adjustment,defect engineering,and dye sensitization in 2D material ***,the future development of 2D nanomaterials is *** is hoped that this paper can provide systematic and useful information for researchers engaged in the field of photocatalysis.

关键词： Photocatalysis Two-dimensional Nanomaterials Bandgap Modification strategy

lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression

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Frontiers of Medicine 2024年第3期18卷 484-498页

作者： Xiang Nie Jiahui fan yanwen Wang Rong Xie chen chen Huaping Li Dao Wen Wang Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan430030China

lncRNA ZNF593 antisense(ZNF593-AS)transcripts have been implicated in heart failure through the regulation of myocardial *** decreased transcriptional activity of ZNF593-AS has also been detected in cardiac ***,the function of ZNF593-AS in cardiac hypertrophy remains ***,we report that the expression of ZNF593-AS reduced in a mouse model of left ventricular hypertrophy and cardiomyocytes in response to treatment with the hypertrophic agonist phenylephrine(PE).In vivo,ZNF593-AS aggravated pressure overload–induced cardiac hypertrophy in knockout *** contrast,cardiomyocyte-specific transgenic mice(ZNF593-AS MHC-Tg)exhibited attenuated TAC-induced cardiac *** vitro,vector-based overexpression using murine or human ZNF593-AS alleviated PE-induced myocyte hypertrophy,whereas GapmeR-induced inhibition aggravated hypertrophic *** using RNA-seq and gene set enrichment analyses,we identified a link between ZNF593-AS and oxidative phosphorylation and found that mitofusin 2(Mfn2)is a direct target of ***593-AS exerts an antihypertrophic effect by upregulating Mfn2 expression and improving mitochondrial ***,it represents a promising therapeutic target for combating pathological cardiac remodeling.

关键词： lncRNA ZNF593-AS cardiac hypertrophy Mfn2 oxidative phosphorylation

Impact crater recognition methods:A review

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Science China Earth Sciences 2024年第6期67卷 1719-1742页

作者： Dong chen fan HU Liqiang ZHANG yunzhao WU Jianli DU Jiju PEETHAMBARAN College of Civil Engineering Nanjing Forestry UniversityNanjing 210037China Department of Geography State Key Laboratory of Remote Sensing ScienceFaculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China Key Laboratory of Space Object and Debris Observation Chinese Academy of SciencesNanjing 210023China Department of Mathematics and Computing Science Saint Mary’s UniversityHalifaxNS B3H 3C3Canada

Impact craters are formed due to the high-speed collisions between small to medium-sized celestial *** is the most significant driving force in the evolution of celestial bodies,and the impact craters provide crucial insights into the formation,evolution,and impact history of celestial *** this paper,we present a detailed review of the characteristics of impact craters,impact crater remote sensing data,recognition algorithms,and applications related to impact *** first provide a detailed description of the geometric texture,illumination,and morphology characteristics observed in remote sensing data of *** we summarize the remote sensing data and cataloging databases for the four terrestrial planets(i.e.,the Moon,Mars,Mercury,and Venus),as well as the impact craters on ***,we study the advancement achieved in the traditional methods,machine learning methods,and deep learning methods applied to the classification,segmentation,and recognition of impact ***,based on the analysis results,we discuss the existing challenges in impact crater recognition and suggest some ***,we explore the implementation of impact crater detection algorithms and provide a forward-looking perspective.

关键词： Terrestrial planets Deep space exploration Impact crater Impact crater recognition Deep learning

Improvement of the conversion efficiency of Mg_(3)Sb_(2)thermoelectric devices through optimizing the resistivity of the MgSbNi barrier layer

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Journal of Materials Science & Technology 2024年第1期168卷 208-214页

作者： Huimin Zhang yachao Wang Zuhair A.Munir yongzhong Zhang Wenhao fan Shaoping chen College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China Capital Aerospace Machinery Company Beijing100076China Department of Material Science and Engineering University of CaliforniaDavisCalifornia95616United States of America College of Physics and Optoelectronics Taiyuan University of TechnologyTaiyuan030024China Instrumental Analysis Center of Taiyuan University of Technology Taiyuan030024China

Mg_(3)Sb_(2)-based thermoelectric materials have been the focus of widespread investigations as promising candidates for the harvesting of waste *** stability and service performance are key points for the commercial applications of these *** utilized Mg_(4.3)Sb_(3)Ni as a barrier layer to improve the thermal stability of Mg 3 Sb 2-based ***,its intrinsic high resistivity contributed nega-tively to the desired performance of the *** this work,we investigated two other Mg-Sb-Ni ternary phases,MgSbNi and MgSbNi_(2),as new barrier layer materials to connect with Mg_(3.2)Sb_(2)y_(0.05).The results show that the efficiency of the Mg_(1.2)SbNi/Mg_(3.2)Sb_(2)y_(0.05)/Mg_(1.2)SbNi joint is increased by 33%relative to the higher Mg-content barriers due to lower *** system exhibited good interfacial compatibility and showed little change with aging at 673 K for 20 days.

关键词： Mg_(3)Sb_(2) Mg_(1.2)SbNi Barrier layer Conversion efficiency

A continuous and long-term in-situ stress measuring method based on fiber optic. Part I: Theory of inverse differential strain analysis

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Petroleum Science 2024年第2期21卷 1171-1189页

作者： Kun-Peng Zhang Mian chen Chang-Jun Zhao Su Wang yong-Dong fan State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China MOE Key Laboratory of Petroleum Engineering in China University of Petroleum Beijing102249China Beijing International Center for Gas Hydrate School of Earth and Space SciencesPeking UniversityBeijing100871China

A method for in-situ stress measurement via fiber optics was proposed. The method utilizes the relationship between rock mass elastic parameters and in-situ stress. The approach offers the advantage of long-term stress measurements with high spatial resolution and frequency, significantly enhancing the ability to measure in-situ stress. The sensing casing, spirally wrapped with fiber optic, is cemented into the formation to establish a formation sensing nerve. Injecting fluid into the casing generates strain disturbance, establishing the relationship between rock mass properties and treatment ***, an optimization algorithm is established to invert the elastic parameters of formation via fiber optic strains. In the first part of this paper series, we established the theoretical basis for the inverse differential strain analysis method for in-situ stress measurement, which was subsequently verified using an analytical model. This paper is the fundamental basis for the inverse differential strain analysis method.

关键词： In-situ stress Fiber optic Orthotropic elastic Differential evolution ABAQUS