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Impact of wastewater treatment plant effluent discharge on the antibiotic resistome in downstream aquatic environments:a mini review

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 131-141页

作者： Zhiguo Su Lyujun chen Donghui wen School of Environment Tsinghua UniversityBeijng 100084China 2 Zhejiang Provincial Key Laboratory of Water Science and Technology Department of Environmental Technology and EcologyYangtze Delta Region Institute of Tsinghua UniversityJiaxing 314050China College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China

Antimicrobial resistance(AMR)has emerged as a significant challenge in human *** treatment plants(WWTPs),acting as a link between human activities and the environment,create ideal conditions for the selection and spread of antibiotic resistance genes(ARGs)and antibioticresistant bacteria(ARB).Unfortunately,current treatment processes are ineffective in removing ARGs,resulting in the release of large quantities of ARB and ARGs into the aquatic environment through WWTP ***,in turn,leads to their dispersion and potential transmission to human through water and the food *** safeguard human and environmental health,it is crucial to comprehend the mechanisms by which WWTP effluent discharge influences the distribution and diffusion of ARGs in downstream *** this study,we examine the latest researches on the antibiotic resistome in various waterbodies that have been exposed to WWTP effluent,highlighting the key influencing ***,recommendations for future research and management strategies to control the dissemination of ARGs from WWTPs to the environment are provided,with the aim to achieve the“One Health”objective.

关键词： Antibiotic resistance genes(ARGs) Wastewater treatment plants(WWTPs) Effluent-receiving waterbodies Environmental risk Influencing mechanism

SSL Depth: self-supervised learning enables 16× speedup in confocal microscopy-based 3D surface imaging [Invited]

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Chinese Optics Letters 2024年第6期22卷 3-7页

作者： Ze-Hao Wang tong-Tian weng Xiang-Dong chen Li Zhao Fang-wen Sun CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Anhui Golden-Shield 3D Technology Co. Ltd.Hefei 230011China

In scientific and industrial research, three-dimensional (3D) imaging, or depth measurement, is a critical tool that provides detailed insight into surface properties. Confocal microscopy, known for its precision in surface measurements, plays a key role in this field. However, 3D imaging based on confocal microscopy is often challenged by significant data requirements and slow measurement speeds. In this paper, we present a novel self-supervised learning algorithm called SSL Depth that overcomes these challenges. Specifically, our method exploits the feature learning capabilities of neural networks while avoiding the need for labeled data sets typically associated with supervised learning approaches. Through practical demonstrations on a commercially available confocal microscope, we find that our method not only maintains higher quality, but also significantly reduces the frequency of the z-axis sampling required for 3D imaging. This reduction results in a remarkable 16×measurement speed, with the potential for further acceleration in the future. Our methodological advance enables highly efficient and accurate 3D surface reconstructions, thereby expanding the potential applications of confocal microscopy in various scientific and industrial fields.

关键词： confocal microscopy 3D surface imaging self-supervised learning

Study of poly-disperse aerosols deposition in turbulent flow with different Reynolds numbers

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Particuology 2024年第6期89卷 32-43页

作者： Zhichao Gao Yongzheng chen Dandi Zhang Peng chen Lili tong Xuewu Cao School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China China Nuclear Power Technology Research Institute Co. Ltd.Shenzhen518000China

The turbulent deposition mechanism is one of the main mechanisms of aerosol deposition in nuclear power plant *** experimental study of poly-disperse aerosol deposition in a horizontal tube is conducted,where the nominal Reynolds number(Re)is in a range of 3600–200,*** aerosol deposition velocity first increases and then decreases with the increase of Res,and at high Re,particle rebound occurs during aerosol deposition in the *** the Re is low,the aerosol deposition velocity increases with the increase of aerosol *** the Re is greater than 60,000,the deposition velocity first increases and then decreases with the increase of aerosol diameter due to particle surface rebound.A new aerosol deposition model has been developed by establishing the energy conservation equation of the rebounded particles in the viscous *** calculated results of the new model are in good agreement with these experimental results,and the error between the aerosol deposition velocity calculated by the model and experimental results is between−60%and 150%.

关键词： Aerosol Turbulent deposition Rebound High Reynolds number

Hepatocyte growth factor promotes retinal pigment epithelium cell activity through MET/AKT signaling pathway

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 806-814页

作者： Si-Rui Zhou Yu-Sheng Zhu wen-Ting Yuan Xiao-Yan Pan tong Wang Xiao-Dong chen Faculty of Life Sciences and Medicine Northwest UniversityXi’an 710069Shaanxi ProvinceChina First Affiliated Hospital of Northwest University Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Shaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi ProvinceXi’an 710002Shaanxi ProvinceChina

AIM:To explore the effects of hepatocyte growth factor(HGF)on retinal pigment epithelium(RPE)cell ***:The human adult retinal pigment epithelial cell line-19(ARPE-19)were treated by HGF or mesenchymalepithelial transition factor(MET)inhibitor SU11274 in *** viability was detected by a Cell Counting Kit-8 *** proliferation and motility was detected by a bromodeoxyuridine incorporation assay and a wound healing assay,*** expression levels of MET,phosphorylated MET,protein kinase B(AKT),and phosphorylated AKT proteins were determined by Western blot *** MET and phosphorylated MET proteins were also determined by immunofluorescence ***:HGF increased ARPE-19 cells’viability,proliferation and migration,and induced an increase of phosphorylated MET and phosphorylated AKT ***11274 significantly reduced cell viability,proliferation,and migration and decreased the expression of MET and AKT ***11274 suppressed HGF-induced increase of viability,proliferation,and migration in ARPE-19 ***,SU11274 also blocked HGF-induced phosphorylation of MET and AKT ***:HGF enhances cellular viability,proliferation,and migration in RPE cells through the MET/AKT signaling pathway,whereas this enhancement is suppressed by the MET inhibitor ***-induced MET/AKT signaling might be a vital contributor of RPE cells survival.

关键词： hepatocyte growth factor mesenchymal epithelial transition factor SU11274 retinal pigment epithelial cells

Ultrahigh performance passive radiative cooling by hybrid polar dielectric metasurface thermal emitters

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Opto-Electronic Advances 2024年第4期7卷 17-25页

作者： Yinan Zhang Yinggang chen tong Wang Qian Zhu Min Gu Institute of Photonic Chips University of Shanghai for Science and TechnologyShanghai 200093China Centre for Artificial-Intelligence Nanophotonics School of Optical-Electrical and Computer EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China

Real-world passive radiative cooling requires highly emissive,selective,and omnidirectional thermal emitters to maintain the radiative cooler at a certain temperature below the ambient temperature while maximizing the net cooling *** various selective thermal emitters have been demonstrated,it is still challenging to achieve these conditions sim-ultaneously because of the extreme difficulty in controlling thermal emission of photonic structures in *** we demonstrated hybrid polar dielectric metasurface thermal emitters with machine learning inverse design,en-abling a high emissivity of~0.92 within the atmospheric transparency window 8-13μm,a large spectral selectivity of~1.8 and a wide emission angle up to 80 degrees,*** selective and omnidirectional thermal emitter has led to a new record of temperature reduction as large as~15.4°C under strong solar irradiation of~800 W/m2,signific-antly surpassing the state-of-the-art *** designed structures also show great potential in tackling the urban heat island effect,with modelling results suggesting a large energy saving and deployment area *** research will make significant impact on passive radiative cooling,thermal energy photonics and tackling global climate change.

关键词： radiative cooling dielectric metasurfaces machine learning thermal emitters

A novel profile modification HPF-Co gel satisfied with fractured low permeability reservoirs in high temperature and high salinity

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Petroleum Science 2024年第1期21卷 683-693页

作者： Ya-Kai Li Ji-Rui Hou Wei-Peng Wu Ming Qu Tuo Liang Wei-Xin Zhong Yu-chen wen Hai-tong Sun Yi-Nuo Pan China University of Petroleum Beijing Beijing102249China PetroChina Tarim Oilfield Company Korla 841000XinjiangChina Key Laboratory of Improving Oil and Gas Recovery of Ministry of Education Northeast Petroleum University Daqing 163318HeilongjiangChina Xi'an Shiyou University Xi'an 710065ShaanxiChina Northwest Oilfield Company SINOPECUrumqi 830011XinjiangChina

Conformance control and water plugging are a widely used EOR method in mature ***,majority of conformance control and water plugging agents are unavoidable dehydrated situation in high-temperature and high-salinity low permeability ***,a novel conformance control system HPF-Co gel,based on high-temperature stabilizer(CoCl_(2)·H_(2)O,CCH)is *** HPF-Co bulk gel has better performances with high temperature(120℃)and high salinity(1×10^(5)mg/L).According to Sydansk coding system,the gel strength of HPF-Co with CCH is increased to code *** dehydration rate of HPF-Co gel is 32.0%after aging for 150 d at 120℃,showing excellent thermal *** rheological properties of HPF gel and HPF-Co gel are also *** results show that the storage modulus(G′)of HPF-Co gel is always greater than that of HPF *** effect of CCH on the microstructure of the gel is *** results show that the HPF-Co gel with CCH has a denser gel network,and the diameter of the three-dimensional network skeleton is 1.5-3.5μ*** 90 d of aging,HPF-Co gel still has a good three-dimensional *** spectroscopy results show that CCH forms coordination bonds with N and O atoms in the gel amide group,which can suppress the vibration of cross-linked sites and improve the stability at high *** core plugging test determines the optimized polymer gel injection strategy and injection velocity with HPF-Co bulk gel system,plugging rate exceeding 98%.Moreover,the results of subsequent waterflooding recovery can be improved by 17%.

关键词： Low permeability reservoir High-temperature resistant gel Complexation reaction Polymer gel injection strategy Plugging rate Enhanced oil recovery

Formation estimation and evolution mechanism of the pressure arch for non-circular tunnels under asymmetrical stress field

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Science China(Technological Sciences) 2024年第9期67卷 2919-2938页

作者： SUN ZhenYu ZHANG DingLi XU tong chen Xu Key Laboratory for Urban Underground Engineering of Ministry of Education Beijing Jiaotong UniversityBeijing 100044China

The tunneling-induced stress redistribution is dependent on the tunnel shape and the in-situ stress field, and the previous arch characterization method based on the circumferential or maximum principal stresses is only suitable for the circular tunnels under the hydrostatic stress field. In this study, a unified characterization method of the pressure arch for non-circular tunnels under the arbitrary stress field is proposed. By comparing the variations of compressive stress in different directions due to excavation, the ratio of the most significant increase in compressive stress is presented to characterize the arch effect, and the corresponding numerical algorithm is given. Since the proposed method takes the stress element as the basic analytical model, it can be easily applied to various complex excavation situations. Thereafter, combined with the established folding catastrophic model, an objective and unified quantitative method of the pressure arch boundaries is given. Using the proposed method, the longitudinal evolution of the pressure arch is analyzed. According to the expansion rate of the arch boundaries, three evolution stages including the initial formation, rapid expansion and stabilization are categorized. Parametric studies are conducted to illustrate the effect of ground properties and support stiffness on the pressure arch formation. It is found that the ground strength parameters and burial depth affect the arch range at a decreasing rate, while they have little effect on the arch shape. The lateral pressure coefficient has a significant effect on both the shape and range of the pressure arch. Increasing the support stiffness helps reduce the pressure arch range with a decreasing rate, while the synchronous variation of the elastic moduli of the surrounding rock and support does not affect the arch range under a certain relative elastic modulus. Finally, field monitoring is conducted to validate the proposed method in actual support design.

关键词： pressure arch stress redistribution numerical simulation quantitative characterization longitudinal evolution parametric study

Exploration of instantaneous frequency for local control assessment in real-time hybrid simulation

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 995-1008页

作者： Xu, Weijie Peng, Changle Guo, tong chen, cheng Key Laboratory of Concrete and Prestressed Concrete Structures of the Ministry of Education Southeast University Nanjing China School of Engineering San Francisco State University San Francisco USA

Local control parameters such as instantaneous delay and instantaneous amplitude play an essential role in evaluating the performance and maintaining the stability of real-time hybrid simulation (RTHS). However, existing methods have limitations in obtaining this local assessment in either the time domain or frequency domain. In this study, the instantaneous frequency is introduced to determine local control parameters for actuator tracking assessment in a real-time hybrid simulation. Instantaneous properties, including amplitude, delay, frequency and phase, are then calculated based on analytic signals translated from actuator tracking signals through the Hilbert transform. Potential issues are discussed and solutions are proposed for calculation of local control parameters. Numerical simulations are first conducted for sinusoidal and chirp signals with time varying amplitude error and delay to demonstrate the potential of the proposed method. Laboratory tests also are conducted for a predefined random signal as well as the RTHS of a single degree of freedom structure with a self-centering viscous damper to experimentally verify the effectiveness of the proposed use of the instantaneous frequency. Results from the ensuing analysis clearly demonstrate that the instantaneous frequency provides great potential for local control assessment, and the proposed method enables local tracking parameters with good accuracy.

关键词： real-time hybrid simulation tracking assessment instantaneous frequency Hilbert transform

Neutron irradiation influence on high-power thyristor device under fusion environment

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Nuclear Science and Techniques 2024年第4期35卷 65-81页

作者： Wei tong Hua Li Meng Xu Zhi-Quan Song Bo chen School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China

Because of their economy and applicability,high-power thyristor devices are widely used in the power supply systems for large fusion *** high-dose neutrons produced by deuterium–tritium(D–T)fusion reactions are irradiated on a thyristor device for a long time,the electrical characteristics of the device change,which may eventually cause irreversible *** this study,with the thyristor switch of the commutation circuit in the quench protection system(QPS)of a fusion device as the study object,the relationship between the internal physical structure and external electrical parameters of the irradiated thyristor is ***,a series of targeted thyristor physical simulations and neutron irradiation experiments are conducted to verify the accuracy of the theoretical *** addition,the effect of irradiated thyristor electrical characteristic changes on the entire QPS is studied by accurate simulation,providing valuable guidelines for the maintenance and renovation of the QPS.

关键词： Fusion device Neutron irradiation effects Thyristor Quench protection