检索结果-南通市图书馆

Safflower Yellow Inhibits Progression of Hepatocellular Carcinoma by Modulating Immunological Tolerance via FAK Pathway

引用

Chinese Journal of Integrative Medicine 2024年第4期30卷 339-347页

作者： JI Hua-feng YANG Zi-qiang HAN Jun-jun LI He-fang JIN Zhao-qing chen wei-qing chen Fei-hua GONG Mou-chun Department of General Surgery First People's Hospital of Hangzhou Lin'an DistrictHangzhou(311300)China

Objective To explore the anti-tumor effect of safflower yellow(SY)against hepatocellular carcinoma(HCC)and the underlying potential *** An in vitro model was established by mixing Luc-Hepa1-6 cells and CD3^(+)CD8^(+)T cells,followed by adding programmed cell death protein 1(PD-1)antibody(Anti-mPD-1)with or without *** apoptosis was detected by flow cytometry and the level of inflammatory cytokines was determined by enzyme-linked immunosorbent *** protein levels of programmed cell death 1 ligand 1(PD-L1),chemokine ligand(CCL5),C-X-C motif chemokine ligand 10(CXCL10)were measured by Western *** in situ animal model was established in mice followed by treatment with anti-mPD-1 with or without *** imaging was monitored with an AniView 100 imaging *** establish the FAK-overexpressed Luc-Hepa1-6 cells,cells were transfected with adenovirus containing pcDNA3.1-FAK for 48 *** The fluorescence intensity,apoptotic rate,release of inflammatory cytokines,and CCL5/CXCL10 secretion were dramatically facilitated by anti-mPD-1(P<0.01),accompanied by an inactivation of PD-1/PD-L1 axis,which were extremely further enhanced by SY(P<0.05 or P<0.01).Increased fluorescence intensity,elevated percentage of CD3+CD8+T cells,facilitated release of inflammatory cytokines,inactivated PD-1/PD-L1 axis,and increased CCL5/CXCL10 secretion were observed in Anti-mPD-1 treated mice(P<0.01),which were markedly enhanced by SY(P<0.05 or P<0.01).Furthermore,the enhanced effects of SY on inhibiting tumor cell growth,facilitating apoptosis and inflammatory cytokine releasing,suppressing the PD-1/PD-L1 axis,and inducing the CCL5/CXCL10 secretion in Anti-mPD-1 treated mixture of Luc-Hepa1-6 cells and CD3+CD8+T cells were abolished by FAK overexpression(P<0.01).Conclusion SY inhibited the progression of HCC by mediating immunological tolerance through inhibiting FAK.

关键词： hepatocellular carcinoma safflower yellow Chinese medicine tumor microenvironment programmed cell death protein 1 focal adhesion kinase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Trace elements in magmatic and hydrothermal quartz:Implications on the genesis of the Xingluokeng Tungsten Deposit,South China

引用

Acta Geochimica 2024年第3期43卷 441-458页

作者： qing-qing Zhang You-wei chen Jian-Feng Gao State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China

The Xingluokeng deposit is the largest gran-ite-related tungsten deposit within the Wuyi metallogenic belt in South *** Xingluokeng intrusion primarily consists of porphyritic biotite granite,biotite granite,andfine-grained *** deposit is represented by veinlet-disseminated mineralization with K-feldspathization and biotitization,alongside quartz-vein mineralization with gre-isenization and *** study investigates in-situ analyses of quartz compositions from both the intrusion and hydrothermal veinlets and *** element correlations indicate that trivalent Al^(3+)and Fe^(3+)replace Si^(4+)within the quartz lattice,with monovalent cations(such as Li^(+),Na^(+),and K^(+))primarily serving as charge *** Ge/Al ratios(<0.013)of quartz from granites suggest a mag-matic *** low Al/Ti and Ge/Ti ratios,accompanied by high Ti contents in quartz,suggest that the porphyritic biotite granite and biotite granite are characterized by rela-tively low levels of differentiation and high crystallization *** contrast,thefine-grained granite exhibits a higher degree of fractionation,lower crystallization tem-peratures,and a closer association with tungsten *** contents in quartz from quartz veins indicate Qz-Ⅰformed at temperatures above 400°C,while Qz-Ⅱto Qz-Ⅴformed at temperatures below 350°*** in different generations of quartz,as indicated by Al content and(Al+Fe)/(Li+Na+K)ratio,suggest that Qz-Ⅰprecipi-tated from a less acidicfluid with a stable pH,whereas Qz-Ⅱto Qz-Ⅴoriginated from a more acidicfluid with notable pH ***,alkaline alteration and acidic alteration supplied the essential Ca and Fe for the precipita-tion of scheelite and wolframite,respectively,highlighting a critical mechanism in tungsten mineralization at the Xin-gluokeng deposit.

关键词： Quartz Xingluokeng Tungsten deposit Trace elements South China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Low Cost, Green Sustainable and Biodegradable Biomass-based Fluorine-free Water and Oil Repellent

引用

Chinese Journal of Polymer Science 2024年第4期42卷 480-491页

作者： Zhi-wei Shen Shu-Feng Hu chen Zeng wei-qing Kong Mei-Fang Zhu State Key Laboratory for Modification of Chemical Fibers&Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China State Key Laboratory of Pulp and Paper Engineering School of Light Industry and EngineeringSouth China University of TechnologyGuangzhou510630China

With the global ban on plastics intensifying, the substitution of plastic with paper has garnered increasing attention. However, the inadequate water and oil repellency of pulp molding hinders its practical applications. Currently, the common method to enhance the oil and water repellency of pulp molding is by adding fluorinated water and oil repellents. Nevertheless, fluorinated compounds are environmentally and physiologically harmful. Therefore, the development of fluorine-free, water and oil repellent alternatives is crucial. In this study, chitosan and stearic acid were utilized as the first and second layers of the oil and water repellent coatings, respectively. The coated samples exhibited favorable water repellency, with a water contact angle of 116.4°, and excellent oil repellency, achieving a 12/12 rating on the kit scale. Importantly, the samples did not exhibit any leakage after being soaked in hot water and hot oil at 95±5℃ for 30 min, demonstrating remarkable performance as a barrier against hot water and oil. Moreover, the coated samples displayed outstanding mechanical properties, thermal stability, biodegradability, and recyclability. The approach presented in this study is simple, cost-effective, environmentally friendly, and represents a promising technique for producing fluoride-free, oil-and water-resistant pulp molding products.

关键词： Biomass Fluoride-free Oil-andwater-resistant Plasticfree

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research progress in CALPHAD assisted metal additive manufacturing

引用

China Foundry 2024年第4期21卷 295-310页

作者： Ya-qing Hou Xiao-qun Li wei-dong Cai qing chen wei-ce Gao Du-peng He Xue-hui chen Hang Su China Iron&Steel Research Institute Group Beijing 100081China Thermo-Calc Software AB SolnaSE-169Sweden KTH Royal Institute of Technology StockholmSE-100Sweden Central Iron and Steel Research Institute Beijing 100081China

Metal additive manufacturing(MAM)technology has experienced rapid development in recent *** both equipment and materials progress towards increased maturity and commercialization,material metallurgy technology based on high energy sources has become a key factor influencing the future development of *** calculation of phase diagrams(CALPHAD)is an essential method and tool for constructing multi-component phase diagrams by employing experimental phase diagrams and Gibbs free energy models of simple *** combining with the element mobility data and non-equilibrium phase transition model,it has been widely used in the analysis of traditional metal *** development of CALPHAD application technology for MAM is focused on the compositional design of printable materials,the reduction of metallurgical imperfections,and the control of microstructural *** endeavor carries considerable theoretical and practical *** paper summarizes the important achievements of CALPHAD in additive manufacturing(AM)technology in recent years,including material design,process parameter optimization,microstructure evolution simulation,and properties ***,the limitations of applying CALPHAD technology to MAM technology are discussed,along with prospective research directions.

关键词： metal additive manufacturing CALPHAD integrated computational material engineering powder bed fusion material design microstructure simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于特征分块的赤足足迹人身识别算法

引用

科学技术与工程 2024年第3期24卷 1125-1130页

作者：金益锋赵晓蕊崔均健陈伟卿王国栋蒋雪梅公安部鉴定中心北京100038 中国人民公安大学侦查学院北京100038 大连恒锐科技股份有限公司大连116085

为了提高赤足足迹人身识别算法的准确率,提出了一种基于深度学习的足迹识别算法。足底各区域所受压力的不同导致了它们包含的信息量存在一定的差异性,为了获取更稳定、区分度更高的特征,该算法采用ResNet50作为基础网络,在特征层进行分... 详细信息

为了提高赤足足迹人身识别算法的准确率,提出了一种基于深度学习的足迹识别算法。足底各区域所受压力的不同导致了它们包含的信息量存在一定的差异性,为了获取更稳定、区分度更高的特征,该算法采用ResNet50作为基础网络,在特征层进行分块处理。构建了一个包含2000人的赤足足迹库进行训练和一个包含3000人的赤足足迹库进行测试,该算法利用500人1000幅测试图在测试库上首位识别准确率达到了98.50%,优于常规的ResNet50网络。实验表明,基于特征分块的足迹识别算法在赤足足迹识别中获得了很好的识别效果。

关键词：足迹学人身识别深度学习特征提取特征分块

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhancement of comprehensive properties of Nb–Si based in-situ composites by Ho rare earth doping

引用

Rare Metals 2024年第9期43卷 4508-4520页

作者： wei wei Qi Wang Rui-Run chen Chao-Wen Zheng Yan-qing Su National Key Laboratory for Precision Hot Processing of Metals School of Materials Science and EngineeringHarbin Institute of Technology

This study examines the microstructure,mechanical properties （with a focus on room-temperature toughness）, and oxidation resistance of Ho-doped NbDSi based in-situ composites. The base alloy consists of the coarse primary Nb5Si3phase and the Nb5Si3+Nbss （Nb solid solution） eutectic cells. Ho doping influences the solidification path. When the Ho doping is higher than0.2 at%, the alloys transform into eutectic alloys. Ho can be solid-solved in trace amounts in the Nbss phase. However, most of Ho forms a stable Ho oxide phase, which alleviates oxygen contamination problem to some ***, the interface separation between Ho oxide and other phases reduces the plastic deformation ***, with 0.4 at%Ho doping, the KQvalue is18.03 MPa·m1/2, which is 31.1%higher than that of the base alloy. The strength of the Ho-doped alloys does not deteriorate with an increase in toughness. However, the large network-like Ho2O3in the 0.8Ho alloy causes a decrease in toughness and strength. In addition, the Ho oxide phase effectively blocks the inward oxygen *** 0.8 at%Ho doping, the oxidation mass gain per unit area is 10.16 mg·cm2, which is 39.7%lower than that of the base alloy.

关键词： Ho Microstructure Nb–Si based composites Properties Rare earth elements

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Properties of collective flow and pion production in intermediate-energy heavy-ion collisions with a relativistic quantum molecular dynamics model

引用

Nuclear Science and Techniques 2024年第1期35卷 155-169页

作者： Si-Na wei Zhao-qing Feng School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

The relativistic mean-field approach was implemented in the Lanzhou quantum molecular dynamics transport model(***). Using the ***, the properties of collective flow and pion production were investigated systematically for nuclear reactions with various isospin asymmetries. The directed and elliptic flows of the *** are able to describe the experimental data of STAR Collaboration. The directed flow difference between free neutrons and protons was associated with the stiffness of the symmetry energy, that is, a softer symmetry energy led to a larger flow difference. For various collision energies, the ratio between the π^(-) and π^(+) yields increased with a decrease in the slope parameter of the symmetry energy. When the collision energy was 270 MeV/nucleon, the single ratio of the pion transverse momentum spectra also increased with decreasing slope parameter of the symmetry energy in both nearly symmetric and neutron-rich ***, it is difficult to constrain the stiffness of the symmetry energy with the double ratio because of the lack of threshold energy correction on the pion production.

关键词： Heavy-ion collision Collective flow Pion production Symmetry energy Relativistic mean field

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pituitary metastasis from lung adenocarcinoma:A case report

引用

World Journal of Clinical Cases 2024年第15期12卷 2597-2605页

作者： qing Wang Xiao-wei Liu Ke-Yu chen Department of Critical Care Medicine Chengdu First People’s HospitalChengdu 610000Sichuan ProvinceChina Department of Neurosurgery Chengdu Second People's HospitalChengdu 610017Sichuan ProvinceChina Department of the First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Evidence Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Pituitary gland metastasis is an unusual event,and pituitary metastasis from lung adenocarcinoma is extremely rare and associated with poor *** date,approximately 15 cases have been *** SUMMARY Here,we present the case of a 64-year-old woman with pituitary metastasis derived from lung adenocarcinoma,which was difficult to distinguish from other sellar *** patient presented to the neurosurgery clinic with blurred vision and intermittent *** hospitalization,brain computed tomography(CT)and magnetic resonance imaging revealed a pituitary *** CT revealed irregular nodules in the basal segment of the lower lobe of the left lung,which were likely lung *** emission tomography-CT revealed a carbohydrate metabolism tumor in the lungs and sellar region,which was considered *** pathological examination of the sellar tumor revealed lung *** Excision of pituitary metastases combined with radiotherapy and chemotherapy should be a priority treatment for patients with pituitary metastasis.

关键词： Pituitary metastasis Lung adenocarcinoma Prolactin Sellar region tumors Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Difference in BOF Slag Splashing in US and China

引用

Journal of Iron and Steel Research(International) 2001年第1期8卷 1-5页

作者： chen wei-qing KENT Peaslee University of Science and Technology Beijing University of Missouri-Rolla

Some differences in slag splashing between BOF steel works in US and China were investigated. The slag composition,melting point, and mineralogical phases of final slags from both countries were studied. The control o... 详细信息

关键词： slag splashing BOF melting point mineralogical phases superheat

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High expression circRALGPS2 in atretic follicle induces chicken granulosa cell apoptosis and autophagy via encoding a new protein

引用

Journal of Animal Science and Biotechnology 2024年第3期15卷 971-986页

作者： Haorong He Yuanhang wei Yuqi chen Xiyu Zhao Xiaoxu Shen qing Zhu Huadong Yin Key Laboratory of Livestock and Poultry Multi‑Omics Ministry of Agriculture and Rural AffairsCollege of Animal Science and TechnologySichuan Agricultural UniversityChengduSichuan 611130China Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengduSichuan 611130China

Background The reproductive performance of chickens mainly depends on the development of ***-mal follicle development can lead to decreased reproductive performance and even ovarian disease among *** is the only non-human animal with a high incidence of spontaneous ovarian *** recent years,the involvement of circRNAs in follicle development and atresia regulation has been *** In the present study,we used healthy and atretic chicken follicles for circRNA *** results showed differential expression of *** was then confirmed that circRALGPS2 can translate into a protein,named cir-cRALGPS2-212aa,which has IRES ***,we found that circRALGPS2-212aa promotes apoptosis and autophagy in chicken granulosa cells by forming a complex with PARP1 and *** Our results revealed that circRALGPS2 can regulate chicken granulosa cell apoptosis and autophagy through the circRALGPS2-212aa/PARP1/HMGB1 axis.

关键词： Apoptosis Autophagy Chicken CircRALGPS2 Follicle atresia PARP1 RNC-seq

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：