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Preparation of AlGaN/GaN Heterostructures on Sapphire Using Light Radiation Heating Metal-Organic Chemical Vapor Deposition at Low Pressure

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Chinese Physics Letters 2000年第8期17卷 617-618页

作者： ZHOU Yu-Gang SHEN Bo ZHANG Rong LI Wei-Ping chen Peng chen Zhi-zhong GU shu-Lin SHI Yi Z.C.Huang ZHENG You-dou Solid State Microstructures Laboratory and Department of Physics Nanjing UniversityNanjing 210093 Raytheon ITSS 4500 Forbes BulivardMD 20771USA

AlGaN/GaN heterostructures on sapphire substrate were fabricated by using light radiation heating metalor ganic chemical vapor *** excitation spectra show that there are two abrupt slopes corresponding to the absorption edges of AlGaN and GaN,respectively.X-ray diffraction spectra clearly exhibit the GaN(0002),(0004),and A1GaN(0002),(0004)diffraction peaks,and no diffraction peak other than those from the GaN{0001}and A1GaN{0001}planes is *** space mapping indicates that there is no tilt between the AlGaN layer and the GaN *** results also indicate that the sample is of sound quality and the Al composition in the AlGaN layer is of high uniformity.

关键词： AlGaN/GaN AlGaN sapphire

Versatile dopamine-functionalized hyaluronic acid-recombinant human collagen hydrogel promoting diabetic wound healing via inflammation control and vascularization tissue regeneration

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Bioactive Materials 2024年第5期35卷 330-345页

作者： Yong Wang Yuan Zhang Yun-Peng Yang Ming-Yuan Jin Sha Huang Ze-Ming Zhuang tao Zhang Li-Li Cao Xiao-Ying Lin Jun chen Yong-Zhong Du Jian chen Wei-Qiang Tan Department of Plastic Surgery Sir Run Run Shaw HospitalZhejiang University School of Medicine3 East Qingchun RoadHangzhou310016China Department of Ultrasound in Medicine The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu322000China Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang University866 Yu-Hang-Tang RoadHangzhou310058China MOE Key Laboratory of Biosystems Homeostasis&Protection College of Life SciencesZhejiang UniversityHangzhou310058China

The management of chronic wounds in diabetes remains challenging due to the complexity of impaired wound healing,delayed healing,susceptibility to infection,and elevated risk of reopening,highlighting the need for effective chronic wound management with innovative approaches such as multifunctional ***,we have produced HA-DA@rhCol hydrogels consisting of dopamine-modified hyaluronic acid and recombinant human collagen type-III(rhCol)by oxidative coupling of the catechol group using the H_(2)O_(2)/HRP catalytic *** post-reactive hydrogel has a good porous structure,swelling rate,reasonable degradation,rheological and mechanical properties,and the catechol group and dopamine impart to the hydrogel tissue adhesiveness,antioxidant capacity,and excellent photothermal effects leading to superior in vitro antimicrobial *** addition,the ability of rhCol to confer hydrogels to promote angiogenesis and wound repair has also been *** and hemolysis tests demonstrated the good biocompatibility of the *** closure,collagen deposition and immunohistochemical examination confirmed the ability of the hydrogel to promote diabetic wound *** summary,the adhesive hemostatic antioxidative hydrogel with rhCol to promote wound healing in diabetic rat is an excellent chronic wound dressing.

关键词： Hyaluronic acid hydrogel Recombinant human collagen Antioxidant and anti-inflammation Antibacterial Diabetic wound

论今文《尚书》使令动词“伻”的来源及相关问题

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语言研究 2018年第2期38卷 65-70页

作者：陈树扬州大学文学院江苏扬州225002

今文《尚书》"伻"应是由甲、金文使令动词"乎"讹变而来。大约从东周开始"乎"主要功能偏向于句尾语气词和介词,加之"乎"与"平"形体相近,《尚书》中的使令动词"乎"便产生讹误。讹字"平"在后世流传过程中受使令动词"使"、"俾"字形影响,增... 详细信息

今文《尚书》"伻"应是由甲、金文使令动词"乎"讹变而来。大约从东周开始"乎"主要功能偏向于句尾语气词和介词,加之"乎"与"平"形体相近,《尚书》中的使令动词"乎"便产生讹误。讹字"平"在后世流传过程中受使令动词"使"、"俾"字形影响,增加意符写作"伻"。在传世典籍中讹字"平"又误读为"釆",使"辩"具有使令的假借义,"平"又通假为"拼"、"荓"等字表使役义。

关键词：使令动词伻乎

248nm准分子激光刻蚀的无裂损石英玻璃表面微通道

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中国激光 2017年第9期44卷 107-116页

作者：杨桂栓陈涛陈虹北京工业大学激光工程研究院北京100124

利用248nm纳秒准分子激光,采用掩模投影和石英玻璃前表面直写刻蚀的方法,研究了激光脉冲能量密度、重复频率、扫描次数对微通道裂损的影响规律,分析了石英玻璃激光刻蚀及裂损的机理。结果表明,248nm纳秒准分子激光刻蚀石英玻璃的机理为... 详细信息

利用248nm纳秒准分子激光,采用掩模投影和石英玻璃前表面直写刻蚀的方法,研究了激光脉冲能量密度、重复频率、扫描次数对微通道裂损的影响规律,分析了石英玻璃激光刻蚀及裂损的机理。结果表明,248nm纳秒准分子激光刻蚀石英玻璃的机理为光致电离及热烧蚀的共同作用;无裂损刻蚀JGS1型石英玻璃的激光能量密度阈值范围为16~30J·cm^(-2),刻蚀率可达每脉冲500nm;随着激光重复频率及扫描次数的增加,微通道容易因热积累及等离子体微爆炸冲击作用而裂损。基于优化的激光加工参数,当微通道宽度小于100μm时,可以实现无裂损的直线型(深度小于或等于50μm)及圆弧型(深度小于或等于28.5μm)微通道的加工。

关键词：激光技术石英玻璃刻蚀准分子激光微加工无裂损加工

Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation of SIRT3/AMPK/ACC Pathway

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Current Medical Science 2019年第1期39卷 37-43页

作者： Yu-pei ZHANG Yuan-jun DENG Kai-rui TANG Run-sen chen shu LIANG Yin-ji LIANG Li HAN Ling JIN Zi-en LIANG Yan-ning chen Qin-he YANG School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632China Department of Traditional Chinese Medicine the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China

This study aimed to verify the effects of berberine(BBR)on the fat metabolism proteins involved in the sirtuin 3(SIRT3)/adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)/acetyl-CoA carboxylase(ACC)pathway in the liver tissues of rats with high-fat diet(HFD)-induced non-alcoholic fatty liver disease(NAFLD).Forty-eight rats were randomly divided into the normal control(NC)group,HFD group or BBR group,with 16 rats in each *** 8 and 16 weeks of treatment,serum and liver samples were ***,body parameters,biochemical parameters and liver pathology were *** expression levels of proteins involved in the SIRT3/AMPK/ACC pathway in the liver were detected by Western *** 8 and 16 weeks of a HFD,the successful establishment of rat models with different degrees of NAFLD was confirmed by hematoxylin and eosin(H&E)and Oil Red O *** rat models exhibited obesity and hyperlipidemia,and the protein expression levels of SIRT3,p-AMPK.p-ACC,and CPT-1A in the liver were significantly decreased compared to those in the NC *** concurrent administration of BBR with the HFD effectively improved serum and liver lipid profiles and ameliorated liver ***,the protein expression levels of SIRT3,p-AMPK,p-ACC,and CPT-1 A in the liver were significantly increased in the BBR group as compared with those in the HFD *** conclusion,our data suggest that the mechanism by which BBR ameliorates HFD-induced hepatic steatosis may be related to the activation of the SIRT3/AMPK/ACC pathway in the liver.

关键词： berberine non-alcoholic fatty liver disease sirtuin 3 lipid metabolism

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中央党校加强党性教育的历史考察

中共中央党校学报 2016年第3期20卷 34-43页

作者：陈述中共中央党校中共党史教研部北京海淀100091

党性教育是共产党人修身养性的必修课。八十多年来中央党校一直按照中共中央的决定、要求和部署,把党性教育落实到教学科研工作中并取得实际成效:1.民主革命时期,为确定党在民族解放战争中的领导地位和推进党的建设伟大工程高度重视党... 详细信息

党性教育是共产党人修身养性的必修课。八十多年来中央党校一直按照中共中央的决定、要求和部署,把党性教育落实到教学科研工作中并取得实际成效:1.民主革命时期,为确定党在民族解放战争中的领导地位和推进党的建设伟大工程高度重视党性教育;2.从马列学院到中央直属高级党校期间,把"增强党性"纳入到教学方针之中;3.从中央党校复校到开创改革开放和现代化建设新时期,把培养觉悟高、党性强、作风好、具有现代知识的领导骨干作为培养目标;4.在经受国内外严重政治风波考验把中国特色社会主义全面推向新世纪期间,提出"理论基础、世界眼光、战略思维、党性修养"的教学布局;5.中共十七届一中全会以后,以坚定理想信念、增强宗旨观念和改进作风为重点增强学员的党性修养。中央党校党性教育有三个突出特点:一是党性教育和理论学习共同提高;二是党性教育与中心工作统一起来;三是把党性教育与作风养成紧密结合。

关键词：中央党校党性党性教育党性修养

Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages

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Signal Transduction and Targeted Therapy 2024年第1期9卷 40-43页

作者： Huili chen Shengyang Fu Xiangyu Li Meng Shi Jiazhen Qian shu Zhao Ping Yuan Lu Ding Xiaohuan Xia Jialin C.Zheng Center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital affiliated to Tongji University School of Medicine200065 ShanghaiChina Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s Hospital affiliated to Tongji University School of Medicine200434 ShanghaiChina

Dear Editor,Major depressive disorder(MDD)is one of the most common psychiatric illnesses that significantly increase the risk of suicide.1 Stress-triggered dysfunctions of microglia have been identified as a commonly occurred pathological feature of MDD.1–3 Microglial dysfunction contributes to the pathogenesis of MDD via immunoresponses/neuroinflammation-mediated neural damage and pathological synapse loss-mediated neural circuit disruption.1 Although the involvement of microglia in MDD has been widely investigated,the molecular mechanisms underlying microglial dysfunction remain largely ***,we identified glutaminase 1(Gls1)as one key protein that participates in microglial dysfunction.4–6 Gls1 catalyzes the hydrolysis of glutamine to produce glutamate in the brain.4 Besides its well-known role in excitatory neurotoxicity,we found Gls1 up-regulation in microglia in animal models of Alzheimer’s disease and ischemic stroke.4,7 Gls1 activates microglia to overproduce cytokines and release inflammatory extracellular vesicles,therefore leading to neuroinflammation in animal models of Alzheimer’s disease and ischemic stroke.4–6 More importantly,Gls1 has been found to be up-regulated in the brains of MDD patients,and microglial Gls1 deficiency mitigated LPS-induced depression-like behaviors.8 However,LPS exposure is not an appropriate model to mimic MDD phenotypes,leaving the involvement of Gls1 in MDD an undetermined question.

关键词： involvement inflammation media

Introgression of lac6/tl1/du13 improves the palatability of japonica rice

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The Crop Journal 2024年第4期12卷 1259-1265页

作者： Yong Yang tao Zhang Yuliang Shi Yan Lu Qianfeng Li Xiaolei Fan Lichun Huang Lu chen Xuetang Song Qing Liu Changquan Zhang Qiaoquan Liu Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Zhongshan Biological Breeding Laboratory/Key Laboratory of Plant Functional Genomics of the Ministry of Education Agricultural College of Yangzhou UniversityYangzhou 225009JiangsuChina Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops/Jiangsu Key Laboratory of Crop Genetics and Physiology Yangzhou UniversityYangzhou 225009JiangsuChina Jiang Su(Wu Jin)Rice Research Institute Changzhou 213175JiangsuChina

Amylose content(AC)is a crucial determinant of the eating and cooking quality(ECQ)of rice,with low AC varieties exhibiting a softer texture and greater stickiness-attributes that enhance palatability and are desirable in specific culinary *** harness these traits,significant efforts have been made to manipulate AC to improve rice *** research utilized the MutMap+approach to identify LAC6/TL1,a gene that is an allele of Du13,responsible for low ***6 encodes a C2H2 zinc finger protein,which specifically increases the splicing efficiency of the Wxb allele without affecting the Wxa *** studies of LAC6 revealed that its proper integration could rectify the undesirable AC phenotype,whereas mutations within this gene led to reduced AC and were associated with shorter grain length and decreased thousand-grain *** these drawbacks,such mutations positively impact rice palatability,presenting a trade-off between grain size and eating *** address the challenges posed by the reduced grain weight associated with LAC6 mutations,we developed a specific molecular marker for LAC6,which has been effectively used in breeding programs to select lac6/tl1/du13 homozygous individuals with larger grain *** findings demonstrate that the“small grain”trait associated with lac6/tl1/du13 can be effectively mitigated through combined phenotype-based and marker-assisted *** study highlights the potential of lac6/tl1/du13 as a valuable gene for breeding novel,high-quality soft rice varieties through targeted breeding strategies.

关键词： Rice Dull endosperm Amylose content Wx Breeding

The allelic distribution and variation analysis of the NAM-B1 gene in Chinese wheat cultivars

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Journal of Integrative Agriculture 2017年第6期16卷 1294-1303页

作者： chen Xue-yan SONG Guo-qi ZHANG shu-juan LI Yu-lian GAO Jie Islam Shahidul MA Wu-jun LI Gen-ying JI Wan-quan College of Agronomy Northwest A&F University Yangling 712100 P.R.China Crop Research Institute Shandong Academy of Agricultural Sciences/Key Laboratory of Wheat Biology & Genetic Improvement on North Yellow & Huai River Valley Ministry of Agriculture/National Engineering Laboratory for Wheat & Maize Jinan 250100 P. R. China Australia-China Centre for Wheat Improvement School of Veterinary and Life Sciences Murdoch University Perth WA 6150 Australia Australia Export Grains Innovation Centre 3 Baron-Hay Court Perth WA 6151 Australia

The NAM-B1 gene is a member of the NAC（NAM,ATAF,and CUC）transcription factor family and plays an important role in regulating wheat grain protein content（GPC）.The ancestral NAM-B1 allele has been discovered in many tetraploid wild emmer（Triticum turgidum ***）accessions and few domesticated emmer accessions（*** ***）,however,it is rarely found in hexaploid bread wheat（Triticum aestivum L.）.There are no systematic reports on the distribution of NAM-B1 alleles in Chinese wheat *** this study,the NAM-B1 alleles in 218 Chinese cultivars were *** cultivars were collected from five major wheat regions（12 provinces）,covering most of the winter wheat growing regions in *** results showed that the NAM-B1 gene is present in 53（24.3%）cultivars and absent in the remaining 165（75.7%）*** analysis revealed that in contrast to the wild-type allele,the NAM-B1 gene in Chinese wheat cultivars contained a 1-bp insertion in the coding *** caused a frame-shift mutation and introduced a stop codon in the middle of the gene,rendering it *** were detected in DNA sequences of 21cultivars among these 53 ***,cD NA sequence analysis suggested that these variations in the exon region were not able to restore NAM-B1 gene（1-bp insertion）***,exploring the distribution of NAM-B1 gene variations（1-bp insertion and deletion）can provide some information for improving the quality of winter wheat in China and other countries.

关键词： NAM-B1 allele variations Chinese wheat cultivars grain protein content