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Drug-target networks for Tanshinone IIA identified by data mining

Chinese Journal of Natural Medicines 2015年第10期13卷 751-759页

作者： chen shao-jun Department of Traditional Chinese Medicine Zhejiang Pharmaceutical College

Tanshinone IIA is a pharmacologically active compound isolated from Danshen(Salvia miltiorrhiza), a traditional Chinese herbal medicine for the management of cardiac diseases and other disorders. But its underlying molecular mechanisms of action are still unclear. The present investigation utilized a data mining approach based on network pharmacology to uncover the potential protein targets of Tanshinone IIA. Network pharmacology, an integrated multidisciplinary study, incorporates systems biology, network analysis, connectivity, redundancy, and pleiotropy, providing powerful new tools and insights into elucidating the fine details of drug-target interactions. In the present study, two separate drug-target networks for Tanshinone IIA were constructed using the Agilent Literature Search(ALS) and STITCH(search tool for interactions of chemicals) methods. Analysis of the ALS-constructed network revealed a target network with a scale-free topology and five top nodes(protein targets) corresponding to Fos, jun, Src, phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha(PIK3CA), and mitogen-activated protein kinase kinase 1(MAP2K1), whereas analysis of the STITCH-constructed network revealed three top nodes corresponding to cytochrome P450 3A4(CYP3A4), cytochrome P450 A1(CYP1A1), and nuclear factor kappa B1(NFκB1). The discrepancies were probably due to the differences in the divergent computer mining tools and databases employed by the two methods. However, it is conceivable that all eight proteins mediate important biological functions of Tanshinone IIA, contributing to its overall drug-target network. In conclusion, the current results may assist in developing a comprehensive understanding of the molecular mechanisms and signaling pathways of in a simple, compact, and visual manner.

关键词： Data mining Network analysis Network pharmacology Tanshinone IIA

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HARTEN SOLUTION FOR ONE-DIMENSIONAL UNSTEADY EQUATION

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Applied Mathematics and Mechanics(English Edition) 1993年第6期14卷 545-554页

作者： chen shao-jun Shanghai University of Technology Shanghai

In order to use the second-order 5-point difference scheme mentioned to compute the solution of one dimension unsteady equations of the direct reflection of the strong plane detonation wave meeting a solid wall barrier,in this paper,we technically construct the difference schemes of the boundary and sub-boundary of the problem,and deduce the auto-analogue analytic solutions of the initial value problem,and at the same time,we present a method for the singular property of the initial value problem,from which we can get a satisfactory computation result of this difficult *** difference scheme used in this paper to deal with the discontinuity problems of the shock wave are valuable and worth generalization.

关键词： one-dimensional unsteady Harten solution difference scheme

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The Effect of Boron on the Properties of Glucomannan: An Experimental and Molecular Dynamics Simulation Study

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Chinese Journal of Structural Chemistry 2005年第12期24卷 1397-1402页

作者： PANG Jie SUN Yu-Jing LI Bin TIAN Shi-Ping chen shao-jun College of Food Science Fu Jian Agriculture And Forestry University Fuzhou Fujian 350002 China Key Laboratory of Photosynthesis and Environmental Molecular Physiology Institute of Botany The Chinese Academy of Sciences Beijing 100093 China College of Food Science and Technology Agriculture University of Middle China Wuhan Hubei 430070 China

The effect of boron on the properties of Konjac Glucomanan （KGM） has been investigated by the method of experiment and molecular dynamic simulation. Upon analysis, the property and structure of KGM are apt to be affected by boron and structural reasons for property change were discussed. In detail, the addition low concentration borax can increase the systematic inherent viscosity, by contrast, high concentration borax has opposite effect on the viscosity. When adding borax, the micropores on KGM film surface decrease or disappear, leading to more compact and uniform on the film surface. The structure of KGM-Boron complex is described as the coordination reaction between KGM and boron. The main reaction points are hydroxyl group on C（6） position of sugar as well as those on C（2） and C（3） positions of mannose with two kinds of complexes formation： B-K2 and KB-K. And KB-K mainly consists of g-b-m.

关键词： glucomannan boron NMR molecular dynamics

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Effects of GLUT4 expression on insulin resistance in patients with advanced liver cirrhosis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第8期12卷 677-682页

作者： Wei-feng SHAN Bing-quan chen shao-jun ZHU Li JIANG Yan-feng ZHOU Department of Anesthesiology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Decreased glucose tolerance and diabetes are frequently observed in advanced liver cirrhosis patients and may be related to insulin *** transporter-4 (GLUT4),one of the most important glucose transporters,plays a key role in the development of type 2 *** order to study the mechanism of insulin resistance in liver cirrhosis patients,we measured the insulin sensitivity index and determined the GLUT4 protein and mRNA contents of skeletal muscle by Western blotting and reverse transcription-polymerase chain reaction (RT-PCR),respectively,in normal people and liver cirrhosis *** results showed that the levels of glucose,insulin,and C-peptide in two liver cirrhosis groups were higher and the insulin sensitivity index lower than those of the normal control *** sensitivity of insulin may decrease with the decline of liver ***,the contents of GLUT4 protein and mRNA in patients with advanced liver cirrhosis were similar to those of normal *** conclusion,insulin resistance is observed in patients with advanced liver cirrhosis but may not be correlated with the skeletal contents of GLUT4 protein and mRNA.

关键词： Glucose transporter-4 (GLUT4) Liver cirrhosis Insulin resistance Skeletal muscle

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Synthesis of a Novel Imidazole Ionic Liquid Modified Mesoporous Silica SBA15 for Selective Separation and Determination of Inorganic Arsenic in Rice

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Chinese Journal of Structural Chemistry 2018年第12期37卷 2024-2035,1848页

作者： chen Tuan-Wei ZHEN Wen-Bo YAN Zhi-Ming LIN He-Tong chen Guo-Ying chen shao-jun College of Food Science Fujian Agriculture and Forestry University United States Department of Agriculture Agricultural Research Service Eastern Regional Research Center

A novel 1-methylimidazole ionic liquid modified SBA15 mesoporous silica(1-MIIL@SBA15) was synthesized and applied to selective separation of inorganic arsenic(iAs) in rice by dispersive solid phase extraction(DSPE), followed by hydride generation-atomic fluorescence spectrometric(HG-AFS) quantification. The prepared sorbent was characterized by FTIR, FESEM, BET and Zeta potential. Key parameters of adsorption and desorption in DSPE were optimized using standard reference material 1568 b rice flour. Under optimal conditions, the limit of detection was 8.776 ng/kg, relative standard deviation was ≤2.0%, and recoveries of iAs were in the 92.3～94.4% range. This method was successfully applied to the determination of iAs in rice. Under acidic condition, the electrostatic interaction between the positively charged 1-MIIL@SBA15 and anionic iAs played an important role in selective iAs separation, rendering this method suitable for iAs analysis.

关键词： SBA15 ionic liquid inorganic arsenic dispersive solid phase extraction hydride generation-atomic fluorescence spectrometric(HG-AFS)

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干旱内陆区自然-人工条件下地下水位动态的ANN模型

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水利学报 2007年第7期38卷 873-878,885页

作者：冯绍元霍再林康绍忠陈绍军中国农业大学中国农业水问题研究中心北京100083

根据我国干旱内陆区自然-人工条件下地下水系统的特点,建立了甘肃省石羊河流域下游地下水位动态的人工神经网络模型,采用附加动量法和学习速率自适应调整策略对反向传播算法(BP)进行改造,以提高计算速度。该模型以前期地下水位、降雨量... 详细信息

根据我国干旱内陆区自然-人工条件下地下水系统的特点,建立了甘肃省石羊河流域下游地下水位动态的人工神经网络模型,采用附加动量法和学习速率自适应调整策略对反向传播算法(BP)进行改造,以提高计算速度。该模型以前期地下水位、降雨量、蒸发量、地表来水量、灌溉面积、灌水定额、人口数量作为输入变量,采用缺省因子检验法分析了上述各个因子对地下水位影响的敏感性,模拟了不同灌溉发展面积及地表来水条件下地下水位动态。结果表明:研究区人类活动及地表来水是影响地下水位动态的主要因子,灌溉面积的扩大及地表来水的减少会使地下水位持续下降。模型具有较高的精度,可以较好地定量描述地下水位动态与上述各因子之间的响应关系;研究结果可应用于该地区地下水系统的管理。

关键词：人工神经网络石羊河流域自然-人工条件地下水动态模拟

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民营科技企业产权制度变迁研究

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特区经济 2008年第12期 132-133页

作者：陈少军烟台大学经管学院山东烟台264000

面对日益激烈的竞争环境和走向国际化的发展目标,民营科技企业在产权制度作出了各种创新性的尝试。本文在分析民营科技企业产权变迁原因的基础上,针对相应的制约制度变迁因素提出了较为具体的产权制度变迁实施途径。

关键词：民营科技企业产权制度制度变迁

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数值计算在VLCC船上层建筑的振动特性研究

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舰船科学技术 2019年第6期41卷 22-24页

作者：陈少军周口科技职业学院河南周口466000

超大型原油船(VLCC)是一个国家非常重要的战略船舶,由于我国在VLCC船舶设计和制造方面起步较晚,与世界先进水平还有一定的差距。VLCC船舶的振动问题一直是船舶工业领域需要解决的重点,由于VLCC船舶的上层建筑质量大、体积大,与船舶产生... 详细信息

超大型原油船(VLCC)是一个国家非常重要的战略船舶,由于我国在VLCC船舶设计和制造方面起步较晚,与世界先进水平还有一定的差距。VLCC船舶的振动问题一直是船舶工业领域需要解决的重点,由于VLCC船舶的上层建筑质量大、体积大,与船舶产生的共振可能会引起严重的事故。本文针对这一问题,分别对VLCC和甲板上层建筑进行振动特性分析,重点研究了VLCC上层甲板的固有频率和振动变形,最后基于Ansys有限元仿真软件,对VLCC船舶的上层建筑进行振动特性仿真。

关键词： VLCC船振动特性仿真 Ansys

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应用X射线光刻的微针阵列及掩模板补偿

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光学精密工程 2010年第2期18卷 420-425页

作者：陈少军李以贵杉山进上海交通大学微纳米科学技术研究院薄膜与微细技术教育部重点实验室微米/纳米加工技术国家级重点实验室上海200240 日本立命馆大学微系统研究中心

提出了一种聚甲基丙烯酸甲酯(PMMA)微针的微细加工工艺,该工艺基于PCT技术,结合X射线以及光刻掩模制作三维微结构。通过移动LIGA掩模板曝光来加工微立体PMMA结构,其加工形状取决于X光光刻掩模板吸收体的形状。实验显示,最终的结构形状... 详细信息

提出了一种聚甲基丙烯酸甲酯(PMMA)微针的微细加工工艺,该工艺基于PCT技术,结合X射线以及光刻掩模制作三维微结构。通过移动LIGA掩模板曝光来加工微立体PMMA结构,其加工形状取决于X光光刻掩模板吸收体的形状。实验显示,最终的结构形状并非完全与掩模板上吸收体的形状一致。如果不对X光光刻掩模板的吸收体形状进行补偿,即会使被加工的微结构侧面变形,从而影响微针的性能。分析了微针阵列侧面变形的原因,认为这种变形是由于显影时间与曝光量之间的非线性关系导致结构形状与曝光量分布不完全一致造成的。利用PCT方法制作的PMMA微针其长度为100～750μm,直径为30～150μm,针尖的直径最小可达100nm。通过对LIGA掩模板上的吸收体图形进行适当的补偿,使吸收体图形从中空的双直角三角形变为中空的半椭圆图形,增强了带沟道的微注射针阵列的强度。

关键词： X射线光刻聚甲基丙烯酸甲酯三维微结构掩模吸收体

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu chen Xue-jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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