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2型糖尿病患者卒中预防及血糖管理专家共识

中华内科杂志 2024年第7期63卷 649-659页

作者：《2型糖尿病患者卒中预防及血糖管理专家共识》编写委员会陈莉明母义明不详天津医科大学朱宪彝纪念医院内分泌科天津300134 解放军总医院第一医学中心内分泌科北京100853

糖代谢异常与卒中关系密切,对卒中的发生、发展及预后均有不良影响。良好的血糖控制对改善卒中预后具有重要意义。部分降糖药物能够减少2型糖尿病患者卒中的发生及复发风险。2型糖尿病合并卒中患者应控制血压、血脂,合理应用抗血小板药... 详细信息

糖代谢异常与卒中关系密切,对卒中的发生、发展及预后均有不良影响。良好的血糖控制对改善卒中预后具有重要意义。部分降糖药物能够减少2型糖尿病患者卒中的发生及复发风险。2型糖尿病合并卒中患者应控制血压、血脂,合理应用抗血小板药物。共识专家组基于循证医学证据和临床实践,并经过多次讨论最终形成本共识,以期为临床提供参考。

关键词：糖尿病 2型卒中预防血糖管理专家共识

Research advances of nanoparticles for CAR-T therapy in solid tumors

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Chinese Chemical Letters 2024年第9期35卷 72-82页

作者： Bohan chen liming Gong Jing Feng Mingji Jin Liqing chen Zhonggao Gao Wei Huang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Department of PharmaceuticsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China School of Pharmacy Qingdao UniversityQingdao 266071China

As one of the most promising adoptive T-cell therapies,chimeric antigen receptor T-cell(CAR-T)therapy has acquired Food and Drug Administration(FDA)approval for a variety of products and has been used successfully in the treatment of malignant hematological ***-T therapy,on the other hand,faces a number of obstacles in the field of solid tumor therapy that limit its widespread clinical *** advances in nanoparticle research in cancer therapy and immunotherapy have been made in recent years,providing novel strategies to address the challenges encountered by CAR-T therapy in the treatment of solid *** review commences with a comprehensive explanation of the basic framework of CAR-T therapy as well as the challenges it faces in the treatment of solid ***,we encapsulate a summary of the developmental research combining nanoparticles with CAR-T cells for the treatment of solid tumors,which includes gene transfection,cell activation and expansion,targeted infiltration,immune escape inhibition,and combination with other *** with the overview of the research progress,a discussion has been initiated on the challenges and perspectives of CAR-T based on nanoparticles.

关键词： CAR-T therapy Nanoparticles Solid tumors Immunotherapy T cell

1954—2020年太湖水位变化的时空差异特征分析

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江苏水利 2024年第2期 42-45页

作者：蔡文美陈少颖孙玉莹陆昊陈黎明潘逸卉南京水利科学研究院水灾害防御全国重点实验室江苏南京210029 江苏省水利科学研究院江苏南京210017 河海大学水文水资源学院江苏南京210098

为探究太湖水位变化的时空差异特征,基于太湖1954—2020年实测水位数据,对太湖的年平均水位、年最高水位、年最低水位以及逐年水位空间变化,采用M-K突变检验等方法开展研究并结合太湖进出水量变化分析原因。结果表明,随着太湖湖体入湖... 详细信息

为探究太湖水位变化的时空差异特征,基于太湖1954—2020年实测水位数据,对太湖的年平均水位、年最高水位、年最低水位以及逐年水位空间变化,采用M-K突变检验等方法开展研究并结合太湖进出水量变化分析原因。结果表明,随着太湖湖体入湖水量的增加,太湖年平均水位及年最低水位均呈上升趋势,且在突变年份之后显著上升;年最高水位也呈上升趋势,但在突变年份后变化不明显。

关键词：太湖流域时空差异突变检验水位

Experimental Study of Ultrasound on MDR in a Human Tumor in Vivo

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Chinese Journal of Clinical Oncology 2007年第6期4卷 390-396页

作者： Baojin Zhai liming chen Yumian Guo ZhiHong Wang Feng Wu Department of Neurological Surgery theAffiliated Hospital of The Medical College ofChinese People＇s Armed Police ForceTianjin300162 China Institute of Ultrasound and Engineering inMedicine Chongqing University of MedicalSciencel Chongqing 400016 China

OBJECTIVE To evaluate the potential efficacy of low-intensity ultrasound （US） in combination with anticancer drugs to reverse multidrug resistance （MDR）in nude mice. METHODS A total of 40 male and female athymic nude mice were inoculated subcutaneously with 5×10^6 HepG2/ADM and HepG2 cells. Ultrasound with pulsed irradiation at an average intensity of 0.5 W/cm^2 was given to the tumor area 10 rain after administration of adriamycin （ADM）. The tumor 3 dimensional diameters were measured by calipers before and after treatment, and the tumor growth indexes （TGI） calculated. RT-PCR was used to detect the gene levels of the HepG2/ADM cells. Immunohistochemical analyses for MDR proteins were conducted on the tumor tissues. RESULTS The ultrasonic treatment resulted in an average reduction in the tumor volume of 62% one month later. The relative mRNA levels of MDR1 and MRP were significantly different among the following 4 groups： untreated group as control, ADM treated; US treated; and ADM plus US treated. The mRNA levels of mdrl and mrp were down-regulated in the US groups compared to those of the non-ultrasound groups by multiple comparisons. The relative mRNA levels of Irp expression were not significantly changed. The results of immunohistochemistry indicated that tumor tissue from animals treated with US had remarkably low mdrl and mrp expression. CONCLUSION The results showed that low-intensity US can effectively reduce the size of adriamycin-resistant human hepotacarcinoma in a nude mouse model, and support the efficacy of US to overcome multiple mechanisms of drug resistance.

关键词： muitidrug resistance (MDR) HepG2/ADM ultrasound (US) nude mice.

Analysis of New Microsatellite Markers Developed From Reported Sequences of Japanese Flounder Paralichthys olivaceus

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Journal of Ocean University of China 2010年第4期9卷 365-370页

作者： YU Haiyang JIANG liming chen Wei WANG Xubo WANG Zhigang ZHANG Quanqi College of Marine Life Sciences Key Laboratory of Marine Genetics and Breeding Ministry of EducationOcean University of China Qingdao 266003 P. R. China

The expressed sequence tags（ESTs）of Japanese flounder,Paralichthys olivaeeus,were selected from GenBank to identify simple sequence repeats（SSRs）or microsatellites.A bioinformatic analysis of 11111 ESTs identified 751 SSR-containing ESTs,including 440 dinucleotide,254 trinucleotide,53 tetranueleotide,95 pentanucleotide and 40 hexanucleotide microsatellites *** CA/TG and GA/TC repeats were the most abundant ***-rich types were predominant among trinucleotide and tetranucleotide *** primers were designed to amplify 10 identified microsatellites *** PCR results from eight pairs of primers showed polymorphisms in wild *** 30 wild individuals,the mean observed and expected heterozygosities of these 8 polymorphic SSRs were 0.71 and 0.83 respectively and the average PIC value was *** microsatellite markers should prove to be a useful addition to the microsatellite markers that are now available for this species.

关键词： bioinformatics data mining microsatellite Japanese flounder EST

Intelligent fault diagnosis methods toward gas turbine: A review

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Chinese Journal of Aeronautics 2024年第4期37卷 93-120页

作者： Xiaofeng LIU Yingjie chen Liuqi XIONG Jianhua WANG chenshuang LUO liming ZHANG Kehuan WANG School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Systems Engineering Research Institute China State Shipbuilding CorporationBeijing 100094China

Fault diagnosis plays a significant role in conducting condition-based maintenance and health management for gas turbines(GTs) to improve reliability and reduce costs. Various diagnosis methods developed by modeling engine systems or certain components implement faults detection and diagnosis based on the measurement of systemic parameters deviations. However, these conventional model-based methods are hindered by limitations of inability to handle the nonlinear nature, measurement uncertainty, fault coupling and other implementing problems. Recently, the development of artificial intelligence algorithms has provided an effective solution to the above problems, triggering broad researches for data-driven fault diagnosis methods with better accuracy,dynamic performance, and universality. This paper presents a systematic review of recently proposed intelligent fault diagnosis methods for GT engines, according to the classification of shallow learning methods, deep learning methods and hybrid intelligent methods. Moreover, the principle of typical algorithms, the evolution of enhanced methods, and the assessment of pros and cons are summarized to conclude the present status and look forward to the future in the field of GT fault diagnosis. Possible directions for development in method validation, information fusion, and interpretability of intelligent diagnosis methods are concluded in the end to provide insightful concepts for scholars in related fields.

关键词： Fault diagnosis Health management Gas turbine Artificial intelligence Intelligent diagnosis method

Target Detection Algorithm in Foggy Scenes Based on Dual Subnets

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Computers, Materials & Continua 2024年第2期78卷 1915-1931页

作者： Yuecheng Yu liming Cai Anqi Ning Jinlong Shi Xudong chen Shixin Huang School of Computer Science Jiangsu University of Science and TechnologyZhenjiang212100China Information Department China Merchants Heavy IndustryNantong226116China

Under the influence of air humidity,dust,aerosols,etc.,in real scenes,haze presents an uneven *** this way,the image quality and contrast will *** this case,It is difficult to detect the target in the image by the universal detection ***,a dual subnet based on multi-task collaborative training(DSMCT)is proposed in this ***,in the training phase,the Gated Context Aggregation Network(GCANet)is used as the supervisory network of YOLOX to promote the extraction of clean information in foggy *** the test phase,only the YOLOX branch needs to be activated to ensure the detection speed of the ***,the deformable convolution module is used to improve GCANet to enhance the model’s ability to capture details of non-homogeneous ***,the Coordinate Attention mechanism is introduced into the Vision Transformer and the backbone network of YOLOX is *** this way,the feature extraction ability of the network for deep-level information can be *** experimental results on artificial fog data set FOG_VOC and real fog data set RTTS show that the map value of DSMCT reached 86.56%and 62.39%,respectively,which was 2.27%and 4.41%higher than the current most advanced detection *** DSMCT network has high practicality and effectiveness for target detection in real foggy scenes.

关键词： Target detection fog target detection YOLOX twin network multi-task learning

胫骨横向骨搬移联合加减桃红四物汤治疗气虚血瘀型糖尿病足的临床疗效观察

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中国老年保健医学 2024年第3期22卷 137-140页

作者：陈重凯曾维铨林东刘宇林桂宇蓝文涛刘美锭陈丽明福建中医药大学附属第二人民医院 350003 福建中医药大学附属康复医院 350001

目的观察胫骨横向骨搬移联合加减桃红四物汤治疗糖尿病足的临床疗效。方法本研究采用对照研究,将纳入的44例糖尿病足患者分为对照组和研究组,每组22例。对照组行胫骨横向骨搬移术治疗,研究组在此基础上联合加减桃红四物汤治疗,治疗8周后... 详细信息

目的观察胫骨横向骨搬移联合加减桃红四物汤治疗糖尿病足的临床疗效。方法本研究采用对照研究,将纳入的44例糖尿病足患者分为对照组和研究组,每组22例。对照组行胫骨横向骨搬移术治疗,研究组在此基础上联合加减桃红四物汤治疗,治疗8周后,观察对比两组患者中医证候积分、患足皮温、踝肱指数、足背动脉血流动力学指标以及临床疗效变化。结果与治疗前相比两组患者中医证候积分、患足皮温、踝肱指数、血管内径及血流流速均较治疗前显著升高(P0.05);研究组临床疗效总有效率为90.91%,显著高于对照组的总有效率为72.73%(P<0.05)。结论加减桃红四物汤联合胫骨横向骨搬移治疗,可以提高糖尿病足临床疗效。

关键词：桃红四物汤胫骨横向骨搬移糖尿病足

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闻一多的诗歌翻译与格律诗学的生成

文艺理论研究 2016年第1期36卷 64-75页

作者：陈历明华侨大学外国语学院

闻一多通过有意识地选择各体英语格律诗进行翻译,又在创作和理论构建中译介、引用并实践英语格律诗学,以此抗拒新文化运动中白话新诗的主流意识形态,质疑其主导地位,为其现代格律诗学的合法性赢得话语权。本文主要通过梳理闻一多几乎湮... 详细信息

闻一多通过有意识地选择各体英语格律诗进行翻译,又在创作和理论构建中译介、引用并实践英语格律诗学,以此抗拒新文化运动中白话新诗的主流意识形态,质疑其主导地位,为其现代格律诗学的合法性赢得话语权。本文主要通过梳理闻一多几乎湮没的译诗《希腊之群岛》,及其他格律译诗,阐述其格律诗学在其翻译与创作的互动、互证中的构建生成;认为他以此反抗主流诗学,扭转了新诗的非诗化发展趋势,同时也为新诗在回归诗歌本体的诉求中开辟了一条融合中西的格律诗学通途。

关键词：闻一多格律诗学《希腊之群岛》翻译抵抗