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贵州省12岁儿童口腔健康相关生活质量及影响因素

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中国儿童保健杂志 2024年第8期32卷 862-867页

作者：张旭彤李娜吴娟娟陈欣月赵南洋陈黎明戴泰鸣贵州大学医学院贵州贵阳550025 贵阳市口腔医院遵义医科大学

目的了解贵州省12岁儿童口腔健康相关生活质量状况,评估其影响因素,为学龄期儿童口腔疾病的健康教育和防治提供参考依据。方法采用多阶段随机分层抽样的方法抽取贵州省12岁儿童1777人纳入研究,按照WHO口腔健康检查标准进行口腔检查,使... 详细信息

目的了解贵州省12岁儿童口腔健康相关生活质量状况,评估其影响因素,为学龄期儿童口腔疾病的健康教育和防治提供参考依据。方法采用多阶段随机分层抽样的方法抽取贵州省12岁儿童1777人纳入研究,按照WHO口腔健康检查标准进行口腔检查,使用儿童日常生活口腔影响量表(Child-OIDP)评估儿童日常生活质量。运用χ2检验、非参数检验和二分类Logistic回归模型分析其影响因素。结果共有73.3%(1303/1777)的12岁儿童显示在过去6个月内至少受到1次口腔健康状况的影响,受到影响最高的是饮食(52.6%),而最低的是上学(16.0%)。居住于农村地区(OR=0.483,95%CI:0.322~0.723)是口腔相关生活质量受影响的保护因素(P<0.001);经济状况为二类经济地区(OR=1.926,95%CI:1.404~2.642)和三类经济地区(OR=5.347,95%CI:3.295~8.677)、每周2~6次的甜食摄入频率(OR=1.518,95%CI:1.143~2.015)和每天1次及以上的甜食摄入频率(OR=1.433,95%CI:1.098~1.871)、良好的口腔健康知识水平(OR=1.693,95%CI:1.145~2.502)、一般的口腔健康态度(OR=1.830,95%CI:1.143~2.928)及积极的口腔健康态度(OR=2.121,95%CI:1.353~3.324)与口腔相关生活质量受影响呈正相关(P<0.05)。结论贵州省12岁儿童的日常生活广泛受到口腔健康状况的影响,但影响的程度相对较轻。

关键词：口腔卫生口腔流行病学学龄期儿童儿童日常生活口腔影响量表

Precision oncology and molecular therapies for hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2022年第6期11卷 882-885页

作者： liming chen Youcai Xu Gu Li Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Surgery People’s Hospital of Jingning She Autonomous CountyLishuiChina Department of Neurosurgery The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

Hepatocellular carcinoma(HCC)is one of the most lethal malignant tumors *** is classified by a continuously increasing morbidity,low resectable rate,high relapse rate after radical surgery,limited response to medicati... 详细信息

关键词： mortality surgery medication

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临床研究护士现状调查与分析

中国临床药理学与治疗学 2024年第4期29卷 455-459页

作者：陈黎明张海燕黄帆赵文艳丁锐曹彩方翼北京大学人民医院临床试验机构研究型病房北京101109 北京大学人民医院护理部北京100044 北京大学药学院北京100083 中关村玖泰药物临床试验技术创新联盟北京100081

目的:调查并分析国内临床研究护士现状与需求,为构建研究护士培训体系、促进研究护士规范化培训以及实现研究护士规范化管理提供科学依据。方法:采用自制调查问卷对国内近70家知名临床试验机构的102名研究护士进行问卷调查,调查内容主... 详细信息

目的:调查并分析国内临床研究护士现状与需求,为构建研究护士培训体系、促进研究护士规范化培训以及实现研究护士规范化管理提供科学依据。方法:采用自制调查问卷对国内近70家知名临床试验机构的102名研究护士进行问卷调查,调查内容主要包括研究护士的一般资料、职业经历与工作内容、从事临床试验工作的成就感及培训需求。结果:参与问卷调查的102名研究护士中,学历为本科及以上者占92.15%,职称中级及以上者占53.92%。兼职研究护士占74.51%;在职业经历中,19.61%具有10年以上的临床试验经历;在临床试验分工中被授权参与过临床试验药品管理、样本管理和质量控制的比例分别为47.06%、40.20%和21.17%。能够在药物临床试验工作中获得较高成就感的研究护士占70.59%;在教育培训方面,研究护士认为临床试验相关法律法规、临床试验方案规范化实施与药物临床试验质量管理规范(good clinical practice,GCP)是最为重要的培训内容。结论:我国临床试验研究护士学历、护龄较高,但相对于飞速发展的创新药物和器械陆续注册上市与临床研究体系亟待完善的迫切需要,国内专业化的专职研究护士缺口较大,需要构建符合我国国情的研究护士培训、考核、评价体系,以提高研究护士专业化水平,助力提升我国的创新药物和器械临床试验研究的数量与质量。

关键词：临床试验研究护士培训培养

Text Recognition of Barcode Images under Harsh Lighting Conditions

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Wuhan University Journal of Natural Sciences 2020年第6期25卷 531-537页

作者： WU Xing GE Yuxi ZHANG Qingfeng chen liming School of Computer Engineering and Science Shanghai UniversityShanghai 200444China Shanghai Institute for Advanced Communication and Data Science Shanghai UniversityShanghai 200444China CAC Supply Chain Management Company Beijing 100016China

The inventory counting of silver ingots plays a key role in silver ***,the manual inventory counting is time-consuming and ***,the silver ingots are stored in warehouses with harsh lighting conditions,which makes the automatic inventory counting *** meet the challenge,we propose an automatic inventory counting method integrating object detection and text recognition under harsh lighting *** the help of our own dataset,the barcode on each silver ingot is detected and cropped by the feature pyramid network(FPN).The cropped image is normalized and corrected for text *** use the PSENet+CRNN(Progressive Scale Expansion Network,Convolutional Recurrent Neural Network)for text detection and recognition to obtain the serial number of the silver ingot *** results show that the proposed automatic inventory counting method achieves good results since the accuracy of the proposed object detection and text recognition under harsh lighting conditions is near 99%.

关键词： barcode object detection text recognition deep learning

Controllably partial removal of thiolate ligands from unsupported Au_(25) nanoclusters by rapid thermal treatments for electrochemical CO_(2)reduction

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Journal of Energy Chemistry 2023年第11期86卷 16-22,I0002页

作者： Liting Huang Yongfeng Lun Yuping Liu liming chen Bowen Li Shuqin Song Yi Wang The Key Lab of Low-carbon Chemistry&Energy Conservation of Guangdong Province PCFM LabSchool of Chemical Engineering and TechnologySchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275GuangdongChina

Colloidal synthesis of metal nanoclusters will inevitably lead to the blockage of catalytically active sites by organic ***,taking[Au_(25)(PET)_(18)]-(PET=2-phenylethanethiol)nanocluster as a model catalyst,this work reports a feasible procedure to achieve the controllably partial removal of thiolate ligands from unsupported[Au_(25)(PET)_(18)]-nanoclusters with the preservation of the core *** procedure shortens the processing duration by rapid heating and cooling on the basis of traditional annealing treatment,avoiding the reconfiguration or agglomeration of Au_(25)nanoclusters,where the degree of dethiolation can be regulated by the control of *** work finds that a moderate degree of dethiolation can expose the Au active sites while maintaining the suppression of the competing hydrogen evolution ***,the activity and selectivity towards CO formation in electrochemical CO_(2)reduction reaction of Au_(25)nanoclusters can be *** work provides a new approach for the removal of thiolate ligands from atomically precise gold nanoclusters.

关键词： Gold nanoclusters Thiolates Ligand removal Electrochemically active surface area Electrochemical CO_(2)reduction

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基于回归分析的发动机HC排放预测模型

小型内燃机与车辆技术 2024年第1期53卷 46-51页

作者：陈利明刘义佳赖海鹏张彬长城汽车股份有限公司河北保定071000 河北省车用发动机技术创新中心

将回归分析方法用在一台经过改造的汽油/柴油双燃料发动机HC排放研究上。以1700r/min@60 N·m工况为例描述了试验设计、模型阶次选择、异常点去除、正态分布假设判断整个过程,获得了精度较高的HC排放模型,通过将试验结果和仿真分析结果... 详细信息

将回归分析方法用在一台经过改造的汽油/柴油双燃料发动机HC排放研究上。以1700r/min@60 N·m工况为例描述了试验设计、模型阶次选择、异常点去除、正态分布假设判断整个过程,获得了精度较高的HC排放模型,通过将试验结果和仿真分析结果进行对比验证了所建模型的正确性。

关键词：回归分析汽油/柴油双燃料发动机 HC排放预测模型试验设计

Voluntary Disclosure of Auditors＇ Report on Internal Control： Firm Characteristics and Economic Consequences

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Frontiers of Business Research in China 2013年第4期7卷 505-534页

作者： Rongli Yuan liming chen Wen Wen School of Business Renmin University of China Beijing 100872 China Guanghua School of Management Peking University Beijing 100871 China

Using propensity score matching （PSM） and the difference-in- difference （DID） approach, this paper explores the characteristics of listed Chinese firms that voluntarily disclose auditors＇ reports on internal control and the economic consequences. Using a sample of non-financial firms listed on the main boards of the Shanghai Stock Exchange and the Shenzhen Stock Exchange between 2006 and 2010, we find that firms are more likely to voluntarily disclose their auditors＇ reports on internal control if they have higher state ownership, lower managerial ownership, sanction records, audit committees, non-Big Four auditors as their auditors of annual financial reports, unqualified auditors＇ opinions on financial reports, less board independence, after controlling for firm size, liabilities, performance, and history. Moreover, as compared to a control group that exhibits similar characteristics, firms that voluntarily disclose auditors＇ reports on internal control are associated with positive earnings quality and negative cost of equity capital.

关键词： auditors' reports on internal control earnings quality cost of equity capital propensity score matching (PSM) difference-in-difference (DID) approach

Effect of CeO_(2) Nanoparticles on the Spread of Antibiotic Resistance in a Reclaimed Water-Soil-Radish System-Shenzhen City,Guangdong Province,China,April 2023

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China CDC weekly 2023年第46期5卷 1029-1037,I0005-I0007页

作者： Kaiqiang Yu Bixi Zhao Yuxi Yan Qing Yang liming chen Yu Xia School of Environmental Science and Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen CityGuangdong ProvinceChina School of Resource Environment and Life ScienceNingxia Normal UniversityGuyuan CityGansu ProvinceChina State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen CityGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen CityGuangdong ProvinceChina

ABSTRACT Introduction:The use of reclaimed water(RW)for irrigation in agricultural practices raises concerns regarding the dissemination of antibiotic resistance genes(ARGs)from soils to edible *** effectiveness of na... 详细信息

关键词： Antibiotic Guangdong claimed

SELENBP1通过减轻氧化应激和炎症改善糖尿病视网膜病变

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国际内分泌代谢杂志 2024年第4期44卷 220-226页

作者：田蕾郭航曲敬茹徐榕陈莉明天津医科大学朱宪彝纪念医院天津市内分泌研究所国家卫生健康委员会激素与发育重点实验室天津市代谢性疾病重点实验室天津300134

目的旨在结合转录组测序的结果,聚焦糖尿病视网膜病变中的氧化应激水平和炎症水平,探讨硒结合蛋白1(selenium binding protein 1,SELENBP1)在糖尿病视网膜病变中的作用。方法对12周龄的db/m和db/db小鼠的视网膜组织进行转录组测序分析... 详细信息

目的旨在结合转录组测序的结果,聚焦糖尿病视网膜病变中的氧化应激水平和炎症水平,探讨硒结合蛋白1(selenium binding protein 1,SELENBP1)在糖尿病视网膜病变中的作用。方法对12周龄的db/m和db/db小鼠的视网膜组织进行转录组测序分析筛选差异基因。实验分为两组:db/m小鼠、db/db小鼠,对视网膜组织切片进行活性氧荧光染色,应用蛋白免疫印迹(Western-blot)检测小鼠视网膜组织中的氧化应激反应相关指标还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶(NOX)2、NOX4、超氧化物歧化酶2(SOD2)和炎性反应相关指标核因子-κB(NF-κB)、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β的变化趋势;用实时荧光定量聚合酶链反应(qRT-PCR)、Western-blot和免疫组化(IHC)分析组织中SELENBP1的水平。在体外,应用高糖干预人视网膜微血管内皮细胞(HRMEC),实验分为两组:正常糖组(NG组)、高糖干预组(HG组)检测活性氧水平及氧化应激和炎性因子的表达;在HRMEC细胞中转染SELENBP1质粒和SELENBP1小干扰RNA,分为正常糖对照组(NG+Vector)、SELENBP1质粒组(NG+SBP1)、高糖对照组(HG+si-NC)、SELENBP1小干扰RNA组(HG+si-SBP1),分析活性氧水平及氧化应激和炎性因子的表达水平。结果与db/m小鼠相比,db/db小鼠视网膜组织中活性氧含量升高、氧化应激相关因子表达增加、抗氧化因子表达下降、炎性因子表达增加,且SELENBP1的mRNA和蛋白水平都明显升高。体外实验表明,高糖干预HRMEC细胞后,细胞中活性氧水平、氧化应激水平和炎症水平明显升高,SELENBP1的mRNA和蛋白表达均明显升高;在HRMEC细胞中过表达SELENBP1后氧化应激水平和炎症水平明显升高;在HRMEC细胞中敲低SELENBP1后氧化应激水平和炎症水平明显下降。结论SELENBP1通过促进视网膜的氧化应激水平和炎症水平加重了糖尿病视网膜病变,抑制该基因的表达可能会成为减轻糖尿病视网膜病变的有效治疗靶点。

关键词：糖尿病视网膜病变氧化应激炎症硒结合蛋白1