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Plasma Science and Technology 2024年第6期26卷 60-69页

作者：陈龙高维富崔作君段萍许雪松阚子晨檀聪琦陈俊宇 School of Science Dalian Maritime UniversityDalian 116026People’s Republic of China

The configuration of electrode voltage and zero magnetic point position has a significant impact on the performance of the double-stage Hall effect thruster. A 2D-3V model is established based on the two-magnetic peak type double-stage Hall thruster configuration, and a particle-in-cell simulation is carried out to investigate the influences of both acceleration electrode voltage value and zero magnetic point position on the thruster discharge characteristics and *** results indicate that increasing the acceleration voltage leads to a larger potential drop in the acceleration stage, allowing ions to gain higher energy, while electrons are easily absorbed by the intermediate electrode, resulting in a decrease in the anode current and ionization rate. When the acceleration voltage reaches 500 V, the thrust and efficiency are maximized, resulting in a 15%increase in efficiency. After the acceleration voltage exceeds 500 V, a potential barrier forms within the channel, leading to a decrease in thruster efficiency. Further study shows that as the second zero magnetic point moves towards the outlet of the channel, more electrons easily traverse the zero magnetic field region, participating in the ionization. The increase in the ionization rate leads to a gradual enhancement in both thrust and efficiency.

关键词： Hall thruster particle-in-cell simulation intermediate electrode zero magnetic point

Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis

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Acta Pharmaceutica Sinica B 2024年第2期14卷 682-697页

作者： Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang Jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He xuesong Liu Lvfen Gao Dongmei Zhang Wencai Ye Minfeng chen State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China School of Medicine Jinan UniversityGuangzhou 510632China School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510630China The First Affiliated Hospital of Jinan University Guangzhou 510632China State Key Laboratory of Chemical Oncogenomics Guangdong Provincial Key Laboratory of Chemical BiologyTsinghua Shenzhen International Graduate SchoolShenzhen 518055China

Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM.

关键词： Lymphaticmetastasis Colorectal cancer Fibroblastactivation proteinα FAPα-activated prodrug Epithelial-mesenchymal

Relay Node Placement with Base Stations in Wireless Sensor Networks Fault-Tolerant

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Chinese Journal of Electronics 2014年第4期23卷 794-800页

作者： GAO Zhipeng chen kan.qiu xuesong State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications

It has been proposed to deploy relay nodes for the sake of prolonging Wireless sensor networks(WSN)lifetime, such that sensors transmit the sensed data to them which in turn delivers the data to base stations. For survivability requirements, relay placements which considers fault tolerant ability have been noticed and studied. While related works are limited or most existing works don't take factors such as fault tolerance, or base stations into account comprehensively in two tired WSN. We focus on fault tolerant relay node placement in two-tiered heterogeneous WSN with base stations. As far as we know,fault tolerance contains two fundamental aspects, for one is multi-coverage and the second is multi-path. It is a NPhard problem and figure out an approximation, whose approximation ratio is enhanced to be(18 +). While a sub-problem approximation is also described as supplementary. Experimental results verify that the number of relay nodes deployed by our algorithm is somewhat superior to existed relay node placement solutions.

关键词： Relay node placement Wireless sensor networks Fault tolerant Connectivity Approximations ratio

草地贪夜蛾对玉米和五种非禾本科作物的寄主选择性与寄主适合度及为害风险

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植物保护学报 2024年第4期51卷 918-927页

作者：邱良妙刘其全陈秀琴卢学松刘必炮福建省农业科学院植物保护研究所福建省作物有害生物监测与治理重点实验室福州350013

为监测和防控草地贪夜蛾Spodoptera frugiperda,采用叶碟法和半田间模拟选择法分别测定该害虫对玉米与5种非禾本科作物的取食选择性和产卵选择性,室内测定取食不同作物后草地贪夜蛾的生长发育、存活率和繁殖力,采用种群增长趋势指数评... 详细信息

为监测和防控草地贪夜蛾Spodoptera frugiperda,采用叶碟法和半田间模拟选择法分别测定该害虫对玉米与5种非禾本科作物的取食选择性和产卵选择性,室内测定取食不同作物后草地贪夜蛾的生长发育、存活率和繁殖力,采用种群增长趋势指数评价寄主适合度,进一步通过田间试验验证其寄主选择性。结果表明:在有玉米可选择条件下,草地贪夜蛾幼虫对玉米的取食选择率最高,其次是花生和甘蓝;在无玉米可选择条件下,草地贪夜蛾对花生和甘蓝的取食选择率最高,但不论有无玉米可选择条件下,草地贪夜蛾对茄子和香蕉的取食选择率均最低,并随时间延长而降低,甚至不取食,表现明显的拒食。在有玉米可选择条件下,5 d内12对成虫在玉米上的产卵量最高,为2452.50粒,分别是在花生、甘蓝和豇豆上的6.29倍、5.79倍和11.43倍,未在茄子和香蕉上产卵,在纱网上的产卵量达468.25粒;在无玉米可选择条件下,在纱网的产卵量高达1812.50粒,显著高于在非禾本科作物上的产卵量,预示该害虫在嗜食寄主缺乏或饱和受害时具有优先向周围环境扩散的习性而非在不适宜寄主上产卵。相较于玉米,取食5种供试作物的草地贪夜蛾发育迟缓,存活率下降,其中取食花生、甘蓝和豇豆的可以完成生活史,适合度分别为0.46、0.07和0.04,但取食茄子和香蕉的不能完成生活史;田间小区试验结果证实该害虫对不同寄主的选择性与适应性有差异。表明该害虫对花生的为害风险大,对甘蓝和豇豆的为害风险小,为害茄子或香蕉的风险极小。

关键词：草地贪夜蛾玉米禾本科植物寄主选择性适合度为害风险

Ultra-compact tunable graphene-based plasmonic multimode interference power splitter in mid infrared frequencies

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Science China(Information Sciences) 2017年第8期60卷 211-216页

作者： Pingping qiu Weibin qiu Zhili LIN Houbo chen Yixin TANG Jiaxian WANG Qiang kan Jiaoqing PAN College of Information Science and Engineering Huaqiao University Institute of Semiconductors Chinese Academy of Sciences

In this paper, we propose graphene-based plasmonic multimode interference power splitters with ultra-compact size working in mid infrared range. Further, the arbitrary-ratio 1×2 power splitter with a size of 140 nm×232 nm, where the splitting ratio can be tuned continuously from 1:1 to 100:0, is numerically demonstrated. Meanwhile, the graphene-based arbitrary-ratio 1×2 power splitters with different frequencies and chemical potentials are also investigated. The proposed multimode interference structure with a deep nanoscale footprint might be a fundamental component of the future high density integrated plasmonic circuit or on-chip plasmonic interconnect techniques.

关键词： graphene multimode interference surface plasmon polaritons power splitter plasmonic integrated circuits

Delay and Energy Consumption Oriented UAV Inspection Business Collaboration Computing Mechanism in Edge Computing Based Electric Power IoT

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Chinese Journal of Electronics 2023年第1期32卷 13-25页

作者： SHAO Sujie LI Yi GUO Shaoyong WANG chenhui chen Xingyu qiu xuesong State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications Blockchain Research Department China Electronics Standardization Institute

With the development of Internet of things(IoT) technology and smart grid infrastructure,edge computing has become an effective solution to meet the delay requirements of the electric power IoT. Due to the limitation of battery capacity and data transmission mode of IoT terminals, the business collaboration computing must consider the energy consumption of the terminals. Since delay and energy consumption are the optimization goals of two co-directional changes, it is difficult to find a business collaboration computing mechanism that simultaneously minimizes delay and energy *** paper takes the unmanned aerial vehicle(UAV) inspection business scenario in the electric power IoT based on edge computing as the representative, and proposes a two-stage business collaboration computing mechanism including resources allocation and task allocation to optimize the business delay and energy consumption of UAV by decoupling the complex correlation between resource allocation and task allocation. A steepest descent resource allocation algorithm is proposed. On the basis of resource allocation, an improved multiobjective evolutionary algorithm based on decomposition by dynamically adjusting the size of neighborhood and the cross distribution index is proposed as a task allocation algorithm to minimize energy consumption and business delay. Simulation results show that our algorithms can respectively reduce the business delay and energy consumption by more than6.4% and 9.5% compared with other algorithms.

关键词： Energy consumption Heuristic algorithms Collaboration Autonomous aerial vehicles Delays Power systems Resource management

IVUS指导DES置入在ACS患者中的长期预后评价:ULTIMATE研究ACS亚组分析

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中华心血管病杂志 2024年第2期52卷 137-143页

作者：高晓飞韩冷钱雪松葛震孔祥权陆曙阚静左广锋张俊杰陈绍良南京医科大学附属南京医院南京市第一医院心内科南京210006 常熟市第一人民医院心内科常熟215500 张家港市第一人民医院心内科张家港215600 太仓市第一人民医院心内科太仓215400

目的评估血管内超声(IVUS)指导药物洗脱支架(DES)置入对急性冠脉综合征(ACS)患者长期临床结局的影响。方法研究对象来源于ULTIMATE研究,该研究是一项前瞻性、多中心、随机对照研究,于2014年8月—2017年5月在国内8家医院入选1448例置入DE... 详细信息

目的评估血管内超声(IVUS)指导药物洗脱支架(DES)置入对急性冠脉综合征(ACS)患者长期临床结局的影响。方法研究对象来源于ULTIMATE研究,该研究是一项前瞻性、多中心、随机对照研究,于2014年8月—2017年5月在国内8家医院入选1448例置入DES的冠心病患者。本研究为ULTIMATE研究的亚组分析,将冠心病患者分为ACS组和非ACS组,2组患者均在IVUS或冠状动脉造影指导下置入DES。主要终点是术后3年靶血管失败(TVF)率,包含心原性死亡、靶血管心肌梗死和临床驱动的靶血管血运重建。结果1448例冠心病患者中,ACS组1136例(78.5%),1423例(98.3%)患者完成术后3年随访。ACS组患者术后3年的TVF发生率为9.6%(109/1136),高于非ACS组的4.5%(14/312),log-rankP=0.005。ACS组中IVUS指导下置入DES者的TVF发生率低于冠状动脉造影指导下置入DES架者[7.6%(43/569)比11.6%(66/567),log-rankP=0.019]。ACS组中IVUS指导下DES置入达标组患者术后3年的TVF发生率为5.4%(16/296),低于IVUS未达标组的9.9%(27/273),log-rankP=0.041。结论ACS患者置入DES后3年的TVF事件率高于无ACS患者;相比于冠状动脉造影,IVUS指导DES置入可以降低ACS患者术后3年的TVF事件,尤其是IVUS指导下DES置入达标的患者获益更明显。

关键词：药物洗脱支架冠状动脉造影血管内超声急性冠脉综合征

Highly Luminescent N-Benzylcarbazole Compound Immobilized in Amino-functionalized Mesoporous SBA-15

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Chemical Research in Chinese Universities 2009年第4期25卷 518-521页

作者： WANG Hong-su GUAN Jing-qi SONG Ke XU chen kan.qiu-bin College of Chemistry Jilin University Changchun 130021 P. R. China Department of Agronomy Jilin University Changchun 130062 P. R. China

An inorganic-organic photoluminescence solid material was obtained by immobilizing N-benzylcarbazole compound to an amino-functionalized mesoporous SBA-15（designated as N-benzylcarbazole-amino-SBA-15）.XRD,SEM,and N2 adsorption-desorption measurements indicate that the mesostructure of parent material SBA-15 was preserved after introducing amino and N-benzylcarbazole *** absorbance and emission studies reveal that the fluorescent N-benzylcarbazole-amino-SBA-15 exhibited red-shift character in comparison to pure N-benzylcarbazole.

关键词： N-Benzylcarbazole SBA-15 BCz-amino-SBA-15 Luminescence

The Establishment of a New Air Health Index Integrating the Mortality Risks Due to Ambient Air Pollution and Non-Optimum Temperature

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Engineering 2022年第7期8卷 156-162页

作者： Qingli Zhang Renjie chen Guanjin Yin Xihao Du Xia Meng Yang qiu Haidong kan Maigeng Zhou Key Laboratory of Public Health Safety Ministry of EducationSchool of Public HealthFudan UniversityShanghai 200032China Shanghai Key Laboratory of Meteorology and Health Shanghai Meteorological Service&Shanghai Typhoon InstituteChina Meteorological AdministrationShanghai 200030China Department of Environmental Sciences and Engineering College of Architecture and Environmental SciencesSichuan UniversityChengdu 610065China Children’s Hospital of Fudan University&National Children’s Medical Center Shanghai 200032China National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China

A composite Air Health Index(AHI)is helpful for separately emphasizing the health risks of multiple stimuli and communicating the overall risks of an adverse atmospheric environment to the *** aimed to establish a new AHI by integrating daily mortality risks due to air pollution with those due to non-optimum temperature in *** on the exposure-response(E-R)coefficients obtained from time-series models,the new AHI was constructed as the sum of excess mortality risk associated with air pollutants and non-optimum temperature in 272 Chinese cities from 2013 to *** examined the association between the“total AHI”(based on total mortality)and total mortality,and further compared the ability of the“total AHI”to predict specific cardiopulmonary mortality with that of“specific AHIs”(based on specific mortalities).On average,air pollution and non-optimum temperature were associated with 28.23%of daily excess mortality,of which 23.47%was associated with non-optimum temperature while the remainder was associated with fine particulate matter(PM2.5)(1.12%),NO2(2.29%,),and O3(2.29%).The new AHI uses a 10-point scale and shows an average across all 272 cities of 6 *** E-R curve for AHI and mortality is approximately linear,without any *** one unit increase in“total AHI”is associated with a 0.84%increase in all-cause mortality and 1.01%,0.98%,1.02%,1.66%,and 1.71%increases in cardiovascular disease,coronary heart disease,stroke,respiratory diseases,and chronic obstructive pulmonary disease mortality,***-specific mortality risk estimates using the“total AHI”are similar to those predicted by“specific AHIs.”In conclusion,the“total AHI”proposed herein could be a promising tool for communicating health risks related to exposure to the ambient environment to the public.

关键词： Air pollution Temperature Air Health Index Mortality Time-series Risk communication

Investigation of plasmonic whispering gallery modes of graphene equilateral triangle nanocavities

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Science China(Information Sciences) 2016年第4期59卷 172-180页

作者： Yixin HUANG Weibin qiu Shangxin LIN Jing ZHAO Houbo chen Jia-Xian WANG Qiang kan Jiao-Qing PAN College of Information Science and Engineering Huaqiao University Institute of Semiconductors Chinese Academy of Sciences

In this paper, a graphene-based equilateral triangle nanocavity is proposed and numerically investigated. The relationship between the mode characteristics and the nanocavity parameters, such as the geometry of nanocavity and the chemical potential of graphene, is systematically explored. A high-order plasmonic WGM(whispering gallery mode) with a high quality factor of 147.93 is obtained in our nanocavity with a wavelength of around 1.415 μm in free space, with a corresponding Purcell factor as high as 7.067×108. The proposed plasmonic WGM nanocavity could be a key component of the high density plasmonic integrated circuits due to its ultra-compactness and performances.

关键词： graphene nanocavity resonator surface plasmonic polaritons whispering gallery mode plasmonic integrated circuits