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Chinese Medical Journal 2012年第21期125卷 3891-3897页

作者： MA Jin-ping PENG Lin qiN Tao LIN Jian-wei chen chuang-qi CAI Shi-rong WANG Liang HE Yu-long Department of Gastrointestinal and Pancreatic Surgery the First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080China Department of General Surgery Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Hepatobiliary Pancreatic Surgery the People's Hospital of Zhengzhou UniversityZhengzhouHenan 450003China

Background Pancreaticogastrostomy （PG） has been proposed as an alternative to pancreaticojejunostomy （PJ）, assuming that postoperative complications are less frequent. The aim of this research was to compare the s... 详细信息

关键词： pancreaticoduodenectomy," pancreaticojejunostomy pancreaticogastrostomy," prospective controlled trials,"meta-analysis

Spleen-preserving distal pancreatectomy with conservation of the spleen vessels

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Chinese Medical Journal 2011年第8期000卷 1217-1220页

作者： MA Jin-ping chen chuang-qi PENG Lin ZHAO Gang CAI Shi-rong HU Shi-xiong HE Yu-long ZHAN Wen-hua Department of Gastrointestinal and Pancreatic Surgery the FirstAffiliated Hospital Sun Yat-sen University GuangzhouGuangdong 510080 China Department of General Surgery Guangdong General HospitalGuangzhou Guangdong 510080 China

Background Distal pancreatectomy traditionally included splenectomy; the spleen, however, is an important organ in the immunologic defense of the host and is worthy of preservation. The aim of this research was to study the feasibility,safety and clinical effects of spleen and splenic vessel-preserving distal *** A retrospective review was performed for 26 patients undergoing distal pancreatectomy for benign or low grade malignant disease with splenectomy （n=13） or splenic preservation （n=13） at the First Hospital of Sun Yat-sen University and Guangdong General Hospital in Southern China from May 2002 to April *** All 26 pancreatectomies with splenectomy or splenic preservation were performed successfully. There was no statistically significant difference between two groups in mean operative time （（172±47） minutes vs. （157±52） minutes, P ＞0.05）, intraoperative estimated blood loss （（183±68） ml vs. （160±51） ml, P ＞0.05）, incidence of noninfectious and infection complication and mean length of postoperative hospital stay （（10.1±2.2） days vs. （12.1 ±4.6） days, P ＞0.05）. The platelet counts examined one week after operation were significantly higher in the distal pancreatectomy with splenectomy group than the other group （（37.3±12.8）×109/L vs. （54.7±13.2）×109/L, P ＜0.05）.Conclusions Spleen-preserving distal pancreatectomy appears to be a feasible and safe procedure. In selected cases of benign or low-grade malignant disease, spleen-preserving distal pancreatectomy is recommended.

关键词： distal pancreatectomy spleen spleen-preserving distal pancreatectomy

Effects of diabetes mellitus on prognosis of the patients with colorectal cancer undergoing resection： a cohort study with 945 patients

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Chinese Medical Journal 2010年第21期123卷 3084-3088页

作者： chen chuang-qi FANG Le-kun CAI Shi-rong MA Jin-ping YANG Guang-xin YANG Wan ZHAN Wen-hua HE Yu-long Department of Gastrointestinal and Colorectal Surgery the First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong 510080 China

Background Diabetes mellitus plays an important role in cancer prevalence and outcomes. The aim of this study was to evaluate the influence of DM on stages and outcomes among patients with colorectal *** The study enrolled 945 patients who were diagnosed as having colorectal carcinoma from August 1994 to December 2002. In the cohort, 26 patients were diagnosed as having DM. With a median follow-up of 45.8 months,differences in overall survival and disease-free survival between the diabetes and non-diabetes groups were *** Kaplan and Meier analysis showed that there were no significant differences between the two groups in overall survival rates at 3 years or 5 years. At 5 years, patients with DM, compared with patients without diabetes, experienced a significantly lower disease-free survival rate （34.2% diabetics vs. 55.1% non-diabetics; P=0.025）.Conclusions DM was associated with an increased risk of recurrence in patients with colorectal cancer.

关键词： colorectal cancer diabetes mellitus survival rate

Role of silencing phosphatase of regenerationg liver-3 expression by microRNA interference in the growth of gastric cancer

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Chinese Medical Journal 2008年第24期121卷 2534-2538页

作者： CAI Shi-rong WANG Zhao chen chuang-qi WU Wen-hui HE Yu-long ZHAN Wen-hua ZHANG Chang-hua CUI Ji WU Hui Department of Gastrointestinal Surgery First Affiliated Hospital Sun Yat-sen University Gastric Cancer Center of Sun Yat-sen University Guangzhou Guangdong 510080 China

Background Accumulated evidences demonstrate that phosphatase of regeneration liver-3 （PRL-3） is associated with metastasis of multiple tumor types, and has been validated as a potential therapeutic target for metastasis. High expression of PRL-3 was implicated in lymph node metastasis of gastric cancer. In the present study, we investigated the role of silencing PRL-3 expression by microRNA （miRNA） interference in gastric cancer growth. Methods RNA interference, mediated by recombinant lentivirus expressing artificial PRL-3 miRNA, was employed to knockdown PRL-3 expression in human SGC7901 gastric cancer cells. MTT assay and tumor implantation experiment were conducted to determine the role of PRL-3 in the proliferation of SGC7901 cells and tumor growth. Results Transfection of recombinant lentivirus expressing artificial PRL-3 miRNA significantly suppressed the proliferation of SGC7901 cells in vitro. The implanted tumor size of the PRL-3 transfection group was （1.92±0.18） cm^3, significantly smaller compared with controls （P 〈0.001）. Conclusions Knockdown of PRL-3 significantly suppressed the proliferation of SGC7901 cells in vitro and tumor growth in vivo. PRL-3 plays a key role in the growth of gastric cancer. PRL-3 should be considered as a potential therapeutic target.

关键词： PRL-3 stomach neoplasms RNA interference

Fast track surgery accelerates the recovery of postoperative insulin sensitivity

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Chinese Medical Journal 2012年第18期125卷 3261-3265页

作者： YANG Dong-jie ZHANG Sheng HE Wei-ling chen Hua-yun CAI Shi-rong chen chuang-qi SONG Xin-ming CUI Ji MAJin-pingI ZHANG Chang-hua HE Yu-long Department of Gastrointestinal-Pancreatic Surgery the FirstAffiliated Hospital of Sun Yat-Sen University Guangzhou China Guangdong 510080

Background Few clinical studies or randomized clinical trial results have reported the impact of fast track surgery on postoperative insulin sensitivity. This study aimed to investigate the effects of fast track surgery on postoperative insulin sensitivity in patients undergoing elective open colorectal resection. Methods Controlled, randomized clinical trial was conducted from November 2008 to January 2009 with one-month post-discharge follow-up. Seventy patients with colorectal carcinoma requiring colorectal resection were randomized into two groups： a fast track group （35 cases） and a conventional care group （35 cases）. All included patients received elective open colorectal resection with combined tracheal intubation and general anesthesia. Clinical parameters （complication rates, return of gastrointestinal function and postoperative length of stay）, stress index and insulin sensitivity were evaluated in both groups perioperatively. Results Sixty-two patients finally completed the study, 32 cases in the fast-track group and 30 cases in the conventional care group. Our findings revealed a significantly faster recovery of postoperative insulin sensitivity on postoperative day 7 in the fast-track group than that in the conventional care group. We also found a significantly shorter length of postoperative stay and a significantly faster return of gastrointestinal function in patients undergoing fast-track rehabilitation. Conclusion Fast track surgery accelerates the recovery of postoperative insulin sensitivity in elective surgery for colorectal carcinoma with a shorter length of postoperative hospital stay.

关键词： fast track surgery colorectal carcinoma, insulin sensitivity, clinical trial

Ammonia pyrolysis oxidation excited by nanosecond pulsed discharge:Global/fluid models hybrid solution

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Journal of Energy Chemistry 2025年第1期100卷 385-396页

作者： Mingming Zhang Hanyu Wu qi chen Jiaxin Yang Bonan Liu School of Mechanical Electronic and Control Engineering Beijing Jiaotong University China University of Petroleum

The kinetic characteristics of plasma-assisted oxidative pyrolysis of ammonia are studied by using the global/fluid models hybrid solution ***,the stable products of plasma-assisted oxidative pyrolysis of ammonia are *** results show that the consumption of NH3/O2and the production of N2/H2change linearly with the increase of voltage,which indicates the decoupling of nonequilibrium molecular excitation and oxidative pyrolysis of ammonia at low ***,the detailed reaction kinetics mechanism of ammonia oxidative pyrolysis stimulated by a nanosecond pulse voltage at low pressure and room temperature is *** on the reaction path analysis,the simplified mechanism is *** detailed and simplified mechanism simulation results are compared with experimental data to verify the accuracy of the simplified ***,based on the simplified mechanism,the fluid model of ammonia oxidative pyrolysis stimulated by the nanosecond pulse plasma is established to study the pre-sheath/sheath behavior and the resultant consumption and formation of key *** results show that the generation,development,and propagation of the pre-sheath have a great influence on the formation and consumption of *** consumption of NH3by the cathode pre-sheath is greater than that by the anode pre-sheath,but the opposite is true for OH and O（1S）.However,within the sheath,almost all reactions do not ***,by changing the parameters of nanosecond pulse power supply voltage,it is found that the electron number density,electron current density,and applied peak voltages are not the direct reasons for the structural changes of the sheath and ***,the discharge interval has little effect on the sheath structure and gas mixture *** research results of this paper not only help to understand the kinetic promotion of non-equilibrium excitation in the process of oxidative pyrolysis but also help to explore th

关键词： Nanosecond pulsed discharge Ammonia Oxidative pyrolysis Fluid model Global model

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi qi Xueying chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

加速康复外科理念下胃肠道手术放置引流管的争议与对策

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消化肿瘤杂志（电子版） 2017年第4期9卷 234-239页

作者：陈创奇中山大学附属第一医院胃肠外科中心结直肠外科中山大学胃癌诊治中心广东广州510080

外科引流在胃肠外科疾病的诊治过程中起着十分重要的作用,特别是在腹腔感染、消化道漏或重症胰腺炎等治疗中是必不可少的治疗措施。加速康复外科理念在国内外已经实践多年,是否放置引流管在胃肠道手术的ERAS临床实践中一直争议不断。本... 详细信息

外科引流在胃肠外科疾病的诊治过程中起着十分重要的作用,特别是在腹腔感染、消化道漏或重症胰腺炎等治疗中是必不可少的治疗措施。加速康复外科理念在国内外已经实践多年,是否放置引流管在胃肠道手术的ERAS临床实践中一直争议不断。本文就外科引流的定义及其分类、引流的目的、适应症、引流物的选择、在ERAS理念下胃肠道手术常见放置引流管(包括鼻胃管、尿管、腹腔或盆腔引流管、肛管引流管)的争议与对策等相关问题做一深入探讨。

关键词：加速康复外科胃肠外科手术曰外科引流治疗

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应重视加速康复外科围术期的全程管理

消化肿瘤杂志（电子版） 2017年第1期9卷 13-17页

作者：陈创奇中山大学附属第一医院胃肠外科中心广东广州510080

加速康复外科(enhanced recovery after surgery,ERAS)是指采用有循证医学证据的围术期处理的一系列优化措施,其核心是减少手术和麻醉对患者生理和心理的创伤应激,减少并发症,达到术后快速康复。目前虽然ERAS已在许多外科专业、麻醉、... 详细信息

加速康复外科(enhanced recovery after surgery,ERAS)是指采用有循证医学证据的围术期处理的一系列优化措施,其核心是减少手术和麻醉对患者生理和心理的创伤应激,减少并发症,达到术后快速康复。目前虽然ERAS已在许多外科专业、麻醉、护理等领域得到广泛应用并取得令人满意的效果,但ERAS在临床实践中仍然面临着诸多困难和挑战。临床上要贯彻落实好ERAS的相关措施并形成规范化流程,就应高度重视ERAS围术期的全程管理,本文就现阶段此热点问题进行系统阐述。

关键词：加速康复外科围术期管理多学科协作团队

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加速康复外科对胃肠手术后胃肠功能的影响

消化肿瘤杂志（电子版） 2017年第2期9卷 86-91页

作者：陈松耀陈创奇中山大学附属第一医院胃肠外科中心广东广州510080

加速康复外科(enhanced recovery after surgery,ERAS)的核心是减少围术期创伤应激,促进各脏器功能快速恢复。围术期创伤应激反应对胃肠功能影响最早,但持续时间最长。围术期各项处理措施对术后胃肠功能恢复均有不同程度的影响,处理不... 详细信息

加速康复外科(enhanced recovery after surgery,ERAS)的核心是减少围术期创伤应激,促进各脏器功能快速恢复。围术期创伤应激反应对胃肠功能影响最早,但持续时间最长。围术期各项处理措施对术后胃肠功能恢复均有不同程度的影响,处理不当将导致术后胃肠功能恢复延迟,直接影响到ERAS的实施。本文针对ERAS的各项措施对术后胃肠功能影响进行论述。

关键词：加速康复外科围术期胃肠功能