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Nuclear Science and Techniques 2013年第6期24卷 56-60页

作者： GAO Shi JI Tiefeng WEN Qiang chen Bin MA Qingjie chen zuowei LIU Lin China-Japan Union Hospital Jilin University Department of Nuclear Medicine People's Hospital of Shenzhen

In this paper,the safety and efficacy of 131I-labeled mouse/human chimeric monoclonal antibody(131I-chTNT)-mediated radioimmunotherapy are evaluated because the patients have non-uptaking 131I pulmonary metastases from differentiated thyroid carcinoma(DTC).The 16 patients were injected intravenously by 29.6±3.7MBq·kg–1 using *** chest computer tomography was performed before treatment,as well as 28 and 70days after *** and safety were assessed during the *** results show that the 131I-chTNT infusion was well tolerated with the 12.5%complete response,18.8%partial response,25.0%progressive disease,and the 43.8%stable disease,indicating that most treatment-related adverse effects are mild transient and ***131I-chTNT is promising for patients with non-uptaking the 131I pulmonary metastases from DTC.

关键词：免疫治疗甲状腺癌吸收分化放射介导肺不良反应

Pharmacokinetics and radiation dosimetry of ^(99m)Tc-3PRGD_2 in healthy individuals:A pilot study

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Nuclear Science and Techniques 2012年第6期23卷 349-354页

作者： chenG Guanghui GAO Shi JI Tiefeng MA Qingjie JIA Bing chen zuowei WANG Qing China-Japan Union Hospital Jilin University Medical Isotopes Research Center Peking University Department of Nuclear Medicine People's Hospital of Shenzhen

99mTc-3PRGD2 is a new SPECT radiotracer for several tumor imaging with high uptake where integrinαvβ3 is highly *** pilot study was to assess the safety,biodistribution and radiation dosimetry of 9,mTc-3PRGD2 in healthy *** 10 healthy male volunteers were injected with 99mTc-3PRGD2（786.7±55.8 MBq,19.1-24.2 mCi）.Baseline measurements of vital signs,laboratory safety tests and 12-lead electrocardiogram were recorded before and after *** and urine samples were collected and radiation counts were obtained at various time ***-body scans and ROIs of identified organs were used for visual analysis and estimating the radiation *** adverse reactions were found during the study.99mTc-3PRGD2 exhibited a rapid clearance from the blood with less than 45%of the initial dosage at 10 min after injection and gradual increasing radioactivity in urine with（52.9±6）%of original dose at 1440 *** whole-body imaging showed high radioactive accumulation in *** the highest 99mTc-3PRGD2 uptake was found in the kidneys(3.50×10-2 mSv/MBq).The 99mTc-3PRGD2 exhibited good pharmacokinetic properties and little radiation *** study showed that 99mTc-3PRGD2 would be a safe and attractive SPECT agent in clinic applications.

关键词：安全试验健康人药代动力学辐射剂量高放射性 SPECT 可视化分析投资回报率

^(99m)Tc-3P_4 -RGD_2 radiotracers for SPECT/CT of esophageal tumor

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Nuclear Science and Techniques 2013年第4期24卷 38-43页

作者： GAO Shi MA Qingjie WEN Qiang JIA Bing LIU Zhaofei chen zuowei ZHANG Haishan LI Dandan China-Japan Union Hospital Jilin University Medical Isotopes Research Center Peking University Department of Nuclear Medicine People’s Hospital of Shenzhen

In recent years,several RGD(Arg-Gly-Asp)-based radiotracers have already been successfully tested in human for the visualization of integrin αvβ3,demonstrating its feasibility in tumor *** this paper,we evaluated the 99mTc-3P4-RGD2 single photon emission computed tomography/computerized tomography(SPECT/CT)in patients suffering from space occupying disease of esophagus.40 patients(34 males and 6 female;mean age: 58.3 years) with a suspected space occupying lesion of esophagus were included,thus finally obtaining their definite pathologic diagnosis(malignant,n=32;benign,n=8).All patients underwent endoscopic,barium esophagography and SPECT/CT imaging *** chest SPECT was performed at 4 h after administration of99mTc-3P4-RGD2 with a dose of 939±118 *** diagnosis precision,sensitivity and specificity among these methods were *** relationship between radioactive uptake and clinical pathological stage of esophageal carcinoma was discussed by calculating the tumor to normal esophagus(T/N).Meanwhile,the integrin αvβ3 expression was assessed immunohistochemically in postoperative esophageal tissues.31 patients were diagnosed as esophageal carcinoma;and 1,leiomyosarcoma;and ***;and 2,esophageal *** accuracy,sensitivity and specificity of barium esophagography,endoscopic and SPECT/CT imaging are 92.5/93.8/87.5%,97.5/96.9/100%,and 90/90.6/87.5%,*** accumulation of radiotracer in 29 malignant lesions is *** SPECT/CT imaging displayed the region of radioactive uptake and lesions matched extremely with the T/N ratio from 1.31 to 2.79(mean 2.04).A case with pulmonary metastases and a case with mediastinal lymph node metastases were found which were missed by barium esophagography and ***99mTc-3P4-RGD2 uptake of the esophageal carcinoma masses had no relevance to the tumor pathologic classification(P>0.05).There was a significant positive correlation between T/N ratio and positive cell per

关键词：放射性示踪剂 SPECT 食管肿瘤计算机断层扫描肿瘤诊断平均年龄恶性肿瘤病理诊断

A pilot study on ^(99m)Tc-3PRGD2 scintigraphy in diagnosis of brain glioma

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Nuclear Science and Techniques 2013年第2期24卷 36-40页

作者： GAO Shi MA Qingjie CUI Qu LIU Lin ZHOU Xueyan JIA Bing chen zuowei ZHANG Haishan China-Japan Union Hospital Jilin University Medical Isotopes Research Center Peking University Department of Nuclear Medicine People's Hospital of Shenzhen

The 99mTc-3PRGD2 targeted SPECT/CT scanning was of significance in detecting differentiated *** this work,the diagnostic value of 99mTc-3PRGD2 scintigraphy in brain glioma was evaluated by the ten clinically verified brain glioma patients after obtaining informed *** patients first accepted X-ray imaging to localize the detecting regions before administrating with 99mTc-3PRGD2 at a mean radioactivity of 849±115 MBq via single intravenous bolus injection 2 h prior to SPECT/CT *** samples for detectingαvβ3 were collected by surgical operations two weeks after the *** results of CT and SPECT scanning were merged and *** correlation between tumor occupation（T/N ratio） andαvβ3 expression level were *** T/N ratios in brain glioma were proportionally correlated to av(33 positive cell percentage（R2=0.9253,p<0.05）.This study primarily evaluated the clinical application of 99mTc-3PRGD2 SPECT scintigraphy on brain *** more pathological types and detecting strategies covering a large amount of samples would aid to clarify the potentials.

关键词：脑胶质瘤诊断价值显像 SPECT 扫描检测 X射线成像临床验证静脉注射

我国体育类核心期刊游泳教学论文的分析研究——以1980-2009年为例

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当代体育科技 2014年第20期4卷 176-178页

作者：陈祚伟韶关学院体育学院广东韶关512005

本文主要运用文献资料、数理统计和逻辑分析等方法,对我国体育类核心期刊游泳教学科研论文从发表数量、选题范围、作者的年龄和职称、研究机构分布等方面进行分析。研究发现,我国游泳教研论文发表在体育类核心期刊上数量偏少,且主要选... 详细信息

本文主要运用文献资料、数理统计和逻辑分析等方法,对我国体育类核心期刊游泳教学科研论文从发表数量、选题范围、作者的年龄和职称、研究机构分布等方面进行分析。研究发现,我国游泳教研论文发表在体育类核心期刊上数量偏少,且主要选题范围是高校游泳,教学方法缺乏足够的创新性,可操作性不强。在教研论文的撰写上,高校讲师和副教授是主要的两大群体,且以独著为主、合著较少,采用研究方法也比较单一。这在一定程度上综合反映了我国游泳教学方面的研究广度和深度有待进一步地加强。

关键词：体育类核心期刊游泳教学教研论文

全身性红斑狼疮患者外周血淋巴细胞内cAMP、血清α干扰素和IgG的关系

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同济医科大学学报 1990年第4期19卷 225-228页

作者：苏作为陈秀珠徐惠堂刘春明同济医科大学基础医学部微生物学教研室

本文测定了25例全身性红斑狼疮(SLE)患者外周血淋巴细胞(PBLs)内cAMP、cGMP含量与比值,血清α干扰素(IFN-α)和兔疫球蛋白G(IgG)水平,结果显示SLE患者PBLs内cAMP为2.79±0.9pmol/10~6细胞,cAMP/cGMP为10.21±3.41(P<0.05),血清IFN-α、IgG水平方明显高于正常对照组。血清IFN-α与PBLs内cAMP含量、血清IFN-α与IgG水平,PBLs内cAMP含量与血清IgG水平等间均呈直线相关(r分别为0.7824,0.8401,0.7641,P值均<0.05)。结果提示:SLE患者血清高水平IFN-α可能是导致PBLs内cAMP含量增高,并由此而产生血清免疫球蛋白水平增加等变化的原因之一。

关键词：红斑狼疮淋巴细胞 CAMP 干扰素

^(18)F-FDG-PET/CT显像对可疑乳腺癌复发的诊断与治疗价值

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现代肿瘤医学 2012年第11期20卷 2276-2279页

作者：陈佐伟郭一玲张英男深圳市人民医院核医学科广东深圳518020

目的:评估18F-FDG-PET/CT显像对可疑乳腺癌复发的诊断与治疗意义。方法:回顾性评估46名有乳腺癌病史且在首次确诊后存在肿瘤标志物增高的患者所做的47份18F-FDG-PET/CT显像结果。结果:30名(65%)患者证实肿瘤复发,16名(35%)患者没有显示... 详细信息

目的:评估18F-FDG-PET/CT显像对可疑乳腺癌复发的诊断与治疗意义。方法:回顾性评估46名有乳腺癌病史且在首次确诊后存在肿瘤标志物增高的患者所做的47份18F-FDG-PET/CT显像结果。结果:30名(65%)患者证实肿瘤复发,16名(35%)患者没有显示肿瘤复发的证据。31名患者得到32份不正常的PET/CT显像结果,15名患者的PET/CT结果正常。灵敏度、特异性、准确度分别为90%、71%、83%。PET/CT结果影响了24(52%)名患者的治疗方案。结论:对伴随肿瘤标志物升高的乳腺癌患者,相对于CT对肿瘤复发的诊断来说,PET/CT显像具有更大的优势,导致大部分患者治疗措施改变。

关键词：正电子发射断层摄影 18F-脱氧葡萄糖乳腺癌肿瘤标志物

SHRIMP Age of Exotic Zircons in the Mengyin Kimberlite,Shandong,and Their Formation

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Acta Geologica Sinica(English Edition) 2005年第5期79卷 654-661页

作者： YIN zuowei LU Fengxiang chen Meihua Gemmological Institute China University of Geosciences Wuhan Hubei 430074 Earth Science Department China University of Geosciences Wuhan Hubei 430074

Due to various courses of formation of zircons from kimbedites, different kinds of zircons can provide useful information about the mantle and the crystallization of kimberlites. We chose 9 typical ones out of 33 zircons from the Shengli- 1 kimberlite pipe in Mengyin County, Shandong Province to study their ages and formation by means of SHRIMP, CL, Raman spectroscopy, etc. The result shows that the ^207Pb/^206Pb ages of many zircons vary from 2567±13 Ma to 2636±42 Ma, which are close to the age of Archaean granitoid （2457.3±47 Ma） in the study area. The contents of U and Th in the samples are higher than those of zircons crystallized in kimbedite and vary from 89 to 398 ppm as well as from 10 to 283 ppm. Color zones are obvious in these samples under the CL. The inclusions are composed of feldspar, quartz, apatite, etc. The above results show that the zircon samples came from the crust of the earth, which means that the kimberlite magmas are contaminated by crustal substances. The position where a great deal of volatile escapes and even explodes during rapid rise of magmas is located at the boundary of the ancient basement and the Precambrian stratum.

关键词： kimberlite exotic zircons ages SHRIMP contamination Shandong

Copper catalyzed/mediated direct B–H alkenylation/alkynylation in carboranes

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Science China Chemistry 2019年第1期62卷 74-79页

作者： Yu chen Yik Ki Au Yangjian Quan zuowei Xie Department of Chemistry and State Key Laboratory of Synthetic Chemistry The Chinese University of Hong Kong

Base metal catalyzed regioselective cage B–H functionalization has been achieved. Under the assistance of a bidentate directing group, Cu-catalyzed [4+2] annulation of carboranyl amides with internal alkynes affords unprecedented C,B-substituted carborane-fused-pyridone derivatives, whereas the use of terminal alkynes leads to B–H/C(sp)–H dehydrocoupling products. The isolation and structural identification of a notably stable Cu(Ⅰ) intermediate shed light on the reaction mechanism, which is proposed to involve a Cu(Ⅲ) intermediate.

关键词： [4+2] annulation alkynylation B-H activation base metal catalysis carborane

Multi-View Dynamic Kernelized Evidential Clustering

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IEEE/CAA Journal of Automatica Sinica 2024年第12期11卷 2435-2450页

作者： Jinyi Xu zuowei Zhang Ze Lin Yixiang chen Weiping Ding the Software Engineering Institute East China Normal University Shanghai Key Laboratory of Trustworthy Computing East China Normal University IEEE the School of Automation Northwestern Polytechnical University the School of Artificial Intelligence and Computer Science Nantong University the Faculty of Data Science City University of Macau

It is challenging to cluster multi-view data in which the clusters have overlapping areas. Existing multi-view clustering methods often misclassify the indistinguishable objects in overlapping areas by forcing them into single clusters, increasing clustering errors. Our solution, the multi-view dynamic kernelized evidential clustering method(MvDKE), addresses this by assigning these objects to meta-clusters, a union of several related singleton clusters, effectively capturing the local imprecision in overlapping areas. MvDKE offers two main advantages: firstly, it significantly reduces computational complexity through a dynamic framework for evidential clustering, and secondly, it adeptly handles non-spherical data using kernel techniques within its objective function. Experiments on various datasets confirm MvDKE's superior ability to accurately characterize the local imprecision in multi-view non-spherical data, achieving better efficiency and outperforming existing methods in overall performance.

关键词： Evidential clustering imprecision characterizing kernel technique multi-view clustering