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Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma Yan Luan xin Wang xinlin chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

基于MODIS数据中国土地覆盖制图分类系统研究

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青岛科技大学学报（社会科学版） 2007年第2期23卷 78-83页

作者：宫攀陈仲新青岛科技大学经济与管理学院山东青岛266061 农业部资源遥感与数字农业重点实验室北京100081

土地覆盖变化是全球变化研究中的一个重要内容,而建立标准的土地覆盖分类系统又是研究土地覆盖变化的前提,它影响分类结果的表达形式,决定土地覆盖数据的应用领域。本文利用FAO的土地覆盖分类系统(LCCS)结合MODIS数据的识别能力建立了... 详细信息

土地覆盖变化是全球变化研究中的一个重要内容,而建立标准的土地覆盖分类系统又是研究土地覆盖变化的前提,它影响分类结果的表达形式,决定土地覆盖数据的应用领域。本文利用FAO的土地覆盖分类系统(LCCS)结合MODIS数据的识别能力建立了中国基于MODIS土地覆盖制图分类系统,最终得到21种土地覆盖类型及各类型的标准定义、制图代码。为利用MODIS数据进行全国的土地覆盖相关研究提供依据。结果表明LCCS能针对不同分类目的、数据制定灵活的分类系统。

关键词： MODIS 土地覆盖分类系统 FAO LCCS

从镇江社区医保政策看社区卫生服务的改革方向

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卫生经济研究 2009年第3期26卷 39-44页

作者：陈新中张毅江苏省镇江市医疗保险局江苏镇江212001

社区卫生服务与社会医疗保险制度相结合是"人人享有基本医疗卫生服务"的关键举措。本文通过总结分析镇江市医保与社区卫生服务融合互动发展的经验,提出了在推动社区卫生服务发展和改革方面所需要关注的政策风险应对、社区首诊制推行、... 详细信息

社区卫生服务与社会医疗保险制度相结合是"人人享有基本医疗卫生服务"的关键举措。本文通过总结分析镇江市医保与社区卫生服务融合互动发展的经验,提出了在推动社区卫生服务发展和改革方面所需要关注的政策风险应对、社区首诊制推行、基本服务功能发挥、社区平台利用、向健康保险过渡和社会力量参与的讨论与思考。

关键词：医疗保险社区卫生服务改革取向

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综合模块化航空电子系统的可靠性设计

计算机工程 2009年第23期35卷 272-273,277页

作者：郑朝辉陈新中张晓先华东计算技术研究所上海200233 中国电子科学研究院北京100041

ASAAC软件体系结构侧重于整个系统的模块化、可扩展性,其节点使用普通操作系统导致系统可靠性不够。针对该问题,将符合ARINC653标准的高可靠性分区操作系统作为ASAAC软件体系结构的节点操作系统,设计新的ASAAC通用系统管理并将其植入ARI... 详细信息

ASAAC软件体系结构侧重于整个系统的模块化、可扩展性,其节点使用普通操作系统导致系统可靠性不够。针对该问题,将符合ARINC653标准的高可靠性分区操作系统作为ASAAC软件体系结构的节点操作系统,设计新的ASAAC通用系统管理并将其植入ARINC653的核心软件层,使两者充分融合以提高综合模块化航空电子系统的可靠性。

关键词：综合模块化航空电子分区操作系统通用系统管理可靠性

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin xintong Ge Dai Li Rongrong zhong Qiang Liu Fanglian chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

QY200/14/31型液压支架关键部件有限元分析

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煤矿开采 2011年第3期16卷 107-110页

作者：宇迪陈新中黄永志中国神华神东煤炭集团内蒙古鄂尔多斯017000 中国矿业大学(北京)机电与信息工程学院北京100083 北京矿大能源安全科技有限公司北京100083

在建立QY200/14/31型液压支架的三维模型基础上,采用虚拟样机技术和有限元分析相结合的方法,分析液压支架在额定载荷作用下关键部件受力特性。将三维模型导入动力学分析软件中,以获取关键部件铰接处作用力的变化规律,然后提取3个极限位... 详细信息

在建立QY200/14/31型液压支架的三维模型基础上,采用虚拟样机技术和有限元分析相结合的方法,分析液压支架在额定载荷作用下关键部件受力特性。将三维模型导入动力学分析软件中,以获取关键部件铰接处作用力的变化规律,然后提取3个极限位置的模型进行有限元分析并比较位移/应力分布的特点。结果表明:液压支架从最小高度上升到最大高度处,柱窝处的作用力和整架刚度先减小后增加;最小高度处关键部件应力值较大,中间高度处居中,而最大高度处最小,说明该支架支撑高度离最大高度越接近,承载能力越强。

关键词：液压支架有限元柱窝动力学应力

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煤矿刮板输送机中部槽强度有限元分析

煤矿机械 2012年第7期33卷 110-112页

作者：陈新中孟云刘冬余范迅中国矿业大学机电与信息学院北京100083

对刮板输送机的中部槽进行强度有限元分析,选取直行截煤工况,先对采煤机和中部槽进行系统力学分析,确定中部槽的受力情况,再建立中部槽三维模型,进而利用Ansys对其进行有限元强度分析,找出最大应力的部位。

关键词：刮板输送机中部槽有限元分析

Chiral phosphoramidite ligand-modulated palladium auto-tandem catalysis for asymmetric dehydrogenative dienylation of imines with α-alkenes

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Science China Chemistry 2025年

作者： zhong-Sheng Nong Hao-Fan Qian Ying-Chun chen Pu-Sheng Wang Liu-Zhu Gong Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China Key Laboratory of Drug Targeting and Drug Delivery System (Sichuan University) Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University School of Materials and Chemistry Southwest University of Science and Technology

The development of efficient processes allowing rapid access to complex chiral molecules from easily available alkenes is a long-term pursuit in the synthetic chemistry community. Transition metal-catalyzed asymmetric functionalization of allylic C–H bond represents a unique alternative toward this goal. However, enantioselective dehydrogenative transformation of olefins to value-added optically enriched molecules remains yet to be discovered. Here, we report a highly enantioselective dehydrogenative dienylation of imines with unactivated α-alkenes driven by the synergistic action of palladium complex and carboxylic acid. Chiral phosphoramidite ligands turned out to be superior in modulating the performance of palladium autotandem catalysis and allowed a broad range of α-alkenes and imines to be transformed into chiral dienylamines. Mechanistic studies suggest that the dienes could be in situ generated from α-alkenes through a palladium(0)-mediated dehydrogenative process in the presence of excess benzoquinone oxidants, and then participated in the Pd-chiral phosphoramidite-catalyzed intermolecular vinylogous-type addition to the imines activated by the carboxylic acid co-catalyst. Notably, the second β-H elimination occurring in the dienylation event might be the turnover-limiting step.

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大学经营理念探析

华中农业大学学报（社会科学版） 2006年第6期 103-107页

作者：李忠云陈新忠华中农业大学高等教育研究所湖北武汉430070

大学经营作为大学建设中的主导式理念,是时代发展的客观要求,是大学自身发展的必然选择。文章较为全面地剖析了大学经营的必要性、迫切性与可能性,探讨了大学经营理念的内涵,并就如何促进大学经营理念的发展与完善提出了建议。

关键词：大学理念大学经营大学经营理念