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Plant Communications 2024年第3期5卷 179-196页

作者： Beifang Wang Pao Xue Yingxin zhang Xiaodeng Zhan Weixun Wu Ping Yu Daibo chen Junlin Fu Yongbo Hong Xihong Shen Lianping Sun Shihua cheng Qunen Liu Liyong Cao State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 311400China Northern Rice Research Center of Bao Qing Shuangyashan 155600China Zhejiang Key Laboratory of Super Rice Research China National Rice Research InstituteHangzhou 311400China

Calcium-dependent protein kinases(CPKs),the best-characterized calcium sensors in plants,regulate many aspects of plant growth and development as well as plant adaptation to biotic and abiotic ***,how CPKs regulate the antioxidant defense system remains largely *** previously found that impaired function of OsCPK12 leads to oxidative stress in rice,with more H2O2,lower catalase(CAT)activity,and lower ***,we explored the roles of OsCPK12 in oxidative stress tolerance in *** results show that OsCPK12 interacts with and phosphorylates OsCATA and OsCATC at *** of either OsCATA or OsCATC leads to an oxidative stress phenotype accompanied by higher accumulation of *** of the phosphomimetic proteins OsCATAS11D and OsCATCS11D in oscpk12-cr reduced the level of H2O2 ***,OsCATAS11D and OsCATCS11D showed enhanced catalase activity in vivo and in ***12-overexpressing plants exhibited higher CAT activity as well as higher tolerance to oxidative *** demonstrate that OsCPK12 affects CAT enzyme activity by phosphorylating OsCATA and OsCATC at Ser11 to regulate H2O2 homeostasis,thereby mediating oxidative stress tolerance in rice.

关键词： OsCPK12 OsCATs oxidative tolerance Oryza sativa L

THE FUNCTION OF LAKES AND THE MANAGEMENT OF FLOOD DISASTER

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Natural Disaster Reduction in China 1995年第4期 155-160页

作者： Sun Shuncai zhang chen and Yu Xiubo (Nanjing Institute of Geography and Limnololgy, Chinese Academy of Scicnces, 210008 Nanjing, China)

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Does China's digital economy contribute to low-carbon transition?

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Ecological Economy 2024年第2期20卷 102-122页

作者： LI Jun-jun HUANG Xin-yu chen Mu zhang Meng-jiang zhang Zhen School of Economics Fujian Normal UniversityFuzhou 350007CHINA College of Mechanical and Electrical Engineering Wuyi UniversityNanping 354300CHINA

The digital economy,as a new emerging economic form,has become an important power for realizing Chinese-style modernization and promoting green development in *** paper measures the digital economy and low-carbon transition index based on the data of 30 provinces in China from 2013 to 2020 and analyzes the mechanism and path of the digital economy affecting low-carbon transition using the fixed effect panel data model and the threshold effect *** is found that,(1)The digital economy and low-carbon transition in China are various in different regions,with characteristics of being unbalanced and insufficient.(2)The digital economy significantly promotes low-carbon transition,with the greatest influence in the Central region,followed by the Eastern region and the Western *** different dimensions,the development of informatization and digital transactions promote low-carbon transition,but the development of the internet plays an inhibiting role.(3)The higher the degree of urbanization and environmental regulation,the greater the influence of the digital economy on low-carbon transition.

关键词： digital economy low-carbon transition threshold effect model instrumental variables quantile regression

Cultivar and Environmental Variation of P-glucan Content in Chinese Barleys

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Journal of Integrative Agriculture 2002年第3期 56-62页

作者： chen Jin-xin, zhang Guo-ping, QIANG Xiao-lin, WANG Jun-mei and DING Shou-ren ( Agronomy Department, Zhejiang University, Hangzhou 310029 Academy of Tibet Agriculture , Lasa 850000)

β-glucan is a polysaccharide compound closely related to the quality of barley used as malting, feed and food. Low β-glucan content is expected for brewing and feed barley, while high β-glucan content is desirable for food barley. The β-glucan content of barley genotypes collected from various areas of China as well as from Canada and Australia were assayed. Meanwhile a multi-locations trial was conducted to determine β-glucan content of 10 barley cultivars in 8 locations for two successive planting years. The results showed that barley genotypes from Tibet and Xinjiang had higher p-glucan content and the genotypes with higher than 8% of P-glucan content were detected in Tibet barleys, being valuable for use in the development of healthy food. Barley cultivars being planted now in winter-sowing areas of China had basically the same β-glucan content as those from Canada and Australia. Barley seeds produced in Hangzhou had lower β-glucan content than seeds from the original areas. There was a highl

关键词： Barley p-glucan Environment Genotypes Quality

Deficiency of circadian gene Per2 blocks luteolin-induced adipocyte browning in mice through weakening liver PPARα/RXRα/FGF21 pathway

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Food Science and Human Wellness 2024年

作者： Shanshan Shui Juan chen Yan Lin Jingjing Yuan Xin Wang Xian zhang Jian Liu Lei Zheng Engineering Research Center of Bio-process， Ministry of Education， Hefei University of Technology Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province， College of Food Science and Pharmacy， Zhejiang Ocean University School of Food and Biological Engineering， Hefei University of Technology

During the development of diet-induced obesity， the change of energy matebolism is closely related to the function of the circadian clock in mammals. Luteolin (LU)， one of the most common natural flavonoids riched in many edible plants， can ameliorate obesity by activating adipose tissue browning， but its effect on circadian clock in this process remains poorly understood. Here we found that dietary LU improved circadian misalignment of energy expenditure in high-fat diet (HFD)-fed wild-type (WT) mice. Moreover， dietary LU efficiently elevated UCP1 levels in adipose tissue during the dark period， which was similar to the LU-increased hepatic PER2 expressions. Hepatic PPARα/RXRα/FGF21 pathway was rhythmically elevated by dietary LU in HFD-fed WT mice， whereas the promotion was inhibited in Per2-/-mice. Meanwhile， Per2 deletion abolished the effects of dietary LU on adipose tissue browning in HFD-fed mice. Further， LU treatment directly activated PPARα/RXRα/FGF21 signaling in primary cultured hepatocytes from WT mice rather than Per2-/-mice. Taken together， the deletion of the core clock component Per2 impedes LU-induced adipose tissue browning through weakening PPARα/RXRα/FGF21 pathway in mice， providing a new insight into the interplay of energy metabolism and circadian clock for the anti-obesity activity of LU.

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Imaging momentum-space Cooper pair formation and its competition with the charge density wave gap in a kagome superconductor

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 142-150页

作者： Yiming Sun Yubing Tu Yang Luo Shuikang Yu Hongyu Li Yunmei zhang Ping Wu Zhuying Wang Fan zhang Wanru Ma Zuowei Liang Jianjun Ying Tao Wu Ziji Xiang Junfeng He Lei Shan Zhenyu Wang Xianhui chen Department of Physics CAS Key Laboratory of Strongly Coupled Quantum Matter Physicsand Hefei National LaboratoryUniversity of Science and Technology of ChinaHefei 230026China Information Materials and Intelligent Sensing Laboratory of Anhui Province Institutes of Physical Science and Information TechnologyAnhui UniversityHefei 230601China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

The superconducting ground state of kagome metals AV_(3)Sb_(5)(where A stands for K,Rb,or Cs)emerges from an exotic charge density wave(CDW)state that potentially breaks both rotational and time reversal ***,the specifics of the Cooper pairing mechanism,and the nature of the interplay between these two states remain elusive,largely due to the lack of momentum-space(k-space)superconducting energy gap *** implementing Bogoliubov quasiparticle interference(B QPI)imaging,we obtain k-space information on the multiband superconducting gap structureΔ_(SC)^(i)(k)in pristine CsV_(3)Sb_(5).We show that the estimated energy gap on the vanadium d_(xy/x^(2)-y^(2))orbital is anisotropic but nodeless,with a minimal value located near the M ***,a comparison ofΔ_(SC)^(i)(k)with the CDW gapΔ_(CDW)^(i)(k)obtained by angle-re solved photoemission spectro scopy(ARPES)reveals direct k-space competition between the se two order parameters,i.e.,the opening of a large(small)CDW gap at a given momentum corresponds to a small(large)superconducting *** the long-range CDW order is suppressed by replacing vanadium with titanium,we find a nearly isotropic energy gap on both the V and Sb *** information will be critical for identifying the microscopic pairing mechanism and its interplay with intertwined electro nic orders in this kagome superconductor family.

关键词： kagome lattice charge density wave superconducting energy gap scanning tunneling microscopy

有机胂添加剂对蛋白核小球藻及大型蚤的急性毒性研究

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华南农业大学学报 2007年第2期28卷 103-106页

作者：王付民张璐陈杖榴华南农业大学兽医学院华南农业大学林学院广东广州510642

为评估有机胂添加剂对水环境的影响,以蛋白核小球藻、大型蚤为研究对象,研究了洛克沙胂、阿散酸对蛋白核小球藻和大型蚤的急性毒性.结果表明:洛克沙胂、阿散酸对蛋白核小球藻的24、48、72、96 h的半数有效抑制浓度(EC50)分别为:190.55、... 详细信息

为评估有机胂添加剂对水环境的影响,以蛋白核小球藻、大型蚤为研究对象,研究了洛克沙胂、阿散酸对蛋白核小球藻和大型蚤的急性毒性.结果表明:洛克沙胂、阿散酸对蛋白核小球藻的24、48、72、96 h的半数有效抑制浓度(EC50)分别为:190.55、263.03、346.74、389.05 mg.L-1;239.88、308.18、418.12、410.40 mg.L-1(以原型药物计);均大于100 mg.L-1,在水环境中为低毒级化合物(急性Ⅲ化学物质以下).对大型蚤24 h-EC50分别是49.77、83.70 mg.L-1;48 h-EC50分别是39.00、57.48 mg.L-1,48 h-LC50分别是44.19、61.97 mg.L-1(均以原型药物计);依据蚤类急性活动抑制毒性分级标准,它们属于中毒级化合物.

关键词：有机胂添加剂蛋白核小球藻大型蚤急性毒性

Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease

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Neural Regeneration Research 2024年第1期19卷 100-115页

作者： Jianjian Chu Weicong zhang Yan Liu Baofeng Gong Wenbo Ji Tong Yin Chao Gao Danqi Liangwen Mengqi Hao Cuimin chen Jianhua Zhuang Jie Gao You Yin Department of Neurology Second Affiliated Hospital(Shanghai Changzheng Hospital)of Naval Medical UniversityShanghaiChina School of Pharmacy University College LondonLondonUK Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineClinical Pharmacy Innovation InstituteShanghai Jiao Tong University School of MedicineShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina

The current therapeutic drugs for Alzheimer's disease only improve symptoms,they do not delay disease *** re,there is an urgent need for new effective *** underlying pathogenic factors of Alzheimer's disease are not clear,but neuroinflammation can link various hypotheses of Alzheimer's disease;hence,targeting neuroinflammation may be a new hope for Alzheimer's disease *** inflammation can restore neuronal function,promote neuro regeneration,reduce the pathological burden of Alzheimer's disease,and improve or even reverse symptoms of Alzheimer's *** review focuses on the relationship between inflammation and various pathological hypotheses of Alzheimer's disease;reports the mechanisms and characteristics of small-molecule drugs(e.g.,nonsteroidal anti-inflammatory drugs,neurosteroids,and plant extracts);macromolecule drugs(e.g.,peptides,proteins,and gene therapeutics);and nanocarriers(e.g.,lipid-based nanoparticles,polymeric nanoparticles,nanoemulsions,and inorganic nanoparticles)in the treatment of Alzheimer's *** review also makes recommendations for the prospective development of anti-inflammatory strategies based on nanocarriers for the treatment of Alzheimer's disease.

关键词： Alzheimer's disease anti-inflammation blood-brain barrier drug delivery microglia nanoparticles neuroinflammation plant extracts

柠檬精油、柠檬烯、茶多酚对变形链球菌表面疏水性及黏附的影响

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实用口腔医学杂志 2016年第4期32卷 471-474页

作者：张晨刘雅丽陈思佳张向宇天津医科大学口腔医学院 300070

目的:研究天然植物成分柠檬精油(LEO)、柠檬烯(LIM)及茶多酚(TP)对变形链球菌(***)细菌表面疏水性及黏附能力的影响。方法:取最小抑菌浓度(MIC)以下浓度作为实验浓度;采用微生物黏着碳氢化合物法(MATH),测定***表面疏水性;采用96孔板结... 详细信息

目的:研究天然植物成分柠檬精油(LEO)、柠檬烯(LIM)及茶多酚(TP)对变形链球菌(***)细菌表面疏水性及黏附能力的影响。方法:取最小抑菌浓度(MIC)以下浓度作为实验浓度;采用微生物黏着碳氢化合物法(MATH),测定***表面疏水性;采用96孔板结晶紫染色法,评价***的黏附。结果:LEO、LIM、TP在低于最小抑菌浓度(MIC)时,对***表面疏水性及粘附具有抑制作用;在一定范围内其抑制作用随浓度增大而逐渐增加(P<0.05);1/2 MIC和1/20MIC时LEO抑制表面疏水性的作用强于LIM和TP(P<0.05)。结论:LEO具有防龋应用前景。

关键词：柠檬精油(LEO) 变形链球菌(S.mutans) 细胞表面疏水性黏附

Killing effect of TNF-related apoptosis inducing ligand regulated by tetracycline on gastric cancer cell line NCI-N87

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World Journal of Gastroenterology 2001年第4期7卷 559-562页

作者： Xiao-Chao Wei Xin-Juan Wang Kai-chen Lei zhang Yu Liang Xin-Li Lin Department of Biochemistry and Molecular Biology,Peking University Health Science Center,Beijing 100083,ChinaProtein Studies,Oklahoma Medical Research Foundation,Oklahoma City,OK 73104,USA Department of Biochemistry and Molecular Biology Peking University Health Science Center 38 Xue Yuan Road Haidian District Beijing 100083 China. xinjuan@***

AIM: To clone the cDNA fragment of human TRAIL (TNF-related apoptosis inducing ligand) into a tetracycline-regulated gene expression system, the RevTet-On system, transduce expression vectors into a gastric carcinoma cell line-NCI-N87 and examine the effects of controlled expression of TRAIL in vitro on the gastric carcinoma cells. METHODS: The full-length cDNA of TRAIL was inserted into a vector under the control of the tetracycline-responsive element (TRE) to obtain the plasmid pRevTRE-TRAIL, which was transfected into a packaging cell line PT67. In addition, vector pRev-Tet On and pRevTRE were also transfected into PT67 separately. After hygromycin and G418 selection, the viral titer was determined. The medium containing retroviral vectors was collected and used to transduce a gastric carcinoma cell line NCI-N87. The resulting cell line NCI-N87-Tet On TRE-TRAIL and a control cell line, NCI-N87 Tet On-TRE, were established. TRAIL expression in the cell line was induced by incubating cells with doxycycline (Dox), which is a tetracycline analogue. The killing effect on gastric carcinoma cells was analyzed after induction. RESULTS: The recombinant plasmid pRev-TRE-TRAIL was constructed. After hygromycin or G418 selection, the producer cell lines PT67-TRE, PT67-TRE-TRAIL and PT67-Tet On were obtained,with titers of about 10(8)CFU.L(-1). By transducing NCI-N87 cells with retroviral vectors from these cell lines, stable cell lines NCI-N87-Tet-On TRE-TRAIL (NN3T) and control cell line NCI-N87-Tet-On-TRE (NN2T) were established. The growth curves of the selected cell lines were the same with the wild type NCI-N87. When Dox was added, cell death was obvious in the test groups (29%-77%), whereas no difference was observed in control and wild type cell lines. With the addition of a medium from the test group, human leukemia cell line Jurkat was activated till death (83%), indicating the secretion of active TRAIL proteins from the test cells to the medium. CONCLUSION: With th

关键词： Stomach Neoplasms 3T3 Cells Animals Anti-Bacterial Agents Apoptosis Apoptosis Regulatory Proteins Doxycycline Gene Expression Regulation, Neoplastic Genetic Vectors Humans Jurkat Cells Membrane Glycoproteins Mice Research Support, Non-U.S. Gov't Retroviridae Transfection Tumor Necrosis Factor-alpha