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Classification Method of Small Reservoir in China Based on Risk Analysis

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Classification Method of Small Reservoir in China Based on R...

Targeting carnitine palmitoyl transferase 1A(CPT1A)induces ferroptosis and synergizes with immunotherapy in lung cancer

作者： Yonghong Zhou Xiaoqing Bian yunping chen Weihua Fang Hydrology and Water Resources Engineering Research Center for Monitoring Ministry of Water Resources

In order to effectively manage more than 90000 small reservoirs in China,aiming at their characteristics,based on risk analysis,this article established a small reservoir dynamic risk Classification method and corresponding indexes including Safety risks factors and connecting with current *** terms of the safety risk factors such as occurrence environment,structural materials,supervision and management,and accident *** solved the standardization and pertinence problems of small reservoir risk management in China.

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1675-1689页

作者： Lei Ma Chong chen Chunxing Zhao Tong Li Lingyu Ma Jiayu Jiang Zhaojun Duan Qin Si Tsung-Hsien Chuang Rong Xiang yunping Luo Department of Immunology Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Collaborative Innovation Center for Biotherapy Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Department of Lung Cancer Surgery Tianjin Medical University General HospitalTianjin 300052China Immunology Research Center National Health Research InstitutesZhunanMiaoliTaiwanROC Department of Immunology Nankai UniversityTianjin 300071China

Despite the successful application of immune checkpoint therapy,no response or recurrence is typical in lung *** stem cells(CSCs)have been identified as a crucial player in immunotherapy-related ***,a form of cell death driven by iron-dependent lipid peroxidation,is highly regulated by cellular metabolism remolding and has been shown to have synergistic effects when combined with *** adaption of CsCs drives tumor resistance,yet the mechanisms of their ferroptosis defense in tumor immune evasion remain ***,through metabolomics,transcriptomics,a lung epithelialspecific Cptla-knockout mouse model,and clinical analysis,we demonstrate that CPT1A,a key rate-limiting enzyme of fatty acid oxidation,acts with L-carnitine,derived from tumor-associated macrophages to drive ferroptosis-resistance and CD8^(+)T cells inactivation in lung ***,CPT1A restrains ubiquitination and degradation of c-Myc,while c-Myc transcriptionally activates CPT1A *** CPT1A/c-Myc positive feedback loop further enhances the cellular antioxidant capacity by activating the NRF2/GPX4 system and reduces the amount of phospholipid polyunsaturated fatty acids through ACSL4 downregulating,thereby suppressing ferroptosis in ***,targeting CPT1A enhances immune checkpoint blockadeinduced anti-tumor immunity and tumoral ferroptosis in tumor-bearing *** results illustrate the potential of a mechanismguided therapeutic strategy by targeting a metabolic vulnerability in the ferroptosis of CsCs to improve the efficacy of lung cancer immunotherapy.

关键词： immunotherapy metabolism peroxidation

Effect of microstructure on lipolysis behavior of milk fat globules during gastrointestinal digestion

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Food Science and Human Wellness 2024年

作者： Xinyun Zhou Ting Guo chen chen Hadiatullah Hadiatullah yunping Yao Changmo Li Xingguo Wang State Key Laboratory of Food Nutrition and Safety， Key Laboratory of Food Nutrition and Safety， Ministry of Education， College of Food Science and Engineering， Tianjin University of Science & Technology Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency， Collaborative Innovation Center of Chemical Science and Engineering， School of Pharmaceutical Science and Technology， Tianjin University Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province， National Engineering Research Center for Functional Food， School of Food Science and Technology， Jiangnan University

Milk fat globules (MFG) are the primary source of energy and functional factor in dairy-based products. To evaluate the suitability of commercial MFG substitutes for infant and adult consumers， the lipolysis properties and regulatory factors in digesting bovine， caprine， and human MFG were compared. The lipolysis kinetic models of bovine and caprine MFG are comparable， with bovine MFG displaying the highest degree of lipolysis (50.21%) during gastric digestion in infants， resulting in the production short-chain saturated fatty acids. Caprine MFG has a high rate of lipolysis due to its weak phospholipid-glycoprotein layer， which is prominent in both infants’ and adults’ digestion. The effects of consuming bovine and caprine MFG for adults are comparable in terms of lipolysis properties and nutritional value of fatty acid. After gastrointestinal digestion， human MFG has the highest digestibility (93.98%). The advantages of human MFG include its phospholipid structure， exogenous lipase， and lipolysis-regulating proteins. This study provides recommendation for the selection of milk fat substitutes and improvements in commercial dairy.

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基于最小生成树编码的配电网恢复遗传算法

电力系统自动化 2007年第14期31卷 81-84页

作者：沈广陈允平刘栋武汉大学电气工程学院湖北省武汉市430072

建立了大停电事故后配电网恢复的数学优化模型。通过改变目标函数参数,可以适应不同的系统恢复方案中各种可用电源容量的情况。遗传算法求解采用实数编码、最小生成树Prim算法解码,避免了不可行解的产生,大大提高了算法的计算效率。配... 详细信息

建立了大停电事故后配电网恢复的数学优化模型。通过改变目标函数参数,可以适应不同的系统恢复方案中各种可用电源容量的情况。遗传算法求解采用实数编码、最小生成树Prim算法解码,避免了不可行解的产生,大大提高了算法的计算效率。配电网潮流采用前推回代法计算,并利用Prim算法的中间结果直接得到各节点间的父子关系,减少了计算量。算例表明文中的算法稳定性好,收敛迅速。

关键词：配电网恢复遗传算法最小生成树前推回代算法

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基于电能质量实时监测系统的电压暂降研究

高电压技术 2006年第5期32卷 97-99页

作者：沈广陈允平李欣武汉大学电气工程学院武汉430072 杭州市电力局城东供电局杭州310018

电压暂降是当前业界所面临的代价最大的电能质量问题之一,针对所研究的配电网,建立了可用于监测电压暂降的分布式电能质量在线监测系统。介绍了监测系统的构成、性能参数及监测点的配置方法。应用UNI-PEDE对监测到的各次电压暂降的下凹... 详细信息

电压暂降是当前业界所面临的代价最大的电能质量问题之一,针对所研究的配电网,建立了可用于监测电压暂降的分布式电能质量在线监测系统。介绍了监测系统的构成、性能参数及监测点的配置方法。应用UNI-PEDE对监测到的各次电压暂降的下凹深度及持续时间进行了统计分析,并根据监测及配电网运行记录对电压暂降发生原因作了分析。研究了电压暂降对研究区域内电力用户的影响,用SARFI-ITIC图对影响用户的电压暂降和短时间中断事件进行了分析。研究结果有助于进一步改善电压暂降并为用户侧解决方案提供依据。

关键词：电压暂降电能质量监测供电可靠性故障分析统计评估

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高压电缆金属护套交叉点行波折反射的规律

高电压技术 2006年第10期32卷 11-14,24页

作者：陈玉林陈允平孙金莉武汉大学电气工程学院武汉430072

高压电缆的金属护套交叉互联导致行波在多个波阻抗不连续点产生了复杂的折反射行为,这对高压电缆线路的行波故障测距产生很大的影响。为研究高压电缆中行波的折反射规律,在波动方程的基础上,从独立的模量域推导出多导体系统在相量域的... 详细信息

高压电缆的金属护套交叉互联导致行波在多个波阻抗不连续点产生了复杂的折反射行为,这对高压电缆线路的行波故障测距产生很大的影响。为研究高压电缆中行波的折反射规律,在波动方程的基础上,从独立的模量域推导出多导体系统在相量域的波阻抗矩阵,并利用相量域的波阻抗矩阵求解出折反射系数矩阵。此折反射系数矩阵表征了行波在护套交叉点的折反射规律。EMTDC仿真结果验证了所求取的折反射规律的正确性。进一步的理论计算和仿真试验表明,经多次折反射,行波线模总量保持不变,且三相线模含量存在着趋于一致的规律。

关键词：高压电缆金属护套行波折反射护套交叉点

Clinical observation on row needling at the Governor Vessel on the head for poststroke insomnia

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Journal of Acupuncture and Tuina Science 2022年第1期20卷 32-39页

作者： XIA Jixing LI Yanhua chen yunping ZHANG Kaiwei Department of Neurology Xianning First People’s HospitalHubei ProvinceXianning 437100China Department of Pain Rehabilitation Xianning First People’s HospitalHubei ProvinceXianning 437100China Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China 不详

Objective:To observe the clinical efficacy of row needling at the Governor Vessel on the head for poststroke insomnia,analyze the changes of sleep structure,serum amino acid neurotransmitters,vascular endothelial cell function and cognitive function,in order to explore the mechanism of this ***:A total of 41 patients with poststroke insomnia were included in an observation group and treated with row needing at the Governor Vessel on the head;33 patients with poststroke insomnia were included in a control group and given routine acupuncture *** patients in both groups were treated consecutively for one *** efficacy was observed and the changes of related indicators were ***:After treatment,the efficacy of the observation group was better than that of the control group(P<0.05).The sleep latency in the observation group was shorter than that in the control group(P<0.05);the total sleep duration,deep sleep duration,light sleep duration and rapid eye movement sleep duration in the observation group were significantly longer than those in the control group(P<0.05);the total waking duration and the waking times over 5 min were significantly less than those in the control group(P<0.05).The serum glutamic acid,γ-aminobutyric acid,calcitonin gene-related peptide,brain-derived neurotrophic factor,nerve growth factor and nitric oxide levels were significantly higher than those in the control group(P<0.01).The tumor necrosis factor-α,interleukin-6,bradykinin,and endothelin-1 levels were lower than those in the control group(P<0.01).The Pittsburgh sleep quality index score in the observation group was lower than that in the control group(P<0.01),and the mini-mental state examination score was higher than that in the control group(P<0.05).Conclusion:Row needling at the Governor Vessel on the head can effectively improve the sleep structure,cognitive function,and sleep quality of patients with poststroke *** possible mechanisms are

关键词： Acupuncture Therapy Governor Vessel Neurotransmitter Endothelial Cells Stoke Insomnia

A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys

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Neuroscience Bulletin 2024年第1期40卷 90-102页

作者： Yefei chen Jingyi Wang Jing Liu Jianbang Lin yunping Lin Jinyao Nie Qi Yue Chunshan Deng Xiaofei Qi Yuantao Li Ji Dai Zhonghua Lu Department of Anesthesiology Shenzhen Maternity and Child Healthcare HospitalThe First School of Clinical MedicineSouthern Medical UniversityShenzhen 518027China Shenzhen Technological Research Center for Primate Translational Medicine Shenzhen Key Laboratory for Molecular Biology of Neural DevelopmentShenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Biomedical Research Institute Hubei University of MedicineShiyan 442000China Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Retrograde adeno-associated viruses(AAVs)are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical and functional characterization of neural ***,few retro-grade AAV capsids have been shown to offer access to cor-tical projection neurons across different species and enable the manipulation of neural function in non-human primates(NHPs).Here,we report the development of a novel retro-grade AAV capsid,AAV-DJ8R,which efficiently labeled cortical projection neurons after local administration into the striatum of mice and *** addition,intrastriatally injected AAV-DJ8R mediated opsin expression in the mouse motor cortex and induced robust behavioral ***,AAV-DJ8R markedly increased motor cortical neuron firing upon optogenetic light stimulation after viral delivery into the macaque *** data demonstrate the usefulness of AAV-DJ8R as an efficient retrograde tracer for cortical projection neurons in rodents and NHPs and indicate its suitability for use in conducting functional interrogations.

关键词： Retrograde AAV Capsid variant Cortical projection neuron Optogenetics Monkey

Genetic mechanism of OsmiR396 regulates rice inflorescence architecture and grain yield

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Genetic mechanism of OsmiR396 regulates rice inflorescence a...