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数字经济发展对安徽省制造业转型升级影响研究

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青岛大学学报（自然科学版） 2024年第1期37卷 116-122页

作者：邓小华袁晨露安徽大学经济学院合肥230601

为探究数字化转型如何推动制造业高质量发展,基于2011—2021年安徽省16地市面板数据,采用熵值法测度各地市数字经济发展水平,运用中介效应和面板门槛模型考察作用机制。研究结果显示,数字经济通过提升地区产业高级化和合理化促进制造业... 详细信息

为探究数字化转型如何推动制造业高质量发展,基于2011—2021年安徽省16地市面板数据,采用熵值法测度各地市数字经济发展水平,运用中介效应和面板门槛模型考察作用机制。研究结果显示,数字经济通过提升地区产业高级化和合理化促进制造业转型升级;科技创新发展水平在数字经济促进产业结构升级中起重要中介作用;经济高质量发展地区数字经济影响制造业转型升级效果更加显著,呈现边际效应递增的非线性特征。

关键词：数字经济制造业转型产业高级化产业合理化科技创新

Relativistic Scattering States of Coulomb Potential Plus a New Ring-Shaped Potential

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Communications in Theoretical Physics 2006年第5期45卷 889-893页

作者： chen Chang-yuan lu Fa-Lin SUN Dong-Sheng Department of Physics Yancheng Teachers College Yancheng 224002 China

In this paper, exact solutions of scattering states of the Klein-Gordon equation with Coulomb potential plus a new ring-shaped potential are studied under the condition that the scalar potential is equal to the vector potential. The normalized wave functions of scattering states on the “k/27π scale” and the calculation formula of phase shifts are presented. Analytical properties of the scattering amplitude are discussed.

关键词： Coulomb potential plus a new ring-shaped potential scattering states phase shifts Klein-Gordon equation

阿奇霉素胶囊在中国健康受试者中的生物等效性研究

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中国临床药理学杂志 2024年第1期40卷 97-101页

作者：谢朋飞陈元璐陈菡周燕杨鹏年立忠左莉英张永东郴州市第一人民医院Ⅰ期临床研究室湖南郴州423000 南华大学医院管理研究所湖南郴州423000 安徽省药品审评查验中心安徽合肥230000 安徽万邦医药科技股份有限公司安徽合肥230000 蚌埠丰原涂山制药有限公司安徽蚌埠233050

目的评价阿奇霉素胶囊受试制剂与参比制剂在中国健康受试者中的生物等效性。方法本研究采用随机、开放、两周期交叉试验设计,共入组48例受试者。受试者单次空腹口服阿奇霉素胶囊受试制剂或参比制剂250 mg。以液相色谱-串联质谱联用法测... 详细信息

目的评价阿奇霉素胶囊受试制剂与参比制剂在中国健康受试者中的生物等效性。方法本研究采用随机、开放、两周期交叉试验设计,共入组48例受试者。受试者单次空腹口服阿奇霉素胶囊受试制剂或参比制剂250 mg。以液相色谱-串联质谱联用法测定人血浆样品中阿奇霉素的血药浓度,用WinNon⁃Lin8.1计算和分析阿奇霉素主要药代动力学参数,并进行生物等效性评价。结果空腹条件下单剂量口服阿奇霉素胶囊受试制剂与参比制剂的主要药代动力学参数:C_(max)分别为(319.89±127.35)和(330.41±122.11)ng·mL^(-1);AUC0-192 h分别为(2423.04±587.15)和(2489.97±685.73)ng·h·mL^(-1);AUC0-∞分别为(2753.40±644.96)和(2851.71±784.05)ng·h·mL^(-1);tmax分别为(2.60±1.11)和(2.62±1.13)h;t1/2分别为(76.76±15.14)和(79.83±17.14)h。空腹条件下,受试制剂与参比制剂C_(max)、AUC0-192 h、AUC0-∞几何均值的90%置信区间分别为87.52%~107.18%、91.46%~105.80%和91.17%~105.06%。结论空腹条件下阿奇霉素胶囊受试制剂与参比制剂具有生物等效性。

关键词：阿奇霉素胶囊药代动力学生物等效性安全性

When mRNA meets gene editing

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Nano Research 2024年第8期17卷 7337-7356页

作者： Weijie Li chen Wang yuan lu Key Laboratory of Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

The critical challenge of gene therapy lies in delivering gene editing *** with DNA,while RNA is less stable and more accessible to degrade,it comes with the benefit of lower off-target effects since permanent insertion is not *** review focuses on mRNA-based delivery of gene editing agents,highlighting novel mRNA delivery *** provide context,a comparison is made between three main gene editing agents:programmable nucleases,base editors,and prime *** potential of Cas\pi and transposons is also discussed in this ***,a summary of four main barriers to mRNAbased in vivo delivery is ***,this review detailedly introduced different delivery systems,both viral(lentivirus)and non-viral vectors(genome editing via oviductal nucleic acids delivery,lipid nanoparticles,polymer-based nanoparticles,viruslike-particles,extracellular vesicles,and migrasome).Each delivery strategy is assessed by comparing its advantages and disadvantages to offer a comprehensive and objective overview of the delivery ***,we emphasized the vital role of the protein corona as a critical regulator for ***,we concluded the challenges of mRNA-based gene editing strategies(RNA stability,targeting,potential immunogenicity,cytotoxicity,heterogeneity,and rational design).The purpose of this review is to guide further research and provide a comprehensive analysis of mRNA-based in vivo delivery of gene editing agents in this promising field.

关键词： gene editing mRNA delivery viral vectors non-viral vectors CRISPR

MWCNTs/SiO2 Composite System:Carrier Transmission,Twin-Percolation and Dielectric Properties

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Chinese Physics Letters 2011年第10期28卷 232-235页

作者： CAO Wen-Qiang lu Ming-Ming WEN Bo chen yuan-lu LI Hong-Bo yuan Jie CAO Mao-Sheng School of Material Science and Engineering Beijing Institute of TechnologyBeijing 100081 School of EMPS University College DublinDublin 4Ireland School of Information Engineering Minzu University of ChinaBeijing 100081

We synthesize composite systems of multi-wall carbon nanotubes(MWCNTs)/SiO_(2) by using the sol−gel *** dielectric properties of the systems with different-concentration MWCNTs are *** our MWCNTs/SiO_(2) inorganic systems,the twin−percolation phenomenon exists when the concentrations of MWCNTs are 5–10%and 15–20%.The permittivity and conductivity have jumping *** twin−percolation phenomenon is attributed to the special transfer mechanism of MWCNTs in the system,determined by hopping and migrating *** of dielectric properties and conductance of the MWCNTs/SiO_(2) systems are conformed to the percolation *** special percolation phenomenon and electric properties of MWCNTs/SiO_(2) can help us comprehend the conductivity mechanism of the MWCNTs/SiO2 systems effectively,and promote the development of a high performance function composite system.

关键词： composite percolation conductivity

Collective Molecular Machines: Multidimensionality and Reconfigurability

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Nano-Micro Letters 2024年第8期16卷 309-340页

作者： Bin Wang yuan lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical *** the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense *** progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and ***,individual molecular machines are only capable of producing nanometer work and generally have only a single *** order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new *** this review,we comprehensively discuss recent developments in the collective behaviors of molecular *** particular,collective behavior is divided into two *** is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional *** other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale *** discuss design strategies for both modes and focus on the modulation of features and ***,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA Biomolecular motors

Surface reconstruction of heterostructures in alkaline medium towards enhanced electrocatalytic hydrogen evolution

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Rare Metals 2024年第6期43卷 2636-2647页

作者： Ming-Yang Yang Ji yuan Xue-Lian Fu Jing-Jing chen Jing Hu Zhou-Guang lu chen Liu Guangdong Research Center for Interfacial Engineering of Functional Materials Shenzhen Key Laboratory of Polymer Science and TechnologyShenzhen Key Laboratory of Energy Electrocatalytic MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Interfacial Science and Engineering of Materials Department of Materials Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China

Constructing heterostructures has proved to be a successful strategy to fabricate electrocatalysts with high efficiency for water ***,the structure evolution in alkaline hydrogen evolution reaction lacks investigation and the specific active center remains ***,we take the well-designed Ni_(3)S_(2)@VO_(2) heterostructures as a model to investigate the electrocatalytic activity and the surface reconstruction process of heterostructure catalysts in alkaline *** Ni_(3)S_(2)@VO_(2) heterostructures,with Ni_(3)S_(2) nanorods as the core and VO_(2) nanoflakes as the shell,coupled with the high conductive Ni_(3)S_(2),the hydrophilic VO_(2) and modulated electronic structures at the interfaces,exhibited prominent activity and superior stability at various current ***,the ex-situ characterizations confirmed that the surface reconstruction from Ni_(3)S_(2)@VO_(2) into Ni_(3)S_(2)@amorphous-Ni(OH)_(2) in alkaline media could optimize the water dissociation barrier and exposed large active area,thereby contributing to improved electrocatalytic *** study not only introduces novel high-performance electrocatalysts for hydrogen evolution reaction(HER),but also provides a new avenue for re-examining hetero-structural catalysts in alkaline solutions.

关键词： Heterostructures Ni_(3)S_(2)@VO_(2) Surface reconstruction Water dissociation Alkaline hydrogen evolution

Cell-free biocatalysis coupled with photo-catalysis and electro-catalysis: Efficient CO2-to-chemical conversion

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Green Energy & Environment 2024年第9期9卷 1366-1383页

作者： Junzhu Yang Chi-Kit Sou yuan lu Key Laboratory of Industrial Biocatalysis Ministry of Education Tsinghua University Department of Chemical Engineering Tsinghua University

The increasing atmospheric carbon dioxide （CO2） concentration has exposed a series of crises in the earth's ecological *** to effectively fix and convert carbon dioxide into products with added value has attracted the attention of many ***-free enzyme catalytic system coupled with electrical and light have been a promising attempt in the field of biological carbon fixation in recent *** this review,the research progresses of photoenzyme catalysis,electroenzyme catalysis and photo-electroenzyme catalysis for converting carbon dioxide into chemical products in cell-free systems are systematically *** focus on reviewing and comparing various coupling methods and principles of photoenzyme catalysis and electroenzyme catalysis in cell-free systems,especially the materials used in the construction of the coupling system,and analyze and point out the characteristics and possible problems of different coupling ***,we discuss the major challenges and prospects of coupling physical signals and cell-free enzymatic catalytic systems in the field of CO2fixation,suggesting possible strategies to improve the carbon sequestration capacity of such systems.

关键词： CO 2 fixation Cell-free system Enzyme Photoenzyme catalysis Electroenzyme catalysis

Evolution of interfacial heat transfer,contact behavior and microstructure during sub-rapid solidification of molten steel with different hydrogen contents

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Journal of Iron and Steel Research International 2024年第1期31卷 215-223页

作者： cheng lu Wan-lin Wang chen-yang Zhu Jie Zeng Xin-yuan Liu Hua-long Li School of Metallurgy and Environment Central South UniversityChangsha410083HunanChina National Center for International Research of Clean Metallurgy Central South UniversityChangsha410083HunanChina Institute of Research of Iron and Steel ShasteelZhangjiagang215625JiangsuChina

Typical Q235 low-carbon steel samples with different hydrogen contents(0.0004,0.0008,and 0.0013 wt.%)were prepared by adjusting the environment humidity and *** effects of hydrogen on interfacial heat transfer,contact behavior,and microstructure evolution were investigated using a novel droplet solidification *** results revealed that when the hydrogen content increases from 0.0004 to 0.0013 wt.%,the maximum heat flux between the molten steel and cooling substrate decreases from 8.01 to 6.19 MW/m^(2),and the total heat removed in the initial 2 s reduces from 10.30 to 8.27 MJ/m^(2).Moreover,the final contact angle between the molten steel and substrate increases from 103.741°to 113.697°,and the number of pores on the droplet bottom surface increases significantly from 21 to 210 with the increase in *** surface roughness of the droplet bottom surface increases from 20.902 to 49.181 *** addition,the average grain size of the droplet increases from 14.778 to 33.548 pm with the increase in the hydrogen *** interfacial contact condition becomes worse due to the escape of hydrogen from the steel matrix during the cooling process,which leads to the reduction in the interfacial heat transfer and the increase in the grain size.

关键词： Strip casting Hydrogen content Interfacial heat transfer behavior Contact behavior Microstructure evolution