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Potential role of tetrandrine in cancer therapy

Acta Pharmacologica Sinica 2002年第12期23卷 49-53页

作者： chen yu-jendepartment of radiation oncology, mackay memorial hospital, taipei, taiwan 104, department of martial arts, chinese culture university, taipei, taiwan 111, china department of radiation oncology Mackay Memorial Hospital Taipei Taiwan 104 China. oncoman@***

Tetrandrine, a bisbenylisoquinoline alkaloid isolated from the dried root of Stephenia tetrandra S Moore, exhib-its very broad pharmacological actions, including anti-tumor activity. The beneficial effects of tetrandrine on tumor cell cytotoxicity and radiosensitization, multidrug resistance, normal tissue radioprotection, and angiogenesis are most promising and deserve great attention. Tetrandrine has potential either as a tumoricidal agent or as an adjunct to chemotherapy and radiotherapy. To evaluate the potential clinical efficacy of tetrandrine for cancer therapy, more mechanism-based pharmacological, pharmacokinetic, and pharmacodynamic studies are required.

关键词： tetrandrine apoptosis radiation-sensitizing agents radiation protection multiple drug resistance angiogenesis

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Cycling and Tai Chi Chuan exercises exert greater immunomodulatory effect on surface antigen expression of human hepatitis B virus

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chinese Medical Journal 2008年第21期121卷 2172-2179页

作者： chen yu-yawn CHIANG Jasson chen yu-jen chen Kung-tung YANG Rong-sen LIN Jaung-geng department and Graduate School of Physical Education National Taiwan Sport University Taichung Taiwan China Graduate Institute of Sport Coaching Science Chinese Culture University Taipei Taiwan China department of Medical Research Department of Radiation Oncology Mackay Memorial Hospital Taipei Taiwan China College of Humanities Social and Natural Sciences Ming Hsin University of Sciences and Technology Taiwan China department of Orthopaedics College of Medicine National Taiwan University & Hospital Taipei Taiwan China Graduate Institute of chinese Medical Science China Medical University. Taichung 404. Taiwan. China

Background Both athletes with intensive exercise and aged people may have weakened immunity against virus infection. This study aimed to evaluate whether people undergoing aerobic exercises including competitive cyclists with moderate training （CMT） and middle-aged people practicing Tai Chi Chuan （TCC） exercise have higher immunity against hepatitis B virus than age-matched sedentary controls including college students （CSC） and middle-aged people （MSC）. Methods Human peripheral blood mononuclear cells from competitive cyclists and sedentary controls were stimulated by phytohemagglutinin （PHA） to prepare conditioned medium （MNC-CM） for the assessment of inhibitory effects on hepatitis B surface antigen （HBsAg） expression in human hepatoma Hep3B cells. Results The inhibitory effects on the relative HBsAg expression of CMT＇s and TCC＇s MNC-CM were greater than those of the controls. The CMT＇s MNC-CM prepared from 5 μg/ml PHA decreased HBsAg expression to 61.5%, whereas that of CSC remained at 83.8%. Similarly, this expression by treatment of TCC group＇ MNC-CM was 68.4% whereas that of MSC group was 84.3%. The levels of cytokines such as interferon-γ（IFN-γ）, tumor necrosis factor-α （TNF-α）, IFN-α and interleukin-1β （IL-1β） in the MNC-CM from the CMT and TCC groups were greater than those in the controls. Antibody neutralization of CMT＇s MNC-CM and addition of recombinant cytokines into CSC＇s MNC-CM indicated that IFN-γ, TNF-α and IFN-α had synergistic effects against HBsAg expression. Similar blocking effect was noted in TCC versus MSC groups. Conclusion These results suggest that the immunomodulatory response to suppress HBsAg expression in CMT and TCC with moderate aerobic exercise is greater than that in age-matched sedentary controls.

关键词： competitive cyclists immunomodulatory hepatitis B surface antigens

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Colchicine sensitizes human hepatocellular carcinoma cells to damages caused by radiation

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World Journal of Gastroenterology 2005年第27期11卷 4237-4240页

作者： Chia-yuan Liu Hui-Fen Liao Shou-Chuan Shih Shee-Chan Lin Wen-Hsiung Chang cheng-Hsin Chu Tsang-En Wang yu-Jen chen Division of Gastroenterology Department of Internal Medic-ine Mackay Memorial Hospital Taipei Taiwan China department of Medical Research Mackay Memorial Hospital TaipeiTaiwan China mackay Medicine Nursing and ManagementCollege Taipei Taiwan China Graduate Institute of Sports Coaching Science Chinese Culture University Taipei Taiwan China department of radiation oncology Mackay Memorial Hospital Taipei Taiwan China department of Molecular Biology and Biochemistry Nation~ Chayi Unversity Chiayi 300 Taiwan China

AIM： We studied the effect of colchicine combined with radiation on the survival of human hepatocellular carcinoma （HCC） HA22T/VGH ***： Twenty-four hours after treatment with 0-8 ng/mL colchicine, HA22T/VGH cells were irradiated at various doses （0, 1, 2, 4, and 8 Gy）. Colony assay was performed to assess the surviving cell fraction. Survival curves were fitted by using a linear-quadratic model to estimate the sensitizer enhancement ratio （SER）. Flow cytometry was used for cell cycle ***： Colchicine at lower concentrations （1 and 2 ng/mL） had obvious synergy with radiation to inhibit HCC cell growth, whereas higher concentrations （4 and 8 ng/mL） had only additive effect to radiation. Pretreatment with 1 and 2 ng/mL colchicine for 24-h enhanced cell killing by radiation with SERs of 1.21 and 1.53, respectively.G2/N arrest was only observed with higher colchicine doses （8 and 16 ng/mL） after 24-h treatment, this effect was neither seen with lower doses （1, 2, and 4 ng/mL）nor with any dose after only 1 h of ***： Our results suggest that colchicine has potential as an adjunct to radiotherapy for HCC *** doses of colchicine possess radiosensitizing effects via some mechanism other than G2/M arrest. Further study is necessary to elucidate the mechanism.

关键词： Colchicine radiation sensitizer Hepatocellularcarcinoma

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