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Associations of prenatal exposure to bisphenols with BMI growth trajectories in offspring within the first two years:evidence from a birth cohort study in China

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World Journal of Pediatrics 2024年第7期20卷 701-711页

作者： Chao Xiong Kai chen Lu-Li Xu Yi-Ming Zhang Hua Liu Meng-Lan Guo Zhi-Guo Xia Yu-Ji Wang Xiao-Feng Mu Xiao-Xuan Fan Jing-Quan chen Yu-Ru Liu yuan-yuan Li Wei Xia you-Jie Wang Ai-Fen Zhou Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital) Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430016China Key Laboratory of Environment and Health Ministry of Education and Ministry of Environmental Protectionand State Key Laboratory of Environmental HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Maternal and Child Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Background Prenatal bisphenol exposure has been reported to be associated with lower birth weight and obesity-related indicators in early *** findings warrant an investigation of the relationship between prenatal bisphenol exposure and the dynamic growth of *** study aimed to evaluate the relationship of maternal bisphenol concentration in urine with the body mass index(BMI)growth trajectory of children aged up to two years and to identify the critical exposure *** A total of 826 mother–offspring pairs were recruited from Wuhan Children’s Hospital between November 2013 and March *** urine samples collected during the first,second,and third trimesters were analyzed for bisphenol A(BPA),bisphenol S,and bisphenol F(BPF)*** of length and weight were taken at 0,1,3,6,8,12,18,and 24 ***'s BMI was standardized using the World Health Organization reference,and group-based trajectory modeling was used to identify BMI growth *** associations between prenatal bisphenol exposure and BMI growth trajectory patterns were assessed using multinomial logistic regression *** The BMI growth trajectories of the 826 children were categorized into four patterns:low-stable(n=134,16.2%),low-increasing(n=142,17.2%),moderate-stable(n=350,42.4%),and moderate-increasing(n=200,24.2%).After adjusting for potential confounders,we observed that prenatal exposure to BPA during the second trimester[odds ratio(OR)=2.20,95%confidence interval(CI)=1.09–4.43]and BPF during the third trimester(OR=3.28,95%CI=1.55–6.95)at the highest quartile concentration were associated with an increased likelihood of the low-increasing BMI ***,in the subgroup analysis by infant sex,the positive association between the highest quartile of prenatal average urinary BPF concentration during the whole pregnancy and the low-increasing BMI trajectory was found only in girls(OR=2.82,95%CI=1.04–7.68).Conclus

关键词： Birth cohort study Bisphenol A Bisphenol S Bisphenol F Body mass index trajectory Prenatal exposure

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Distribution and geochemical significance of alkylbenzenes for crude oil with different depositional environments and thermal maturities

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Petroleum Science 2024年第2期21卷 777-790页

作者： Bing-Kun Meng Dao-Fu Song yuan chen Sheng-Bao Shi School of Petroleum Engineering and Environmental Engineering Yan'an UniversityYan'an716000ShaanxiChina State Key Laboratory of Petroleum Resources and Prospecting College of GeosciencesChina University of PetroleumBeijing102249China

A total of 45 alkylbenzenes were detected and identified in crude oils with different depositional environments and thermal maturities from the Tarim Basin,Beibuwan Basin,and Songliao Basin using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry(GC×GCTOFMS).By analyzing the distribution characteristics of C0-C5alkylbenzenes,it is found that the content of some alkylbenzenes varies greatly in crude *** on the distribution characteristics of 1,2,4,5-tetramethylbenzene(Te MB)and 1,2,3,4-Te MB,the ratio of 1,2,4,5-Te MB to 1,2,3,4-Te MB is proposed to indicate the organic matter origin and depositional environment of ancient *** samples originated mainly from lower hydrobiont,algae,bacteria and source rocks deposited under reducing/anoxic conditions have low 1,2,4,5-/1,2,3,4-Te MB values(less than 0.6),while oil samples originated mainly from terrestrial higher plants and source rocks deposited under oxic/sub-oxic conditions have higher 1,2,4,5-/1,2,3,4-Te MB values(greater than 1.0).The significant difference of 1,2,4,5-/1,2,3,4-Te MB values is controlled by 1,2,4,5-Te MB content.1,2,4,5-Te MB content in oils derived from source rocks deposited in oxidized sedimentary environment(greater than 1.0 mg/g whole oil)is higher than that in oils from source rocks deposited in reduced sedimentary environment(less than 1.0 mg/g whole oil).1,2,4,5-/1,2,3,4-Te MB ratio might not or slightly be affected by evaporative fractionation,biodegradation and thermal maturity.1,2,4,5-/1,2,3,4-Te MB ratio and 1,2,4,5-Te MB content can be used as supplementary parameter for the identification of sedimentary environment and organic matter *** should be noted that compared to the identification of organic matter sources,the 1,2,4,5-/1,2,3,4-Te MB parameter is more effective in identifying sedimentary environments.

关键词： 1 2 4 5-Tetramethylbenzene GC×GC-TOFMS Organic matter origin Depositional environment

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Extreme single-excitation subradiance from two-band Bloch oscillations in atomic arrays

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Photonics Research 2024年第3期12卷 571-580页

作者： LUOJIA WANG DA-WEI WANG LUQI yuan YAPING YANG XIANFENG chen State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Interdisciplinary Center for Quantum Information and State Key Laboratory of Modern Optical Instrumentation Zhejiang Province Key Laboratory of Quantum Technology and Deviceand School of PhysicsZhejiang UniversityHangzhou 310027China MOE Key Laboratory of Advanced Micro-Structured Materials School of Physics Science and EngineeringTongji UniversityShanghai 200092China Shanghai Research Center for Quantum Sciences Shanghai 201315China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China

Atomic arrays provide an important quantum optical platform with photon-mediated dipole–dipole interactions that can be engineered to realize key applications in quantum information processing.A major obstacle for such applications is the fast decay of the excited *** controlling two-band Bloch oscillations of single excitation in an atomic array under an external magnetic field,here we show that exotic subradiance can be realized and maintained with orders of magnitude longer than the spontaneous decay time in atomic arrays with the finite *** key finding is to show a way for preventing the wavepacket of excited states scattering into the dissipative zone inside the free space light cone,which therefore leads to the excitation staying at a subradiant state for an extremely long decay *** show that such operation can be achieved by introducing a spatially linear potential from the external magnetic field in the atomic arrays and then manipulating interconnected two-band Bloch oscillations along opposite *** results also point out the possibility of controllable switching between superradiant and subradiant states,which leads to potential applications in quantum storage.

关键词： excitation Bloch decay

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Research on the prognostic value of adjusting intraperitoneal threedimensional quality evaluation mode in laparoscopic cholecystectomy patients

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1078-1086页

作者： yuan Zhou Zhan-Qing chen Operating Room Lianyungang Hospital of Traditional Chinese MedicineLianyungang 222000Jiangsu ProvinceChina Operating Room The Second People's Hospital of Lianyungang Affiliated to Kangda College of Nanjing Medical UniversityLianyungang 222000Jiangsu ProvinceChina

BACKGROUND Benign gallbladder diseases have become a high-prevalence condition not only in China but also *** main types of benign gallbladder diseases include gallbladder polyps,acute and chronic cholecystitis,and gallstones,with gallstones being the most common,accounting for over 70%of *** the mortality rate of benign gallbladder diseases is low,they carry obvious potential *** have shown that an increased incidence of benign gallbladder diseases can increase the risk of cardiovascular diseases and gallbladder cancer,resulting in a substantial disease burden on patients and their *** To assess the medical utility of the Configuration-Procedure-Consequence(CPC)three-dimensional quality evaluation model in modulating the prognosis of laparoscopic cholecystectomy *** A total of 98 patients who underwent laparoscopic cholecystectomy in our hospital from February 2020 to January 2022 were selected as the *** to the random number table method,they were divided into a study group and a control group,with 49 patients in each *** control group received routine perioperative care,while the study group had the addition of the CPC three-dimensional quality *** postoperative recovery-related indicators(time to first flatus,time to oral intake,time to ambulation,hospital stay),stress indicators(cortisol and adrenaline levels),distinctions in anxiety and RESULTS The time to first flatus,time to oral intake,time to ambulation,and hospital stay of the study group patients were obviously lower than those of the control group patients,with statistical significance(P0.05).However,on the 3rd day after surgery,the cortisol and adrenaline leve

关键词： Configuration-Procedure-Consequence Three-dimensional quality evaluation Laparoscopic Cholecystectomy Recovery process Anxiety and depression Complications

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Asymmetric alkenylation reaction of benzoxazinones with diarylethylenes catalyzed by B(C_(6)F_(5))_(3)/chiral phosphoric acid

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Chinese Chemical Letters 2024年第5期35卷 135-140页

作者： Zhen Liu Zhi-yuan Ren chen Yang Xiangyi Shao Li chen Xin Li State Key Laboratory of Elemento-Organic Chemistry Frontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin 300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Zhenhai High School of Zhejiang Ningbo 315299China

Catalytic enantioselective alkenylation is an efficient method to construct chiral alkene molecules,but the asymmetric alkenylation of simple alkenes catalyzed by metal-free catalysts remains an elusive ***,we reported an asymmetric alkenylation of benzoxazinones with diarylethylenes by utilizing a B(C_(6)F_(5))_(3)/chiral phosphoric acid catalyst.A broad of benzoxazinones and diarylethylenes with electron-withdrawing and electron-donating groups were tolerated(up to 95%yield and 97.5:2.5 e.r.)in the methodology under mild reaction ***,the synthetic utility was confirmed by the scaled-up reaction and transformations of the *** mechanism was preliminarily explored by control reactions,nonlinear effect experiment and DFT calculations.

关键词： Asymmetric alkenylation Simple alkenes Benzoxazinones B(C_(6)F_(5))_(3)/chiral phosphoric acid Theoretical calculations

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Coexistence of All-Order Topological States in a Three-Dimensional Phononic Topological Crystalline Insulator

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Research 2024年第2期2023卷 511-518页

作者： Hua-Shan Lai Hao chen Chu-Hao Xia Si-yuan Yu cheng He Yan-Feng chen National Laboratory of Solid State Microstructures&Department of Materials Science and Engineering Nanjing UniversityNanjng 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjng 210093China Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University Nanjing 210093China

Classical-wave topological materials lacking intrinsic half-integer spins are less robust while more ***,we explore a single 3-dimensional phononic topological crystalline insulator that simultaneously exhibits a whole family of first-order quadratic surface,second-order hinge,and third-order corner states within the same *** a topological crystalline insulator hosting all-order phases originates from the different topological nature when hierarchically projected onto different facets and lower dimensions,thus free from trivial cladding *** work offers an ideal platform for either robust wave propagation or localization in on-demand dimensions and may facilitate dimension division multiplexing technology.

关键词： topological dimensions crystalline

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LH-Nts Neurons Regulate VTA Calcium Dynamics Via Releasing GABA and Nts

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Neuroscience Bulletin 2024年第4期40卷 550-552页

作者： Danni chen Yinfeng yuan Zhihui Huang Yongjie Wang School of Pharmacy Hangzhou Normal UniversityHangzhou311121ZhejiangChina Key Laboratory of Element Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou311121ZhejiangChina

The peripheral and central nervous systems have numerous examples of two or more neuroactive products co-existing in the same neuron[1],which can simultaneously be released as both fast-acting neurotransmitters and slow-acting regulatory neuropeptides[2].For example,neurons in the lateral hypothalamus(LH)release both irritant neurotensin(Nts)and inhibitory-aminobutyric acid(GABA),two counterproductive substances[3].LH-Nts neurons project to the ventral tegmental area(VTA)and form synaptic connections with dopamine(DA)neurons to regulate reward[4-6].More critically,VTA-DA neurons express the Nts receptor Ntsrl and play a crucial role in cognition,anesthesia,reward,and disgust[4,7,8].Nevertheless,a mechanistic understanding of how stimulation and inhibition work together to control the output of neural circuits remains *** is very difficult to selectively isolate these signaling pathways in cell and circuit-specific manners.

关键词： anesthesia stimulation dopamine

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Low interleukin-10 level indicates a good prognosis in Salmonella enterica serovar typhimurium-induced pediatric hemophagocytic lymphohistiocytosis:A case report

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World Journal of Clinical Cases 2024年第9期12卷 1660-1668页

作者： yuan-yuan chen Xiang-Zhi Xu Xiao-Jun Xu Division/Center of Pediatric Hematology Oncology Children’s HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Pediatric Intensive Care Unit Children’s Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Secondary hemophagocytic lymphohistiocytosis(sHLH)triggered by Salmonella enterica serovar Typhimurium is rare in pediatric *** is no consensus on how to treat ***-triggered *** SUMMARY A 9-year-old boy with intermittent fever for 3 d presented to our hospital with positive results for ***,human rhinovirus,and Mycoplasma pneumoniae *** the time of admission to our institution,the patient’s T helper 1/T helper 2 cytokine levels were 326 pg/mL for interleukin 6(IL-6),9.1 pg/mL for IL-10,and 246.7 pg/mL for interferon-gamma(IFN-γ),for which the ratio of IL-10 to IFN-γwas *** this study,the patient received meropenem,linezolid,and cefoperazone/sulbactam in combination with high-dose methylprednisolone therapy(10 mg/kg/d for 3 d)and antishock supportive treatment *** careful evaluation,this patient did not receive HLH chemotherapy and recovered *** *** infection-triggered sHLH patient had a ratio of IL-10 to IFN-γ≤1.33,an IL-10 concentration≤10.0 pg/mL,and/or an IFN-γconcentration≤225 pg/mL at *** antimicrobial and supportive treatment was sufficient,and the HLH-94/2004 protocol was not necessary under these conditions.

关键词： Hemophagocytic lymphohistiocytosis Cytokine pattern Interferon gamma Interleukin-10 Salmonella enterica serovar Typhimurium Case report

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CSCO guidelines for colorectal cancer version 2024:Updates and discussions

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Chinese Journal of Cancer Research 2024年第3期36卷 233-239页

作者： Liubo chen Hanguang Hu Ying yuan Shanshan Weng Department of Medical Oncology(Key Laboratory of Cancer Prevention and Intervention China National Ministry of EducationKey Laboratory of Molecular Biology in Medical SciencesZhejiang ProvinceChina)the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Zhejiang Provincial Clinical Research Center for CANCER Hangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310058China

According to the latest global cancer statistics,colorectal cancer(CRC)is the most common malignancy of the digestive system and the second most lethal among all cancer types(1).In China,CRC is the second most prevalent cancer,following only after lung cancer(2).The first version of the Chinese Society of Clinical Oncology(CSCO)guideline was launched in 2017 and has been updated annually based on the latest findings of clinical research,drug accessibility and expert consensus(3-8).Here,we present the main updates of the 2024 version compared to the 2023 version.

关键词： CSCO colorectal cancer

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On Robust Cross-view Consistency in Self-supervised Monocular Depth Estimation

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Machine Intelligence Research 2024年第3期21卷 495-513页

作者： Haimei Zhao Jing Zhang Zhuo chen Bo yuan Dacheng Tao School of Computer Science University of SydneySydney2008Australia Shenzhen International Graduate School Tsinghua UniversityShenzhen518055China School of Information Technology&Electrical Engineering University of QueenslandBrisbane4072Australia

Remarkable progress has been made in self-supervised monocular depth estimation (SS-MDE) by exploring cross-view consistency, e.g., photometric consistency and 3D point cloud consistency. However, they are very vulnerable to illumination variance, occlusions, texture-less regions, as well as moving objects, making them not robust enough to deal with various scenes. To address this challenge, we study two kinds of robust cross-view consistency in this paper. Firstly, the spatial offset field between adjacent frames is obtained by reconstructing the reference frame from its neighbors via deformable alignment, which is used to align the temporal depth features via a depth feature alignment (DFA) loss. Secondly, the 3D point clouds of each reference frame and its nearby frames are calculated and transformed into voxel space, where the point density in each voxel is calculated and aligned via a voxel density alignment (VDA) loss. In this way, we exploit the temporal coherence in both depth feature space and 3D voxel space for SS-MDE, shifting the “point-to-point” alignment paradigm to the “region-to-region” one. Compared with the photometric consistency loss as well as the rigid point cloud alignment loss, the proposed DFA and VDA losses are more robust owing to the strong representation power of deep features as well as the high tolerance of voxel density to the aforementioned challenges. Experimental results on several outdoor benchmarks show that our method outperforms current state-of-the-art techniques. Extensive ablation study and analysis validate the effectiveness of the proposed losses, especially in challenging scenes. The code and models are available at https://***/sunnyHelen/RCVC-depth.

关键词： 3D vision depth estimation cross-view consistency self-supervised learning monocular perception

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