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Role of the reduction site in the fluorinated or sulfated TiO_2 photocatalytic process

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Journal of Environmental Sciences 2007年第10期19卷 1239-1244页

作者： YANG Shi-ying HU Hong chen you-yuan ZHENG Jian-guo CUI Ying-jie Key Lab of Marine Environmental Science and Ecology Ministry of Education Ocean University of China Qingdao 266100 China College of Environmental Science and Engineering Ocean University of China Qingdao 266100 China

In this article, the effects of ZiO2 surface fluorination and sulfation, on the active oxygen species formed at the reduction site in the photocatalytic process, namely O2^＊- and H2O2, were investigated from a new perspective. The superoxide radical, （O2^＊-）, was determined by colorimetry of nitroblue tetrazolium, a prominent O2^＊- scavenger. Hydrogen peroxide （H2O2） was estimated by using the iodide-starch method. In the naked TiO2 photocatalysis, O2^＊-, though less reactive, was a very important intermediate. When the TiO2 surface was fluorinated, more O2^＊- and H2O2 were produced, which indicated that the surface modification could greatly reduce the recombination of photogenerated electrons and holes, thus enhancing the photocatalytic rate. In the sulfated system, photocatalysis proceeded with a more complicated mechanism. These results added support to the view of fluoride-induced enhancement and sulfide＇s nonappreciable inhibition effect.

关键词： TiO2 photocatalysis superoxide radicals surface modification initial mechanism

Large-Scale CRISPR Screen of LDLR Pathogenic Variants

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Research 2024年第2期2023卷 213-225页

作者： Mengjing Li Lerong Ma Yiwu chen Jianing Li Yanbing Wang Wenni you Hongming yuan Xiaochun Tang Hongsheng Ouyang Daxin Pang Key Lab for Zoonoses Research Ministry of EducationAnimal Genome Editing Technology Innovation CenterCollege of Animal SciencesJilin UniversityChangchunJilin Province 130062China The Institute of Translational Medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300071China Chongqing ResearchInstitute Jilin UniversityChongqing 401123China Chongqing Jitang Biotechnology Research Institute Co.Ltd. ChongqingChina

Familial hypercholesterolemia(FH)is a frequently occurring genetic disorder that is linked to early-onset cardiovascular *** left untreated,patients with this condition can develop severe cardiovascular ***,many patients remain undiagnosed,and even when diagnosed,the treatment is often not *** mutations in the LDLR gene are the primary cause of FH,predicting whether novel variants are pathogenic is not a straightforward *** the functionality of LDLR variants is crucial in uncovering the genetic basis of *** study utilized CRISPR/Cas9 cytosine base editors in pooled screens to establish a novel approach for functionally assessing tens of thousands of LDLR variants on a large scale.A total of more than 100 single guide RNAs(sgRNAs)targeting LDLR pathogenic mutations were successfully screened with relatively high *** of these,5 sgRNAs were further subjected to functional verification studies,including 1 in the promoter,1 in the antisense RNA,1 in the exon,and 2 in the *** for the variant caused by the sgRNA located at intron 16,the functionalities of the other LDLR variants were all *** high similarity of LDLR intron sequences may lead to some false ***,these results confirm the reliability of the large-scale screening strategy for functional analysis of LDLR variants,and the screened candidate pathogenic mutations could be used as an auxiliary means of clinical gene detection to prevent FH-induced heart disease.

关键词： LDLR Screen straight

Engineering classification recycling of spent lithium-ion batteries through pretreatment:a comprehensive review from laboratory to scale-up application

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Rare Metals 2024年第3期43卷 915-941页

作者： Shu-Xuan Yan you-Zhou Jiang Xiang-Ping chen Lu yuan Ting-Ting Min Yu Cao Wan-Li Peng Tao Zhou Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangsha 410083China School of Public Policy and Management Tsinghua UniversityBeijing 100084China China Nonferrous Metal Industry's Foreign Engineering and Construction Co. LtdBeijing 100029China

The lithium-ion batteries(LIBs)have been widely equipped in electric/hybrid electric vehicles(EVs/HEVs)and the portable electronics due to their excellent electrochemical ***,a large number of retired LIBs that consist of toxic substances(e.g.,heavy metals,electrolytes)and valuable metals(e.g.,Li,Co)will inevitably flow into the waste stream,and their incineration or landfill treatment will cause severe risks to ecosystem and human *** sustainable and efficient treatment or recycling of valuable resources from spent LIBs should be fully recognized for environmental and resource *** one of the most important processes for spent LIBs recycling,the pretreatment is an indispensable step,which is directly related to the subsequent metal extraction and separation *** considerable progresses have been made regarding the pretreatment technologies,there are few summarized reports concerning critical processes of spent LIBs recycling,especially combination of currently available recycling technologies with industrialized applications during ***,comprehensive review of the current prevailing pretreatment technologies in laboratory to existing scale-up applications is quite necessary to reveal cutting-edge development in the field of *** this review,the current pretreatment technologies are systematically categorized and introduced,along with critical *** review focused on the various options for pretreatment processes itself,instead of general spent LIBs recycling technologies without the focused topics that have been sophisticatedly reviewed by previous ***,the deactivation,discharge,dismantling,separation,liberation of active material and electrolyte treatment have been summarized with the in-depth discussion of the technology development and current status of each ***,current states of industrial development are also reviewed and discussed for the development of

关键词： Spent lithium-ion batteries(LIBs) Recycling Pretreatment Valuable metals Cutting-edge technologies Industrialized application

Toward Artificial Peptide Nanocapsules

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Nano-Micro Letters 2024年第10期16卷 240-243页

作者： yuan Wang Bing chen Laboratory for Biomaterials and Drug Delivery Department of AnesthesiologyDivision of Critical Care MedicineBoston Children's HospitalHarvard Medical SchoolBostonMA 02115USA College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023People's Republic of China

HIGHLIGHTS The formation of peptide nanocapsules is facilitated by a gradient interface,where the differential solvent concentration drives the peptides to preferentially localize and *** peptide nanocapsules,characterized by their hollow structures,demonstrated potential as carriers for targeted drug delivery.1 Introduction Peptide nanocapsules are a type of nanoscale delivery system that encapsulates active substances within a shell composed of peptides,leveraging the unique properties of peptides such as biocompatibility and biodegradability[1].Historically,the development of peptide nanocapsules was inspired primordially by the natural biological processes.

关键词： Peptide nanocapsules Self-assembly Drug delivery Nanomedicine

A highly sensitive fluorescent probe RN-NA reveals peroxynitrite as a novel biomarker for primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 219-227页

作者： Bo Qin yuan Lei Luo Bao you-Jia Zhang Ke-Yin Liu Yu-Hong chen Department of Ophthalmology&Visual Science Eye&ENT HospitalShanghai Medical CollegeFudan UniversityShanghai 200031China Key Laboratory of Myopia NHFPC(Fudan University)Shanghai Key Laboratory of Visual Impairment and Restoration(Fudan University)Shanghai 200031China State Key Laboratory of Biobased Material and Green Papermaking Key Laboratory of Pulp&Paper Science and Technology of Shandong Province/Ministry of EducationQilu University of TechnologyShandong Academy of SciencesJinan 250353Shandong ProvinceChina

AIM:To directly quantify peroxynitrite(ONOO-)using a highly sensitive fluorescence resonance energy transfer probe RN-NA,investigate the association between ONOOand primary open angle glaucoma(POAG),and clarify whether RN-NA could be used as a potential tool for POAG ***:Plasma and aqueous humor(AH)samples were collected from POAG patients(n=100,age:59.70±6.87y)and age-related cataract(ARC)patients(n=100,age:61.15±4.60y)admitted to our ***,RN-NA was used to detect ONOO-in plasma and AH samples,and the relationship between ONOO-level and POAG was analyzed using binary logistic ***,Pearson correlation analysis was applied to characterize the correlation of the levels of ONOO-with the patients’age,intraocular pressure(IOP),and mean deviation of visual field *** ONOO-scavenger MnTMPyP was employed to treat the 3-morpholinosyndnomine(SIN-1)-induced ocular hypertension in mice(n=7,6-8wk).Finally,the IOP and ONOO-in both eyes were measured 30min after the last drug ***:ONOO-levels of AH and plasma were significantly higher in the POAG group than in the ARC group(P<0.01).Additionally,ONOO-levels were closely correlated with POAG in a binary logistic regression analysis[odds ratio(OR)=1.008,95%confidence interval(CI):1.002-1.013,P<0.01 for AH;OR=1.004,95%CI:1.002-1.006,P<0.001 for plasma].Pearson correlation analysis showed that ONOO-levels in AH or plasma were positively associated with visual field defects(R=0.51,P<0.01 for AH;R=0.45,P<0.001 for plasma),and ONOO-levels in plasma and AH were correlated in the POAG group(R=0.69,P<0.001).However,administering MnTMPyP to mouse eyes reversed the elevated IOP caused by SIN-1(P<0.05).CONCLUSION:ONOO-levels in AH and plasma,detected by RN-NA,are significantly related to POAG and positively correlated with visual field defects in POAG ***,ONOO-is a potential biomarker of POAG,especially advanced ***,anti-nitration compounds may be novel ocular hypotens

关键词： peroxynitrite fluorescent probe RN-NA primary open angle glaucoma 3-morpholinosyndnomine

Hydrogen sulfide responsive nanoplatforms: Novel gas responsive drug delivery carriers for biomedical applications

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 1-17页

作者： Jiafeng Zou Zeting yuan Xiaojie chen you chen Min Yao Yang chen Xiang Li Yi chen Wenxing Ding Chuanhe Xia Yuzheng Zhao Feng Gao Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism School of PharmacyEast China University of Science and TechnologyShanghai 200237China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China Shanghai Key Laboratory of Functional Materials Chemistry East China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and TechnologyShanghai 200237China Optogenetics and Synthetic Biology Interdisciplinary Research Center State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237China CAS Center for Excellence in Brain Science Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Research Unit of New Techniques for Live-cell Metabolic Imaging Chinese Academy of Medical SciencesBeijing 100050China

Hydrogen sulfide(H_(2)S)is a toxic,essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas *** studies have mainly focused on the production and pharmacological side effects caused by H_(2)***,effective strategies to remove H_(2)S has become a key research ***,the development of novel nanoplatforms has provided new tools for the targeted removal of H_(2)*** paper was performed to review the association between H_(2)S anddisease,relatedH_(2)S inhibitory drugs,aswell as H_(2)S responsive nanoplatforms(HRNs).This review first analyzed the role of H_(2)S in multiple tissues and ***,common drugs used to eliminate H_(2)S,as well as their potential for combination with anticancer agents,were *** only the existing studies on HRNs,but also the inhibition H_(2)S combined with different therapeutic methods were both sorted out in this ***,this review provided in-depth analysis of the potential of HRNs about treatment or detection in ***,potential challenges of HRNs were *** study demonstrates the excellent potential of HRNs for biomedical applications.

关键词： Hydrogen sulfide Disease mechanisms Removal of hydrogen sulfide Responsive nanoplatforms Challenges Biomedical applications

SDGNN: Symmetry-Preserving Dual-Stream Graph Neural Networks

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1717-1719页

作者： Jiufang chen Ye yuan Xin Luo the College of Computer Science and Technology Chongqing University of Posts and TelecommunicationsChongqing 400065 the Chongqing Key Laboratory of Big Data and Intelligent Computing Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China the College of Computer and Information Science Southwest UniversityChongqing 400715China IEEE

Dear Editor,This letter proposes a symmetry-preserving dual-stream graph neural network(SDGNN) for precise representation learning to an undirected weighted graph(UWG). Although existing graph neural networks(GNNs) are influential instruments for representation learning to a UWG, they invariably adopt a unique node feature matrix for illustrating the sole node set of a UWG.

关键词： representation preserving undirected

When mRNA meets gene editing

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Nano Research 2024年第8期17卷 7337-7356页

作者： Weijie Li chen Wang yuan Lu Key Laboratory of Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

The critical challenge of gene therapy lies in delivering gene editing *** with DNA,while RNA is less stable and more accessible to degrade,it comes with the benefit of lower off-target effects since permanent insertion is not *** review focuses on mRNA-based delivery of gene editing agents,highlighting novel mRNA delivery *** provide context,a comparison is made between three main gene editing agents:programmable nucleases,base editors,and prime *** potential of Cas\pi and transposons is also discussed in this ***,a summary of four main barriers to mRNAbased in vivo delivery is ***,this review detailedly introduced different delivery systems,both viral(lentivirus)and non-viral vectors(genome editing via oviductal nucleic acids delivery,lipid nanoparticles,polymer-based nanoparticles,viruslike-particles,extracellular vesicles,and migrasome).Each delivery strategy is assessed by comparing its advantages and disadvantages to offer a comprehensive and objective overview of the delivery ***,we emphasized the vital role of the protein corona as a critical regulator for ***,we concluded the challenges of mRNA-based gene editing strategies(RNA stability,targeting,potential immunogenicity,cytotoxicity,heterogeneity,and rational design).The purpose of this review is to guide further research and provide a comprehensive analysis of mRNA-based in vivo delivery of gene editing agents in this promising field.

关键词： gene editing mRNA delivery viral vectors non-viral vectors CRISPR

Structural engineering of hard carbon through spark plasma sintering for enhanced sodium-ion storage

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Rare Metals 2024年第9期43卷 4274-4285页

作者： Hao-Ming Xiao Heng Zheng Ping yuan Jun-Hui Luo Lin-Lin Shen Jie-Feng Tan Xian-you Luo De Li Yong chen Guangdong Key Laboratory for Hydrogen Energy Technologies School of Materials Science and Hydrogen EnergyFoshan University State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti ResourcesHainan University

Hard carbon （HC） has emerged as one of the superior anode materials for sodium-ion batteries （SIBs）,with its electrochemical performance significantly influenced by the presence of oxygen functional groups and its closed pore ***,current research on the structural adjustment of these oxygen functional groups and the closed pore architecture within HC remains ***,energy-efficient and contamination-free spark plasma sintering technology was employed to tune the structure of coconut-shell HC,resulting in significant adjustments to the content of carboxyl （decreasing from 5.71 at%to 2.12 at%） and hydroxyl groups （decreasing from 7.73 at % to 6.26 at%）.Crucially,these modifications reduced the irreversible reaction of oxygen functional groups with Na+.Simultaneously,a substantial number of closed pores with an average diameter of 1.22 nm were generated within the HC,offering an ideal environment for efficient Na+*** structural changes resulted in a remarkable improvement in the electrochemical performance of the modified *** reversible specific capacity of the modified HC surged from 73.89 mAh·g-1to an impressive 251.97 m Ah·g-1at a current density of 50 mA·*** at 400 mA·g-1,the reversible specific capacity increased significantly from 14.55 to 85.44 mAh·***,this study provides a novel perspective for designing tailored HC materials with the potential to develop high-performance SIBs.

关键词： Closed pores Hard carbon Oxygen functional groups Sodium-ion batteries Spark plasma sintering