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Prolonged SARS-CoV-2 Viral Shedding in Patients with COVID-19 was Associated with Delayed Initiation of Arbidol Treatment and Consulting Doctor Later: A Retrospective Cohort Study

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Current Medical Science 2021年第6期41卷 1096-1104页

作者： xin-liang HE Ya-ya ZHOU Wei FU Yu-e XUE Meng-yuan liANG Bo-han YANG Wan-li MA Qiong ZHOU Long chen Jian-chu zhang Xiao-rong WANG department of Respiratory and Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective:To study data about SARS-CoV-2 virus shedding and clarify the risk factors for prolonged virus ***:Data were retrospectively collected from adults hospitalized with laboratory-confirmed coronavirus disease-19(COVID-19)in Wuhan Union *** compared clinical features among patients with prolonged(a positive SARS-CoV-2 RNA on day 23 after illness onset)and short virus shedding and evaluated risk factors associated with prolonged virus shedding by multivariate regression ***:Among 238 patients,the median age was 55.5 years,57.1%were female,92.9%(221/238)were administered with arbidol,58.4%(139/238)were given arbidol in combination with *** median duration of SARS-CoV-2 virus shedding was 23 days(IQR,17.8-30 days)with a longest one of 51 *** patients with prolonged virus shedding had higher value of D-dimer(P=0.002),IL-6(P<0.001),CRP(P=0.005)and more lobes lung lesion(P=0.014)on admission,as well as older age(P=0.017)and more patients with hypertension(P=0.044)than in those the virus shedding less than 23 *** regression analysis revealed that prolonged viral shedding was significantly associated with initiation arbidol≥8 days after symptom onset[OR:2.447,95%CI(1.351-4.431)],≥3 days from onset of symptoms to first medical visitation[OR:1.880,95%CI(1.035-3.416)],illness onset before Jan.31,2020[OR:3.289,95%CI(1.474-7.337)].Arbidol in combination with interferon was also significantly associated with shorter virus shedding[OR:0.363,95%CI(0.191-0.690)].Conclusion:Duration of SARS-CoV-2 virus shedding was *** initiation of arbidol and arbidol in combination with interferon as well as consulting doctor timely after illness onset were helpful for SARS-CoV-2 clearance.

关键词： SARS-CoV-2 viral shedding risk factors antiviral treatment arbidol

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Perfect invisibility concentrator with simplified material parameters

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Frontiers of physics 2018年第5期13卷 3-8页

作者： Meng-Yin Zhou lin Xu Lu-Chan zhang Jiang Wu Yan-Bo li Huan-Yang chen Institute of Electromagnetics and Acoustics and department of Electronic Science Xiamen University Xiamen 361005 China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China Chengdu 610054 China

We present a series of invisibility concentrators with simplified material parameters beyond trans- formation optics. One of them can achieve the perfect invisible effect at frequencies of Fabry-Perot resonances, while others have very small scattering. The required materials are feasible in practice. Analytical calculations and numerical simulations confirm the functionalities of these devices.

关键词： perfect-invisibility concentrator simplified material parameters Fabry-Perot resonances scattering cross section

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鼻窦鳞癌免疫联合动脉灌注化疗后完全缓解1例

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中华耳鼻咽喉头颈外科杂志 2024年第9期59卷 947-949页

作者：寇秀娟李铮杨超张金龙丁一鸣马廷耀武骏赵洪伟陈晓红首都医科大学附属北京同仁医院甲状腺头颈外科北京100730 首都医科大学附属北京同仁医院放射科北京100730

近年来, 免疫联合化疗越来越多地应用在头颈部鳞状细胞癌(简称鳞癌), 本文报道1例鼻窦鳞癌患者应用免疫联合动脉灌注化疗后完全缓解的病例。患者为中年男性, 诊断为上颌窦鳞癌(T4aN0M0 Ⅳa期), 经5周期动脉灌注化疗联合静脉免疫治疗后... 详细信息

近年来, 免疫联合化疗越来越多地应用在头颈部鳞状细胞癌(简称鳞癌), 本文报道1例鼻窦鳞癌患者应用免疫联合动脉灌注化疗后完全缓解的病例。患者为中年男性, 诊断为上颌窦鳞癌(T4aN0M0 Ⅳa期), 经5周期动脉灌注化疗联合静脉免疫治疗后疗效评价为完全缓解。行唇龈入路上颌窦肿物切除术, 术后辅助放疗及替雷利珠单抗维持治疗, 随访11个月余未见局部复发及远处转移。

关键词：完全缓解动脉灌注化疗

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基于UPLC-Q-TOF-MS的龙牡清心合剂成分鉴定及其治疗注意缺陷多动障碍的物质基础研究

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中成药 2024年第2期46卷 490-498页

作者：李雪军姜之炎肖臻陈秀峰王淑敏张奕星蒲文焱上海中医药大学附属龙华医院儿科上海200032

目的采用UPLC-Q-TOF-MS技术鉴定龙牡清心合剂化学成分,探究其治疗注意缺陷多动障碍的物质基础。方法采用Waters CORTECS?UPLC?T3色谱柱在正、负离子模式下对样品进行质谱检测,以Peakview 1.2软件进行数据分析,与Natural Products HR-M... 详细信息

目的采用UPLC-Q-TOF-MS技术鉴定龙牡清心合剂化学成分,探究其治疗注意缺陷多动障碍的物质基础。方法采用Waters CORTECS?UPLC?T3色谱柱在正、负离子模式下对样品进行质谱检测,以Peakview 1.2软件进行数据分析,与Natural Products HR-MS/MS Spectral library 1.0数据库匹配,结合文献报道进行成分鉴定,结合鉴定结果分析龙牡清心合剂治疗注意缺陷多动障碍的物质基础。结果共鉴定出40种化学成分,包括黄酮类11种、单萜苷类6种、三萜皂苷类4种、酚酸类3种、生物碱类6种等,主要来源于黄芪、白芍、黄芩、甘草、钩藤等。黄芩苷、黄芩素、芒柄花黄素、黄芪甲苷、钩藤碱可能是龙牡清心合剂治疗注意缺陷多动障碍的物质基础。结论 UPLC-Q-TOF-MS可快速对龙牡清心合剂中的化学成分进行鉴定,黄酮类、三萜皂苷类、生物碱类成分可能是龙牡清心合剂治疗注意缺陷多动障碍的物质基础,可为该方的物质基础研究、质量标准建立、拆方药理学研究提供依据。

关键词：龙牡清心合剂注意缺陷多动障碍 UPLC-Q-TOF-MS 指纹图谱化学成分药理作用

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Adult Subdural Empyema Caused By Salmonella Typhi Misdiagnosed As Chronic Subdural Hematoma:Case Report

Adult Subdural Empyema Caused By Salmonella Typhi Misdiagnos...

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2009年浙江省神经外科学术年会

作者： department of Neurosurgery,The Second Hospital Affiliated to The School of Medicine,zhejiang university Hu Hua zhang Jian-min chen Gao Wu Qun department of Neurosurgery,The First People’ s Hospital of Xiaoshan District Hu Dian-xiang

History and Examination:A 49-year-old man presented with a three-week history of mild *** months before presentation,he suffered a moderate closed-head injury with no coma,and one month before presentation he had a lo...

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Effect and Safety of CX-DZ-ⅡIntelligent Electroacupuncture Therapeutic Instrument for Neck Pain Caused by Cervical Spondylos:Study Protocol for A Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2020年第5期26卷 375-381页

作者： chen Zhi-han liANG Fan-rong YANG Ming-xiao li De-hua zhang Ya REN Yu-lan School of Acupuncture Moxibustion and Tuina Chengdu University of Traditional Chinese MedicineChengdu(610075)China School of Chinese Medicine University of Hong Kong Li Ka Shing Faculty of MedicineHong Kong SARChina department of Acupuncture and Moxibustion A ffiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu(610075)China School of Chinese Classics Chengdu University of Traditional Chinese MedicineChengdu(610075)China

Background: Neck pain caused by cervical spondylosis(CS) is a chronic pain condition, with an increasingly high incidence in the general population. Electroacupuncture is a common analgesic modality that has been widely applied in neck pain treatment. However, current electroacupuncture instruments used in the clinic have low intelligence levels and obscure parameter standards. We here designed this study for assessing the effect and safety of a new, intelligent electroacupuncture instrument, the CX-DZ-Ⅱ, in treating neck pain. Methods: The present study is a prospective, two-center, randomized, controlled, open-label, non-inferiority trial for CX-DZ-Ⅱ on treating neck pain caused by CS. Totally 160 eligible patients will be included in this trial and randomly assigned to an experimental group and a control group in a 1:1 ratio. A semi-standard acupoint selection strategy will be employed. In the experimental group, selected acupoints will be stimulated by CX-DZ-Ⅱ. Electroacupuncture treatment will be accomplished by a pre-existing electroacupuncture instrument in the control group. The duration of treatment will be 2 weeks. The primary outcome is the change of Visual Analog Scale(VAS) score after one course of treatment. The secondary outcomes include the VAS scores after each treatment, the responder rate, drug-usage rate of non-steroidal antipyretic analgesics, the rate of adverse events occurrence, and the performance of instrument. Discussion: This study will evaluate the effect and safety of the CX-DZ-Ⅱ intelligent electroacupuncture therapeutic instrument in comparison with a pre-existing non-intelligent instrument in the treatment of neck pain caused by CS. The results will hopefully demonstrate a more optimal electroacupuncture instrument for the treatment of neck pain.(Trial registration No. gov NCT03005301).

关键词： neck pain electroacupuncture therapeutic instrument translational medicine randomized controlled trial protocol

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Antitumor Compound Identification from Zanthoxylum bungeanum Essential Oil Based on Composition-activity Relationship

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Chemical Research in Chinese Universities 2013年第6期29卷 1068-1071页

作者： li Zi-dan HAN Sheng-nan JIANG Jian-lan zhang Xiao-hang li Yan chen Hao YUAN Ying-jin Key Laboratory of Systems Bioengineering Ministry of Education Tianjin Key Laboratory of Biological and Pharmaceutical Engineering Department of Pharmaceutical Engineering School of Chemical Engineering and Technology Tianjin University Tianjin 300072 P.R.China

The chemical composition of Zanthoxylum bungeanum（Z bungeanum） essential oi1（39 batches） was analyzed by gas chromatography-mass spectrometry（GC-MS） analysis（23 ingredients）, and the antitumor activity against HeLa cells was detected via the MTT[3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide] assay. Two composition-activity relationship（CAR） models, generalized regression neural network（GRNN） and support vector regression（SVR） were respectively used to calculate the mean impact value（MIV） so as to identify bioactive com- pounds. Among them 9 ingredients（peaks 4, 15, 7, 8, 13, 3, 16, 9 and 11） were selected due to their high absolute MIVs. All of them have been confirmed with potential antitumor activity by previous researches. The CAR model combined with MIV was expected to be a credible tool for the active compound identification from herbs.

关键词： Zanthoxylum bungeanum essential oil HeLa cell Composition-activity relationship model Active compound identification

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Genome-wide analysis of AP2/ERF superfamily in Isatis indigotica

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Journal of Integrative Medicine 2023年第1期21卷 77-88页

作者： liang Xiao Jun-ze Ren Qing li Bin Yang Zhen-jiang liu Rui-bing chen Lei zhang department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China Medical School of Nantong university Nantong 226001Jiangsu ProvinceChina department of Pharmacy Changzheng HospitalNaval Medical UniversityShanghai 200433China School of Chemical and Environmental Engineering Shanghai Institute of TechnologyShanghai 201418China

Objective AP2/ERF(APETALA2/ethylene-responsive factor)superfamily is one of the largest gene families in plants and has been reported to participate in various biological processes,such as the regulation of biosynthesis of active ***,few studies have investigated the genome-wide role of the AP2/ERF superfamily in Isatis *** study establishes a complete picture of the AP2/ERF superfamily in *** and contributes valuable information for further functional characterization of IiAP2/ERF genes and supports further metabolic *** To identify the IiAP2/ERF superfamily genes,the AP2/ERF sequences from Arabidopsis thaliana and Brassica rapa were used as query sequences in the basic local alignment search *** analyses were conducted to investigate the protein structure,motif composition,chromosome location,phylogenetic relationship,and interaction network of the IiAP2/ERF superfamily *** accuracy of omics data was verified by quantitative polymerase chain reaction and heatmap *** One hundred and twenty-six putative IiAP2/ERF genes in total were identified from the *** genome database in this *** sequence alignment and phylogenetic analysis,the IiAP2/ERF genes were classified into 5 groups including AP2,ERF,DREB(dehydration-responsive element-binding factor),Soloist and RAV(related to abscisic acid insensitive 3/viviparous 1)*** which,122 members were unevenly distributed across seven *** alignment showed that *** and *** had 30 pairs of orthologous genes,and we constructed their interaction *** comprehensive analysis of gene expression pattern in different tissues suggested that these genes may play a significant role in organ growth and development of *** that may regulate lignan biosynthesis in roots were also preliminarily *** acid sequencing analysis revealed that the expression of 76 IiAP2

关键词： Isatis indigotica AP2/ERF Genomean alysis Expression pattern lignan biosynthesis

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Volumetric modulation arc radiotherapy with flattening filter-free beams compared with conventional beams for nasopharyngeal carcinoma:a feasibility study

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Chinese Journal of Cancer 2013年第7期32卷 397-402页

作者： Mingzan Zhuang Tuodan zhang Zhijian chen Zhixiong lin Derui li Xun Peng Qingchun Qiu Renhua Wu department of Radiation Oncology Tumor Hospital of Shantou University Medical College department of Medical Physics and Computer Application Shantou University Medical College department of Radiation The Second Affiliated Hospital of Shantou University Medical College

There is increasing interest in the clinical use of flattening filter-free(FFF) *** this study,we aimed to investigate the dosimetric characteristics of volumetric modulated arc radiotherapy(VMAT) with FFF beams for nasopharyngeal carcinoma(NPC).Ten NPC patients were randomly selected to undergo a RapidArc plan with either FFF beams(RA-FFF) or conventional beams(RA-C).The doses to the planning target volumes(PTVs),organs at risk(OARs),and normal tissues were *** technical delivery parameters for RapidArc plans were also assessed to compare the characteristics of FFF and conventional *** techniques delivered adequate doses to *** PTVs,RA-C delivered lower maximum and mean doses and improved conformity and homogeneity compared with *** techniques provided similar maximum doses to the optic nerves and *** the brain stem,spinal cord,larynx,parotid glands,oral cavity,and skin,RA-FFF showed significant dose increases compared to *** dose to normal tissue was lower in *** monitor units(MUs) were(536 ± 46) MU for RA-FFF and(501± 25) MU for *** treatment duration did not significantly differbetween *** both treatment plans could meet clinical needs,RA-C is dosimetrically superior to RA-FFF for NPC radiotherapy.

关键词：无滤波器鼻咽癌无梁放疗剂量学特性传统平坦调制

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青少年刷牙频率与血液指标的相关性:横断面观察性研究

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协和医学杂志 2024年第4期15卷 960-967页

作者：张旭杜函泽翟文昊宋帅华郭晓湲温琳琳黄蕾陈适李道伟潘慧吉林大学白求恩口腔医学院长春130021 中国医学科学院北京协和医院内分泌科国家卫生健康委内分泌重点实验室北京100730

目的分析青少年刷牙频率对血液指标的相关性,初步探讨刷牙频率对青少年全身健康的影响。方法采用便利抽样法,纳入济宁市第七中学2021级学生和济宁市体育训练中心体育训练学生为研究对象。采用单因素和多因素线性回归分析青少年刷牙频率... 详细信息

目的分析青少年刷牙频率对血液指标的相关性,初步探讨刷牙频率对青少年全身健康的影响。方法采用便利抽样法,纳入济宁市第七中学2021级学生和济宁市体育训练中心体育训练学生为研究对象。采用单因素和多因素线性回归分析青少年刷牙频率对嗜酸性粒细胞百分比(eosinophil percentage,EOS%)、嗜酸性粒细胞计数(eosinophil count,EOS#)、嗜碱性粒细胞百分比(basophil percentage,BAS%)、嗜碱性粒细胞计数(basophil count,BAS#)、过氧化物歧化酶(superoxide dismutase,SOD)、胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)、尿酸(uric acid,UA)等血液指标的影响。结果共纳入305名青少年(济宁市第七中学167名、济宁市体育训练中心138名),其中男性192名(62.95%),女性113名(37.05%)。根据每日刷牙频率分为3组,分别为≤1次组(40.33%,123/305)、2次组(53.77%,164/305)和≥3次组(5.90%,18/305)。单因素线性回归分析显示,每日刷牙2次与EOS%、EOS#、BAS%和BAS#均呈显著负相关(β均0,P=0.028,P=0.007);每日刷牙≥3次与UA呈显著负相关[β(95%CI):-0.16(-0.27~0.04),P=0.008]。多因素线性回归分析显示,每日刷牙2次与BAS%呈显著负相关(β0,P=0.036,P=0.012);每日刷牙≥3次与UA呈显著负相关(β0,P=0.044),女性青少年每日刷牙≥3次与UA呈显著负相关(β<0,P=0.014)。结论青少年刷牙频率与多项影响全身健康的血液指标具有相关性,提示口腔健康与全身健康可能存在潜在关联。

关键词：刷牙频率血液指标全身健康口腔护理

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