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Comparison of compensatory sweating and quality of life following thoracic sympathetic block for palmar hyperhidrosis： electrocautery hook versus titanium clip

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Chinese Medical Journal 2011年第21期124卷 3495-3498页

作者： WANG Fei-ge chen yong-bing YANG Wen-tao SHI Li Department of Cardiothoracic Surgery Second Affiliated Hospital Soochow University Suzhou Jiangsu 215004 China

Background Video-assisted thoracic sympathetic block is an effective, safe, and minimally invasive method for treatment of primary hyperhidrosis. The purpose of this study was to decide which one of using electrocautery hook and titanium clip is the appropriate procedure for primary palmar hyperhidrosis by assessing the compensatory sweating （CS） and quality of life （QOL） of patients after sympathetic block. Methods Between October 2007 to August 2010, 120 patients with primary palmar hyperhidrosis were randomly divided into two groups, electrocautery hook group （60 patients） and titanium clip group （60 patients）. All patients were treated by sympathetic block at T4 level. The CS was graded based on severity and location; the QOL was classified to 5 different levels based upon the summed total scores （range from 20 to 100） before and after surgery. The variables were compared. Results The postoperative follow-up period was 2 months. All patients were cured. Three patients in electrocautery hook group and 1 patient in titanium clip group had a unilateral pneumothorax on chest X-ray, but none of them was necessary to have chest drainage. Neither perioperative mortality nor serious complications such as cardiac arrhythmia or arrest were observed during the operation. No bradycardia or Horner＇s syndrome occured. CS was not more common in patients in titanium clip group than in those in electrocautery hook group （P=0.001）. Moderate and severe CS was few in all patients, and there was no significant difference between two groups （P=0.193）. Most of the patients feel a notable improvement of the the QOL; nevertheless, there was no significant difference between the groups （P=0.588）. Conclusions Both electrocautery hook and titanium clip used for sympathetic block at the T4 level are effective, safe, and minimally invasive for palmar hyperhidrosis. Because of the lower severity of CS and the similar improvements in the QOL after operation, we prefer to use of titanium clip f

关键词： compensatory sweating quality of life thoracic sympathetic block palmar hyperhidrosis

Meta-analysis of randomized trials comparing the effectiveness of on-pump and off-pump coronary artery bypass

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Chinese Medical Journal 2012年第2期125卷 338-344页

作者： chen yong-bing Shu Jian Yang Wen-tao Shi Li Guo Xu-feng Wang Fei-ge Qian yong-yue Soochow Univ Affiliated Hosp 2 Dept Cardiothorac Surg Suzhou 215004 Jiangsu Peoples R China

Background The growing enthusiasm for coronary artery bypass grafting （CABG） without cardiopulmonary bypass （CPB） is emerging,but the role of off-pump coronary artery bypass （OPCAB） in clinical practice remains *** purpose of this study was to assess differences in the incidences of stroke,atrial fibrillation （AF）,and myocardial infarction （MI） between OPCAB and conventional coronary artery bypass grafting （CCABG） by meta-analyses of randomized clinical *** A literature search for the period before March 2010 supplemented with manual bibliographic review was performed for all Chinese or English publications in Medline,the Science Citation Index Expanded,the Cochrane Central Register of Controlled Trials （CENTRAL） and CBMdisc.A systematic overview （meta-analyses） of randomized clinical trials was conducted to evaluate the differences between OPCAB and CCABG in the incidences of stroke,AF,and *** meta-analysis was performed using RevMan 5 *** Forty-three randomized clinical trials were selected for meta-analysis after screening a total of 356 references,with 8104 patients in the OPCAB group and 8724 cases in the CCABG *** meta-analyses of these trials showed no significant difference between OPCAB and CCABG in the incidences of stroke （odds ratio （OR）=0.80,95% confidence interval （CI）=0.52-1.22,P=0.30） and MI （OR=0.73,95%CI=0.52-1.02,P=0.06）.However,we found a significantly reduced risk of AF （OR=0.65,95%CI =0.52-0.82,P=0.0002）in off-pump *** Our meta-analyses suggest that OPCAB reduces the risk of postoperative AF compared with CCABG,but there is no significant difference in the incidences of stroke and MI between OPCAB and CCABG.

关键词： coronary artery bypass grafting off pump stroke atrial fibrillation myocardial infarction randomized clinical trials

XAF1 as a prognostic biomarker and therapeutic target in squamous cell lung cancer

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Chinese Medical Journal 2011年第20期124卷 3238-3243页

作者： chen yong-bing SHU Jian YANG Wen-tao SHI Li GUO Xu-feng WANG Fei-ge QIAN yong-yue Department of Cardiothoracic Surgery Second Affiliated HospitalSoochow University Suzhou Jiangsu 215004 China

Background X-linked inhibitor of apoptosis （XlAP）-associated factor 1 （XAF1） is a new tumor suppressor. Low expression of XAF1 is associated with poor prognosis of human cancers. However, the effect of XAF1 on lung cancer remains unknown. In this study, we investigated the expression of XAF1 and its role in squamous cell lung cancer. Methods Cancer tissues, cancer adjacent tissues and normal lung tissues were collected from 51 cases of squamous cell lung cancer. The expression of XAF1 mRNA was determined by reverse transcription-polymerase chain reaction （RT-PCR）. The expression of XAF1 protein was determined by Western blotting and immunohistochemical staining. Ad5/F35-XAF1 virus was generated. Cell proliferation and apoptosis were measured by 3-（4, 5-dimethylthiazol-2-yl）-2, 5-diphenyltetrazolium bromide （MTT） method and flow cytometry （FACS）, respectively. Results The levels of XAF1 protein and mRNA in cancer tissues were significantly lower than those in cancer adjacent and normal lung tissues （P 〈0.05）. The low expression of XAF1 was associated with tumor grade, disease stage, differentiation status and lymph node metastasis in squamous cell lung cancer patients. The restoration of XAF1 expression mediated by Ad5/F35-XAF1 virus significantly inhibited cell proliferation and induced apoptosis in a dose- and time-dependent manner. Conclusion XAF1 is a valuable prognostic marker in squamous cell lung cancer and may be a potential candidate gene for lung cancer therapy.

关键词： XAF1 human lung cancer cell lines cell proliferation apoptosis prognosis, biomarker

Uniportal versus biportal video-assisted thoracoscopic sympathectomy for palmar hyperhidrosis

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Chinese Medical Journal 2009年第13期122卷 1525-1528页

作者： chen yong-bing YE Wu YANG Wen-tao SHI Li GUO Xu-feng XU Zhong-hua QIAN yong-yue Department of Cardiothoracic Surgery the Second Affiliated Hospital Soochow University Suzhou Jiangsu 215004 China

Background Video-assisted thoracoscopic sympathectomy had replaced open surgery. The aim of this study was to compare the outcomes of using a single port and two ports to perform video-assisted thoracoscopic sympathectomy for palmar hyperhidrosis. Methods Between April 2006 and February 2008, 20 cases underwent video-assisted thoracoscopic sympathectomy through one port （uniportal group） and 25 cases through two ports （biportal group）. The variables including the operating time, hospital stay, pain scores, postoperative complications, incidence of symptom recurrence and patient satisfaction were compared. The mean postoperative follow-up period was 11.5 months （range, 3-25 months）. Results The hands of all patients were warm and dry after operation. No conversion to open surgery was necessary, and no operative mortality was recorded in either group. The mean inpatient pain scores were significantly higher in the biportal group （1.2±0.6） than that in the uniportal group （0.8±0.5, P=0.025）. For the first three weeks after operation, four out of 20 （20%） patients in the uniportal group constantly suffered from mild or moderate residual pain while eight out of 25 （32%） cases in the biportal group （P=0.366）. Among them, two cases in the uniportal group and five cases in the biportal group need to take analgesics. Our mean operative time （bilateral sympathectomy） in the uniportal group （（39.5±10.0） minutes） was shorter than that in biportal group （（49.7±10.6） minutes, P=0.02）. There were no significant differences between two groups in terms of the mean hospital stay, compensatory sweating, and patient satisfaction. Two patients in the biportal group and three in the uniportal group experienced a unilateral pneumothorax. None of them required chest drainage. No patient experienced Homer＇s syndrome, and no recurrent symptoms were observed in either groups Conclusions Both uniportal and biportal video-assisted thoracoscopic sympathectomy are effective, safe, and minimally i

关键词： uniportal hyperhidrosis thoracic surgery, video-assisted sympathectomy

Role of hepatic arterial ischaemia in biliary fibrosis following liver transplantation

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Chinese Medical Journal 2010年第7期123卷 907-911页

作者： LU Hong-wei chen yong-bing LI Yi-ming DONG Jia-hong YANG Hui-ning Department of Hepatobiliary Surgery Chinese People's Liberation Army General Hospital Beijing 100853 China Department of General Surgery Second Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710004 China Department of Hepatobiliary Surgery Beijing Military Region General Hospital Beijing 100700 China Department of General Surgery Second Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710004 China Department of Hepatobiliary Surgery Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Nosocomial Infection Management and Disease Control Armed Police General Hospital Beijing 100039 China

Background In clinical liver transplantation, whether the delay of hepatic arterial ischaemia increases biliary fibrosis or not is controversial. We designed a liver transplantation model to test this controversy and explore its mechanism. Methods Twelve dogs were divided into two groups randomly： hepatic arterial ischaemia （HAI） and control groups. In HAI group, hepatic artery was perfused 60 minutes after portal perfusion, but in control group, hepatic arterial perfusion was simultaneous with portal perfusion. The pathological changes of intrahepatic bile ducts were observed. Transforming growth factor beta 1 （TGF-β1）, expressed in epithelial cells of intrahepatic bile duct, was detected by immunohistochemical streptoadividin-biotin complex method. Expressions of Smad3, P-Smad3 and the transcriptional levels of alpha smooth muscle actin （α-SMA） mRNA in intrahepatic bile ducts were detected by Western blotting and RT-PCR *** Compared with the control group, more collagen deposition and leucocytic infiltration could be seen in biliary vessel walls. Significantly more buffy particles, which are the proteins of TGF-β1, could be seen in biliary epithelial cells. P-Smad3 and α-SMA mRNA （as ratio to corresponding β-actin） in intrahepatic bile ducts were 1.82±0.18 and 1.86±0.73 respectively in HAI group, significantly higher than those in control group （0.59±0.09 and 0.46±0.18, respectively）. Conclusions Hepatic arterial ischaemia could increase the deposition of collagen fibres, trigger the transdifferentiation of myofibroblasts in intrahepatic bile duct and might result in biliary fibrosis by activating the TGF-β1 signalling pathway.

关键词： liver transplantation biliary fibrosis hepatic arterial ischaemia transforming growth factor-beta 1

Recombinant adenovirus with human indoleamine-2,3- dioxygenase and hepatitis B virus preS was constructed and expressed in HepG2 cells

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Chinese Medical Journal 2011年第19期124卷 3159-3163页

作者： chen yong-bing SHI Xian-jie LU Gang NIE Hong-feng SHEN Xiao-qing YU Cong-hui GONG Jian-ping Department of Hepatobilliary Surgery Beijng Military Region General Hospital Beijing 100700 China Department of Burn Surgery Beijng Military Region General Hospital Beijing 100700 China Department of Hepatobilliary Surgery General Hospital of People＇s Liberation Army Beijing 100853 China Department of Hepatobiliary Surgery Second Hospital Affiliated to Chongqing University of Medical Sciences Chongqing 400010 China

Background Indoleamine-2,3-dioxygenase （IDO） is proven to suppress hepatitis B virus （HBV） specific immune response and depletion of IDO may be a useful approach for HBV therapy. To test this concept, we constructed recombinant adenovirus with human IDO and HBV preS, which would form the basis for future in vivo *** The fragment of human IDO and HBV preS cDNA were subcloned into multiple cloning sites in an adenoviral vector system containing two cytomegalovirus （CMV） promoters. Recombination was conducted in the Escherichia coli BJ5183. The recombinant adenovirus containing hlDO gene and HBVpreS gene was packaged and amplified in 293 *** was confirmed by polymerase chain reaction as well as the quantification of viral titers. HepG2 cells were infected with the recombinant adenovirus and mRNA and protein specific for hlDO and HBVpreS was detected by RT-PCR and Western blotting *** The recombinant adenovirus was produced successfully. Its titer was 2.5x109 efu/ml. IDO and HBVpreS mRNA as well as the encoded proteins could be found in transfected HepG2 cells, but not in control HepG2 *** The transfer of hlDO-HBVpreS with double-promoter adenoviral vector was efficient. The recombinant adenovirus with hlDO and HBVpreS would provide the experimental basis for future studies.

关键词： indoleamine-2,3-dioxygenase recombined adenovirus hepatitis B virus HepG2 cell

Toward Artificial Peptide Nanocapsules

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Nano-Micro Letters 2024年第10期16卷 240-243页

作者： Yuan Wang bing chen Laboratory for Biomaterials and Drug Delivery Department of AnesthesiologyDivision of Critical Care MedicineBoston Children's HospitalHarvard Medical SchoolBostonMA 02115USA College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023People's Republic of China

HIGHLIGHTS The formation of peptide nanocapsules is facilitated by a gradient interface,where the differential solvent concentration drives the peptides to preferentially localize and *** peptide nanocapsules,characterized by their hollow structures,demonstrated potential as carriers for targeted drug delivery.1 Introduction Peptide nanocapsules are a type of nanoscale delivery system that encapsulates active substances within a shell composed of peptides,leveraging the unique properties of peptides such as biocompatibility and biodegradability[1].Historically,the development of peptide nanocapsules was inspired primordially by the natural biological processes.

关键词： Peptide nanocapsules Self-assembly Drug delivery Nanomedicine

2D all-organic perovskites refine flexible electronics

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Science China Materials 2024年第7期67卷 2365-2366页

作者： Wei Zhou bing chen College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China

Recent years have witnessed a paradigm shift with the advent of perovskites,a class of materials with a distinct CaTiO_(3)-type crystalline structure that show remarkable promise across a wide array of applications,including photovoltaics,photodetectors,lighting,lasers,and so *** them,the development of two-dimensional(2D)perovskites has garnered significant attention due to their tunable structures(mainly Dion-Jacobson and Ruddlesden-Popper structures)and enhanced stability in comparison with their 3D counterparts[1].Amidst the burgeoning research on perovskites,on the other side,all-organic perovskites stand out as a particularly intriguing subset[2].Unlike traditional perovskites that typically comprise all-inorganic(e.g.,CsPbBr_(3))or organic-inorganic hybrid components(e.g.,(PEA)_(2)PbI_(4)),all-organic perovskites are composed entirely of carbon-or nitrogen-based molecules.

关键词： perovskite inorganic entirely

Alanine aminotransferase as a risk marker for new-onset metabolic dysfunction-associated fatty liver disease

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World Journal of Gastroenterology 2024年第25期30卷 3132-3139页

作者： Di Wang bing-Yan Zhou Lei Xiang Xu-yong chen Jie-Xiong Feng Department of Pediatric Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

In this editorial,we comment on the article by chen et *** dysfunction-associated fatty liver disease(MAFLD)is a global public health burden whose incidence has risen concurrently with overweight and *** its detri-mental health impact,early identification of at-risk individuals is *** diagnosis is based on evidence of hepatic steatosis indicated by liver biopsy,imaging,or blood biomarkers,and one of the following conditions:Overweight/obesity,type 2 diabetes mellitus,or metabolic ***,in large-scale epidemiological studies,liver biopsies are not *** application of techniques such as ultrasonography,computed tomography,magnetic resonance imaging,and magnetic resonance spectroscopy is restricted by their limited sensitivity,low effectiveness,high costs,and need for specialized *** biomarkers offer several advantages,particularly in large-scale epidemiological studies or clinical scenarios where traditional imaging techniques are *** of cumulative effects of excess high-normal blood alanine aminotrans-ferase(ALT)levels of blood ALT levels could facilitate identification of at-risk patients who might not be detected through conventional imaging ***,investigating the utility of blood biomarkers in MAFLD should enhance early detection and monitoring,enabling timely inter-vention and management and improving patient outcomes.

关键词： Nonalcoholic fatty liver disease Metabolic dysfunction-associated fatty liver disease Alanine aminotransferase Screening Risk marker