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Chinese Medical Journal 2010年第3期123卷 375-378页

作者： chen yi-zhi zhao xue-zhi wu jun mei chang-lin Kidney Institute of Chinese People's Liberation Army Shanghai Kidney Disease Quality Control Center Division of Nephrology Shanghai Changzheng Hospital Second Military Medical University Shanghai 200003 China

Spondyloarthropathies （SpAs） include five categories： ankyloslng spondyllns （AS）, reactive arthritis （ReA）,psoriatic arthritis （PsA）, enteropathic arthritis （EA） and undifferentiated spondyloarthropathy （USpA）.2 ReA is an aseptic arthritis occurring after extra-articular infections, particularly genitourinary （GU） or gastrointestinal （GI） tracts. When arthritis is accompanied by conjunctivitis and urethritis, the diagnosis of Reiter syndrome will be suitable for this clinical triad; however, the term ＂ReA＂ has been proposed to substitute for Reiter syndrome.

关键词： arthritis, reactive glomerulonephritis, IgA female leflunomide methylprednisolone

PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

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World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-Hong Kong mei-ling Xu jun-jun Zhang Guang-Qiang chen zhi-Hui Hong Hong Zhang Xiao-Xiao Dai yi-Fu Ma Xiang-Rong zhao chen-Yang Zhang Rong-Zheng chen Peng-Fei Xing Li-Yuan Zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of Hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao Zhang Sen Luo Hai Li Shu-Ning Sun Xian-Bo Wang Xin Zheng Yan Huang Bei-ling Li Yan-Hang Gao zhi-Ping Qian Feng Liu Xiao-Bo Lu jun-Ping Liu Hao-Tang Ren Yu-Bao Zheng Hua-Dong Yan Guo-Hong Deng Liang Qiao Yan Zhang Wen-yi Gu Xiao-mei Xiang yi Zhou yi-Xin Hou Qun Zhang Yan Xiong Cong-Cong Zou jun chen Ze-Bing Huang Xiu-Hua Jiang Ting-Ting Qi Yuan-Yuan chen Na Gao Chun-Yan Liu Wei Yuan xue mei Jing Li Tao Li Rong-Jiong Zheng Xin-yi Zhou jun zhao Zhong-Ji Meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic Liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/100)for type-B ACLF,27.0%(58/215)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure Liver cirrhosis Clinical features Prognosis

2019—2020年160例儿童肺炎链球菌脑膜炎临床流行病学多中心研究

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中国当代儿科杂志 2024年第2期26卷 131-138页

作者：王彩云许红梅刘钢刘静俞蕙陈必全郑帼舒敏杜丽君徐志伟黄丽素李海波汪东白松婷单庆文朱春晖田健美郝建华林爱伟林道炯吴谨准张新华曹清陶仲宾陈源朱国龙薛萍汤正珍苏学文曲政海赵仕勇庞琳邓慧玲舒赛男陈英虎浙江大学医学院附属儿童医院感染科浙江杭州310052 重庆医科大学附属儿童医院感染科重庆400014 首都医科大学附属北京儿童医院感染科北京100045 湖南省儿童医院感染科湖南长沙410007 复旦大学附属儿科医院感染科上海201102 安徽省儿童医院感染科安徽合肥230022 南京医科大学附属儿童医院神经科江苏南京210008 四川大学华西第二医院儿科四川成都610044 山西省儿童医院神经内科山西太原030006 温州医科大学附属第二医院/育英儿童医院普儿科浙江温州325027 上海交通大学医学院附属新华医院感染科上海200092 吉林大学第一医院儿科门诊吉林长春130061 西安交通大学附属儿童医院陕西西安710002 郑州大学第一附属医院儿科河南郑州450052 广西医科大学第一附属医院儿科广西南宁530021 江西省儿童医院感染科江西南昌330006 苏州大学附属儿童医院感染科江苏苏州215002 河南开封市儿童医院感染科河南开封475000 山东大学儿童院感染科山东济南250022 海南省妇幼保健院感染科海南海口571103 厦门大学附属妇女儿童医院儿科福建厦门361003 山西省儿童医院新生儿科山西太原030006 上海交通大学医学院附属上海儿童医学中心感染科上海200127 兰州大学第一医院儿科甘肃兰州730013 河北医科大学第二医院儿科河北石家庄050004 青海省妇女儿童医院感染消化科青海西宁810007 太原市妇幼保健院儿内科山西太原030012 遵义市第一人民医院儿科贵州遵义563099 内蒙古自治区人民医院儿科内蒙古呼和浩特750306 青岛大学附属医院儿科山东青岛266003 杭州市儿童医院感染科浙江杭州310005 首都医科大学附属北京地坛医院儿科北京100102 西安市中心医院儿科陕西西安710004 华中科技大学同济医学院附属同济医院儿科湖北武汉430030

目的研究中国儿童肺炎链球菌脑膜炎(pneumococcal meningitis,PM)的临床特征、转归和分离菌株肺炎链球菌(Streptococcus pneumoniae,SP)的药物敏感性。方法回顾性分析2019年1月—2020年12月全国33家三级甲等医院160例<15岁的PM住院患儿... 详细信息

目的研究中国儿童肺炎链球菌脑膜炎(pneumococcal meningitis,PM)的临床特征、转归和分离菌株肺炎链球菌(Streptococcus pneumoniae,SP)的药物敏感性。方法回顾性分析2019年1月—2020年12月全国33家三级甲等医院160例<15岁的PM住院患儿的临床信息、实验室资料和微生物学资料。结果160例PM患儿中,男103例,女57例;年龄15 d至15岁,其中3月龄至<3岁109例(68.1%)。脑脊液培养分离SP菌株95例(59.4%),血培养分离SP菌株57例(35.6%)。脑脊液宏基因组二代测序和脑脊液SP抗原检测阳性率分别为40%(35/87)、27%(21/78)。55例(34.4%)患儿存在1个或多个化脓性脑膜炎高危因素;113例(70.6%)患儿有1个或多个颅外感染病灶;18例(11.3%)有明确基础疾病。临床症状以发热最常见(147例,91.9%),其次是精神萎靡(98例,61.3%)、呕吐(61例,38.1%)等。69例(43.1%)患儿住院期间发生颅内并发症,常见并发症为硬膜下积液和/或积脓(43例,26.9%)、脑积水(24例,15.0%)、脑脓肿(23例,14.4%)、脑出血(8例,5.0%)。硬膜下积液和/或积脓和脑积水主要发生在<1岁患儿,分别为91%(39/43)、83%(20/24)。SP菌株对万古霉素(100%,75/75)、利奈唑胺(100%,56/56)、厄他培南(100%,6/6)完全敏感;对左氧氟沙星(81%,22/27)、莫西沙星(82%,14/17)、利福平(96%,25/26)和氯霉素(91%,21/23)敏感率高;对青霉素(16%,11/68)、克林霉素(6%,1/17)敏感率低;对红霉素完全耐药(100%,31/31)。痊愈和好转出院率分别为22.5%(36/160)、66.2%(106/160);18例(11.3%)出现不良结局。结论儿童PM多见于3月龄至<3岁婴幼儿,颅内并发症多发生在<1岁患儿,发热是PM患儿最常见的临床表现,硬膜下积液和/或积脓、脑积水是最常见的并发症。脑脊液非培养检测方法有助于提高病原菌检出率。超过10%PM患儿出现不良结局。SP菌株对万古霉素、利奈唑胺、厄他培南、左氧氟沙星、莫西沙星、利福平、氯霉素敏感率高。

关键词：肺炎链球菌脑膜炎流行病学多中心研究儿童

Overproduction of OsRACK1A,an effector-targeted scaffold protein promoting OsRBOHB-mediated ROS production,confers rice floral resistance to false smut disease without yield penalty

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Molecular Plant 2022年第11期15卷 1790-1806页

作者： Guo-Bang Li Jia-xue He Jin-Long wu He Wang Xin Zhang Jie Liu Xiao-Hong Hu Yong Zhu Shuai Shen yi-Fei Bai Zong-lin Yao Xin-Xian Liu Jing-Hao zhao De-Qiang Li Yan Li Fu Huang Yan-Yan Huang zhi-xue zhao Ji-Wei Zhang Shi-Xin Zhou Yun-Peng Ji mei Pu Peng Qin Shigui Li xuewei chen Jing Wang Min He Weitao Li Xian-jun wu Zheng-jun Xu Wen-Ming Wang Jing Fan State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130China Rice Research Institute Sichuan Agricultural UniversityChengdu 611130China

Grain formation is fundamental for crop yield but is vulnerable to abiotic and biotic *** grain production is threatened by the false smut fungus Ustilaginoidea virens,which specifically infects rice floral organs,disrupting fertilization and seed ***,little is known about the molecular mechanisms of the ***-rice interaction and the genetic basis of floral ***,we report that *** secretes a cytoplasmic effector,UvCBP1,to facilitate infection of rice ***,UvCBP1 interacts with the rice scaffold protein OsRACK1A and competes its interaction with the reduced nicotinamide adenine dinucleotide phosphate oxidase OsRBOHB,leading to inhibition of reactive oxygen species(ROS)*** the analysis of natural variation revealed no OsRACK1A variants that could avoid being targeted by UvCBP1,expression levels of OsRACK1A are correlated with field resistance against *** in rice *** of OsRACK1A restores the OsRACK1A-OsRBOHB association and promotes OsRBOHB phosphorylation to enhance ROS production,conferring rice floral resistance to *** without yield *** together,our findings reveal a new pathogenic mechanism mediated by an essential effector from a flower-specific pathogen and provide a valuable genetic resource for balancing disease resistance and crop yield.

关键词： rice flower false smut fungal effector scaffold protein reactive oxygen species disease resistance

Charge density wave order and electron-boson coupling in ternary superconductor Bi_(2)Rh_(3)Se_(2)

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Science China(Physics,Mechanics & Astronomy) 2023年第7期66卷 120-126页

作者： Zi-Teng Liu chen Zhang Qi-yi wu Hao Liu Bo chen zhi-Bo yin Sheng-Tao Cui Zhe Sun Shuang-Xing Zhu Jiao-Jiao Song yin-Zou zhao Hong-yi Zhang xue-Qing Ye Fan-ying wu Shu-Yu Liu Xiao-Fang Tang Ya-Hua Yuan Yun-Peng Wang jun He Hai-Yun Liu Yu-Xia Duan Jian-Qiao Meng School of Physics and Electronics Central South UniversityChangsha 410083China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Department of Physics and Electronic Science Hunan University of Science and TechnologyXiangtan 411201China Beijing Academy of Quantum Information Sciences Beijing 100085China

The newly discovered ternary chalcogenide superconductor Bi_(2)Rh_(3)Se_(2) has attracted growing attention,which provides an opportunity to explore the interplay between charge density wave(CDW)order and ***,whether the phase transition around 240 K can be attributed to the formation of CDW remains *** help resolve the debate,we study the electronic structure of Bi_(2)Rh_(3)Se_(2) by angle-resolved photoemission spectroscopy,focusing on the nature of its high-temperature phase transition around 240 *** measurements demonstrate that the phase transition at 240 K is a second-order CDW phase *** results reveal(i)a 2×2 CDW order in Bi_(2)Rh_(3)Se_(2),accompanied by the reconstruction of electronic structure,such as band folding,band splitting,and opening of CDW gaps at and away from the Fermi level;(ii)the existence of electron-boson coupling,which is manifested as an apparent kink and peak-dip-hump structure in *** observations thus enable us to shed light on the nature of CDW order and superconductivity in Bi_(2)Rh_(3)Se_(2).

关键词： charge density wave electron-boson coupling angle-resolved photoemission spectroscopy electronic structure Chalcogenide

抗菌药物临床应用信息化辅助决策系统专家共识

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中华医院感染学杂志 2024年第12期34卷 1761-1766页

作者：高晓东张尧金文婷杜明梅陈璋璋陈佰义丁昉胡付品黄文祥李家斌李军李六亿李晓宇林丽开刘丁刘晓琳刘运喜刘正印倪语星王辉吴安华肖永红徐英春杨帆杨文杰杨小强俞云松张浩军赵彩彦赵烁卓超宗志勇李太生王贵强王明贵胡必杰复旦大学附属中山医院感染管理科上海200032 复旦大学附属中山医院感染科上海200032 中国人民解放军总医院第一医学中心疾病预防控制科北京100853 复旦大学附属中山医院药剂科上海200032 北京大学第一医院感染疾病科北京100034 复旦大学附属华山医院抗生素研究所上海200040 中国医学科学院北京协和医院感染科北京100730 中国医科大学附属第一医院感染病科辽宁沈阳110001 复旦大学附属中山医院医务处上海200032 重庆医科大学附属第一医院感染科重庆400042 江苏省人民医院感染科江苏南京210029 安徽医科大学第一附属医院感染科安徽合肥230022 北京大学第一医院感染管理科北京100034 武汉大学医院管理研究所湖北武汉430071 重庆市医院感染控制中心重庆408107 国家卫生健康委合理用药专家委员会北京100044 上海交通大学医学院附属瑞金医院感染管理科上海200025 北京大学人民医院检验科北京100044 中南大学湘雅医院感染科湖南长沙410008 浙江大学医学院附属第一医院传染病诊治国家重点实验室浙江杭州310003 中国医学科学院北京协和医学院北京协和医院检验科北京100730 天津市第一中心医院感染科天津300190 国家卫健委医院管理研究所药事管理研究部北京100044 浙江大学医学院附属邵逸夫医院感染科浙江杭州310003 甘肃省人民医院感染科甘肃兰州730099 河北医科大学第三医院感染科河北石家庄050051 国家卫生健康委医院管理研究所医疗服务与安全研究部北京100044 广州医科大学附属第一医院感染科广东广州510120 四川大学华西医院四川成都610041

目的规范我国抗菌药物临床应用信息化辅助决策系统的开发和应用,以促进我国抗菌药物管理的信息化建设.方法组织感染病学、感染防控、临床药学等抗菌药物临床应用管理小组的相关专家,在深入研究国内外抗菌药物临床应用信息化建设最新... 详细信息

目的规范我国抗菌药物临床应用信息化辅助决策系统的开发和应用,以促进我国抗菌药物管理的信息化建设.方法组织感染病学、感染防控、临床药学等抗菌药物临床应用管理小组的相关专家,在深入研究国内外抗菌药物临床应用信息化建设最新进展的基础上,结合我国临床实际需求,共同制定本共识.结果形成有关抗菌药物临床应用信息化辅助决策系统的17条专家共识.结论此专家共识供医疗机构抗菌药物临床应用管理小组在研发和应用信息系统进行临床决策支持时参考.

关键词：抗菌药物抗菌药物临床应用信息化辅助决策系统专家共识

XELOX doublet regimen versus EOX triplet regimen as first-line treatment for advanced gastric cancer:An open-labeled,multicenter,randomized,prospective phase III trial(EXELOX)

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Cancer Communications 2022年第4期42卷 314-326页

作者： Xiao-Dong Zhu Ming-Zhu Huang Yu-Sheng Wang Wan-Jing Feng zhi-Yu chen yi-Fu He Xiao-Wei Zhang Xin Liu chen-chen Wang Wen Zhang Jie-Er ying jun wu Lei Yang Yan-Ru Qin Jian-Feng Luo Xiao-ying zhao Wen-Hua Li Zhe Zhang Li-Xin Qiu Qi-Rong Geng Jian-ling Zou Jie-Yun Zhang Hong Zheng xue-Feng Song Shu-Sheng wu cheng-Yan Zhang Zhe Gong Qin-Qin Liu Xiao-Feng Wang Qi Xu Qi Wang Jian-mei Ji Jian zhao Wei-Jian Guo Department of Gastrointestinal Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032P.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Department of Gastroenterology Shanxi Cancer HospitalTaiyuanShanxi 030013P.R.China Department of Medical Oncology The First Affiliated HospitalDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230031P.R.China Department of Abdominal Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Cancer and Basic Medicine(IBMC)Chinese Academy of SciencesHangzhouZhejiang 310005P.R.China Department of Medical Oncology The First People’s Hospital of ChangzhouChangzhouJiangsu 213004P.R.China Department of Gastroenterology Nantong Tumor HospitalNantongJiangsu 226006P.R.China Department of Oncology Zhengzhou University First Affiliated HospitalZhengzhouHenan 450052P.R.China Department of Biostatistics School of Public HealthFudan UniversityShanghai 200032P.R.China Department of medical oncology Cancer Hospital of Fudan UniversityMinhang BranchShanghai 200032P.R.China

Background:There is no consensus on whether triplet regimen is better than doublet regimen in the first-line treatment of advanced gastric cancer(AGC).We aimed to compare the efficacy and safety of oxaliplatin plus capecitabine(XELOX)and epirubicin,oxaliplatin,plus capecitabine(EOX)regimens in treating ***:This phase III trial enrolled previously untreated patients with AGC whowere randomly assigned to receive the XELOXor *** primary endpoint was non-inferiority in progression-free survival(PFS)for XELOX as compared with EOX on an intention-to-treat ***:Between April 10,2015 andAugust 20,2020,448AGCpatientswere randomized to receive XELOX(n=222)or EOX(n=226).The median PFS(mPFS)was 5.0 months(95%confidence interval[CI]=4.5-6.0 months)in the XELOX arm and 5.5 months(95%CI=5.0-6.0 months)in the EOX arm(hazard ratio[HR]=0.989,95%CI=0.812-1.203;P_(non-inferiority)=0.003).There was no significant difference inmedian overall survival(mOS)(12.0 vs.12.0months,P=0.384)or objective response rate(37.4%vs.45.1%,P=0.291)between the two *** patients with poorly differentiated adenocarcinoma and liver metastasis,the EOX arm had a significantly longer mOS(P=0.021)and a trend of longer mPFS(P=0.073)than the XELOX *** rate of grade 3/4 adverse events(AEs)was 42.2%(90/213)in the XELOX arm and 72.5%(156/215)in the EOX arm(P=0.001).The global health-related quality of life(QoL)score was significantly higher in the XELOX arm than in the EOX arm during ***:This non-inferiority trial demonstrated that the doublet regimen was as effective as the triplet regimen and had a better safety profile and QoL as a first-line treatment for AGC ***,the triplet regimen might have a survival advantage in patients with poorly differentiated adenocarcinoma and liver metastasis.

关键词： Advanced gastric cancer chemotherapy XELOX doublet regimen EOX triplet regimen noninferiority quality of life phase III trial

Estimated prevalence and sociodemographic correlates of mental disorders in medical students of Hebei Province,China:A crosssectional study

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World Journal of Psychiatry 2023年第5期13卷 215-225页

作者： Wen-Ting Lu Pei-Hua Hu Na Li Lan Wang Ran Wang Zeng Wang mei Song Tian-Yu zhao Shi-Jie Guo Fan-Fan Huang Bu-Fan Liu Ruo-Jia Ren Li Yang Quan lin Yue-Hang Xu Na Jin Huan chen Yuan-Yuan Gao zhi-Feng wu Guang-Yu Shi Da-Peng Liu Zhong-Qi Pan Chun-Chao Du Cui-Xia An xue-yi Wang Mental Health Center Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Hebei Technical Innovation Center Mental Health Assessment and InterventionShijiazhuang 050031Hebei ProvinceChina Hebei Clinical Research Center of Mental Disorders Institute of Mental HealthShijiazhuang 050031Hebei ProvinceChina Counseling and Mental Health Research Center Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Hebei Saitron Information Technology Co. LtdCangzhou 060000Hebei ProvinceChina

BACKGROUND In China,the identification rate and treatment rate of mental disorders are low,and there are few surveys on the prevalence of mental disorders among college students using diagnostic tools such as Mini-International Neuropsychiatric Interview(MINI),so the prevalence and treatment of mental disorders among college students are *** To estimate prevalence of mental disorders among medical students in Hebei Province,and provide guidance for improving their mental *** This was a cross-sectional study based on an Internet-based *** levels of medical students in Hebei Province were randomly selected(by cluster sampling)for *** the information network assessment system,the subjects scanned the 2D code with their mobile phones,clicked to sign the informed consent,and answered a scale.A self-designed general status questionnaire was used to collect information about age,gender,ethnicity,grade,and origin of *** MINI *** used to investigate mental *** analysis was performed with SPSS *** significant findings were determined using a two-tailed P value of *** A total of 7117 subjects completed the survey between October 11 and November 7,*** estimated prevalence of any mental disorders within 12 mo was 7.4%.Mood disorders were the most common category(4.3%),followed by anxiety disorders(3.9%);15.0%had been to psychological counseling,while only 5.7%had been to a psychiatric consultation,and only 10%had received drug therapy in the past 12 *** Although the estimated prevalence of mental disorders in medical students is lower than in the general population,the rate of adequate treatment is *** determined that improving the mental health of medical students is an urgent matter.

关键词： Hebei sectional college

Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China

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World Journal of Gastroenterology 2022年第31期28卷 4417-4430页

作者： Zi-Xuan Shen Dan-Dan wu Jie Xia Xian-Bo Wang Xin Zheng Yan Huang Bei-ling Li Zhong-Ji Meng Yan-Hang Gao zhi-Ping Qian Feng Liu Xiao-Bo Lu Jia Shang Hua-Dong Yan Yu-Bao Zheng Wen-yi Gu Yan Zhang Jian-yi Wei Wen-Ting Tan yi-Xin Hou Qun Zhang Yan Xiong Cong-Cong Zou jun chen Ze-Bing Huang Xiu-Hua Jiang Sen Luo Yuan-Yuan chen Na Gao Chun-Yan Liu Wei Yuan xue mei Jing Li Tao Li Xin-yi Zhou Guo-Hong Deng Jin-jun chen Xiong Ma Hai Li Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Institute of Digestive Disease Key Laboratory of Gastroenterology and HepatologyChinese Ministry of HealthShanghai Jiao Tong UniversityShanghai 200001China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400038China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100102China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Infectious Disease Taihe HospitalHubei University of MedicineShiyan 430418Hubei ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130031Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 201508China Tianjin Institute of Hepatology Nankai University Second People’s HospitalTianjin 300102China Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054XinjiangChina Department of Infectious Diseases Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Infectious Diseases Hwamei HospitalThe Second Hospital of NingboUniversity of Chinese Academy of SciencesNingbo 315153Zhejiang ProvinceChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 5

BACKGROUND Autoimmune liver disease(AILD)has been considered a relatively uncommon disease in China,epidemiological data for AILD in patients with cirrhosis and acute decompensation(AD)is *** To investigate the prevalence,outcome and risk factors for AILD in cirrhotic patients complicated with AD in *** We collected data from patients with cirrhosis and AD from two prospective,multicenter cohorts in hepatitis B virus endemic *** were regularly followed up at the end of 28-d,90-d and 365-d,or until death or liver transplantation(LT).The primary outcome in this study was 90-d LTfree ***-on-chronic liver failure(ACLF)was assessed on admission and during 28-d hospitalization,according to the diagnostic criteria of the European Association for the Study of the Liver(EASL).Risk factors for death were analyzed with logistic regression *** In patients with cirrhosis and AD,the overall prevalence of AILD was 9.3%(242/2597).Prevalence of ACLF was significantly lower in AILD cases(14%)than those with all etiology groups with cirrhosis and AD(22.8%)(P<0.001).Among 242 enrolled AILD patients,the prevalence rates of primary biliary cirrhosis(PBC),autoimmune hepatitis(AIH)and PBC-AIH overlap syndrome(PBC/AIH)were 50.8%,28.5%and 12.0%,*** ACLF patients,the proportions of PBC,AIH and PBC/AIH were 41.2%,29.4% and 20.6%.28-d and 90-d mortality were 43.8% and 80.0% in AILD-related *** etiology of AILD had no significant impact on 28-d,90-d or 365-d LTfree mortality in patients with cirrhosis and AD in both univariate and multivariate *** bilirubin(TB),hepatic encephalopathy(HE)and blood urea nitrogen(BUN)were independent risk factors for 90-d LT-free mortality in multivariate *** development of ACLF during hospitalization only independently correlated to TB and international normalized *** AILD was not rare in hospitalized patients with cirrhosis and AD in China,among which PBC was the m

关键词： Prevalence Autoimmune liver disease Cirrhosis and acute decompensation Mortality Acuteon-chronic liver failure