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A mutation in TBXT causes congenital vertebral malformations in humans and mice

Journal of Genetics and Genomics 2024年第4期51卷 433-442页

作者： Shuxia chen Yunping Lei Yajun Yang chennan Liu Lele Kuang Li Jin Richard HFinnell Xueyan Yang Hongyan {2. Obstetrics and Gynecology Hospital State Key Laboratory of Genetic Engineering at School of Life SciencesKey Laboratory of Reproduction Regulation of NPFPCInstitute of Reproduction and DevelopmentFudan UniversityShanghai 200438China shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China Center for Precision environmental Health Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonTX 77030USA MOE Key Laboratory of Contemporary Anthropology School of Life SciencesFudan UniversityShanghai 200438China Department of Assisted Reproduction Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Children’s Hospital Fudan University399 Wanyuan RoadShanghai 201102China

T-box transcription factor T(TBXT;T)is required for mesodermal formation and axial skeletal *** it has been extensively studied in various model organisms,human congenital vertebral malformations(CVMs)involving T are not well ***,we report a family with 15 CVM patients distributed across 4 *** affected individuals carry a heterozygous mutation,T c.596A>G(p.Q199R),which is not found in unaffected family members,indicating co-segregation of the genotype and *** vitro assays show that T p.Q199R increases the nucleocytoplasmic ratio and enhances its DNA-binding affinity,but reduces its transcriptional activity compared to the *** determine the pathogenicity of this mutation in vivo,we generated a Q199R knock-in mouse model that recapitulates the human CVM *** heterozygous Q199R mice show subtle kinked or shortened tails,while homozygous mice exhibit tail filaments and severe vertebral ***,we show that the Q199R mutation in T causes CVM in humans and mice,providing previously unreported evidence supporting the function of T in the genetic etiology of human CVM.

关键词： Congenital vertebral malformation TBXT T gene Loss-of-function mutation

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多形态氚的环境行为及辐射评价系统研究进展

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中国科学：技术科学 2024年第1期54卷 15-30页

作者：聂保杰陈德仪王亮郑善良谢锋李厚文朱月龙李凤臣王德忠上海交通大学核科学与工程学院上海200240 生态环境部核与辐射安全中心北京100082 中国科学院合肥物质科学研究院等离子体物理研究所合肥230031 清华大学核能与新能源技术研究院先进核能技术协同创新中心先进反应堆工程与安全教育部重点实验室北京100084 中核核电运行管理有限公司海盐314300 天津大学机械工程学院中低温热能高效利用教育部重点实验室天津300350

氚是核工业发展中向环境排放的主要放射性核素之一,且随乏燃料后处理厂、聚变堆等系统的实施,涉氚量将大幅度增加,可能会对环境和公众带来一定的辐射影响.氚形态多样、环境行为复杂且易受环境因素影响,需针对性开发评价系统对环境氚水... 详细信息

氚是核工业发展中向环境排放的主要放射性核素之一,且随乏燃料后处理厂、聚变堆等系统的实施,涉氚量将大幅度增加,可能会对环境和公众带来一定的辐射影响.氚形态多样、环境行为复杂且易受环境因素影响,需针对性开发评价系统对环境氚水平及公众辐射剂量进行准确评价.本文系统总结了氚基本特点、不同设施涉氚特点及氚环境行为特性,论述了氚辐射环境评价系统研发现状.在我国先进核能与后处理技术蓬勃发展背景下,在多形态氚的多介质环境迁移转化规律掌握、自主化氚辐射环境评价系统开发与验证、氚辐射环境评价标准体系建立等三个方面提出了研究建议.

关键词：核设施氚环境行为氚辐射评价系统

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Lewis Base Catalyzed Selenofunctionalization of Alkynes with Acid-Controlled Divergent Chemoselectivity

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Chinese Journal of Chemistry 2024年第14期42卷 1623-1629页

作者： ling-ling {2. Ren-Fei Cao Hua Ke Zhi-Min {2. school of Chemistry and Chemical engineering Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai200240 China engineering Technology Research Center for environmental Protection Materials Pingxiang UniversityPingxiangJiangxi337055 China

Lewis base catalyzed and Brønsted acid controlled chemodivergent electrophilic selenofunctionalizations of alkynes were developed for the first *** selenium-containing tetrasubstituted alkenes were readily obtained in moderate to excellent yields with complete E/Z *** the substrates were 1-ethynyl naphthol derivatives,linear selenium-containing tetrasubstituted alkenes were produced via intermolecular oxygen nucleophilic attack in the absence of acid additive;in contrast,cyclic selenium-containing tetrasubstituted alkenes were generated through intramolecular carbon nucleophilic capture with the addition of Brønsted acid.

关键词： Alkynes Electrophilic addition Chemoselectivity Lewis base catalysis Selenofunctionalization

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Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks {2. Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun wang Yuhao Fu Zhong Wei Rainer Lohmann Changer chen Yang Song Concepcion Sanchez-Cid Yu wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang Natàlia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin chen Baoshan Xing wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China university of Chinese Academy of sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical university of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany school of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of environmental science&{2. Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of environmental science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA school of Environment Tsinghua UniversityBeijing 100084China school of Civil and environmental {2. Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China school of environmental {2. and engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

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Operando investigation of particle re-entrainment mechanism in electrostatic capture process on the lab-on-a-chip

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Journal of environmental sciences 2024年第2期136卷 337-347页

作者： Yong Zhu Yikun Zhang Xiaoyong Yang Shanlong Tao Mingxia chen Wenfeng Shangguan Research Center for Combustion and environmental Technology School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Inhalable particle is a harmful air pollutant that causes a significant threat to people's health and ecological environments,which should be removed to purify air,but there exists limited removal efficiency due to particle ***,Operando observation system based on microscopic visualization method is developed to make in situ test of particle migration,deposition and re-entrainment characteristics on a lab-on-a-chip to achieve the investigation in micro-level *** deposition evolution of charged particles is recorded in electric field region intuitively,which confirms the fracture of particle chain occurs during the growth process of deposited *** captures the instantaneous process that a larger particle with micron size due to the coagulation of submicron particles fractures from main body of the particle chain for the first *** analysis of migration behavior of a single submicron particle near electrode surface demonstrates the direct influence of drag force on the fracture of particle *** work is the first-time visualization of dynamic process and mechanism elucidation of particle re-entrainment at the micron level,and the findings will provide the theory support for the particle re-entrainment mechanism and bring inspires of enhancing capture efficiency of inhalable particle.

关键词： Inhalable particle Re-entrainment mechanism Operando observation Lab-on-a-chip Capture efficiency

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2.2.年度国家自然科学基金委员会化学工程与工业化学领域科学基金项目申请与评审工作综述

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化工进展 2024年第1期43卷 560-564页

作者：王天富周晨张国俊国家自然科学基金委员会化学科学部北京100085 上海交通大学环境科学与工程学院上海200240

总结了2.2.年度国家自然科学基金委员会化学工程与工业化学(B08)领域科学基金各类项目的申请、受理和资助概况,对B08下属16个二级代码的各类项目申请与资助情况进行了分析,为下一年度国家的项目申报提出了建议。

关键词：国家自然科学基金化学工程与工业化学申请受理资助

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Biological data processing based on bio-processor unit(BPU), a new concept for next generation computational biology

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science china(Life sciences) 2018年第5期61卷 597-598页

作者： Di Liu Dongbo Bu Tieliu Shi Jianxiao Quan Depeng wang yongyong Shi Xiao-{2. Bo Wenbao Han Computational Virology Group Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China Key Laboratory of InteUigent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China Center for Bioinformatics and Computational Biology and the Institute of Biomedical Sciences School of Life Sciences East China Normal University Shanghai 200214 China State Key Laboratory of Mathematical engineering and Advanced Computation Wuxi 214122 China Jiangsu Variable Supercomputer Tech Co Ltd. Wuxi 214125 China NextOmics Blosctences Wuhan 430074 China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University Shanghai 200030 China Beijing Institute of Radiation Medicine Beifing 100850 China

The revolution of biotechnology has pushed forward life sciences into the Big Data ***,high-throughput bio-techniques have greatly accelerated the integration of biology,computing and informatics,and hence substantially pushed forward the development of bioinformatics and computational *** to the latest report of data deposition within National Centre for Biotechnology Information（NCBI）,the genome sequencing projects have increased 49.94%.

关键词：计算生物学简历处理器数据基信息科学生物信息学生命科学 NCBI

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Magnetic evidence for heavy metal pollution of topsoil in shanghai, china

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Frontiers of Earth science 2018年第1期12卷 125-133页

作者： Guan wang Yuan LIU jiao {2. Feifan REN Yuying {2. Fangzhou YE Weiguo ZHANG school of Urban Construction and environmental {2. University of Shanghai for Science and Technology Shanghai 200093 China State Key Laboratory of Estuarine and Coastal Research East China Normal University Shanghai 200062 China Department of Geography East China Normal University Shanghai 200062 China Department of Geotechnical engineering College of Civil Engineering Tongji University Shanghai 200092 China

This study presents the results obtained from magnetic susceptibility and heavy metal （Cu, Zn, Pb, and Cr） concentration measurements of soil profiles collected from arable land and urban parks in Baoshan District, an industrial district of shanghai, china. The study focuses on the investigation of vertical variations in magnetic susceptibilities and heavy metal concentrations and on correlations between magnetic susceptibilities and heavy metal concentrations in soil profiles. The results demon- strate that magnetic enhancement in the surface layer of the soil profile is associated with increased heavy metal pollution. The enrichment factors （EF） and the Tom{2.son Pollution Load Index （PLI-EF） are calculated for estimat- ing the level of heavy metal pollution of soil profiles in the study. The significant positive correlations between heavy metal contents, enrichment factors （EF）, Tom{2.son pollution load index （PLI-CF）, modified Tom{2.son pollution load index （PLI-EF）, and magnetic susceptibility （X） indicate that much of the heavy metal contamination in the study area is {2.ked to combustion derived particulate emissions. The results confirm that the combined magnetic measurement and heavy metal concentration analysis could provide useful information for soil monitoring in urban environments. However, the use of magnetic technique to locate the heavy metal pollution boundary in the soil profile of this studied area should be confirmed by further geochemical analysis.

关键词： soil pollution magnetic susceptibility heavymetals shanghai

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Advances in Electrostatic Plasma Methods for Purification of Airborne Pathogenic Microbial Aerosols:Mechanism,Modeling and Application

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Environment & Health 2024年第9期2卷 596-617页

作者： Shanlong Tao Yong Zhu Mingxia chen Wenfeng Shangguan Research Center for Combustion and environmental Technology School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240PR China school of Mechanical and Power engineering East China University of Science and TechnologyShanghai 200237PR China

The transmission of pathogenic airborne microorganisms significantly impacts public health and societal *** healthy indoor air quality in public spaces is *** various air purification technologies,electrostatic precipitation and atmospheric pressure nonthermal plasma are notable for their broad-spectrum effectiveness,high efficiency,cost-effectiveness,and *** review investigates the primary mechanisms by which these electrostatic methods collect and disinfect pathogenic *** also delves into recent advancements in enhancing their physical and chemical mechanisms for improve ***,a thorough summary of mathematical models related to the migration and deactivation of pathogenic aerosols in electrostatic purifiers is *** will help us to understand the behavior of aerosols in purification ***,the review discusses the current research on creating a comprehensive health protection system and addresses the challenges of balancing byproduct control with *** aim is to establish a foundation for future research and development in electrostatic aerosol purification and develop integrated air purification technologies that are both efficient and safe.

关键词： electrostatic microbial aerosols inactivation collection air purification

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Spatio-temporal control of the phase separation of chemically active immotile colloids

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National science Open 2024年第4期3卷 17-28页

作者： Yixin Peng Longfei Li Shutong Guo Xi chen Chao Zhou Dingyu Xing Hepeng Zhang Mingcheng Yang Wei {2. school of Materials science and {2. Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Beijing National Laboratory for Condensed Matter Physics and Laboratory of Soft Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China school of Physics and Astronomy Institute of Natural Sciences and MOE-LSCShanghai Jiao Tong UniversityShanghai 200240China school of Civil and environmental {2. Harbin Institute of Technology(Shenzhen)Shenzhen 518055China school of Physical sciences University of Chinese Academy of SciencesBeijing 100049China

Understanding and controlling phase separation in nonequilibrium colloidal systems are of both fundamental and applied *** this article,we investigate the spatiotemporal control of phase separation in chemically active immotile *** show that a population of silver colloids can spontaneously phase separate into dense clusters in hydrogen peroxide(H_(2.O_(2.)due to phoretic *** characteristic length of the formed pattern was quantified and monitored over time,revealing a growth and coarsening phase with different growth *** tuning the trigger frequency of light,the lengths and growth kinetics of the clusters formed by silver colloids in H_(2.O_(2.can be *** addition,structured light was used to precisely control the shape,size,and contour of the phase-separated *** study provides insight into the microscopic details of the phase separation of chemically active colloids induced by phoretic attraction,and presents a generic strategy for controlling the spatiotemporal evolution of the resulting mesoscopic patterns.

关键词： phase separation colloids active matter non-equilibrium structured light pattern formation

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