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Effect of alkali metals on the performance of CoCu/TiO_2 catalysts for CO_2 hydrogenation to long-chain hydrocarbons

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Chinese Journal of Catalysis 2018年第8期39卷 1294-1302页

作者： Zhibiao Shi Haiyan Yang Peng Gao xinqing chen Hongjiang Liu Liangshu Zhong Hui Wang Wei Wei Yuhan Sun[1 3a] Department of chemistry College of SciencesShanghai UniversityShanghai 200444China CAS Key Laboratory of Low‐Carbon Conversion Science and Engineering Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China School of physical Science and Technology ShanghaiTech UniversityShanghai 201210China

CoCu/TiO_2 catalysts promoted using alkali metals（Li, Na, K, Rb, and Cs） were prepared by the homogeneous deposition-precipitation method followed by the incipient wetness impregnation method. The influences of the alkali metals on the physicochemical properties of the CoCu/TiO_2 catalysts and the catalytic performance for CO_2 hydrogenation to long-chain hydrocarbons（C_（5＋））were investigated in this work. According to the characterization of the catalysts based on X-ray photoelectron spectroscopy, X-ray diffraction, CO_2 temperature-programmed desorption（TPD）, and H_2-TPD, the introduction of alkali metals could increase the CO_2 adsorption and decrease the H_2 chemisorption, which could suppress the formation of CH_4, enhance the production of C_（5＋）, and decrease the hydrogenation activity. Among all the promoters, the Na-modified CoCu/TiO_2 catalyst provided the maximum C_（5＋） yield of 5.4%, with a CO_2 conversion of 18.4% and C_（5＋） selectivity of42.1%, because it showed the strongest basicity and a slight decrease in the amount of H_2 desorption;it also exhibited excellent catalytic stability of more than 200 h.

关键词： Carbon dioxide hydrogenation Long-chain hydrocarbons Carbon dioxide Fischer-Tropsch synthesis Alkali metal promoters Cobalt-coper based catalysts

Novel DNA methylation markers for early detection of gastric cardia adenocarcinoma and esophageal squamous cell carcinoma

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Science China Life Sciences 2024年

作者： Zhiyuan Fan Jiajie Hao Feifan He Hao Jiang Jinwu Wang Minjuan Li xinqing Li Ru chen Wenqiang Wei Office of National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of Molecular Oncology Center for Cancer Precision MedicineNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology Linzhou Cancer Hospital Department of Orthopedic Surgery Beijing Jishuitan HospitalCapital Medical University Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University

Gastric cardia adenocarcinoma (GCA) and esophageal squamous cell carcinoma (ESCC) present significant health challenges in China,often diagnosed at advanced stages with poor ***,effective biomarkers for early detection remain *** study aimed to integrate methylome and transcriptome data to identify DNA methylation markers for the early detection of GCA and *** the discovery stage,we conducted Infinium MethylationEPIC array analysis on 36 paired GCA and non-tumor adjacent tissues (NAT),identifying differentially methylated CpG sites (DMCs) between GCA/ESCC and NAT through combined analyses of in-house and publicly available *** the validation stage,targeted pyrosequencing and quantitative real-time RT-PCR were performed on paired tumor and NAT samples from 50GCA and 50 ESCC *** the application stage,an independent set of 438 samples,including GCA,ESCC,high-and low-grade dysplasia(HGD/LGD),and normal controls,was tested for selected DMCs using *** analysis validated three GCA-specific,two ESCC-specific,and one tumor-shared DMCs,exhibiting significant hypermethylation and decreased expression of target genes in tumor samples compared with *** these DMCs,we developed a GCA-specific 4-marker panel (cg27284428,cg11798358,cg07880787,and cg00585116) with an area under the receiver operating characteristic curve (AUC) of 0.917,effectively distinguishing between cardia HGD/GCA patients and cardia LGD/normal ***,an ESCC-specific 3-marker panel (cg14633892,cg04415798,and cg00585116)achieved an AUC of 0.865 in distinguishing esophageal HGD/ESCC ***,integrating cg00585116,age,and alcohol consumption yielded a tumor-shared logistic model with good discrimination for two cancer/HGD (AUC,0.767;95%confidence interval,0.720–0.813).The mean AUC of the model after 5-fold cross-validation was *** summary,our study identifies novel DNA methylation markers capable of accurately distinguishing

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氯酚在D301树脂上吸附机理的研究

离子交换与吸附 2005年第3期21卷 209-215页

作者：李晓弢潘丙才孟凡伟陈新庆潘丙军陈金龙污染控制与资源化研究国家重点实验室南京大学环境学院南京210093 南京大学环境学院

研究了酸性条件下氯酚在大孔弱碱树脂D301上的吸附机理。研究表明,在一定的吸附质浓度及pH值下,D301树脂对对氯酚和邻氯酚的吸附量与溶液平衡浓度之间存在良好的线性关系,吸附过程类似于固相萃取过程,且分配系数与相应pH值下X射线光电... 详细信息

研究了酸性条件下氯酚在大孔弱碱树脂D301上的吸附机理。研究表明,在一定的吸附质浓度及pH值下,D301树脂对对氯酚和邻氯酚的吸附量与溶液平衡浓度之间存在良好的线性关系,吸附过程类似于固相萃取过程,且分配系数与相应pH值下X射线光电子能谱(XPS)测得的树脂上自由叔胺基团含量呈线性关系。

关键词：氯酚吸附机理 D301树脂 XPS pH值

Identification of potential immune-related mechanisms related to the development of multiple myeloma

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Chinese Medical Journal 2024年第13期137卷 1603-1613页

作者： Yaomei Wang Wenli Zhang Tiandong Li Mengmeng Liu Mengya Gao xinqing Li Yufei chen Yongping Song Wei Li Chunyan Du Fang Wang Lina Liu Department of Hematology The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China The Academy of Medical Science College of MedicalZhengzhou UniversityZhengzhouHenan 450052China College of Public Health Zhengzhou UniversityZhengzhouHenan 450000China Department of Research and Foreign Affairs The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhouHenan 450008China Department of Clinical Medicine Zhengzhou UniversityZhengzhouHenan 450052China Department of Hematology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Laboratory Animal Center School of Medical SciencesZhengzhou UniversityZhengzhouHenan 450052China

Background:Although significant advances have been made in the treatment of multiple myeloma(MM),leading to unprecedented response and survival rates among patients,the majority eventually relapse,and a cure remains *** situation is closely related to an incomplete understanding of the immune microenvironment,especially monocytes/macrophages in patients with treatment-naïve *** aim of this study was to provide insight into the immune microenvironment,especially monocytes/macrophages,in patients with treatment-naïve ***:This study used the single-cell RNA sequencing(scRNA-seq)data of both patients with MM and heathy donors to identify immune cells,including natural killer(NK)cells,T cells,dendritic cells(DCs),and monocytes/*** data and flow cytometry analysis of monocytes/macrophages were used to further examine the effect of monocytes/macrophages in treatment-naïve MM ***:A significant difference was observed between the bone marrow(BM)immune cells of the healthy controls and treatment-naïve MM patients through *** is noteworthy that,through an scRNA-seq data analysis,this study found that interferon(IFN)-induced NK/T cells,terminally differentiated effector memory(TEMRA)cells,T-helper cells characterized by expression of IFN-stimulated genes(ISG^(+)Th cells),IFN-responding exhausted T cells,mannose receptor C-type 1(MRC1)^(+)DCs,IFN-responding DCs,MHCII^(+)DCs,and immunosuppressive monocytes/macrophages were enriched in patients with treatment-naïve ***,transcriptomic data of monocytes/macrophages demonstrated that"don’t eat me"-related genes and IFN-induced genes increase in treatment-naïve MM ***,scRNA-seq,transcriptomic data,and flow cytometry also showed an increased proportion of CD16^(+)monocytes/macrophages and expression level of ***-cell communication analysis indicated that monocytes/macrophages,whose related important signaling pathways include migration i

关键词： Multiple myeloma Monocytes/macrophages Single-cell RNA sequencing Immune cell Microenvironment Bone marrow Molecular characterization

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盐对超高交联树脂吸附苯酚机理的影响

离子交换与吸附 2005年第5期21卷 406-414页

作者：潘丙军郑建中陈新庆张炜铭陶仙聪潘丙才陈一良张全兴南京210037 南京大学环境学院南京林业大学化学系污染控制与资源化研究国家重点实验室南京210093 污染控制与资源化研究国家重点实验室南京大学现代分析中心

以超高交联吸附树脂NDA-101吸附苯酚为例,研究了水溶液中无机盐(NaCl)对吸附的影响规律,探讨了可能的吸附机理,并通过吸附等温线分析及吸附热力学结果给出了合理的解释。同时采用恒定波振荡理论和吸附等温方程联合模型可以很好的拟合相... 详细信息

以超高交联吸附树脂NDA-101吸附苯酚为例,研究了水溶液中无机盐(NaCl)对吸附的影响规律,探讨了可能的吸附机理,并通过吸附等温线分析及吸附热力学结果给出了合理的解释。同时采用恒定波振荡理论和吸附等温方程联合模型可以很好的拟合相关穿透曲线。

关键词：超高交联吸附树脂苯酚盐效应吸附机理

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一种协调的科技文献分类方法

计算机工程与应用 2003年第26期39卷 91-93页

作者：陈鑫卿张永奎李荣陆山西大学计算机科学系太原030006

科技文献之间的相互引证关系反映了一种科学交流活动,显示了科学文献之间(甚至是学科之间)的内在联系,而通过追溯文献之间的这种关系,可以改善和提高传统的基于内容的科技文献的分类的方法。论文利用有相互引证关系,有同引关系,以及有... 详细信息

科技文献之间的相互引证关系反映了一种科学交流活动,显示了科学文献之间(甚至是学科之间)的内在联系,而通过追溯文献之间的这种关系,可以改善和提高传统的基于内容的科技文献的分类的方法。论文利用有相互引证关系,有同引关系,以及有耦合关系的两篇文献一般是属于同一类的这一特点,提出了文献之间的引用相似度,同引相似度,耦合相似度这三个概念,再利用这三个概念生成了文献之间的“结构相似度”,并将它用于K-NN分类法中得出一种基于结构的分类法。最后,论文将这种基于结构的分类法和基于内容的NaveBayes分类法结合起来提出了一种新的协调分类法。

关键词：分类科技文献引用同引耦合

生成式人工智能对医患共享决策的影响机制探究

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中国医学伦理学 2024年第9期37卷 1087-1092页

作者：陈安天卢军张新庆北京协和医学院/中国医学科学院/阜外医院/国家心血管病中心心内科北京100037 北京大学第三医院普通外科北京100191 北京协和医学院马克思主义学院/人文和社会科学学院北京100730

随着大型语言模型日臻成熟,以ChatGPT/GPT-4为代表的生成式人工智能(GenAI)有望深度嵌入临床决策之中。然而,GenAI的临床应用同样存在莫拉维克悖论等隐忧,WHO发布的《卫生领域人工智能的伦理与治理:多模态大模型指南》提出了大模型应用... 详细信息

随着大型语言模型日臻成熟,以ChatGPT/GPT-4为代表的生成式人工智能(GenAI)有望深度嵌入临床决策之中。然而,GenAI的临床应用同样存在莫拉维克悖论等隐忧,WHO发布的《卫生领域人工智能的伦理与治理:多模态大模型指南》提出了大模型应用于医疗领域时应遵守的六项原则。GenAI参与临床决策需要医患双方的共同参与。临床医生参与到GenAI的研发与推广应用,把控好技术发展方向。GenAI赋能患者参与决策,贴近医疗实际情况,满足患者价值选择偏好。深化GenAI可解释性、责任分配体系,赋能医患共享决策,妥善处理GenAI对传统告知与理解带来的挑战,实现临床效益最大化。

关键词：生成式人工智能临床应用医患关系共享决策伦理挑战

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技术、资本和权力对临床决策的影响机制探究

医学与哲学 2024年第6期45卷 7-10,18页

作者：仲凤行陈安天张新庆中国中医科学院医学实验中心北京100005 中国医学科学院阜外医院国家心血管病中心北京100037 北京协和医学院人文和社会科学学院北京100730

技术、资本、权力给医学决策带来了双重效应。技术至上观念的行动会忽视人文关怀,资本的逐利性诱发过度医疗,权力的误用、滥用也会削弱临床决策质量。三者间的良性互动能够推进技术的研发和临床应用,提升临床决策的方向和质量。用制度... 详细信息

技术、资本、权力给医学决策带来了双重效应。技术至上观念的行动会忽视人文关怀,资本的逐利性诱发过度医疗,权力的误用、滥用也会削弱临床决策质量。三者间的良性互动能够推进技术的研发和临床应用,提升临床决策的方向和质量。用制度、美德消解资本任性、技术至上与权力滥用;通过构筑道德防线提升认知强自律,健全制度强他律,促成人本临床决策的实现。三条道德防线彼此关联,相互作用,最终实现驾驭资本、技术、权力,促成兼顾道德规范和充分个性化临床决策的顺利实现。

关键词：技术资本权力临床伦理

基于多区域面积分方程的电大非均匀等离子体电磁特性高效计算方法

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电波科学学报 2024年第1期39卷 26-38页

作者：张慧雯陈宇浩黄晓伟盛新庆北京理工大学集成电路与电子学院射频技术与软件研究所

针对临近空间等离子体包覆目标的电磁特性快速准确评估这一迫切需求，本文运用基于多区域面积分方程(multi-region surface integral equation, MR-SIE)的全波数值计算方法，展现电大尺度、非均匀、高负介电常数等离子体的电磁散射与辐... 详细信息

针对临近空间等离子体包覆目标的电磁特性快速准确评估这一迫切需求，本文运用基于多区域面积分方程(multi-region surface integral equation, MR-SIE)的全波数值计算方法，展现电大尺度、非均匀、高负介电常数等离子体的电磁散射与辐射问题的仿真能力。首先，推导了非均匀等离子体的MR-SIE，使用间断伽辽金(discontinuous Galerkin, DG)方法提高对多区域复杂等离子体目标的建模与计算效率，研究了不同方程的数值性能；随后针对电子密度较大的高负介电常数区等离子体，运用一种简洁高效的截断策略，进一步提升了多层快速多极子算法的鲁棒性，避免了SIE计算高损耗介质内问题面临的数值不稳定性。数值实验表明，该方法在计算多种分割方式的多区域等离子体鞘套模型时具有良好的精度和效率，可用于大尺度复杂等离子体目标电磁辐射与散射特性的快速精确评估。

关键词：多区域目标面积分方程(MR-SIE) 等离子体鞘套负介电常数多层快速多极子算法(MLFMA) 间断伽辽金(DG)